Identification
HMDB Protein ID CDBP03742
Secondary Accession Numbers Not Available
Name Rab3 GTPase-activating protein non-catalytic subunit
Description Not Available
Synonyms
  1. RGAP-iso
  2. Rab3 GTPase-activating protein 150 kDa subunit
  3. Rab3-GAP p150
  4. Rab3-GAP regulatory subunit
  5. Rab3-GAP150
Gene Name RAB3GAP2
Protein Type Enzyme
Biological Properties
General Function Involved in GTPase activator activity
Specific Function Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters
GO Classification Not Available
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1q41
SNPs RAB3GAP2
Gene Sequence
>4182 bp
ATGGCCTGCTCCATTGTCCAGTTCTGCTACTTCCAGGACCTCCAGGCCGCCCGGGACTTC
CTCTTTCCTCACCTGCGGGAGGAGATCCTCAGCGGCGCCTTGCGGAGGGACCCCAGTAAA
TCAACAGACTGGGAAGATGATGGTTGGGGAGCATGGGAAGAAAATGAACCACAAGAACCT
GAAGAAGAAGGAAATACTTGCAAAACACAAAAAACTTCCTGGCTCCAAGATTGTGTTTTA
TCCTTATCTCCAACCAATGATCTTATGGTGATAGCTCGAGAGCAAAAAGCTGTATTTCTA
GTGCCAAAATGGAAATATAGTGATAAAGGAAAGGAAGAAATGCAATTTGCTGTTGGCTGG
AGTGGTTCCTTAAATGTCGAAGAAGGGGAATGTGTAACCAGTGCTCTATGTATCCCACTA
GCAAGCCAAAAGAGGAGTTCCACTGGGCGTCCTGACTGGACCTGCATTGTGGTGGGTTTT
ACTTCAGGTTATGTACGCTTCTACACTGAGAATGGTGTGCTCTTGCTTGCACAGCTTTTG
AATGAGGACCCAGTACTTCAACTTAAATGCAGAACCTATGAAATACCACGACATCCCGGC
GTGACTGAGCAGAATGAAGAGTTGAGTATCTTATATCCAGCTGCCATTGTGACTATTGAT
GGATTTAGCCTTTTTCAATCTCTTCGTGCTTGTCGAAATCAGGTAGCAAAAGCTGCAGCA
TCAGGCAACGAGAACATACAACCACCACCATTAGCTTATAAGAAATGGGGTCTACAAGAT
ATTGACACTATTATTGATCATGCTAGTGTTGGTATTATGACTCTGTCCCCCTTTGATCAA
ATGAAGACTGCCTCCAATATAGGTGGATTTAATGCAGCAATTAAAAATAGTCCACCTGCC
ATGTCTCAGTATATCACTGTAGGGTCCAATCCATTTACTGGCTTCTTCTATGCTTTAGAG
GGAAGCACACAACCATTATTATCCCATGTTGCACTAGCAGTTGCAAGTAAACTCACTTCT
GCTTTATTTAATGCTGCCAGTGGTTGGCTTGGTTGGAAAAGTAAGCACGAAGAAGAAGCT
GTCCAAAAGCAAAAGCCGAAGGTTGAGCCAGCTACCCCATTAGCTGTAAGATTTGGACTT
CCAGATTCTAGACGCCATGGTGAAAGCATATGTCTGTCTCCATGTAACACACTGGCAGCA
GTAACAGATGATTTCGGCAGAGTTATTTTATTGGATGTAGCTAGAGGAATTGCAATACGC
ATGTGGAAAGGGTACCGCGACGCACAAATTGGATGGATTCAAACTGTAGAGGACCTCCAT
GAAAGAGTGCCAGAAAAGGCAGATTTTTCCCCCTTTGGAAATTCTCAGGGTCCAAGTCGA
GTAGCTCAATTCCTTGTGATCTATGCGCCAAGAAGGGGAATTTTAGAAGTGTGGAGCACA
CAGCAGGGACCTAGAGTAGGAGCTTTCAATGTGGGGAAGCACTGCAGGCTGCTGTATCCT
GGCTATAAAATAATGGGTTTAAATAATGTTACCAGTCAGAGTTGGCAGCCACAGACTTAT
CAGATCTGTCTGGTTGATCCAGTGTCTGGAAGTGTGAAAACAGTGAACGTTCCCTTCCAT
TTAGCACTGAGTGATAAGAAGAGTGAACGAGCCAAGGATATGCACCTAGTGAAGAAACTA
GCAGCCTTACTGAAAACAAAATCTCCCAATCTTGATTTGGTTGAAACAGAAATAAAGGAA
TTAATTCTTGATATTAAATACCCTGCAACCAAAAAACAAGCTTTGGAAAGCATTTTGGCA
AGTGAACGTTTACCATTTTCTTGCCTTAGAAACATCACTCAGACTTTAATGGACACTTTA
AAAAGTCAAGAACTTGAGTCTGTTGATGAAGGATTGCTACAGTTTTGTGCCAATAAACTA
AAACTGCTGCAACTCTATGAGTCTGTCAGTCAATTAAATTCCCTTGATTTTCATTTAGAC
ACACCATTCTCTGATAATGACTTGGCTCTGTTACTAAGGCTTGATGAAAAAGAACTGCTT
AAGCTCCAGGCATTACTAGAGAAATATAAGCAAGAGAACACCAGGACAAATGTTCGATTT
TCTGATGATAAAGATGGTGTGTTGCCTGTAAAAACATTCTTGGAATATTTAGAATATGAA
AAGGATGTGCTCAACATAAAGAAAATAAGTGAAGAGGAATATGTGGCTTTAGGTAGTTTC
TTTTTTTGGAAGTGTTTGCATGGAGAAAGCTCCACTGAGGATATGTGTCACACTTTGGAG
TCGGCTGGTCTTAGCCCTCAGCTGTTGTTGTCTCTGCTCCTGAGTGTTTGGCTTTCAAAG
GAAAAGGATATTTTGGATAAACCACAGTCAATCTGCTGTCTTCATACCATGCTGTCCCTC
CTGAGCAAGATGAAAGTGGCCATCGATGAGACCTGGGATTCTCAGTCTGTGTCCCCATGG
TGGCAGCAGATGCGCACAGCCTGTATTCAGTCTGAGAACAATGGAGCCGCTCTGTTGTCT
GCGCATGTTGGGCATTCTGTTGCTGCACAGATATCAAACAACATGACAGAGAAAAAATTT
TCCCAAACAGTTTTGGGTGCTGATTCAGAGGCCCTCACTGATTCCTGGGAGGCACTTTCT
CTTGACACTGAGTACTGGAAACTCCTTCTGAAACAGCTGGAGGATTGTCTCATACTTCAG
ACTCTGCTTCACAGCAAAGGGAACACTCAGACCTCCAAAGTGTCATCACTGCAGGCTGAG
CCACTTCCAAGGCTTTCTGTTAAAAAGTTATTAGAAGGAGGAAAAGGTGGCATTGCAGAC
AGTGTAGCCAAGTGGATATTTAAACAGGACTTCAGCCCTGAAGTATTAAAACTGGCTAAT
GAAGAAAGAGATGCAGAAAACCCAGATGAACCCAAAGAAGGTGTTAACAGAAGTTTCCTT
GAGGTATCAGAGATGGAGATGGACTTAGGAGCCATACCAGACTTACTGCATTTAGCCTAT
GAGCAGTTTCCTTGTAGCCTTGAGCTCGATGTCTTGCATGCACATTGCTGCTGGGAGTAC
GTTGTTCAGTGGAATAAAGATCCAGAGGAAGCACGTTTTTTTGTTAGGTCAATAGAACAC
TTGAAGCAAATATTTAATGCACATGTTCAAAATGGCATTGCACTGATGATGTGGAATACG
TTCTTAGTTAAAAGATTTTCTGCTGCTACATACTTAATGGATAAGGTTGGAAAATCACCA
AAAGATAGGTTATGCCGAAGGGATGTGGGAATGAGTGACACAGCAATGACATCTTTCCTC
GGCTCCTGTTTGGATCTTCTTCAGATCTTAATGGAGGCAGATGTTAGCAGGGATGAAATA
CAGGTGCCTGTGCTGGATACTGAGGATGCGTGGCTCTCCGTGGAAGGACCAATCTCCATA
GTGGAACTGGCCCTTGAACAGAAGCACATCCACTACCCACTGGTGGAGCACCACTCCATC
CTGTGCTCCATCTTGTATGCAGTCATGAGGTTTTCTCTGAAGACCGTGAAGCCACTTTCA
CTTTTTGACAGTAAGGGAAAAAATGCATTTTTCAAAGACCTAACTTCAATTCAGTTATTA
CCTAGTGGGGAAATGGATCCAAATTTTATTTCTGTACGACAACAGTTCTTATTGAAAGTT
GTCAGTGCAGCTGTCCAGGCCCAACATTCAGCCACAAAGGTCAAAGATCCCACAGAAGAG
GCCACACCCACTCCTTTTGGGAAAGACCAAGATTGGCCAGCTCTAGCTGTGGATTTAGCC
CATCACCTTCAAGTTAGTGAAGATGTTGTTAGAAGGCATTATGTGGGGGAACTATACAAC
TATGGAGTTGACCACTTAGGAGAAGAGGCCATTCTACAGGTTCATGACAAAGAGGTCCTT
GCCTCTCAGCTGCTGGTGCTCACGGGGCAAAGGCTGGCTCATGCGCTTCTCCACACCCAG
ACAAAAGAAGGAATGGAGCTGCTTGCCAGACTTCCACCCACACTGTGTACTTGGCTGAAA
GCAATGGACCCCCAGGACCTTCAAAACACTGAAGTGCCAATTGCAACAACAGCTAAACTA
GTAAATAAAGTAATTGAGCTTTTACCAGAAAAACATGGGCAATATGGTCTAGCCTTACAC
CTCATTGAAGCTGTGGAAGCCATATCTCTTCCTTCTTTATGA
Protein Properties
Number of Residues 1393
Molecular Weight 155983.3
Theoretical pI 5.34
Pfam Domain Function Not Available
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Rab3 GTPase-activating protein non-catalytic subunit
MACSIVQFCYFQDLQAARDFLFPHLREEILSGALRRDPSKSTDWEDDGWGAWEENEPQEP
EEEGNTCKTQKTSWLQDCVLSLSPTNDLMVIAREQKAVFLVPKWKYSDKGKEEMQFAVGW
SGSLNVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLL
NEDPVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAA
SGNENIQPPPLAYKKWGLQDIDTIIDHASVGIMTLSPFDQMKTASNIGGFNAAIKNSPPA
MSQYITVGSNPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEA
VQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIR
MWKGYRDAQIGWIQTVEDLHERVPEKADFSPFGNSQGPSRVAQFLVIYAPRRGILEVWST
QQGPRVGAFNVGKHCRLLYPGYKIMGLNNVTSQSWQPQTYQICLVDPVSGSVKTVNVPFH
LALSDKKSERAKDMHLVKKLAALLKTKSPNLDLVETEIKELILDIKYPATKKQALESILA
SERLPFSCLRNITQTLMDTLKSQELESVDEGLLQFCANKLKLLQLYESVSQLNSLDFHLD
TPFSDNDLALLLRLDEKELLKLQALLEKYKQENTRTNVRFSDDKDGVLPVKTFLEYLEYE
KDVLNIKKISEEEYVALGSFFFWKCLHGESSTEDMCHTLESAGLSPQLLLSLLLSVWLSK
EKDILDKPQSICCLHTMLSLLSKMKVAIDETWDSQSVSPWWQQMRTACIQSENNGAALLS
AHVGHSVAAQISNNMTEKKFSQTVLGADSEALTDSWEALSLDTEYWKLLLKQLEDCLILQ
TLLHSKGNTQTSKVSSLQAEPLPRLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLAN
EERDAENPDEPKEGVNRSFLEVSEMEMDLGAIPDLLHLAYEQFPCSLELDVLHAHCCWEY
VVQWNKDPEEARFFVRSIEHLKQIFNAHVQNGIALMMWNTFLVKRFSAATYLMDKVGKSP
KDRLCRRDVGMSDTAMTSFLGSCLDLLQILMEADVSRDEIQVPVLDTEDAWLSVEGPISI
VELALEQKHIHYPLVEHHSILCSILYAVMRFSLKTVKPLSLFDSKGKNAFFKDLTSIQLL
PSGEMDPNFISVRQQFLLKVVSAAVQAQHSATKVKDPTEEATPTPFGKDQDWPALAVDLA
HHLQVSEDVVRRHYVGELYNYGVDHLGEEAILQVHDKEVLASQLLVLTGQRLAHALLHTQ
TKEGMELLARLPPTLCTWLKAMDPQDLQNTEVPIATTAKLVNKVIELLPEKHGQYGLALH
LIEAVEAISLPSL
GenBank ID Protein 20521672
UniProtKB/Swiss-Prot ID Q9H2M9
UniProtKB/Swiss-Prot Entry Name RBGPR_HUMAN
PDB IDs Not Available
GenBank Gene ID AB020646
GeneCard ID RAB3GAP2
GenAtlas ID RAB3GAP2
HGNC ID HGNC:17168
References
General References Not Available