Identification
HMDB Protein ID CDBP03606
Secondary Accession Numbers Not Available
Name FYVE, RhoGEF and PH domain-containing protein 3
Description Not Available
Synonyms
  1. Zinc finger FYVE domain-containing protein 5
Gene Name FGD3
Protein Type Metal Binding
Biological Properties
General Function Involved in Rho guanyl-nucleotide exchange factor activity
Specific Function Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape
GO Classification
Component
cell part
intracellular
Function
transition metal ion binding
zinc ion binding
enzyme regulator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
small gtpase regulator activity
ion binding
cation binding
metal ion binding
binding
ras guanyl-nucleotide exchange factor activity
rho guanyl-nucleotide exchange factor activity
Process
regulation of ras protein signal transduction
regulation of rho protein signal transduction
biological regulation
regulation of biological process
regulation of cellular process
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
Cellular Location
  1. Cytoplasm
  2. Cytoplasm (Probable)
  3. cytoskeleton (Probable)
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs FGD3
Gene Sequence
>2178 bp
ATGGAGTCAGGCAGGGGGTCCTCAACCCCTCCAGGACCCATTGCTGCCCTAGGGATGCCA
GACACTGGGCCTGGCAGTTCCTCCCTAGGGAAGCTTCAGGCGCTCCCTGTTGGGCCCAGA
GCCCACTGTGGGGACCCTGTCAGCCTGGCTGCAGCAGGGGACGGCTCTCCAGACATAGGC
CCCACGGGAGAGCTGAGTGGTAGCTTAAAGATCCCCAACCGGGACAGCGGGATCGACAGT
CCCTCCTCCAGTGTGGCTGGAGAGAACTTTCCCTGCGAGGAGGGCTTGGAGGCTGGCCCA
AGCCCCACTGTACTGGGGGCGCACGCAGAGATGGCCCTGGACAGCCAGGTCCCGAAGGTC
ACCCCCCAGGAGGAGGCGGACAGCGACGTGGGTGAGGAACCTGACTCTGAGAACACCCCC
CAGAAGGCTGACAAGGATGCCGGCCTGGCCCAGCACTCTGGCCCCCAGAAGCTTCTCCAC
ATTGCCCAGGAGCTCCTGCACACCGAGGAGACCTATGTGAAGCGGCTGCACCTGCTGGAC
CAGGTTTTCTGCACCAGGCTGACGGATGCGGGGATCCCTCCAGAAGTCATCATGGGCATA
TTCTCTAACATCTCCTCCATCCACCGCTTCCACGGGCAGTTCCTGCTGCCGGAGCTGAAG
ACGCGGATCACGGAGGAGTGGGACACAAACCCACGGCTCGGGGACATCCTGCAGAAGCTG
GCCCCATTCCTGAAGATGTACGGCGAGTATGTCAAGAACTTTGACCGAGCCGTAGGGCTG
GTGAGCACGTGGACCCAGCGCTCCCCACTGTTTAAAGACGTCGTCCACAGCATCCAGAAG
CAGGAGGTATGCGGGAACCTGACGCTGCAGCACCACATGCTGGAGCCCGTGCAGAGGGTC
CCCCGGTACGAGCTGCTGCTCAAGGACTATCTGAAGAGGCTCCCGCAGGACGCCCCAGAC
CGGAAGGATGCGGAGAGGTCCTTGGAGCTCATCTCCACAGCCGCCAACCACTCCAATGCT
GCCATTCGGAAAGTGGAGAAAATGCACAAGCTCTTGGAGGTGTACGAGCAGCTGGGTGGG
GAAGAAGACATTGTCAACCCGGCCAATGAACTGATCAAGGAGGGCCAAATCCAGAAACTG
TCAGCCAAGAACGGCACCCCCCAGGACCGCCACCTCTTCCTGTTCAACAGCATGATCCTT
TACTGTGTGCCCAAGCTGCGGCTCATGGGCCAGAAGTTCAGCGTCCGGGAGAAGATGGAC
ATCTCAGGCCTCCAGGTGCAGGATATCGTCAAGCCAAACACAGCACATACATTCATCATA
ACAGGAAGAAAAAGGTCCCTGGAGCTGCAGACGCGGACAGAGGAAGAGAAGAAAGAATGG
ATTCAGATCATCCAGGCCACCATCGAGAAGCACAAACAGAACAGCGAAACCTTCAAGGCT
TTTGGTGGCGCCTTCAGCCAGGATGAGGACCCCAGCCTCTCTCCAGACATGCCTATCACG
AGCACCAGCCCTGTGGAGCCTGTGGTGACCACCGAAGGCAGTTCGGGTGCAGCAGGGCTC
GAGCCCAGAAAACTATCCTCTAAGACCAGACGTGACAAGGAGAAGCAGAGCTGTAAGAGC
TGTGGTGAGACCTTCAACTCCATCACCAAGAGGAGGCATCACTGCAAGCTGTGTGGGGCG
GTCATCTGTGGGAAGTGCTCCGAGTTCAAGGCCGAGAACAGCCGGCAGAGCCGTGTCTGC
AGAGATTGTTTCCTGACACAGCCAGTGGCCCCTGAGAGCACAGAGAAGACACCCACTGCA
GACCCCCAGCCCAGCCTGCTCTGCGGCCCCCTGCGGCTGTCAGAGAGCGGTGAGACCTGG
AGCGAGGTGTGGGCCGCCATCCCCATGTCAGATCCCCAGGTGCTGCACCTGCAGGGAGGC
AGCCAGGACGGCCGGCTGCCCCGCACCATCCCTCTCCCCAGCTGCAAACTGAGTGTGCCG
GACCCTGAGGAGAGGCTGGACTCGGGGCATGTGTGGAAGCTGCAGTGGGCCAAGCAGTCC
TGGTACCTGAGCGCCTCCTCCGCAGAGCTGCAGCAGCAGTGGCTGGAAACCCTAAGCACT
GCTGCCCATGGGGACACGGCCCAGGACAGCCCGGGGGCCCTGCAGCTTCAGGTCCCTATG
GGCGCAGCTGCTCCGTGA
Protein Properties
Number of Residues 725
Molecular Weight 79400.1
Theoretical pI 6.08
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>FYVE, RhoGEF and PH domain-containing protein 3
MESGRGSSTPPGPIAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIG
PTGELSGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEAGPSPTVLGAHAEMALDSQVPKV
TPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLD
QVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKL
APFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRV
PRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGG
EEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMD
ISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQNSETFKA
FGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRRDKEKQSCKS
CGETFNSITKRRHHCKLCGAVICGKCSEFKAENSRQSRVCRDCFLTQPVAPESTEKTPTA
DPQPSLLCGPLRLSESGETWSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSVP
DPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETLSTAAHGDTAQDSPGALQLQVPM
GAAAP
GenBank ID Protein 57209237
UniProtKB/Swiss-Prot ID Q5JSP0
UniProtKB/Swiss-Prot Entry Name FGD3_HUMAN
PDB IDs Not Available
GenBank Gene ID AL389924
GeneCard ID FGD3
GenAtlas ID FGD3
HGNC ID HGNC:16027
References
General References Not Available