Cannabis Compound Database: Showing Protein FYVE, RhoGEF and PH domain-containing protein 3 (CDBP03606)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03606

Secondary Accession Numbers

Not Available

Name

FYVE, RhoGEF and PH domain-containing protein 3

Description

Not Available

Synonyms

Zinc finger FYVE domain-containing protein 5

Gene Name

FGD3

Protein Type

Metal Binding

Biological Properties

General Function

Involved in Rho guanyl-nucleotide exchange factor activity

Specific Function

Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape

GO Classification

Component
cell part
intracellular
Function
transition metal ion binding
zinc ion binding
enzyme regulator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
small gtpase regulator activity
ion binding
cation binding
metal ion binding
binding
ras guanyl-nucleotide exchange factor activity
rho guanyl-nucleotide exchange factor activity
Process
regulation of ras protein signal transduction
regulation of rho protein signal transduction
biological regulation
regulation of biological process
regulation of cellular process
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction

Cellular Location

Cytoplasm
Cytoplasm (Probable)
cytoskeleton (Probable)

Pathways

Not Available

Gene Properties

Chromosome Location

Not Available

Locus

Not Available

SNPs

FGD3

Gene Sequence

>2178 bp
ATGGAGTCAGGCAGGGGGTCCTCAACCCCTCCAGGACCCATTGCTGCCCTAGGGATGCCA
GACACTGGGCCTGGCAGTTCCTCCCTAGGGAAGCTTCAGGCGCTCCCTGTTGGGCCCAGA
GCCCACTGTGGGGACCCTGTCAGCCTGGCTGCAGCAGGGGACGGCTCTCCAGACATAGGC
CCCACGGGAGAGCTGAGTGGTAGCTTAAAGATCCCCAACCGGGACAGCGGGATCGACAGT
CCCTCCTCCAGTGTGGCTGGAGAGAACTTTCCCTGCGAGGAGGGCTTGGAGGCTGGCCCA
AGCCCCACTGTACTGGGGGCGCACGCAGAGATGGCCCTGGACAGCCAGGTCCCGAAGGTC
ACCCCCCAGGAGGAGGCGGACAGCGACGTGGGTGAGGAACCTGACTCTGAGAACACCCCC
CAGAAGGCTGACAAGGATGCCGGCCTGGCCCAGCACTCTGGCCCCCAGAAGCTTCTCCAC
ATTGCCCAGGAGCTCCTGCACACCGAGGAGACCTATGTGAAGCGGCTGCACCTGCTGGAC
CAGGTTTTCTGCACCAGGCTGACGGATGCGGGGATCCCTCCAGAAGTCATCATGGGCATA
TTCTCTAACATCTCCTCCATCCACCGCTTCCACGGGCAGTTCCTGCTGCCGGAGCTGAAG
ACGCGGATCACGGAGGAGTGGGACACAAACCCACGGCTCGGGGACATCCTGCAGAAGCTG
GCCCCATTCCTGAAGATGTACGGCGAGTATGTCAAGAACTTTGACCGAGCCGTAGGGCTG
GTGAGCACGTGGACCCAGCGCTCCCCACTGTTTAAAGACGTCGTCCACAGCATCCAGAAG
CAGGAGGTATGCGGGAACCTGACGCTGCAGCACCACATGCTGGAGCCCGTGCAGAGGGTC
CCCCGGTACGAGCTGCTGCTCAAGGACTATCTGAAGAGGCTCCCGCAGGACGCCCCAGAC
CGGAAGGATGCGGAGAGGTCCTTGGAGCTCATCTCCACAGCCGCCAACCACTCCAATGCT
GCCATTCGGAAAGTGGAGAAAATGCACAAGCTCTTGGAGGTGTACGAGCAGCTGGGTGGG
GAAGAAGACATTGTCAACCCGGCCAATGAACTGATCAAGGAGGGCCAAATCCAGAAACTG
TCAGCCAAGAACGGCACCCCCCAGGACCGCCACCTCTTCCTGTTCAACAGCATGATCCTT
TACTGTGTGCCCAAGCTGCGGCTCATGGGCCAGAAGTTCAGCGTCCGGGAGAAGATGGAC
ATCTCAGGCCTCCAGGTGCAGGATATCGTCAAGCCAAACACAGCACATACATTCATCATA
ACAGGAAGAAAAAGGTCCCTGGAGCTGCAGACGCGGACAGAGGAAGAGAAGAAAGAATGG
ATTCAGATCATCCAGGCCACCATCGAGAAGCACAAACAGAACAGCGAAACCTTCAAGGCT
TTTGGTGGCGCCTTCAGCCAGGATGAGGACCCCAGCCTCTCTCCAGACATGCCTATCACG
AGCACCAGCCCTGTGGAGCCTGTGGTGACCACCGAAGGCAGTTCGGGTGCAGCAGGGCTC
GAGCCCAGAAAACTATCCTCTAAGACCAGACGTGACAAGGAGAAGCAGAGCTGTAAGAGC
TGTGGTGAGACCTTCAACTCCATCACCAAGAGGAGGCATCACTGCAAGCTGTGTGGGGCG
GTCATCTGTGGGAAGTGCTCCGAGTTCAAGGCCGAGAACAGCCGGCAGAGCCGTGTCTGC
AGAGATTGTTTCCTGACACAGCCAGTGGCCCCTGAGAGCACAGAGAAGACACCCACTGCA
GACCCCCAGCCCAGCCTGCTCTGCGGCCCCCTGCGGCTGTCAGAGAGCGGTGAGACCTGG
AGCGAGGTGTGGGCCGCCATCCCCATGTCAGATCCCCAGGTGCTGCACCTGCAGGGAGGC
AGCCAGGACGGCCGGCTGCCCCGCACCATCCCTCTCCCCAGCTGCAAACTGAGTGTGCCG
GACCCTGAGGAGAGGCTGGACTCGGGGCATGTGTGGAAGCTGCAGTGGGCCAAGCAGTCC
TGGTACCTGAGCGCCTCCTCCGCAGAGCTGCAGCAGCAGTGGCTGGAAACCCTAAGCACT
GCTGCCCATGGGGACACGGCCCAGGACAGCCCGGGGGCCCTGCAGCTTCAGGTCCCTATG
GGCGCAGCTGCTCCGTGA

Protein Properties

Number of Residues

725

Molecular Weight

79400.1

Theoretical pI

6.08

Pfam Domain Function

PH (PF00169 )
FYVE (PF01363 )
RhoGEF (PF00621 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>FYVE, RhoGEF and PH domain-containing protein 3
MESGRGSSTPPGPIAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIG
PTGELSGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEAGPSPTVLGAHAEMALDSQVPKV
TPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLD
QVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKL
APFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRV
PRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGG
EEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMD
ISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQNSETFKA
FGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRRDKEKQSCKS
CGETFNSITKRRHHCKLCGAVICGKCSEFKAENSRQSRVCRDCFLTQPVAPESTEKTPTA
DPQPSLLCGPLRLSESGETWSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSVP
DPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETLSTAAHGDTAQDSPGALQLQVPM
GAAAP

External Links

GenBank ID Protein

57209237

UniProtKB/Swiss-Prot ID

Q5JSP0

UniProtKB/Swiss-Prot Entry Name

FGD3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AL389924

GeneCard ID