| Identification |
|---|
| HMDB Protein ID
| CDBP02000 |
| Secondary Accession Numbers
| Not Available |
| Name
| Uridine-cytidine kinase 2 |
| Description
| Not Available |
| Synonyms
|
- Cytidine monophosphokinase 2
- Testis-specific protein TSA903
- UCK 2
- Uridine monophosphokinase 2
|
| Gene Name
| UCK2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
|
| GO Classification
|
| Biological Process |
| CTP salvage |
| UMP salvage |
| cellular response to oxygen levels |
| feeding behavior |
| response to axon injury |
| pyrimidine nucleoside salvage |
| pyrimidine nucleobase metabolic process |
| Cellular Component |
| cytosol |
| Function |
| phosphotransferase activity, alcohol group as acceptor |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| Molecular Function |
| phosphotransferase activity, alcohol group as acceptor |
| ATP binding |
| nucleoside kinase activity |
| uridine kinase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | UMP biosynthesis via salvage pathway | Not Available | Not Available | | CTP biosynthesis via salvage pathway | Not Available | Not Available | | Drug metabolism - other enzymes | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q23 |
| SNPs
| UCK2 |
| Gene Sequence
|
>786 bp
ATGGCCGGGGACAGCGAGCAGACCCTGCAGAACCACCAGCAGCCCAACGGCGGCGAGCCC
TTCCTTATAGGCGTCAGCGGGGGAACAGCTAGCGGCAAGTCTTCCGTGTGTGCTAAGATC
GTGCAGCTCCTGGGGCAGAATGAGGTGGACTATCGCCAGAAGCAGGTGGTCATCCTGAGC
CAGGATAGCTTCTACCGTGTCCTTACCTCGGAGCAGAAGGCCAAAGCCCTGAAGGGCCAG
TTCAACTTTGACCACCCGGATGCCTTTGACAATGAACTCATTCTCAAAACACTCAAAGAA
ATCACTGAAGGGAAAACAGTCCAGATCCCCGTGTATGACTTTGTCTCCCATTCCCGGAAG
GAGGAGACAGTTACTGTCTATCCCGCAGACGTGGTGCTCTTTGAAGGGATCCTGGCCTTC
TACTCCCAGGAGGTACGAGACCTGTTCCAGATGAAGCTTTTTGTGGATACAGATGCGGAC
ACCCGGCTCTCACGCAGAGTATTAAGGGACATCAGCGAGAGAGGCAGGGATCTTGAGCAG
ATTTTATCTCAGTACATTACGTTCGTCAAGCCTGCCTTTGAGGAATTCTGCTTGCCAACA
AAGAAGTATGCTGATGTGATCATCCCTAGAGGTGCAGATAATCTGGTGGCCATCAACCTC
ATCGTGCAGCACATCCAGGACATCCTGAATGGAGGGCCCTCCAAACGGCAGACCAATGGC
TGTCTCAACGGCTACACCCCTTCACGCAAGAGGCAGGCATCGGAGTCCAGCAGCAGGCCG
CATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 261 |
| Molecular Weight
| 29298.92 |
| Theoretical pI
| 6.698 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Uridine-cytidine kinase 2
MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILS
QDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRK
EETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQ
ILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNGGPSKRQTNG
CLNGYTPSRKRQASESSSRPH
|
| External Links |
|---|
| GenBank ID Protein
| 18699734 |
| UniProtKB/Swiss-Prot ID
| Q9BZX2 |
| UniProtKB/Swiss-Prot Entry Name
| UCK2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_012474.3 |
| GeneCard ID
| UCK2 |
| GenAtlas ID
| UCK2 |
| HGNC ID
| HGNC:12562 |
| References |
|---|
| General References
| Not Available |