| Identification |
|---|
| HMDB Protein ID
| CDBP03673 |
| Secondary Accession Numbers
| Not Available |
| Name
| Importin subunit alpha-6 |
| Description
| Not Available |
| Synonyms
|
- Karyopherin subunit alpha-5
|
| Gene Name
| KPNA5 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non- classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS |
| GO Classification
|
| Component |
| nuclear pore |
| organelle part |
| intracellular organelle part |
| nuclear part |
| cell part |
| intracellular part |
| cytoplasm |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| Function |
| binding |
| protein transporter activity |
| transporter activity |
| substrate-specific transporter activity |
| Process |
| establishment of localization |
| transport |
| protein transport |
| protein import into nucleus |
| intracellular protein transport |
| protein targeting |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q22.1 |
| SNPs
| KPNA5 |
| Gene Sequence
|
>1611 bp
ATGGCTAGTCCAGGGAAAGATAACTATAGAATGAAAAGTTATAAGAATAAAGCCCTAAAT
CCTCAAGAGATGCGTAGACGAAGAGAAGAAGAAGGAATACAGCTTAGAAAACAAAAAAGA
GAAGAACAGTTGTTCAAACGCAGAAATGTCTATTTGCCCAGAAATGATGAATCTATGCTT
GAAAGTCCTATACAGGATTCAGATATTAGTTCCACTGTACCCATTCCAGAGGAAGGAGTT
GTTACTACAGATATGGTTCAAATGATTTTTTCTAATAATGCTGATCAACAGCTAACAGCA
ACACAGAAATTTAGAAAGCTGCTTTCTAAAGAACCTAATCCACCAATAGATCAAGTTATA
CAGAAACCAGGAGTTGTACAGAGATTTGTGAAATTTCTTGAAAGAAATGAAAATTGCACT
TTACAATTTGAAGCTGCATGGGCATTAACAAATATAGCATCTGGAACTTTTCTGCATACC
AAGGTAGTGATTGAAACTGGGGCTGTTCCGATTTTTATCAAACTTCTTAATTCTGAACAT
GAAGATGTTCAGGAACAGGCTGTTTGGGCACTTGGTAATATTGCTGGTGACAATGCAGAA
TGCAGAGATTTTGTTTTGAATTGTGAAATACTTCCACCTCTTTTAGAGTTATTAACAAAT
TCAAACAGACTCACAACAACAAGAAATGCCGTGTGGGCCCTCTCAAATTTATGTAGAGGC
AAAAACCCTCCTCCAAACTTTAGTAAGGTTTCACCTTGCTTAAATGTCCTGTCACGACTG
TTGTTTAGCAGTGACCCAGATGTGTTAGCAGACGTGTGTTGGGCCCTTTCTTATCTTTCC
GATGGACCCAATGATAAAATTCAAGCAGTCATTGATTCTGGAGTCTGTCGAAGATTGGTG
GAACTTTTGATGCACAATGATTATAAAGTTGTATCACCTGCATTAAGGGCAGTTGGTAAT
ATTGTGACTGGTGATGATATTCAAACACAGGTAATTTTGAATTGTTCTGCATTACCCTGT
CTCTTACATTTATTGAGTAGCCCAAAGGAGTCAATTAGAAAAGAAGCCTGCTGGACTGTT
TCTAACATCACTGCTGGAAATAGAGCTCAGATTCAGGCTGTTATAGATGCAAATATTTTT
CCTGTTTTGATTGAGATTCTTCAGAAAGCAGAGTTTCGTACCAGAAAAGAAGCAGCTTGG
GCTATAACTAATGCAACATCAGGAGGTACTCCAGAGCAAATAAGGTATTTGGTAGCTTTA
GGCTGCATTAAACCACTTTGTGATCTTTTGACTGTTATGGACTCCAAAATAGTCCAAGTG
GCTTTAAATGGACTTGAAAATATTTTACGTCTTGGAGAACAAGAATCTAAGCAGAATGGA
ATAGGCATTAATCCATACTGTGCTCTCATTGAAGAAGCATATGGTCTGGATAAAATTGAG
TTTTTGCAAAGCCATGAAAATCAGGAAATTTACCAGAAGGCATTTGATCTGATTGAACAT
TACTTTGGTGTAGAAGAAGATGACCCCAGCATTGTACCTCAGGTGGATGAAAACCAACAA
CAGTTTATATTTCAGCAGCAGGAAGCACCAATGGATGGATTTCAACTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 536 |
| Molecular Weight
| 60348.4 |
| Theoretical pI
| 4.8 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Importin subunit alpha-6
MASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESML
ESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVI
QKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEH
EDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRG
KNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLV
ELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTV
SNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVAL
GCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIE
FLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL
|
| External Links |
|---|
| GenBank ID Protein
| 2343116 |
| UniProtKB/Swiss-Prot ID
| O15131 |
| UniProtKB/Swiss-Prot Entry Name
| IMA5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF005361 |
| GeneCard ID
| KPNA5 |
| GenAtlas ID
| KPNA5 |
| HGNC ID
| HGNC:6398 |
| References |
|---|
| General References
| Not Available |