| Identification |
|---|
| HMDB Protein ID
| CDBP03709 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphatidylinositol 4-kinase type 2-beta |
| Description
| Not Available |
| Synonyms
|
- PI4KII-BETA
- Phosphatidylinositol 4-kinase type II-beta
|
| Gene Name
| PI4K2B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphotransferase activity, alcohol group as acceptor |
| Specific Function
| Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking |
| GO Classification
|
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| phosphotransferase activity, alcohol group as acceptor |
|
| Cellular Location
|
- Cytoplasm
- Membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4p15.2 |
| SNPs
| PI4K2B |
| Gene Sequence
|
>1446 bp
ATGGAGGATCCCTCCGAGCCCGACCGGTTGGCGTCCGCGGACGGCGGGAGCCCGGAGGAG
GAGGAGGATGGGGAGCGGGAGCCGCTGCTACCGCGGATCGCCTGGGCCCACCCGCGGAGA
GGCGCCCCAGGCAGCGCCGTGAGGCTGCTGGACGCTGCCGGGGAGGAGGGCGAGGCCGGC
GACGAGGAGCTGCCCCTCCCGCCCGGGGACGTGGGGGTCTCCCGGAGTTCGCCCGCCGAG
CTGGACCGGAGCCGCCCCGCGGTTTCAGTAACTATTGGTACTTCAGAGATGAATGCATTC
TTGGATGACCCAGAATTTGCTGATATTATGCTGAGAGCAGAGCAAGCAATAGAAGTTGGA
ATTTTTCCAGAAAGAATCTCTCAAGGTTCAAGTGGAAGTTACTTTGTGAAGGATCCTAAG
AGGAAAATTATTGGTGTGTTTAAACCCAAATCAGAAGAGCCTTATGGTCAACTCAATCCA
AAATGGACCAAATATGTCCATAAGGTCTGCTGCCCTTGCTGCTTTGGCCGAGGCTGCCTG
ATTCCTAATCAGGGGTACCTTTCCGAAGCGGGTGCCTATCTTGTGGACAACAAGCTTCAT
CTGAGCATTGTACCTAAAACAAAGGTGGTTTGGCTTGTCAGTGAGACATTTAACTATAAT
GCGATTGACCGTGCAAAATCAAGAGGCAAAAAGTATGCTTTAGAAAAAGTGCCAAAAGTG
GGTAGAAAGTTTCATAGGATAGGACTCCCTCCTAAGATTGGTTCCTTTCAGTTATTTGTT
GAAGGTTACAAGGAGGCTGAATATTGGCTTAGGAAATTTGAAGCTGACCCTTTGCCTGAG
AATATTAGAAAACAATTTCAGTCACAATTTGAAAGATTAGTTATTTTGGATTACATCATC
AGAAATACAGACAGGGGCAATGATAATTGGTTAGTCAGATACGAAAAGCAGAAATGTGAA
AAGGAAATTGACCATAAGGAATCAAAATGGATTGATGATGAAGAATTCCTTATTAAAATA
GCTGCAATTGATAATGGTCTAGCATTTCCTTTTAAACATCCTGATGAATGGAGAGCATAT
CCATTTCACTGGGCTTGGCTTCCTCAAGCAAAAGTTCCCTTTTCTGAAGAAATAAGAAAT
TTGATTCTACCATATATTTCTGACATGAACTTTGTGCAAGATTTATGTGAAGATCTCTAT
GAACTTTTTAAGACTGACAAAGGATTTGACAAAGCCACTTTTGAAAGTCAGATGTCTGTG
ATGAGGGGTCAGATCTTAAACCTTACTCAGGCATTGAGAGACGGGAAGAGTCCTTTCCAG
CTAGTACAGATACCTTGTGTGATTGTGGAACGCAGTCAAGGTGGAAGTCAGGGTCGGATT
GTCCACCTGAGCAATTCCTTTACCCAGACTGTCAATTGCAGGAAGCCATTTTTTTCCTCC
TGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 481 |
| Molecular Weight
| 54743.7 |
| Theoretical pI
| 5.77 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Phosphatidylinositol 4-kinase type 2-beta
MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAHPRRGAPGSAVRLLDAAGEEGEAG
DEELPLPPGDVGVSRSSSAELDRSRPAVSVTIGTSEMNAFLDDPEFADIMLRAEQAIEVG
IFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCL
IPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSETFNYNAIDRAKSRGKKYALEKVPKV
GRKFHRIGLPPKIGSFQLFVEGYKEAEYWLRKFEADPLPENIRKQFQSQFERLVILDYII
RNTDRGNDNWLVRYEKQKCEKEIDHKESKWIDDEEFLIKIAAIDNGLAFPFKHPDEWRAY
PFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDLCEDLYELFKTDKGFDKATFESQMSV
MRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGGSQGRIVHLSNSFTQTVNCRKPFFSS
W
|
| External Links |
|---|
| GenBank ID Protein
| 15625544 |
| UniProtKB/Swiss-Prot ID
| Q8TCG2 |
| UniProtKB/Swiss-Prot Entry Name
| P4K2B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF411320 |
| GeneCard ID
| PI4K2B |
| GenAtlas ID
| PI4K2B |
| HGNC ID
| HGNC:18215 |
| References |
|---|
| General References
| Not Available |