Cannabis Compound Database: Showing Protein Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] (CDBP00588)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP00588

Secondary Accession Numbers

Not Available

Name

Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Description

Not Available

Synonyms

Ap4A hydrolase
Ap4Aase
Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase
Diadenosine tetraphosphatase
Nucleoside diphosphate-linked moiety X motif 2
Nudix motif 2

Gene Name

NUDT2

Protein Type

Enzyme

Biological Properties

General Function

Involved in hydrolase activity

Specific Function

Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.

GO Classification

Biological Process
induction of apoptosis
nucleobase-containing compound metabolic process
Cellular Component
mitochondrion
Function
pyrophosphatase activity
catalytic activity
hydrolase activity
nucleotide diphosphatase activity
bis(5'-nucleosyl)-tetraphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Molecular Function
GTP binding
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

Cellular Location

Cytoplasmic

Pathways

Name	SMPDB/Pathwhiz	KEGG
Purine Metabolism
Adenosine Deaminase Deficiency		Not Available
Adenylosuccinate Lyase Deficiency		Not Available
Gout or Kelley-Seegmiller Syndrome		Not Available
Lesch-Nyhan Syndrome (LNS)		Not Available

Gene Properties

Chromosome Location

Locus

9p13

SNPs

NUDT2

Gene Sequence

>444 bp
ATGGCCTTGAGAGCATGTGGCTTGATCATCTTCCGAAGATGCCTCATTCCCAAAGTGGAC
AACAATGCAATTGAGTTTTTACTGCTGCAGGCATCAGATGGCATTCATCACTGGACTCCT
CCCAAAGGCCATGTGGAACCAGGAGAGGATGACTTGGAAACAGCCCTGAGGGAGACCCAA
GAGGAAGCAGGCATAGAAGCAGGCCAGCTGACCATTATTGAGGGGTTCAAAAGGGAACTC
AATTATGTGGCCAGGAACAAGCCTAAAACAGTCATTTACTGGCTGGCGGAGGTGAAGGAC
TATGACGTGGAGATCCGCCTCTCCCATGAGCACCAAGCCTACCGCTGGCTGGGGCTGGAG
GAGGCCTGCCAGTTGGCTCAGTTCAAGGAGATGAAGGCAGCGCTCCAAGAAGGACACCAG
TTTCTTTGCTCCATAGAGGCCTGA

Protein Properties

Number of Residues

147

Molecular Weight

16829.09

Theoretical pI

5.354

Pfam Domain Function

NUDIX (PF00293 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
MALRACGLIIFRRCLIPKVDNNAIEFLLLQASDGIHHWTPPKGHVEPGEDDLETALRETQ
EEAGIEAGQLTIIEGFKRELNYVARNKPKTVIYWLAEVKDYDVEIRLSHEHQAYRWLGLE
EACQLAQFKEMKAALQEGHQFLCSIEA

External Links

GenBank ID Protein

55958893

UniProtKB/Swiss-Prot ID

P50583

UniProtKB/Swiss-Prot Entry Name

AP4A_HUMAN

PDB IDs