Identification
HMDB Protein ID CDBP04965
Secondary Accession Numbers Not Available
Name Ras guanyl-releasing protein 3
Description Not Available
Synonyms
  1. Calcium and DAG-regulated guanine nucleotide exchange factor III
  2. Guanine nucleotide exchange factor for Rap1
Gene Name RASGRP3
Protein Type Metal Binding
Biological Properties
General Function Involved in calcium ion binding
Specific Function Guanine nucleotide exchange factor (GEF) for Ras and Rap1
GO Classification
Component
intracellular
cell part
Function
ion binding
cation binding
metal ion binding
binding
enzyme regulator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
guanyl-nucleotide exchange factor activity
calcium ion binding
Process
signaling pathway
intracellular signal transduction
small gtpase mediated signal transduction
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
intracellular signaling pathway
signaling
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 2p25.1-p24.1
SNPs RASGRP3
Gene Sequence
>2073 bp
ATGGGATCAAGTGGCCTTGGGAAAGCAGCAACATTAGATGAACTGCTGTGCACTTGCATT
GAGATGTTTGATGACAATGGAGAGCTGGATAATAGTTATTTGCCAAGAATAGTTCTACTG
ATGCACCGATGGTATTTATCTTCCACTGAATTGGCAGAAAAACTTCTCTGCATGTATCGA
AATGCCACTGGAGAAAGCTGCAATGAATTTCGATTAAAGATCTGCTACTTCATGAGGTAC
TGGATTCTGAAGTTTCCTGCAGAGTTTAATTTGGATCTTGGTTTGATTCGTATGACTGAG
GAATTTCGGGAAGTAGCTAGTCAACTAGGATATGAAAAACACGTCAGCCTCATCGACATA
TCCAGCATTCCTTCCTATGACTGGATGAGAAGAGTCACACAGAGGAAAAAAGTATCCAAG
AAGGGAAAAGCCTGTCTGCTGTTTGACCATCTGGAGCCCATTGAATTGGCTGAGCACCTC
ACTTTTCTGGAGCATAAATCTTTTAGAAGGATCTCATTCACTGATTACCAAAGCTATGTC
ATCCATGGCTGCCTGGAGAATAATCCAACCTTGGAAAGATCGATTGCTTTATTTAATGGA
ATCTCTAAGTGGGTCCAGTTGATGGTTCTTAGCAAACCAACCCCCCAGCAAAGGGCAGAA
GTCATCACAAAGTTTATCAATGTTGCAAAGAAGCTCCTTCAGCTCAAAAATTTTAACACC
CTGATGGCAGTGGTGGGAGGCCTCAGTCATAGTTCCATTTCACGCCTCAAAGAGACCCAT
TCTCATCTTTCTTCAGAAGTTACAAAGAACTGGAATGAAATGACAGAGTTGGTCTCCTCC
AACGGCAATTACTGCAATTACCGCAAGGCCTTTGCCGACTGCGATGGCTTCAAAATCCCC
ATCCTTGGAGTACACTTGAAAGACTTGATAGCTGTCCATGTCATTTTCCCAGACTGGACA
GAGGAGAACAAAGTGAACATTGTGAAAATGCACCAGCTCTCCGTTACCCTGAGTGAACTA
GTCTCCCTGCAGAATGCCTCTCACCACTTAGAACCCAACATGGATTTGATCAACCTGCTC
ACGCTTTCCCTGGACCTCTATCACACTGAAGATGATATTTACAAACTGTCACTGGTGCTG
GAGCCTAGAAATTCTAAATCGCAGCCTACCTCCCCTACGACGCCCAACAAGCCTGTGGTA
CCCCTGGAGTGGGCATTAGGGGTGATGCCAAAGCCAGACCCCACGGTCATCAACAAGCAC
ATAAGGAAATTAGTGGAGTCTGTATTTAGAAACTATGATCACGACCATGATGGGTACATT
TCCCAAGAGGACTTTGAAAGTATAGCTGCCAATTTTCCCTTCTTGGATTCCTTCTGTGTT
CTGGACAAAGATCAGGATGGCCTAATTAGTAAAGATGAAATGATGGCTTACTTCCTGAGA
GCTAAATCCCAACTACACTGTAAAATGGGACCAGGATTTATCCATAATTTTCAGGAGATG
ACCTATCTCAAGCCAACCTTCTGCGAACACTGTGCGGGATTTCTCTGGGGCATAATCAAG
CAAGGATACAAATGCAAAGACTGTGGAGCCAATTGTCACAAACAGTGCAAAGACCTCCTG
GTTCTGGCCTGCAGGAGATTTGCCCGGGCGCCCTCCTTGAGCAGTGGTCATGGGTCACTG
CCTGGAAGCCCCTCGCTGCCCCCAGCGCAGGATGAGGTGTTTGAGTTCCCTGGAGTCACT
GCTGGACACAGGGATTTAGACAGCAGAGCCATCACACTGGTTACAGGCTCTTCTCGCAAG
ATCTCTGTGAGGCTACAGAGGGCCACCACCAGCCAGGCCACCCAGACTGAACCTGTCTGG
TCAGAGGCTGGCTGGGGGGACTCGGGGTCCCACACCTTCCCTAAAATGAAATCCAAGTTC
CATGACAAAGCAGCAAAGGACAAAGGCTTTGCCAAATGGGAAAATGAGAAGCCCAGGGTG
CATGCTGGTGTGGATGTTGTAGACCGGGGCACGGAGTTTGAACTTGACCAGGATGAAGGA
GAAGAGACCAGACAGGATGGTGAGGATGGCTGA
Protein Properties
Number of Residues 690
Molecular Weight 78330.9
Theoretical pI 6.79
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Ras guanyl-releasing protein 3
MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR
NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI
SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV
IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT
LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP
ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL
TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH
IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR
AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL
VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK
ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV
HAGVDVVDRGTEFELDQDEGEETRQDGEDG
GenBank ID Protein 213385270
UniProtKB/Swiss-Prot ID Q8IV61
UniProtKB/Swiss-Prot Entry Name GRP3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001139488.1
GeneCard ID RASGRP3
GenAtlas ID RASGRP3
HGNC ID HGNC:14545
References
General References Not Available