Identification |
HMDB Protein ID
| CDBP03605 |
Secondary Accession Numbers
| Not Available |
Name
| FYVE, RhoGEF and PH domain-containing protein 2 |
Description
| Not Available |
Synonyms
|
- Zinc finger FYVE domain-containing protein 4
|
Gene Name
| FGD2 |
Protein Type
| Metal Binding |
Biological Properties |
General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
Specific Function
| Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate |
GO Classification
|
Component |
cell part |
intracellular |
Function |
enzyme regulator activity |
nucleoside-triphosphatase regulator activity |
gtpase regulator activity |
small gtpase regulator activity |
ion binding |
cation binding |
metal ion binding |
binding |
ras guanyl-nucleotide exchange factor activity |
rho guanyl-nucleotide exchange factor activity |
transition metal ion binding |
zinc ion binding |
Process |
regulation of ras protein signal transduction |
regulation of rho protein signal transduction |
biological regulation |
regulation of biological process |
regulation of cellular process |
regulation of cell communication |
regulation of signal transduction |
regulation of small gtpase mediated signal transduction |
|
Cellular Location
|
- Nucleus
- Cytoplasm
- Cytoplasm
- Cell projection
- Early endosome
- cytoskeleton (Probable)
- Early endosome membrane
- ruffle membrane
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:6 |
Locus
| 6p21.2 |
SNPs
| FGD2 |
Gene Sequence
|
>1968 bp
ATGAAGGGGGCAAGTGAGGAGAAGCTGGCATCTGTGTCCAACCTGGTCACTGTGTTTGAG
AATAGCAGGACCCCAGAAGCAGCACCCAGAGGCCAGAGGCTAGAGGACGTGCATCACCGC
CCTGAGTGCAGGCCTCCCGAGTCCCCAGGACCACGGGAGAAGACGAATGTCGGGGAGGCC
GTGGGGTCTGAGCCCAGGACAGTCAGCAGGAGGTACCTGAACTCCCTGAAGAACAAGCTG
TCCAGCGAAGCCTGGAGGAAATCTTGCCAGCCTGTGACCCTCTCAGGATCGGGGACGCAG
GAGCCAGAGAAGAAGATCGTCCAGGAGCTGCTGGAGACAGAGCAGGCCTATGTGGCGCGC
CTCCACCTGCTAGACCAGGTGTTTTTCCAGGAGCTGCTGAAGACAGCCCGCAGCAGCAAG
GCCTTCCCAGAGGATGTGGTCAGGGTCATCTTCTCCAACATCTCCTCCATCTATCAGTTC
CATTCTCAGTTCTTCCTCCCAGAGCTGCAGCGGCGCCTGGACGACTGGACAGCTAACCCC
CGCATCGGTGACGTGATCCAGAAGCTGGCCCCCTTCCTGAAGATGTACAGTGAGTATGTC
AAGAACTTTGAGCGAGCGGCTGAGCTGCTGGCCACCTGGACCGACAAGTCTCCACTCTTC
CAGGAGGTTCTCACTCGCATCCAGAGCAGCGAGGCTTCGGGCAGCCTGACCCTGCAGCAC
CACATGCTGGAACCAGTGCAGAGAATTCCACGTTACGAGCTGCTGCTCAAGGAGTACATC
CAGAAGCTGCCAGCCCAGGCCCCAGACCAGGCCGATGCCCAGAAAGCCCTGGACATGATC
TTCTCAGCTGCCCAGCACTCCAATGCAGCCATCACTGAGATGGAGCGGCTGCAGGACCTG
TGGGAGGTGTACCAGCGCCTGGGCCTCGAGGACGACATAGTAGACCCCTCTAACACCCTG
CTCCGTGAGGGCCCGGTCCTCAAGATCTCCTTCCGCCGCAACGACCCCATGGAGCGCTAC
CTTTTCTTGTTCAACAACATGCTGCTCTACTGTGTGCCCAGGGTGATCCAGGTGGGCGCC
CAGTTCCAGGTGAGGACCCGCATCGATGTGGCCGGGATGAAGGTGCGGGAGCTGATGGAT
GCTGAGTTTCCCCACTCCTTCCTGGTGTCCGGGAAGCAGCGCACCCTGGAGCTGCAAGCC
CGGTCCCAGGAGGAAATGATTTCCTGGATGCAGGCCTTCCAAGCAGCCATTGACCAAATC
GAGAAGCGGAATGAAACCTTCAAGGCTGCGGCCCAGGGGCCTGAGGGAGACATCCAGGAG
CAGGAGCTGCAGTCTGAGGAGCTGGGCCTCCGGGCACCGCAGTGGGTCCGGGACAAGATG
GTGACCATGTGCATGCGCTGCCAGGAGCCCTTCAACGCTCTGACGCGCCGTCGCCACCAC
TGCCGGGCCTGCGGCTATGTGGTGTGTGCCAGGTGCTCCGACTACCGGGCCGAACTGAAA
TACGACGACAACAGGCCCAACCGAGTCTGCCTCCACTGCTACGCATTCCTCACTGGAAAT
GTGCTGCCTGAGGCCAAGGAGGACAAGAGGCGGGGCATCCTGGAGAAAGGGTCCTCAGCC
ACGCCTGACCAGAGCCTGATGTGCAGCTTCCTGCAGCTCATCGGGGACAAGTGGGGCAAG
AGCGGCCCCCGGGGCTGGTGTGTGATCCCTCGGGATGACCCCCTCGTGCTCTATGTCTAT
GCTGCCCCTCAGGACATGAGGGCTCACACCTCCATCCCCCTGCTGGGCTACCAGGTGACT
GTTGGGCCCCAGGGGGACCCTCGGGTCTTCCAGCTACAGCAGTCAGGCCAGCTCTACACC
TTCAAGGCCGAGACGGAGGAGCTGAAGGGCCGCTGGGTGAAGGCCATGGAGCGGGCGGCC
AGTGGCTGGAGCCCCAGCTGGCCCAACGATGGGGACCTGTCCGACTGA
|
Protein Properties |
Number of Residues
| 655 |
Molecular Weight
| 74891.7 |
Theoretical pI
| 6.93 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>FYVE, RhoGEF and PH domain-containing protein 2
MKGASEEKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEA
VGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVAR
LHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANP
RIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQH
HMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDL
WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGA
QFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQI
EKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHH
CRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSA
TPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVT
VGPQGDPRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASGWSPSWPNDGDLSD
|
External Links |
GenBank ID Protein
| 189217917 |
UniProtKB/Swiss-Prot ID
| Q7Z6J4 |
UniProtKB/Swiss-Prot Entry Name
| FGD2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_173558.3 |
GeneCard ID
| FGD2 |
GenAtlas ID
| FGD2 |
HGNC ID
| HGNC:3664 |
References |
General References
| Not Available |