| Identification |
|---|
| HMDB Protein ID
| CDBP03753 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rab11 family-interacting protein 4 |
| Description
| Not Available |
| Synonyms
|
- Arfophilin-2
- FIP4-Rab11
- Rab11-FIP4
|
| Gene Name
| RAB11FIP4 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6 |
| GO Classification
|
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| Function |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| ion binding |
| Process |
| establishment of localization |
| transport |
| protein transport |
|
| Cellular Location
|
- Peripheral membrane protein
- Cleavage furrow
- Midbody
- Recycling endosome membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q11.2 |
| SNPs
| RAB11FIP4 |
| Gene Sequence
|
>1914 bp
ATGGCGGGCGGCGCGGGCTGGTCGGGCGCCCCCGCGGCTCTGCTGCGCTCCGTGCGCCGC
CTGCGCGAGGTGTTCGAGGTGTGCGGCCGCGACCCCGACGGCTTCCTGCGCGTGGAGCGC
GTCGCGGCGCTCGGACTGCGCTTCGGCCAGGGCGAGGAGGTGGAAAAACTTGTGAAATAT
TTGGATCCCAACGACCTGGGGAGAATCAACTTCAAGGACTTTTGCCGGGGGGTGTTCGCC
ATGAAAGGGTGCGAGGAGCTGCTGAAGGATGTGCTGTCGGTGGAGAGCGCGGGGACGCTG
CCGTGCGCGCCAGAGATCCCAGACTGCGTGGAGCAGGGCAGCGAGGTCACAGGCCCCACC
TTTGCTGATGGCGAGCTCATCCCCAGGGAACCCGGCTTTTTTCCCGAGGACGAGGAGGAG
GCTATGACGCTGGCGCCACCTGAGGGCCCCCAGGAGTTGTACACAGACAGCCCCATGGAG
AGCACTCAGAGCCTGGAGGGGTCTGTCGGGAGTCCTGCCGAGAAGGACGGGGGACTTGGG
GGCCTGTTTCTGCCAGAAGACAAGTCCCTGGTCCACACTCCATCCATGACGACCTCAGAC
CTTTCTACACACTCCACCACCTCGCTCATCAGCAATGAGGAGCAGTTTGAAGACTATGGG
GAGGGTGACGATGTGGACTGTGCCCCCAGCAGCCCTTGCCCCGATGATGAGACCAGGACC
AACGTCTACTCGGACCTGGGGTCTTCGGTGTCTTCCAGTGCGGGGCAGACGCCTAGGAAA
ATGCGGCACGTGTACAACAGCGAATTGCTAGATGTTTACTGCTCTCAATGCTGCAAGAAA
ATCAACCTGCTCAATGACTTGGAAGCCCGACTGAAAAACCTGAAGGCCAACAGCCCCAAC
CGAAAGATCTCCAGCACGGCCTTTGGACGGCAGCTCATGCACAGCAGCAACTTCAGCAGC
AGCAATGGCAGCACCGAAGACCTGTTCCGGGACAGCATTGACTCTTGCGACAATGACATC
ACAGAGAAGGTAAGCTTCCTGGAAAAGAAGGTGACAGAGCTGGAGAATGACAGCCTGACC
AATGGGGACCTGAAGAGCAAGCTGAAGCAAGAGAACACACAGCTGGTGCACAGGGTGCAT
GAGCTGGAGGAGATGGTGAAGGATCAGGAGACCACGGCCGAGCAGGCTCTGGAGGAGGAG
GCGCGGCGCCACCGCGAGGCCTACGGCAAGCTGGAGAGGGAGAAGGCTACCGAGGTGGAG
CTGCTCAATGCCAGGGTGCAGCAGTTGGAGGAAGAAAATACAGAGCTTAGAACAACAGTG
ACTCGGCTCAAGTCTCAAACAGAGAAACTGGATGAGGAGCGGCAGCGCATGTCTGACCGT
CTGGAGGACACCAGCCTGCGGCTCAAAGATGAGATGGACCTGTACAAGCGCATGATGGAC
AAGCTGCGACAGAACCGCCTTGAGTTCCAGAAGGAGCGGGAGGCGACGCAGGAGCTCATC
GAGGACTTGCGGAAGGAGCTGGAGCACCTGCAGATGTACAAGCTGGACTGCGAGCGGCCA
GGCAGGGGCCGCAGTGCCTCCTCTGGCCTAGGCGAGTTCAATGCCAGGGCCCGCGAGGTG
GAGCTCGAGCACGAGGTCAAGCGGCTCAAGCAGGAGAATTATAAGCTGCGGGATCAGAAC
GACGACTTGAATGGGCAGATTTTGAGCCTCAGCCTCTACGAAGCAAAAAACCTCTTTGCT
GCCCAGACTAAAGCCCAGTCTCTGGCTGCGGAGATAGACACCGCCTCGCGCGATGAGCTA
ATGGAAGCCCTGAAGGAGCAGGAGGAGATCAACTTCCGGCTGAGGCAGTACATGGACAAG
ATTATCCTCGCCATCCTGGACCACAATCCCTCCATCCTCGAGATCAAACACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 637 |
| Molecular Weight
| 71927.5 |
| Theoretical pI
| 4.5 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rab11 family-interacting protein 4
MAGGAGWSGAPAALLRSVRRLREVFEVCGRDPDGFLRVERVAALGLRFGQGEEVEKLVKY
LDPNDLGRINFKDFCRGVFAMKGCEELLKDVLSVESAGTLPCAPEIPDCVEQGSEVTGPT
FADGELIPREPGFFPEDEEEAMTLAPPEGPQELYTDSPMESTQSLEGSVGSPAEKDGGLG
GLFLPEDKSLVHTPSMTTSDLSTHSTTSLISNEEQFEDYGEGDDVDCAPSSPCPDDETRT
NVYSDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPN
RKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLT
NGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVE
LLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMD
KLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREV
ELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDEL
MEALKEQEEINFRLRQYMDKIILAILDHNPSILEIKH
|
| External Links |
|---|
| GenBank ID Protein
| 28195388 |
| UniProtKB/Swiss-Prot ID
| Q86YS3 |
| UniProtKB/Swiss-Prot Entry Name
| RFIP4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_032932.3 |
| GeneCard ID
| RAB11FIP4 |
| GenAtlas ID
| RAB11FIP4 |
| HGNC ID
| HGNC:30267 |
| References |
|---|
| General References
| Not Available |