| Identification |
|---|
| HMDB Protein ID
| CDBP03761 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rho GTPase-activating protein 21 |
| Description
| Not Available |
| Synonyms
|
- Rho GTPase-activating protein 10
- Rho-type GTPase-activating protein 21
|
| Gene Name
| ARHGAP21 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| binding |
| protein binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
|
| Cellular Location
|
- Cytoplasm
- Golgi apparatus membrane
- Peripheral membrane protein
- Peripheral membrane protein
- cytoskeleton
- Cell junction
- Cytoplasmic vesicle membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10p12.1|10p12.3 |
| SNPs
| ARHGAP21 |
| Gene Sequence
|
>5874 bp
ATGGCCACGCGTCGGACTGGTCTGTCTGAGGGAGATGGTGACAAGCTCAAGGCCTGCGAG
GTCTCAAAAAATAAAGATGGAAAAGAACAAAGTGAAACTGTATCACTGTCTGAAGATGAA
ACATTCTCCTGGCCAGGTCCCAAAACAGTTACGTTGAAAAGAACATCTCAAGGCTTTGGT
TTTACATTAAGACATTTTATTGTTTATCCCCCAGAGTCTGCAATTCAATTTTCATATAAG
GATGAAGAAAATGGAAACAGAGGAGGAAAACAAAGAAACCGCTTGGAACCAATGGATACC
ATATTTGTTAAGCAAGTTAAAGAAGGAGGACCTGCTTTTGAAGCTGGATTATGTACAGGT
GACCGAATTATAAAAGTCAATGGAGAAAGTGTTATTGGCAAAACCTATTCCCAAGTAATT
GCTTTAATTCAAAACAGTGATACAACATTGGAACTTAGTGTTATGCCAAAAGATGAAGAC
ATTCTCCAAGTGCTACAGTTTACAAAGGATGTCACAGCACTGGCATATTCTCAAGATGCC
TACCTGAAAGGCAACGAAGCTTATAGCGGCAATGCCCGCAATATACCTGAACCTCCACCA
ATCTGCTATCCCTGGCTGCCATCTGCCCCATCAGCCATGGCACAGCCAGTTGAAATATCT
CCTCCTGACTCATCATTGAGCAAACAGCAAACCAGTACACCAGTACTGACACAACCTGGT
AGGGCCTATAGAATGGAAATACAAGTGCCTCCATCACCAACAGATGTTGCAAAATCAAAC
ACAGCAGTGTGTGTTTGCAATGAAAGTGTAAGGACTGTCATTGTGCCTTCTGAGAAGGTT
GTAGATTTGTTATCCAATAGAAACAACCATACAGGTCCTTCACATAGAACTGAAGAAGTG
AGGTATGGCGTGAATGAGCAGACCTCTTTAAAAACAGTGTCAAGAACCACATCACCACCA
TTATCAATTCCCACCACTCATCTAATTCATCAGCCTGCAGGCTCCAGATCACTGGAACCT
TCTGGAATTTTACTTAAGTCTGGAAATTACAGTGGACATTCTGATGGAATCTCAAGCAGC
AGATCTCAAGCTGTGGAGGCTCCCTCTGTATCTGTTAATCACTATTCGCCAAATTCCCAT
CAGCACATAGACTGGAAAAACTATAAAACTTACAAAGAGTATATTGATAACAGACGATTG
CACATAGGTTGTCGGACAATACAAGAAAGATTAGATAGTTTAAGAGCAGCATCTCAAAGC
ACGACAGATTATAACCAGGTCGTCCCCAACCGCACTACTTTGCAGGGACGACGTCGAAGC
ACCTCTCATGATCGAGTGCCCCAGTCTGTCCAGATACGGCAACGCAGTGTGTCCCAAGAA
AGACTGGAAGATTCTGTGCTAATGAAGTATTGTCCAAGAAGTGCATCTCAAGGAGCACTG
ACGTCTCCATCTGTTAGTTTTAGTAATCATAGAACTCGTTCATGGGATTATATTGAGGGA
CAGGATGAAACCTTAGAAAATGTCAATTCTGGAACTCCAATACCTGATTCCAATGGAGAG
AAAAAACAGACTTACAAGTGGAGTGGGTTTACTGAACAGGATGATAGACGAGGTATTTGT
GAAAGACCTAGGCAGCAAGAAATTCATAAATCTTTTCGAGGTTCCAATTTTACTGTGGCT
CCAAGCGTTGTTAATTCTGATAACAGGCGAATGAGTGGTAGAGGAGTGGGATCTGTGTCG
CAGTTTAAAAAAATTCCACCAGATCTAAAAACATTGCAGTCAAACAGAAATTTTCAGACT
ACTTGTGGAATGTCACTGCCTCGGGGTATTTCACAAGACAGGTCACCTCTTGTGAAAGTC
CGAAGTAATTCTCTGAAAGCTCCTTCCACGCATGTCACAAAACCATCATTTAGCCAGAAA
TCATTTGTTTCTATCAAAGACCAAAGACCAGTAAATCACTTGCATCAGAACAGTCTGTTG
AATCAGCAGACATGGGTAAGGACTGACAGTGCCCCCGATCAGCAAGTGGAGACTGGGAAA
TCCCCCTCTTTATCTGGAGCCTCTGCCAAGCCTGCCCCTCAGTCGAGTGAAAACGCTGGT
ACTTCAGATTTAGAACTACCTGTCAGTCAAAGGAGTCAAGATTTAAGTTTACAAGAGGCT
GAAACTGAGCAATCAGATACTTTAGATAATAAAGAAGCTGTCATCCTAAGGGAAAAACCT
CCATCTGGACGCCAGACACCGCAGCCTTTAAGGCATCAGTCTTACATCTTGGCAGTAAAT
GACCAGGAGACCGGGTCAGACACTACCTGCTGGCTGCCCAATGATGCACGTCGAGAGGTC
CACATAAAAAGAATGGAGGAAAGAAAAGCCTCGAGTACCAGTCCGCCTGGCGATTCTTTG
GCTTCCATCCCATTTATAGATGAACCAACTAGCCCTAGCATTGATCATGATATTGCACAT
ATCCCTGCCTCTGCTGTTATATCAGCCTCTACCTCTCAGGTCCCCTCCATAGCAACAGTT
CCTCCTTGCCTCACAACTTCAGCTCCATTAATTCGCCGTCAGCTCTCACATGACCACGAA
TCTGTTGGCCCTCCTAGCCTGGATGCTCAGCCCAACTCAAAGACAGAAAGATCAAAATCA
TATGATGAGGGTCTGGATGATTACAGAGAAGATGCAAAATTGTCCTTTAAGCACGTACCT
AGTCTGAAGGGAATCAAGATCGCAGACAGCCAAAAGTCATCAGAAGACTCTGGGTCCAGA
AAAGATTCTTCCTCAGAGGTCTTCAGTGATGCTGCCAAGGAAGGGTGGCTTCATTTCCGA
CCCCTTGTCACCGATAAGGGCAAGCGAGTTGGTGGAAGTATTCGGCCATGGAAACAGATG
TATGTTGTCCTTCGGGGTCATTCACTTTACCTGTACAAAGATAAAAGAGAGCAGACGACT
CCGTCTGAGGAAGAGCAGCCCATCAGTGTTAATGCTTGCTTGATAGACATCTCTTACAGT
GAGACCAAGAGGAAAAATGTGTTTCGACTCACCACGTCCGACTGTGAATGCCTGTTTCAG
GCTGAAGACAGAGATGATATGCTAGCTTGGATCAAGACGATCCAGGAGAGCAGCAACCTA
AACGAAGAGGACACTGGAGTCACTAACAGGGATCTAATTAGTCGAAGAATAAAAGAATAC
AACAATCTGATGAGCAAAGCAGAACAGTTGCCAAAAACACCTCGCCAGAGTCTCAGCATC
AGGCAAACTTTGCTTGGTGCTAAATCAGAGCCAAAGACTCAAAGCCCACACTCTCCGAAG
GAAGAGTCGGAAAGGAAACTTCTCAGTAAAGATGATACCAGTCCCCCAAAAGACAAAGGC
ACATGGAGAAAAGGCATTCCAAGTATCATGAGAAAGACATTTGAGAAAAAGCCAACTGCT
ACAGGAACTTTCGGCGTCCGACTAGATGACTGCCCACCAGCTCATACTAATCGGTATATT
CCATTAATAGTTGACATATGTTGCAAATTAGTTGAAGAAAGAGGTCTTGAATATACAGGT
ATTTATAGAGTTCCTGGAAATAATGCAGCCATCTCAAGTATGCAAGAAGAACTCAACAAG
GGAATGGCTGATATTGATATACAAGATGATAAATGGCGAGATTTGAATGTGATAAGCAGT
TTACTAAAATCCTTCTTCAGAAAACTCCCTGAGCCTCTCTTCACAAATGATAAATATGCT
GATTTTATTGAAGCCAATCGTAAAGAAGATCCTCTAGATCGTCTGAAAACATTAAAAAGA
CTAATTCACGATTTGCCTGAACATCATTATGAAACACTTAAGTTCCTTTCAGCTCATCTG
AAGACAGTGGCAGAAAATTCAGAAAAAAATAAGATGGAACCAAGAAACCTAGCAATAGTG
TTTGGTCCCACCCTTGTTCGAACATCAGAAGACAACATGACCCACATGGTCACCCACATG
CCTGACCAGTACAAGATTGTAGAAACGCTCATCCAGCACCATGACTGGTTTTTCACAGAA
GAAGGTGCTGAAGAGCCTCTTACAACAGTGCAGGAGGAAAGCACAGTAGACTCCCAGCCA
GTGCCAAACATAGATCATTTACTCACCAACATTGGAAGGACAGGAGTCTCCCCAGGAGAT
GTATCAGATTCAGCTACTAGTGACTCAACAAAATCTAAGGGTTCTTGGGGATCTGGAAAG
GATCAGTATAGCAGGGAACTGCTTGTGTCCTCCATCTTTGCAGCTGCTAGTCGCAAGAGG
AAGAAGCCGAAAGAAAAAGCACAGCCTAGCAGCTCAGAAGATGAACTGGACAATGTATTT
TTTAAGAAAGAAAATGTGGAACAGTGTCACAATGATACTAAAGAGGAGTCCAAAAAAGAA
AGTGAGACACTGGGCAGAAAACAGAAGATCATCATTGCCAAAGAAAACAGCACTAGGAAA
GACCCCAGCACGACAAAAGATGAAAAGATATCACTAGGAAAAGAGAGCACGCCTTCTGAA
GAACCCTCACCACCACACAACTCAAAACACAACAAGTCACCAACTCTCAGCTGTCGCTTT
GCCATCCTGAAAGAGAGCCCCAGGTCACTTCTGGCACAGAAGTCCTCCCACCTTGAAGAG
ACAGGCTCTGACTCTGGCACTTTGCTCAGCACGTCTTCCCAGGCCTCCCTGGCAAGGTTT
TCCATGAAGAAATCAACCAGTCCAGAAACGAAACATAGCGAGTTTTTGGCCAACGTCAGC
ACCATCACCTCAGATTATTCCACCACATCGTCTGCTACATACTTGACTAGCCTGGACTCC
AGTCGACTGAGCCCTGAGGTGCAATCCGTGGCAGAGAGCAAGGGGGACGAGGCAGATGAC
GAGAGAAGCGAACTCATCAGTGAAGGGCGGCCTGTGGAAACCGACAGCGAGAGCGAGTTT
CCCGTGTTCCCCACAGCCTTGACTTCAGAGAGGCTTTTCCGAGGAAAACTGCAAGAAGTG
ACTAAGAGCAGCCGGAGAAATTCTGAAGGAAGTGAATTAAGTTGCACCGAGGGAAGTTTA
ACATCAAGTTTAGATAGCCGGAGACAGCTCTTCAGTTCCCATAAACTCATCGAATGTGAT
ACTCTTTCCAGGAAAAAATCAGCTAGATTCAAGTCAGATAGTGGAAGTCTAGGAGATGCC
AAGAATGAGAAAGAAGCACCTTCGTTAACTAAAGTGTTTGATGTTATGAAAAAAGGAAAG
TCAACTGGGAGTTTACTGACACCCACCAGAGGCGAATCCGAAAAACAGGAACCCACATGG
AAAACGAAAATAGCAGATCGGTTAAAACTGAGACCCAGAGCCCCTGCGGATGACATGTTT
GGAGCAGGGAATCACAAAGTGAATGCCGAGACTGCTAAAAGGAAAAGCATCCGGCGCAGA
CATACACTAGGAGGGCACAGAGATGCTACCGAAATCAGCGTTTTGAATTTTTGGAAAGTG
CATGAGCAGAGCGGGGAGAGAGAATCTGAACTTTCAGCTGTAAACCGGTTAAAACCAAAA
TGCTCAGCCCAGGACCTTTCCATCTCAGACTGGCTGGCCAGGGAACGCCTACGCACCAGT
ACCTCTGACCTTAGCAGAGGAGAAATCGGAGATCCCCAGACAGAGAACCCAAGCACACGA
GAAATAGCCACGACCGACACACCTTTGTCTCTTCATTGCAACACAGGCAGTTCTTCCAGC
ACCTTGGCTTCAACAAACAGGCCCCTTCTTTCCATACCACCACAGTCACCTGACCAAATA
AACGGAGAAAGCTTCCAGAACGTGAGCAAAAATGCTAGTTCTGCAGCGAATGCCCAACCT
CATAAACTGTCTGAAACCCCAGGCACTAAAGCAGAGTTTCATCCCTGTCTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1957 |
| Molecular Weight
| 217328.9 |
| Theoretical pI
| 7.87 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rho GTPase-activating protein 21
MATRRTGLSEGDGDKLKACEVSKNKDGKEQSETVSLSEDETFSWPGPKTVTLKRTSQGFG
FTLRHFIVYPPESAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCTG
DRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPKDEDILQVLQFTKDVTALAYSQDA
YLKGNEAYSGNARNIPEPPPICYPWLPSAPSAMAQPVEISPPDSSLSKQQTSTPVLTQPG
RAYRMEIQVPPSPTDVAKSNTAVCVCNESVRTVIVPSEKVVDLLSNRNNHTGPSHRTEEV
RYGVSEQTSLKTVSRTTSPPLSIPTTHLIHQPAGSRSLEPSGILLKSGNYSGHSDGISSS
RSQAVEAPSVSVNHYSPNSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQS
TTDYNQVVPNRTTLQGRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGAL
TSPSVSFSNHRTRSWDYIEGQDETLENVNSGTPIPDSNGEKKQTYKWSGFTEQDDRRGIC
ERPRQQEIHKSFRGSNFTVAPSVVNSDNRRMSGRGVGSVSQFKKIPPDLKTLQSNRNFQT
TCGMSLPRGISQDRSPLVKVRSNSLKAPSTHVTKPSFSQKSFVSIKDQRPVNHLHQNSLL
NQQTWVRTDSAPDQQVETGKSPSLSGASAKPAPQSSENAGTSDLELPVSQRNQDLSLQEA
ETEQSDTLDNKEAVILREKPPSGRQTPQPLRHQSYILAVNDQETGSDTTCWLPNDARREV
HIKRMEERKASSTSPPGDSLASIPFIDEPTSPSIDHDIAHIPASAVISASTSQVPSIATV
PPCLTTSAPLIRRQLSHDHESVGPPSLDAQPNSKTERSKSYDEGLDDYREDAKLSFKHVS
SLKGIKIADSQKSSEDSGSRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQM
YVVLRGHSLYLYKDKREQTTPSEEEQPISVNACLIDISYSETKRKNVFRLTTSDCECLFQ
AEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLSI
RQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPTA
TGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNK
GMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKR
LIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHM
PDQYKIVETLIQHHDWFFTEEGAEEPLTTVQEESTVDSQPVPNIDHLLTNIGRTGVSPGD
VSDSATSDSTKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDNVF
FKKENVEQCHNDTKEESKKESETLGRKQKIIIAKENSTRKDPSTTKDEKISLGKESTPSE
EPSPPHNSKHNKSPTLSCRFAILKESPRSLLAQKSSHLEETGSDSGTLLSTSSQASLARF
SMKKSTSPETKHSEFLANVSTITSDYSTTSSATYLTSLDSSRLSPEVQSVAESKGDEADD
ERSELISEGRPVETDSESEFPVFPTALTSERLFRGKLQEVTKSSRRNSEGSELSCTEGSL
TSSLDSRRQLFSSHKLIECDTLSRKKSARFKSDSGSLGDAKNEKEAPSLTKVFDVMKKGK
STGSLLTPTRGESEKQEPTWKTKIADRLKLRPRAPADDMFGVGNHKVNAETAKRKSIRRR
HTLGGHRDATEISVLNFWKVHEQSGERESELSAVNRLKPKCSAQDLSISDWLARERLRTS
TSDLSRGEIGDPQTENPSTREIATTDTPLSLHCNTGSSSSTLASTNRPLLSIPPQSPDQI
NGESFQNVSKNASSAANAQPHKLSETPGSKAEFHPCL
|
| External Links |
|---|
| GenBank ID Protein
| 20514209 |
| UniProtKB/Swiss-Prot ID
| Q5T5U3 |
| UniProtKB/Swiss-Prot Entry Name
| RHG21_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF480466 |
| GeneCard ID
| ARHGAP21 |
| GenAtlas ID
| ARHGAP21 |
| HGNC ID
| HGNC:23725 |
| References |
|---|
| General References
| Not Available |