Cannabis Compound Database: Showing Protein Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (CDBP03597)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03597

Secondary Accession Numbers

Not Available

Name

Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

Description

Not Available

Synonyms

Eukaryotic peptide chain release factor subunit 3b
G1 to S phase transition protein 2 homolog
eRF3b

Gene Name

GSPT2

Protein Type

Enzyme

Biological Properties

General Function

Involved in GTPase activity

Specific Function

Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression

GO Classification

Function
purine nucleotide binding
binding
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
gtpase activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity

Cellular Location

Cytoplasm (Probable)

Pathways

Not Available

Gene Properties

Chromosome Location

Not Available

Locus

Not Available

SNPs

GSPT2

Gene Sequence

>1887 bp
ATGGATTCGGGCAGCAGCAGCAGCGACTCGGCGCCCGATTGCTGGGACCAGGTGGACATG
GAATCCCCGGGGTCGGCCCCGAGCGGGGATGGAGTCTCCTCTGCGGTGGCCGAGGCCCAG
CGCGAGCCCCTCAGCTCGGCTTTCAGCCGTAAGCTCAACGTCAACGCCAAGCCCTTCGTG
CCTAACGTACACGCCGCGGAGTTCGTGCCGTCCTTCCTGCGGGGCCCGACTCAGCCGCCC
ACCCTCCCGGCCGGCTCCGGCAGCAACGATGAAACCTGCACCGGCGCGGGATACCCTCAA
GGTAAAAGGATGGGACGGGGGGCACCTGTGGAACCTTCCCGAGAGGAACCGTTAGTGTCG
CTTGAAGGTTCCAATTCAGCCGTTACCATGGAACTTTCAGAACCTGTTGTAGAAAATGGA
GAGGTGGAAATGGCCCTAGAAGAATCATGGGAGCACAGTAAAGAAGTAAGTGAAGCCGAG
CCTGGGGGTGGTTCCTCGGGAGATTCAGGGCCCCCAGAAGAAAGTGGCCAGGAAATGATG
GAGGAAAAAGAGGAAATAAGAAAATCCAAATCTGTGATCGTACCCTCAGGTGCACCTAAG
AAAGAACACGTAAATGTAGTATTCATTGGCCATGTAGACGCTGGCAAGTCAACCATCGGA
GGACAGATAATGTTTTTGACTGGAATGGTTGACAAAAGAACACTGGAGAAATATGAAAGA
GAAGCTAAGGAAAAAAACAGAGAAACCTGGTATTTGTCCTGGGCCTTAGATACAAATCAG
GAGGAACGAGACAAGGGTAAAACAGTCGAAGTGGGTCGTGCCTATTTTGAAACAGAAAGG
AAACATTTCACAATTTTAGATGCCCCTGGCCACAAGAGTTTTGTCCCAAATATGATTGGT
GGTGCTTCTCAAGCTGATTTGGCTGTGCTGGTCATCTCTGCCAGGAAAGGAGAGTTTGAA
ACTGGATTTGAAAAAGGTGGACAGACAAGAGAACATGCGATGTTGGCAAAAACGGCAGGG
GTAAAACATTTAATAGTGCTTATTAATAAGATGGATGATCCCACAGTAAATTGGAGCATC
GAGAGATATGAAGAATGTAAAGAAAAACTGGTGCCCTTTTTGAAAAAAGTAGGCTTCAGT
CCAAAAAAGGACATTCACTTTATGCCCTGCTCAGGACTGACCGGAGCAAATATTAAAGAG
CAGTCAGATTTCTGCCCTTGGTACACTGGATTACCATTTATTCCGTATTTGGATAACTTG
CCAAACTTCAACAGATCAATTGATGGACCAATAAGACTGCCAATTGTGGATAAGTACAAA
GATATGGGCACCGTGGTCCTGGGAAAGCTGGAATCCGGGTCCATTTTTAAAGGCCAGCAG
CTCGTGATGATGCCAAACAAGCACAATGTAGAAGTTCTTGGAATACTTTCTGATGATACT
GAAACTGATTTTGTAGCCCCAGGTGAAAACCTCAAAATCAGACTGAAGGGAATTGAAGAA
GAAGAGATTCTTCCAGGATTCATACTTTGTGATCCTAGTAACCTCTGCCATTCTGGACGC
ACGTTTGATGTTCAGATAGTGATTATTGAGCACAAATCCATCATCTGCCCAGGTTATAAT
GCGGTGCTGCACATTCATACTTGTATTGAGGAAGTTGAGATAACAGCGTTAATCTCCTTG
GTAGACAAAAAATCAGGAGAAAAAAGTAAGACACGACCCCGCTTCGTGAAACAAGATCAA
GTATGCATTGCTCGTTTAAGGACAGCAGGAACCATCTGCCTCGAGACGTTCAAAGATTTT
CCTCAGATGGGTCGTTTTACTTTAAGAGATGAGGGTAAGACCATTGCAATTGGAAAAGTT
CTGAAATTGGTCCCAGAGAAGGACTAA

Protein Properties

Number of Residues

628

Molecular Weight

68882.7

Theoretical pI

5.11

Pfam Domain Function

GTP_EFTU (PF00009 )
GTP_EFTU_D2 (PF03144 )
GTP_EFTU_D3 (PF03143 )
PAM2 (PF07145 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Eukaryotic peptide chain release factor GTP-binding subunit ERF3B
MDSGSSSSDSAPDCWDQVDMESPGSAPSGDGVSSAVAEAQREPLSSAFSRKLNVNAKPFV
PNVHAAEFVPSFLRGPTQPPTLPAGSGSNDETCTGAGYPQGKRMGRGAPVEPSREEPLVS
LEGSNSAVTMELSEPVVENGEVEMALEESWEHSKEVSEAEPGGGSSGDSGPPEESGQEMM
EEKEEIRKSKSVIVPSGAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDKRTLEKYER
EAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETERKHFTILDAPGHKSFVPNMIG
GASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSI
ERYEECKEKLVPFLKKVGFSPKKDIHFMPCSGLTGANIKEQSDFCPWYTGLPFIPYLDNL
PNFNRSIDGPIRLPIVDKYKDMGTVVLGKLESGSIFKGQQLVMMPNKHNVEVLGILSDDT
ETDFVAPGENLKIRLKGIEEEEILPGFILCDPSNLCHSGRTFDVQIVIIEHKSIICPGYN
AVLHIHTCIEEVEITALISLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDF
PQMGRFTLRDEGKTIAIGKVLKLVPEKD

External Links

GenBank ID Protein

7799910

UniProtKB/Swiss-Prot ID

Q8IYD1

UniProtKB/Swiss-Prot Entry Name

ERF3B_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AJ251548

GeneCard ID