| Identification |
|---|
| HMDB Protein ID
| CDBP03679 |
| Secondary Accession Numbers
| Not Available |
| Name
| Importin-5 |
| Description
| Not Available |
| Synonyms
|
- Imp5
- Importin subunit beta-3
- Karyopherin beta-3
- Ran-binding protein 5
- RanBP5
|
| Gene Name
| IPO5 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev |
| GO Classification
|
| Function |
| protein transporter activity |
| transporter activity |
| substrate-specific transporter activity |
| binding |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
|
| Cellular Location
|
- Nucleus
- Nucleus
- Cytoplasm
- nucleolus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q32.2 |
| SNPs
| IPO5 |
| Gene Sequence
|
>3348 bp
ATGCCTGAGGATCAAGTTGGAAAACTAGAAGCAACAGAAAACACAATAAGCGCAATGGCG
GCGGCCGCGGCGGAGCAGCAACAGTTCTACCTGCTCCTGGGAAACCTGCTCAGCCCCGAC
AATGTGGTCCGGAAACAGGCAGAGGAAACCTATGAGAATATCCCAGGCCAGTCAAAGATC
ACATTCCTCTTACAAGCCATCAGAAATACAACAGCTGCTGAAGAGGCTAGACAAATGGCC
GCCGTTCTCCTAAGACGTCTCTTGTCCTCTGCATTTGATGAAGTCTATCCAGCACTTCCC
TCTGATGTTCAGACTGCCATCAAGAGTGAGCTACTCATGATTATTCAGATGGAAACACAA
TCTAGCATGAGGAAAAAAGTTTGTGATATTGCGGCAGAACTGGCCAGGAATTTAATAGAT
GAGGATGGCAATAACCAGTGGCCCGAAGGTTTGAAGTTCCTTTTTGATTCAGTCAGCTCT
CAAAATGTGGGACTGCGGGAAGCTGCCCTTCACATTTTCTGGAACTTTCCTGGAATTTTT
GGGAACCAGCAACAACACTATTTAGATGTCATCAAACGAATGTTAGTTCAGTGTATGCAA
GATCAGGAACACCCGTCGATCAGGACGTTATCTGCTAGAGCTACAGCTGCATTTATACTT
GCAAATGAGCATAATGTTGCTCTGTTCAAACATTTTGCAGACTTGCTACCGGGATTCCTA
CAGGCGGTAAATGACTCGTGCTACCAGAATGATGATTCTGTCCTAAAATCCCTCGTTGAG
ATTGCAGATACTGTTCCAAAGTATTTGCGTCCTCACTTGGAAGCAACTCTACAGCTAAGT
CTAAAGTTGTGTGGAGACACTAGCCTCAACAATATGCAACGCCAGCTTGCCCTTGAAGTG
ATCGTCACCCTCTCTGAGACTGCAGCTGCTATGTTAAGAAAACATACCAATATTGTTGCA
CAGACTATTCCTCAGATGTTAGCAATGATGGTTGATTTGGAAGAAGATGAGGACTGGGCA
AATGCAGATGAACTAGAAGATGATGATTTTGACAGCAATGCAGTTGCAGGCGAGAGTGCT
CTAGATCGAATGGCTTGCGGACTTGGTGGAAAGCTCGTTCTGCCGATGATCAAGGAACAC
ATTATGCAAATGCTTCAAAATCCTGACTGGAAATACCGGCATGCAGGATTGATGGCCTTA
TCTGCCATTGGTGAAGGGTGCCACCAGCAAATGGAAGGAATTCTAAATGAGATCGTAAAT
TTTGTTTTACTTTTTCTCCAGGATCCTCATCCAAGAGTAAGGTATGCAGCCTGTAATGCC
GTGGGACAGATGGCTACAGATTTTGCACCTGGTTTCCAAAAGAAATTTCATGAGAAGGTG
ATTGCAGCTCTGCTGCAGACCATGGAAGACCAAGGCAATCAACGTGTGCAGGCCCATGCA
GCTGCTGCCCTCATTAACTTTACTGAAGACTGTCCCAAGTCACTACTTATTCCATACTTG
GATAATTTGGTGAAACATCTGCATTCCATTATGGTACTGAAGCTTCAAGAGCTGATTCAG
AAAGGCACCAAGTTAGTTTTGGAACAAGTTGTGACATCCATTGCATCAGTTGCCGATACT
GCAGAAGAAAAATTTGTCCCCTACTATGATTTATTTATGCCATCACTGAAGCACATCGTT
GAGAATGCGGTTCAAAAAGAACTGAGACTTCTGAGAGGAAAAACTATTGAATGCATTAGC
CTCATTGGTCTGGCTGTTGGGAAGGAAAAATTCATGCAGGATGCATCAGATGTGATGCAG
CTTTTGTTAAAGACCCAGACAGACTTCAATGATATGGAAGATGATGATCCTCAGATCTCT
TACATGATCTCAGCATGGGCCAGAATGTGCAAAATCCTTGGAAAAGAATTTCAGCAATAC
CTTCCAGTGGTTATGGGGCCTTTAATGAAGACGGCTTCAATTAAGCCCGAAGTAGCCCTT
TTAGATACCCAAGACATGGAGAATATGAGTGATGATGATGGTTGGGAATTTGTGAACCTT
GGAGATCAGCAAAGCTTTGGTATTAAAACTGCAGGACTAGAAGAAAAATCAACTGCTTGC
CAGATGTTGGTTTGCTATGCTAAGGAGTTAAAGGAAGGCTTTGTGGAGTACACCGAACAG
GTTGTCAAACTGATGGTCCCTTTACTGAAATTTTATTTCCACGATGGTGTTCGAGTGGCA
GCAGCGGAATCCATGCCTCTTCTCCTGGAGTGTGCAAGAGTCCGTGGTCCTGAGTATCTC
ACACAGATGTGGCATTTTATGTGTGATGCTCTAATTAAGGCCATTGGTACAGAACCAGAT
TCAGACGTCCTCTCAGAAATAATGCATTCTTTTGCAAAGTGCATTGAAGTAATGGGAGAT
GGATGCCTTAATAATGAACACTTTGAAGAACTGGGAGGTATATTGAAAGCAAAGCTTGAA
GAACATTTTAAAAATCAAGAATTACGACAAGTTAAAAGACAAGATGAAGACTATGATGAA
CAGGTCGAAGAGTCACTACAAGATGAGGATGATAATGATGTTTATATTCTGACCAAAGTG
TCAGATATTTTACACTCAATATTCAGTAGCTACAAAGAAAAGGTGTTACCATGGTTTGAA
CAGCTGCTTCCATTAATTGTCAACCTCATTTGTCCACATAGACCATGGCCAGACAGACAA
TGGGGATTATGCATCTTTGATGATGTCATAGAACACTGTAGTCCAGCCTCATTTAAATAC
GCAGAATATTTCTTAAGACCAATGCTCCAATATGTATGTGACAACAGCCCAGAAGTCAGG
CAAGCAGCTGCATATGGCCTGGGAGTCATGGCACAGTACGGTGGAGATAATTATCGCCCT
TTTTGTACAGAAGCACTTCCCCTGCTGGTAAGAGTTATTCAGTCTGCGGATTCTAAGACC
AAAGAAAATGTCAATGCTACAGAGAACTGCATCTCAGCAGTAGGGAAAATCATGAAGTTC
AAGCCTGACTGTGTAAACGTTGAAGAGGTCCTTCCACACTGGTTGTCTTGGCTTCCACTA
CATGAAGATAAAGAAGAAGCTGTTCAGACTTTCAATTATCTGTGTGACCTGATTGAAAGT
AATCATCCAATTGTTCTTGGCCCAAACAATACCAATCTGCCCAAAATATTTAGTATAATT
GCGGAAGGAGAAATGCACGAGGCAATTAAACATGAAGATCCTTGTGCCAAACGTCTGGCC
AATGTCGTTCGCCAAGTACAGACTTCTGGAGGACTGTGGACTGAGTGCATAGCACAGCTC
AGTCCTGAGCAGCAGGCCGCCATTCAGGAGCTCCTGAACTCTGCGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1097 |
| Molecular Weight
| 123628.9 |
| Theoretical pI
| 4.57 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Importin-5
MAAAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNTTAAEEARQ
MAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNL
IDEDGNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQC
MQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSL
VEIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTNI
VAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLPMIK
EHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAAC
NAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTEDCPKSLLIP
YLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKH
IVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFNDMEDDDPQ
ISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFV
NLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVR
VAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVM
GDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILT
KVSDILHSIFSSYKEKVLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDVIEHCSPASF
KYAEYFLRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADS
KTKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLI
ESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIA
QLSPEQQAAIQELLNSA
|
| External Links |
|---|
| GenBank ID Protein
| 24797086 |
| UniProtKB/Swiss-Prot ID
| O00410 |
| UniProtKB/Swiss-Prot Entry Name
| IPO5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_002271 |
| GeneCard ID
| IPO5 |
| GenAtlas ID
| IPO5 |
| HGNC ID
| HGNC:6402 |
| References |
|---|
| General References
| Not Available |