| Identification |
|---|
| HMDB Protein ID
| CDBP03671 |
| Secondary Accession Numbers
| Not Available |
| Name
| Importin subunit alpha-3 |
| Description
| Not Available |
| Synonyms
|
- Importin alpha Q2
- Karyopherin subunit alpha-3
- Qip2
- SRP1-gamma
|
| Gene Name
| KPNA3 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9 |
| GO Classification
|
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| nuclear pore |
| organelle part |
| intracellular organelle part |
| nuclear part |
| Function |
| binding |
| protein transporter activity |
| transporter activity |
| substrate-specific transporter activity |
| Process |
| establishment of localization |
| transport |
| protein transport |
| protein import into nucleus |
| intracellular protein transport |
| protein targeting |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q14.3 |
| SNPs
| KPNA3 |
| Gene Sequence
|
>1566 bp
ATGGCCGAGAACCCCAGCTTGGAGAACCACCGCATCAAGAGCTTCAAGAACAAGGGCCGC
GATGTGGAAACAATGCGAAGACATAGAAATGAAGTGACAGTGGAACTGCGGAAGAACAAA
AGAGATGAACACTTATTGAAAAAGAGAAATGTTCCCCAAGAAGAAAGTCTAGAAGATTCA
GATGTTGATGCTGATTTTAAAGCACAAAATGTAACCCTAGAAGCTATATTGCAGAATGCC
ACAAGTGATAACCCAGTGGTCCAATTGAGTGCTGTCCAGGCAGCAAGAAAACTGTTATCC
AGTGACAGAAATCCACCGATTGATGACTTAATAAAATCTGGGATTTTACCAATTCTAGTC
AAATGTCTAGAAAGGGATGATAATCCTTCATTACAGTTTGAAGCTGCTTGGGCATTAACT
AACATAGCATCAGGAACTTCTGCACAGACTCAAGCTGTTGGGCAGTCTAATGCAGTACCT
CTTTTTCTGAGACTTCTTCGTTCACCACATCAGAATGTTTGTGAACAAGCAGTATGGGCT
TTGGGAAACATAATAGGTGATGGTCCTCAATGTAGAGATTATGTCATATCACTGGGAGTT
GTCAAACCTCTTCTGTCCTTCATCAGCCCCTCCATCCCCATCACCTTCCTTCGGAACGTC
ACATGGGTCATTGTCAATCTCTGCAGGAATAAGGATCCCCCACCGACTATGGAGACAGTT
CAGGAGATTTTACCAGCTTTATGTGTCCTCATATACCATACAGATATAAACATTCTTGTA
GACACTGTTTGGGCTCTGTCATACTTGACAGATGGAGGTAATGAACAGATACAGATGGTT
ATTGATTCAGGAGTTGTGCCCTTTCTTGTGCCCCTTCTGAGCCATCAGGAAGTCAAAGTT
CAAACAGCAGCCCTCAGAGCAGTTGGCAACATAGTGACTGGCACCGACGAGCAGACCCAG
GTTGTTCTCAATTGTGATGTCCTGTCACACTTCCCAAATCTCTTATCACACCCAAAAGAG
AAGATAAATAAGGAAGCAGTGTGGTTCCTTTCCAACATAACAGCAGGCAACCAGCAACAA
GTTCAAGCTGTAATAGATGCTGGATTAATTCCTATGATAATTCATCAGCTTGCTAAGGGG
GACTTTGGAACACAAAAAGAAGCTGCTTGGGCAATCAGCAACTTAACAATAAGTGGCAGA
AAAGATCAGGTTGAGTACCTTGTACAGCAGAATGTAATACCACCGTTCTGTAATTTACTG
TCAGTGAAAGATTCTCAAGTGGTTCAGGTGGTTCTAGATGGTCTAAAAAACATTCTGATA
ATGGCCGGTGATGAAGCAAGCACAATAGCTGAAATAATAGAGGAATGTGGAGGTTTGGAG
AAAATTGAAGTTTTACAGCAACATGAAAATGAAGACATATATAAATTAGCATTTGAAATC
ATAGATCAGTATTTCTCTGGTGATGATATTGATGAAGATCCCTGCCTCATTCCTGAAGCA
ACACAAGGAGGTACCTACAATTTTGATCCAACAGCCAACCTTCAAACAAAAGAATTTAAT
TTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 521 |
| Molecular Weight
| 57810.4 |
| Theoretical pI
| 4.55 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Importin subunit alpha-3
MAENPSLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDS
DVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILV
KCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWA
LGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETV
QEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKV
QTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQ
VQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLL
SVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEI
IDQYFSGDDIDEDPCLIPEATQGGTYNFDPTANLQTKEFNF
|
| External Links |
|---|
| GenBank ID Protein
| 2654139 |
| UniProtKB/Swiss-Prot ID
| O00505 |
| UniProtKB/Swiss-Prot Entry Name
| IMA3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF034756 |
| GeneCard ID
| KPNA3 |
| GenAtlas ID
| KPNA3 |
| HGNC ID
| HGNC:6396 |
| References |
|---|
| General References
| Not Available |