Identification |
HMDB Protein ID
| CDBP03822 |
Secondary Accession Numbers
| Not Available |
Name
| Transportin-2 |
Description
| Not Available |
Synonyms
|
- Karyopherin beta-2b
|
Gene Name
| TNPO2 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in binding |
Specific Function
| Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus |
GO Classification
|
Function |
binding |
protein transporter activity |
transporter activity |
substrate-specific transporter activity |
Process |
establishment of localization |
transport |
protein transport |
intracellular protein transport |
|
Cellular Location
|
- Nucleus
- Cytoplasm
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 19p13.2 |
SNPs
| TNPO2 |
Gene Sequence
|
>2694 bp
ATGGACTGGCAGCCAGACGAGCAGGGCCTGCAGCAGGTCCTGCAGCTGCTCAAAGACTCA
CAGTCGCCCAACACAGCCACTCAGCGCATCGTGCAGGATAAACTCAAACAACTCAATCAG
TTTCCTGACTTCAACAACTACCTGATTTTCGTCCTGACCAGACTCAAGTCAGAAGATGAG
CCAACGCGCTCTCTCAGTGGCCTCATCCTCAAGAACAACGTGAAGGCACACTATCAGAGC
TTCCCACCCCCTGTGGCAGACTTCATCAAACAGGAGTGTCTCAACAACATTGGCGATGCC
TCCTCGCTCATCCGAGCCACCATTGGCATTCTCATCACCACCATCGCTTCCAAGGGTGAG
CTGCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTGCAACCTGCTTAACTCGGAGGATTAC
AACACTTGTGAGGGAGCCTTTGGAGCCCTGCAGAAGATCTGTGAAGACTCATCAGAGCTT
CTGGACAGTGACGCCCTCAACAGGCCCCTCAACATCATGATCCCCAAGTTCCTGCAGTTC
TTCAAGCACTGCAGTCCCAAGATCCGGTCCCACGCCATCGCCTGCGTGAACCAGTTCATC
ATGGACCGGGCCCAGGCGCTGATGGACAATATTGACACCTTCATCGAGCACCTATTTGCC
CTGGCTGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTGCCGTGCCCTGGTGATGCTT
CTGGAAGTGCGGATTGACAGGCTCATCCCCCACATGCACAGCATCATCCAGTACATGCTG
CAGAGGACCCAGGACCATGATGAGAACGTTGCCCTTGAGGCCTGTGAGTTCTGGCTGACG
CTGGCCGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCATCTGGTCCAGTTGATCCCC
ATCTTGGTGAATGGGATGAAGTACTCGGAAATTGACATCATCCTGCTCAAGGGGGATGTG
GAGGAGGATGAGGCTGTCCCCGACAGTGAGCAGGACATCAAGCCACGCTTCCACAAGTCA
CGCACGGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGGCTCCGAGGACGCGGAGGAT
GACGATGATGATGATGCTCTGTCCGACTGGAATTTGAGGAAGTGCTCAGCGGCTGCACTG
GACGTCCTCGCCAATGTCTTCCGGGAGGAACTGCTGCCCCACCTACTCCCACTACTCAAA
GGCCTCCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGGCATCCTGGTGCTGGGCGCC
ATTGCTGAGGGCTGCATGCAGGGCATGGTGCCCTACCTGCCTGAGCTGATCCCGCACCTG
ATCCAGTGCCTGTCGGATAAGAAGGCCTTGGTCCGCTCCATCGCCTGCTGGACGCTGAGC
CGCTATGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCACCTCAAGCCCCTGATGACA
GAGCTGCTCAAACGCATCCTGGATGGCAACAAGAGGGTACAGGAGGCGGCCTGCAGTGCT
TTTGCCACCCTGGAGGAAGAGGCCTGCACGGAGCTGGTGCCCTACCTCAGCTACATCCTG
GACACCCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAACCTGCTCATCCTCTATGAC
GCCATTGGCACCCTGGCCGACTCTGTAGGCCACCACCTCAACCAGCCGGAATACATCCAG
AAGCTGATGCCCCCACTGATCCAGAAGTGGAATGAGCTCAAGGACGAAGACAAGGACCTC
TTCCCCCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCTGCAGAGTGGCTTCCTGCCT
TACTGTGAGCCCGTCTACCAGCGCTGTGTCACCCTGGTGCAGAAGACACTGGCTCAGGCC
ATGATGTACACCCAGCACCCTGAGCAGTATGAGGCTCCCGACAAGGACTTCATGATCGTA
GCACTGGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGGTCACGTGGAGCAGCTGGTG
GCCCGCAGCAACATCATGACATTGCTGTTCCAGTGCATGCAGGACTCGATGCCTGAGGTC
CGGCAGAGCTCCTTTGCCCTCCTGGGAGACCTCACCAAAGCCTGCTTCATCCATGTCAAG
CCCTGTATCGCCGAGTTCATGCCCATTCTGGGCACCAACCTGAACCCAGAGTTCATCTCC
GTCTGCAACAACGCCACCTGGGCCATTGGTGAAATCTGCATGCAGATGGGGGCAGAGATG
CAGCCTTATGTGCAGATGGTCCTCAACAACCTGGTGGAAATCATTAACCGACCCAACACA
CCCAAGACACTGCTGGAAAACACAGGTCGCCTGACGAGTCCCTCTGCCATTCCAGCCATC
ACCATCGGCCGCTTGGGCTACGTGTGCCCCCAGGAGGTGGCACCCATGCTGCAGCAGTTC
ATCCGGCCTTGGTGCACGTCCCTCAGGAACATCAGGGACAACGAGGAGAAGGACTCAGCC
TTCCGCGGCATCTGCATGATGATCGGTGTCAACCCGGGGGGCGTTGTGCAGGACTTTATT
TTCTTCTGCGATGCTGTAGCCTCCTGGGTGAGCCCGAAGGATGACCTTCGGGACATGTTT
TATAAGATTCTCCACGGCTTCAAAGACCAAGTTGGGGAAGATAACTGGCAGCAGTTCTCT
GAGCAATTCCCGCCGCTGCTCAAGGAGAGGCTGGCGGCTTTCTATGGGGTCTAG
|
Protein Properties |
Number of Residues
| 897 |
Molecular Weight
| 101387.1 |
Theoretical pI
| 4.63 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Transportin-2
MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDE
PTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGE
LQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQF
FKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVML
LEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIP
ILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAED
DDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA
IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT
ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD
AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP
YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV
ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS
VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTGRLTSPSAIPAI
TIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFI
FFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV
|
External Links |
GenBank ID Protein
| 209969838 |
UniProtKB/Swiss-Prot ID
| O14787 |
UniProtKB/Swiss-Prot Entry Name
| TNPO2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_001136196.1 |
GeneCard ID
| TNPO2 |
GenAtlas ID
| TNPO2 |
HGNC ID
| HGNC:19998 |
References |
General References
| Not Available |