| Identification |
|---|
| HMDB Protein ID
| CDBP03608 |
| Secondary Accession Numbers
| Not Available |
| Name
| FYVE, RhoGEF and PH domain-containing protein 5 |
| Description
| Not Available |
| Synonyms
|
- Zinc finger FYVE domain-containing protein 23
|
| Gene Name
| FGD5 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| metal ion binding |
| binding |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| transition metal ion binding |
| zinc ion binding |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| small gtpase regulator activity |
| ion binding |
| cation binding |
| Process |
| regulation of small gtpase mediated signal transduction |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| regulation of cell communication |
| regulation of signal transduction |
|
| Cellular Location
|
- Cytoplasm
- Cytoplasm (Probable)
- cytoskeleton (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p25.1 |
| SNPs
| FGD5 |
| Gene Sequence
|
>4389 bp
ATGTTCAGGGGTCCGAAGCCCCCCATTGCCCCCAAGCCCAGGCTGACTGCCCCAAACGAG
TGGAGAGCCAGTGTGTACCTGAATGACAGCTTGAACAAATGCAGCAACGGGCGGCTGCCC
TGTGTAGACAGGGGGCTTGATGAGGGGCCCCGGTCCATCCCAAAGTGCTCTGAGTCGGAG
ACCGACGAGGATTACATCGTGGTCCCCAGGGTTCCGCTGAGGGAGGATGAACCCAAGGAC
GAGGGCAGTGTGGGGAACAAAGCCCTGGTGTCTCCCGAGTCCTCTGCGGAAGAGGAAGAG
GAGCGTGAAGAGGGAGGCGAGGCATGTGGCCTGGAGGGTACAGGAGCTGGTGAGGATTCA
GTGGCCCCTGCTGCTCCGGGTGCAGGAGCGCTGAGCAGGGAGGGTGAGGAAGGCACAGAC
CTTGCTCTTGAGGATGAAGGGGAGGGCTGCGCTGATGAGCCAGGGACACTGGAGCAGGTG
TCCAGAAGTGAGGAGGAAGAGAAGCTAGTGCAGCCACACAGGGAGTGCAGCCTGGAGGAC
AGTGGGCCTTGGGCTGGAGAGGGGGTCTTCCAGAGCGACCTCCTCCTGCCTCACATCCAT
GGAGAGGACCAGGAGCCCCCCGACACCCCCGGGGAGGCAGAGGAGGATGATGAGGAAGGC
TGTGCCAGCACAGACCCAGCAGGGGCAGATGAGGGTTCGGGTCCTGACAGGCCCACGGAG
GACATGGGACAGGATGCTGAGGACACCAGTGAGGAGCCCCCTGAGAAGGAGGAGCTGGCC
GGGGTCCAGGAGGCAGAGACAGCCACAGACTGCCCTGAAGTTCTTGAGGAGGGATGTGAA
GAGGCCACGGGTGTCACAGGTGGGGAACAGGTTGACCTCAGTGAACCACCTGACCACGAG
AAGAAAACCAACCAAGAAGTGGCAGCCGCCACCCTGGAGGACCATGCACAGGATGAGTCC
GCCGAGGAGAGCTGCCAGATTGTCCCTTTTGAGAATGACTGCATGGAGGACTTCGTGACT
TCCCTCACAGGAAGCCCCTATGAGTTCTTCCCAACTGAGAGCACCTCTTTTTGCAGCGAG
AGCTGTTCTCCTCTTTCTGAATCAGCGAAAGGTTTAGAATCAGAGCAGGCACCAAAGCTG
GGGCTGCGTGCGGAGGAGAACCCCATGGTGGGGGCTTTGTGTGGCCAGTGTGGCTCCCTA
CAGGGTGGAGCGGCCGAGGGTCCCGCAGCCCCTGATGTGGTGGTCGTGCTGGAGGAGGAG
GCCTTGGATGATGCACTGGCCAACCCCTATGTGATGGGAGTGGGCCTGCCCGGTCAGGCG
GCCCCTGGAGAAGGAGGGCAGGCTGCATCGGACGCCCTGGGTGGTTATGGCTCGAAAGAA
GAATTGAACTGTGAGGCAGAGGGTGGCCTGGTTCCCGCGGACAGGAAGAACACCAGCACG
AGGGTCCGGCCCCACTCTGGGAAGGTGGCCGGCTATGTCCCAGAAACCGTCCCTGAAGAA
ACCGGACCTGAGGCGGGCTCGTCAGCCCCTGGCATTGGAGGTGCCGCAGAGGAGGTGGGA
AAGACGCTTTTGTCATTGGAGGGGAAGCCCTTGGAAGCCAGCAGGGCCTTGCCAGCAAAG
CCCAGGGCCTTTACTTTATACCCTCGGTCGTTCTCCGTGGAAGGCCGAGAGATTCCAGTG
TCCGTGTACCAGGAGCCTGAGGGGTCAGGGTTGGATGACCACAGGATAAAGAGGAAAGAG
GACAATCTCTCTCTGTCGTGTGTAATTGGCTCCTCTGGGAGTTTCTCCCAGAGAAACCAC
CTTCCGTCCAGCGGCACCTCCACGCCTTCTTCCATGGTCGACATCCCACCTCCTTTCGAC
CTGGCCTGCATCACCAAGAAGCCCATCACAAAGAGCTCTCCCTCACTCCTGATCGAGAGC
GACTCCCCGGACAAGTACAAGAAGAAGAAGTCATCCTTTAAGCGCTTCCTGGCACTGACG
TTTAAGAAGAAGACGGAGAACAAATTGCATGTGGATGTGAACGTGTCTTCCTCTAGGTCC
TCTTCAGAGTCCAGCTACCACGGGCCTTCCAGGATTCTGGAAGTTGACCGGAGAAGCCTC
AGCAACTCCCCTCAGCTTAAGTCTCGGACTGGGAAGCTCCGGGCTTCTGAATCCCCCTCC
TCCCTCATCTTTTATAGAGATGGCAAGAGGAAAGGTGTCCCCTTCAGCAGGACGGTGTCC
AGAGTGGAGTCCTTTGAAGACCGCTCCCGGCCGCCCTTCCTGCCCTTGCCACTGACCAAG
CCACGGTCCATCTCCTTCCCCAGCGCTGACACTTCAGACTATGAGAACATTCCAGCCATG
AACTCGGACTATGAGAATATCCAGATTCCACCCCGGAGACCTGCCAGGGCTGGCGCGTTC
ACGAAGCTGTTTGAAGATCAGAGCAGAGCCCTGTCCACAGCAAACGAAAATGATGGCTAC
GTGGACATGAGCAGCTTCAACGCCTTTGAGAGCAAACAGCAGAGTGCAGACCAGGACGCA
GAAAGCGCCTACACAGAGCCCTACAAAGTCTGTCCCATCTCGTCGGCAGCCCCCAAAGAG
GACCTTACGTCGGATGAAGAGCAGAGAAGCTCGGAGGAGGAGGACAGTGCTTCAAGAGAC
CCCAGTGTCACCCACAAGGTGGAAGGACAGTCCAGAGCCCTTGTCATCGCACAGGAACTG
CTATCTTCAGAGAAAGCATACGTGGAGATGCTCCAGCACTTAAATCTGGATTTCCATGGA
GCTGTCATGAGGGCCTTGGATGACATGGACCATGAAGGCAGAGACACATTGGCCCGGGAG
GAGCTGAGGCAGGGCCTGAGTGAACTCCCAGCCATCCACGACCTTCATCAAGGCATCCTG
GAGGAGCTGGAGGAAAGGCTGTCAAATTGGGAGAGCCAGCAGAAGGTAGCTGACGTCTTC
CTGGCCCGGGAGCAGGGGTTTGATCACCACGCCACTCACATCCTGCAGTTCGACAGGTAC
CTAGGTCTGCTCAGTGAGAATTGCCTCCACTCTCCCCGGCTGGCAGCTGCTGTCCGTGAA
TTTGAGCAGAGTGTACAAGGAGGCAGCCAGACTGCGAAGCATCGGCTGCTGCGGGTGGTT
CAACGCCTCTTCCAGTACCAAGTGCTCCTCACAGACTATTTAAACAACCTTTGTCCGGAC
TCCGCCGAGTACGACAACACACAGGGTGCACTGAGCCTCATCTCCAAAGTCACAGACCGT
GCCAACGACAGCATGGAGCAAGGGGAAAACCTGCAGAAGCTGGTCCACATTGAGCACAGC
GTCCGGGGCCAAGGGGATCTCCTCCAGCCAGGAAGGGAGTTTCTGAAGGAAGGGACGCTG
ATGAAAGTAACAGGGAAAAACAGACGGCCCCGGCACCTATTTCTGATGAACGATGTGCTC
CTGTACACCTATCCCCAGAAGGATGGGAAGTACCGGCTGAAGAACACATTGGCTGTGGCC
AACATGAAGGTCAGCCGCCCTGTGATGGAGAAAGTGCCCTACGCTCTAAAGATTGAGACT
TCCGAGTCCTGCCTGATGCTGTCTGCGAGCTCCTGTGCAGAGAGGGACGAGTGGTATGGC
TGTCTGAGCAGAGCCCTCCCTGAGGACTACAAGGCCCAGGCGCTGGCTGCATTCCACCAT
AGCGTGGAGATACGAGAGAGGCTGGGGGTTAGCCTTGGGGAGAGGCCCCCCACCCTGGTG
CCTGTCACACACGTCATGATGTGCATGAACTGCGGCTGCGACTTCTCCCTCACCCTGCGG
CGTCATCACTGTCACGCCTGTGGCAAGATCGTGTGCCGGAACTGTTCGCGGAACAAGTAC
CCGCTGAAGTACCTGAAGGACAGGATGGCCAAGGTCTGCGACGGCTGCTTCGGGGAGCTG
AAGAAGCGGGGCAGGGCTGTCCCGGGCCTGATGAGAGAGCGGCCTGTGAGCATGAGCTTC
CCGCTGTCTTCACCCCGCTTCTCGGGCAGTGCCTTTTCATCCGTCTTCCAGAGCATTAAC
CCCTCGACCTTCAAGAAGCAGAAGAAAGTCCCTTCAGCCCTGACAGAGGTGGCTGCCTCT
GGAGAGGGCTCTGCCATCAGTGGCTATCTCAGCCGGTGTAAGAGGGGCAAGCGGCACTGG
AAGAAGCTCTGGTTTGTCATCAAAGGCAAAGTTCTCTACACCTACATGGCCAGTGAGGAC
AAAGTGGCCTTGGAGAGTATGCCTCTGCTAGGCTTCACCATTGCTCCAGAAAAGGAAGAG
GGCAGCAGTGAAGTAGGACCTATTTTTCACCTTTACCACAAGAAAACCCTATTTTATAGC
TTCAAAGCAGAAGATACCAATTCAGCTCAGAGGTGGATCGAGGCCATGGAAGATGCGAGT
GTGTTATAG
|
| Protein Properties |
|---|
| Number of Residues
| 1462 |
| Molecular Weight
| 159889.4 |
| Theoretical pI
| 4.66 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>FYVE, RhoGEF and PH domain-containing protein 5
MFRGPKPPIAPKPRLTAPNEWRASVYLNDSLNKCSNGRLPCVDRGLDEGPRSIPKCSESE
TDEDYIVVPRVPLREDEPKDEGSVGNKALVSPESSAEEEEEREEGGEACGLEGTGAGEDS
VAPAAPGAGALSREGEEGTDLALEDEGEGCADEPGTLEQVSRSEEEEKLVQPHRECSLED
SGPWAGEGVFQSDLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTE
DMGQDAEDTSEEPPEKEELAGVQEAETATDCPEVLEEGCEEATGVTGGEQVDLSEPPDHE
KKTNQEVAAATLEDHAQDESAEESCQIVPFENDCMEDFVTSLTGSPYEFFPTESTSFCSE
SCSPLSESAKGLESEQAPKLGLRAEENPMVGALCGQCGSLQGGAAEGPAAPDVVVVLEEE
ALDDALANPYVMGVGLPGQAAPGEGGQAASDALGGYGSKEELNCEAEGGLVPADRKNTST
RVRPHSGKVAGYVPETVPEETGPEAGSSAPGIGGAAEEVGKTLLSLEGKPLEASRALPAK
PRAFTLYPRSFSVEGREIPVSVYQEPEGSGLDDHRIKRKEDNLSLSCVIGSSGSFSQRNH
LPSSGTSTPSSMVDIPPPFDLACITKKPITKSSPSLLIESDSPDKYKKKKSSFKRFLALT
FKKKTENKLHVDVNVSSSRSSSESSYHGPSRILEVDRRSLSNSPQLKSRTGKLRASESPS
SLIFYRDGKRKGVPFSRTVSRVESFEDRSRPPFLPLPLTKPRSISFPSADTSDYENIPAM
NSDYENIQIPPRRPARAGAFTKLFEDQSRALSTANENDGYVDMSSFNAFESKQQSADQDA
ESAYTEPYKVCPISSAAPKEDLTSDEEQRSSEEEDSASRDPSVTHKVEGQSRALVIAQEL
LSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGIL
EELEERLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVRE
FEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDR
ANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRPRHLFLMNDVL
LYTYPQKDGKYRLKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSASSCAERDEWYG
CLSRALPEDYKAQALAAFHHSVEIRERLGVSLGERPPTLVPVTHVMMCMNCGCDFSLTLR
RHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKRGRAVPGLMRERPVSMSF
PLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEGSAISGYLSRCKRGKRHW
KKLWFVIKGKVLYTYMASEDKVALESMPLLGFTIAPEKEEGSSEVGPIFHLYHKKTLFYS
FKAEDTNSAQRWIEAMEDASVL
|
| External Links |
|---|
| GenBank ID Protein
| 194018497 |
| UniProtKB/Swiss-Prot ID
| Q6ZNL6 |
| UniProtKB/Swiss-Prot Entry Name
| FGD5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_152536.3 |
| GeneCard ID
| FGD5 |
| GenAtlas ID
| FGD5 |
| HGNC ID
| HGNC:19117 |
| References |
|---|
| General References
| Not Available |