Identification |
HMDB Protein ID
| CDBP03595 |
Secondary Accession Numbers
| Not Available |
Name
| Eukaryotic peptide chain release factor subunit 1 |
Description
| Not Available |
Synonyms
|
- Eukaryotic release factor 1
- Protein Cl1
- TB3-1
- eRF1
|
Gene Name
| ETF1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in translation release factor activity, codon specific |
Specific Function
| Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA |
GO Classification
|
Component |
cell part |
intracellular part |
cytoplasm |
Function |
binding |
translation termination factor activity |
translation release factor activity |
translation release factor activity, codon specific |
nucleic acid binding |
translation factor activity, nucleic acid binding |
rna binding |
Process |
macromolecular complex disassembly |
cellular macromolecular complex disassembly |
cellular protein complex disassembly |
translational termination |
cellular component organization or biogenesis |
cellular component organization |
cellular component disassembly |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:5 |
Locus
| 5q31.1 |
SNPs
| ETF1 |
Gene Sequence
|
>1314 bp
ATGGCGGACGACCCCAGTGCTGCCGACAGGAACGTGGAGATCTGGAAGATCAAGAAGCTC
ATTAAGAGCTTGGAGGCGGCCCGCGGCAATGGCACCAGCATGATATCATTGATCATTCCT
CCCAAAGACCAGATTTCACGAGTGGCAAAAATGTTAGCGGATGAGTTTGGAACTGCATCT
AACATTAAGTCACGAGTAAACCGCCTTTCAGTCCTGGGAGCCATTACATCTGTACAACAA
AGACTCAAACTTTATAACAAAGTACCTCCAAATGGTCTGGTTGTATACTGTGGAACAATT
GTAACAGAAGAAGGAAAGGAAAAGAAAGTCAACATTGACTTTGAACCTTTCAAACCAATT
AATACGTCATTGTATTTGTGTGACAACAAATTCCATACAGAGGCTCTTACAGCACTACTT
TCAGATGATAGCAAGTTTGGATTCATTGTAATAGATGGTAGTGGTGCACTTTTTGGCACA
CTCCAAGGAAACACAAGAGAAGTCCTGCACAAATTCACTGTGGATCTCCCAAAGAAACAC
GGTAGAGGAGGTCAGTCAGCCTTGCGTTTTGCCCGTTTAAGAATGGAAAAGCGACATAAC
TATGTTCGGAAAGTAGCAGAGACTGCTGTGCAGCTGTTTATTTCTGGGGACAAAGTGAAT
GTGGCTGGTCTAGTTTTAGCTGGATCCGCTGACTTTAAAACTGAACTAAGTCAATCTGAT
ATGTTTGATCAGAGGTTACAATCAAAAGTTTTAAAATTAGTTGATATATCCTATGGTGGT
GAAAATGGATTCAACCAAGCTATTGAGTTATCTACTGAAGTCCTCTCCAACGTGAAATTC
ATTCAAGAGAAGAAATTAATAGGACGATACTTTGATGAAATCAGCCAGGACACGGGCAAG
TACTGTTTTGGCGTTGAAGATACACTAAAGGCTTTGGAAATGGGAGCTGTAGAAATTCTA
ATAGTCTATGAAAATCTGGATATAATGAGATATGTTCTTCATTGCCAAGGCACAGAAGAG
GAGAAAATTCTCTATCTAACTCCAGAGCAAGAAAAGGATAAATCTCATTTCACAGACAAA
GAGACCGGACAGGAACATGAGCTTATCGAGAGCATGCCCCTGTTGGAATGGTTTGCTAAC
AACTATAAAAAATTTGGAGCTACGTTGGAAATTGTCACAGATAAATCACAAGAAGGGTCT
CAGTTTGTGAAAGGATTTGGTGGAATTGGAGGTATCTTGCGGTACCGAGTAGATTTCCAG
GGAATGGAATACCAAGGAGGAGACGATGAATTTTTTGACCTTGATGACTACTAG
|
Protein Properties |
Number of Residues
| 437 |
Molecular Weight
| 49030.5 |
Theoretical pI
| 5.41 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Eukaryotic peptide chain release factor subunit 1
MADDPSAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTAS
NIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGKEKKVNIDFEPFKPI
NTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLPKKH
GRGGQSALRFARLRMEKRHNYVRKVAETAVQLFISGDKVNVAGLVLAGSADFKTELSQSD
MFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGK
YCFGVEDTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKSHFTDK
ETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVKGFGGIGGILRYRVDFQ
GMEYQGGDDEFFDLDDY
|
External Links |
GenBank ID Protein
| 5499721 |
UniProtKB/Swiss-Prot ID
| P62495 |
UniProtKB/Swiss-Prot Entry Name
| ERF1_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AF095901 |
GeneCard ID
| ETF1 |
GenAtlas ID
| ETF1 |
HGNC ID
| HGNC:3477 |
References |
General References
| Not Available |