| Identification |
|---|
| HMDB Protein ID
| CDBP03680 |
| Secondary Accession Numbers
| Not Available |
| Name
| Importin-7 |
| Description
| Not Available |
| Synonyms
|
- Imp7
- Ran-binding protein 7
- RanBP7
|
| Gene Name
| IPO7 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev |
| GO Classification
|
| Function |
| transporter activity |
| substrate-specific transporter activity |
| binding |
| protein transporter activity |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11p15.4 |
| SNPs
| IPO7 |
| Gene Sequence
|
>3117 bp
ATGGACCCCAACACCATTATCGAGGCCCTGCGGGGCACCATGGACCCAGCCCTGCGTGAG
GCCGCGGAGCGCCAGCTCAATGAAGCACACAAGTCTCTGAATTTTGTCTCAACACTGCTC
CAGATTACTATGTCGGAACAGCTGGATTTACCTGTGAGACAGGCAGGTGTTATCTATCTG
AAAAATATGATAACACAGTATTGGCCTGATCGAGAAACAGCACCAGGGGATATATCCCCT
TATACTATTCCAGAAGAAGATCGCCATTGTATTCGAGAAAATATTGTAGAAGCCATTATC
CATTCTCCTGAGCTCATCAGGGTACAGCTTACTACATGCATTCATCACATCATCAAACAT
GATTATCCAAGCCGCTGGACTGCCATTGTGGACAAAATTGGCTTTTATCTTCAGTCCGAT
AACAGTGCTTGTTGGCTAGGAATTCTTCTTTGCCTTTATCAGCTTGTGAAAAATTATGAG
TATAAAAAACCAGAGGAGCGGAGTCCATTGGTAGCAGCAATGCAGCATTTTCTGCCAGTT
CTAAAGGATCGTTTTATCCAGCTTCTTTCTGACCAGTCTGATCAGTCTGTCCTCATCCAG
AAACAGATATTCAAGATCTTCTATGCTCTTGTTCAGTATACACTACCACTGGAACTGATA
AACCAACAGAACCTGACAGAATGGATAGAAATTTTAAAGACTGTTGTGAACAGGGATGTA
CCTAATGAAACACTTCAAGTTGAAGAAGATGATCGACCTGAGTTACCATGGTGGAAATGC
AAGAAGTGGGCCTTACATATTTTAGCAAGACTTTTTGAAAGATATGGAAGCCCTGGCAAT
GTTTCCAAGGAGTATAATGAATTTGCTGAAGTATTTCTGAAGGCATTTGCTGTTGGTGTC
CAGCAAGTTTTATTGAAGGTGTTATATCAGTACAAGGAGAAGCAATATATGGCTCCTCGA
GTTTTACAACAGACATTAAATTATATTAATCAAGGAGTTTCTCATGCTCTCACCTGGAAG
AATCTGAAGCCCCATATACAAGGCATTATCCAAGATGTTATTTTTCCATTGATGTGCTAT
ACAGATGCTGATGAGGAACTTTGGCAAGAAGACCCTTACGAATATATACGCATGAAGTTT
GATGTGTTTGAAGATTTCATTTCTCCTACCACTGCTGCCCAGACACTTTTGTTTACAGCC
TGTAGTAAGAGGAAAGAGGTACTGCAAAAGACTATGGGATTTTGTTACCAGATTCTTACA
GAACCAAATGCTGACCCTCGAAAAAAAGATGGAGCCCTGCATATGATTGGCTCTTTAGCT
GAAATACTTCTGAAGAAAAAGATCTATAAAGATCAGATGGAATACATGTTGCAGAATCAT
GTATTCCCTCTCTTCAGCAGTGAACTAGGCTACATGAGAGCAAGGGCTTGCTGGGTACTT
CACTATTTTTGTGAAGTGAAGTTCAAAAGTGATCAGAACCTTCAAACAGCCTTAGAGCTA
ACAAGAAGATGTCTGATTGATGATAGAGAAATGCCTGTGAAAGTGGAAGCTGCCATTGCC
CTTCAAGTATTGATCAGCAATCAAGAAAAAGCTAAAGAATATATCACACCATTCATCAGA
CCTGTAATGCAGGCTCTTCTTCACATTATAAGAGAAACAGAAAATGATGACCTTACCAAT
GTAATTCAGAAAATGATCTGTGAATATAGTGAAGAAGTTACTCCTATTGCAGTAGAAATG
ACACAACATTTGGCAATGACATTTAACCAAGTAATCCAGACGGGGCCAGATGAAGAAGGT
AGTGATGACAAAGCAGTTACTGCTATGGGAATTCTGAATACAATTGATACACTTCTTAGT
GTAGTTGAAGATCATAAAGAGATAACCCAACAGCTTGAGGGAATCTGCTTACAGGTCATT
GGTACTGTTTTACAACAGCATGTCTTAGAATTCTATGAGGAGATCTTCTCTTTAGCGCAC
AGTTTGACATGTCAACAAGTGTCTCCACAGATGTGGCAGCTACTACCCCTTGTATTTGAA
GTCTTTCAGCAAGATGGCTTTGATTACTTTACAGATATGATGCCCCTCCTTCATAATTAT
GTAACAGTTGATACAGACACACTTCTGTCTGACACCAAGTATCTTGAAATGATATACAGT
ATGTGCAAAAAGGTTCTTACAGGAGTTGCAGGAGAAGATGCAGAGTGTCATGCAGCAAAA
TTGTTAGAGGTCATCATTCTGCAGTGCAAAGGGCGTGGCATTGACCAGTGCATTCCCTTA
TTCGTGGAAGCAGCCTTAGAAAGACTGACAAGAGAGGTTAAGACAAGTGAACTTCGAACT
ATGTGTCTGCAAGTTGCAATTGCAGCTTTGTATTATAATCCACACCTACTACTCAATACC
TTAGAAAATCTTCGCTTCCCTAATAATGTTGAACCAGTTACAAATCATTTTATTACACAG
TGGCTTAATGATGTTGACTGTTTCTTGGGGCTTCATGACAGAAAGATGTGTGTTCTCGGA
CTCTGTGCTCTTATTGATATGGAACAGATACCCCAAGTTTTAAATCAGGTTTCTGGACAG
ATTTTGCCGGCTTTTATCCTTTTATTTAACGGATTGAAAAGAGCATATGCCTGCCATGCA
GAACATGAGAATGACAGTGATGATGATGATGAAGCTGAAGATGATGATGAAACCGAGGAA
CTGGGGAGTGATGAAGATGATATTGATGAAGATGGGCAAGAATATTTGGAGATTCTGGCT
AAGCAGGCTGGTGAAGATGGAGATGATGAAGATTGGGAAGAAGATGATGCTGAAGAGACT
GCTCTGGAAGGCTATTCCACAATCATTGATGATGAAGATAACCCTGTTGATGAGTATCAG
ATATTTAAAGCTATCTTTCAAACTATTCAAAATCGTAATCCTGTGTGGTATCAGGCACTG
ACTCACGGTCTTAATGAAGAACAAAGAAAACAGTTACAGGACATAGCAACTCTGGCTGAT
CAAAGAAGAGCAGCCCATGAATCCAAAATGATTGAGAAGCATGGAGGATACAAATTCAGT
GCTCCAGTTGTGCCAAGTTCTTTCAATTTTGGAGGCCCAGCACCAGGGATGAATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1038 |
| Molecular Weight
| 119515.5 |
| Theoretical pI
| 4.44 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Importin-7
MDPNTIIEALRGTMDPALREAAERQLNEAHKSLNFVSTLLQITMSEQLDLPVRQAGVIYL
KNMITQYWPDRETAPGDISPYTIPEEDRHCIRENIVEAIIHSPELIRVQLTTCIHHIIKH
DYPSRWTAIVDKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLVAAMQHFLPV
LKDRFIQLLSDQSDQSVLIQKQIFKIFYALVQYTLPLELINQQNLTEWIEILKTVVNRDV
PNETLQVEEDDRPELPWWKCKKWALHILARLFERYGSPGNVSKEYNEFAEVFLKAFAVGV
QQVLLKVLYQYKEKQYMAPRVLQQTLNYINQGVSHALTWKNLKPHIQGIIQDVIFPLMCY
TDADEELWQEDPYEYIRMKFDVFEDFISPTTAAQTLLFTACSKRKEVLQKTMGFCYQILT
EPNADPRKKDGALHMIGSLAEILLKKKIYKDQMEYMLQNHVFPLFSSELGYMRARACWVL
HYFCEVKFKSDQNLQTALELTRRCLIDDREMPVKVEAAIALQVLISNQEKAKEYITPFIR
PVMQALLHIIRETENDDLTNVIQKMICEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEG
SDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQHVLEFYEEIFSLAH
SLTCQQVSPQMWQLLPLVFEVFQQDGFDYFTDMMPLLHNYVTVDTDTLLSDTKYLEMIYS
MCKKVLTGVAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVEAALERLTREVKTSELRT
MCLQVAIAALYYNPHLLLNTLENLRFPNNVEPVTNHFITQWLNDVDCFLGLHDRKMCVLG
LCALIDMEQIPQVLNQVSGQILPAFILLFNGLKRAYACHAEHENDSDDDDEAEDDDETEE
LGSDEDDIDEDGQEYLEILAKQAGEDGDDEDWEEDDAEETALEGYSTIIDDEDNPVDEYQ
IFKAIFQTIQNRNPVWYQALTHGLNEEQRKQLQDIATLADQRRAAHESKMIEKHGGYKFS
APVVPSSFNFGGPAPGMN
|
| External Links |
|---|
| GenBank ID Protein
| 5453998 |
| UniProtKB/Swiss-Prot ID
| O95373 |
| UniProtKB/Swiss-Prot Entry Name
| IPO7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_006391.2 |
| GeneCard ID
| IPO7 |
| GenAtlas ID
| IPO7 |
| HGNC ID
| HGNC:9852 |
| References |
|---|
| General References
| Not Available |