| Identification |
|---|
| HMDB Protein ID
| CDBP03587 |
| Secondary Accession Numbers
| Not Available |
| Name
| EH domain-containing protein 2 |
| Description
| Not Available |
| Synonyms
|
- PAST homolog 2
|
| Gene Name
| EHD2 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in GTPase activity |
| Specific Function
| Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP |
| GO Classification
|
| Function |
| calcium ion binding |
| hydrolase activity, acting on acid anhydrides |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| pyrophosphatase activity |
| ion binding |
| cation binding |
| metal ion binding |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| catalytic activity |
| hydrolase activity |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| gtpase activity |
| nucleoside-triphosphatase activity |
|
| Cellular Location
|
- Cell membrane
- Peripheral membrane protein
- Peripheral membrane protein
- Endosome membrane
- Cytoplasmic side
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.3 |
| SNPs
| EHD2 |
| Gene Sequence
|
>1632 bp
ATGTTCAGCTGGCTGAAGCGGGGCGGGGCACGGGGCCAGCAGCCCGAGGCCATCCGCACG
GTGACCTCGGCCCTCAAGGAGCTGTACCGCACGAAGCTGCTGCCGCTGGAGGAGCACTAC
CGCTTTGGGGCCTTCCACTCGCCGGCCCTGGAGGACGCAGACTTCGACGGCAAGCCCATG
GTGCTGGTGGCCGGCCAGTACAGCACGGGCAAGACCAGCTTCATCCAGTACCTGCTGGAG
CAGGAGGTGCCCGGCTCCCGCGTTGGGCCTGAGCCCACCACCGACTTCTTTGTGGCCGTC
ATGCACGGGGACACTGAGGGCACCGTGCCCGGCAACGCCCTCGTCGTGGACCCGGACAAG
CCCTTCCGCAAACTCAACCCTTTCGGAAACACCTTCCTCAACAGGTTCATGTGTGCCCAG
CTCCCTAATCAGGTCCTGGAGAGCATCAGCATCATCGACACCCCGGGTATCCTGTCGGGT
GCCAAGCAGGGAGTGAGCCGCGGCTACGACTTCCCGGCCGTGCTGCGCTGGTTCGCGGAG
CGCGTGGACCTCATCATCCTGCTCTTTGATGCGCACAAGCTGGAGATCTCGGACGAGTTC
TCAGAGGCCATCGGCGCGTTGCGGGGCCATGAGGACAAGATCCGCGTGGTGCTCAACAAG
GCCGACATGGTGGAGACGCAGCAGCTGATGCGCGTCTACGGCGCGCTCATGTGGGCGCTG
GGCAAGGTGGTGGGCACGCCCGAGGTGCTGCGCGTCTACATCGGCTCCTTCTGGTCCCAG
CCCCTCCTCGTGCCCGACAACCGGCGCCTCTTCGAGCTGGAGGAGCAGGACCTCTTCCGC
GACATCCAGGGCCTGCCCCGGCACGCAGCCTTGCGCAAGCTCAACGACCTGGTGAAGAGG
GCCCGGCTGGTGCGAGTTCACGCTTACATCATCAGCTACCTGAAGAAGGAGATGCCCTCT
GTGTTTGGGAAGGAGAACAAGAAGAAGCAGCTGATCCTCAAACTGCCCGTCATCTTTGCG
AAGATTCAGCTGGAACATCACATCTCCCCTGGGGACTTTCCTGATTGCCAGAAAATGCAG
GAGCTGCTGATGGCGCACGACTTCACCAAGTTTCACTCGCTGAAGCCGAAGCTGCTAGAG
GCACTGGACGAGATGCTGACGCACGACATCGCCAAGCTCATGCCCCTGCTGCGGCAGGAG
GAGCTGGAGAGCACCGAGGTGGGCGTGCAGGGGGGCGCTTTTGAGGGCACCCACATGGGC
CCGTTTGTGGAGCGGGGACCTGACGAGGCCATGGAGGACGGCGAGGAGGGCTCGGACGAC
GAGGCCGAGTGGGTGGTGACCAAAGACAAGTCCAAATACGACGAGATCTTCTACAACCTG
GCGCCTGCCGACGGCAAGCTGAGCGGCTCCAAGGCCAAGACCTGGATGGTGGGGACCAAG
CTCCCCAACTCAGTGCTGGGGCGCATCTGGAAGCTCAGCGATGTGGACCGCGACGGCATG
CTGGATGATGAGGAGTTCGCGCTGGCCAGCCACCTCATCGAGGCCAAGCTGGAAGGCCAC
GGGCTGCCCGCCAACCTGCCCCGTCGCCTGGTGCCACCCTCCAAGCGACGCCACAAGGGC
TCCGCCGAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 543 |
| Molecular Weight
| 61160.9 |
| Theoretical pI
| 6.42 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>EH domain-containing protein 2
MFSWLKRGGARGQQPEAIRTVTSALKELYRTKLLPLEEHYRFGAFHSPALEDADFDGKPM
VLVAGQYSTGKTSFIQYLLEQEVPGSRVGPEPTTDCFVAVMHGDTEGTVPGNALVVDPDK
PFRKLNPFGNTFLNRFMCAQLPNQVLESISIIDTPGILSGAKQRVSRGYDFPAVLRWFAE
RVDLIILLFDAHKLEISDEFSEAIGALRGHEDKIRVVLNKADMVETQQLMRVYGALMWAL
GKVVGTPEVLRVYIGSFWSQPLLVPDNRRLFELEEQDLFRDIQGLPRHAALRKLNDLVKR
ARLVRVHAYIISYLKKEMPSVFGKENKKKQLILKLPVIFAKIQLEHHISPGDFPDCQKMQ
ELLMAHDFTKFHSLKPKLLEALDEMLTHDIAKLMPLLRQEELESTEVGVQGGAFEGTHMG
PFVERGPDEAMEDGEEGSDDEAEWVVTKDKSKYDEIFYNLAPADGKLSGSKAKTWMVGTK
LPNSVLGRIWKLSDVDRDGMLDDEEFALASHLIEAKLEGHGLPANLPRRLVPPSKRRHKG
SAE
|
| External Links |
|---|
| GenBank ID Protein
| 7212807 |
| UniProtKB/Swiss-Prot ID
| Q9NZN4 |
| UniProtKB/Swiss-Prot Entry Name
| EHD2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF181263 |
| GeneCard ID
| EHD2 |
| GenAtlas ID
| EHD2 |
| HGNC ID
| HGNC:3243 |
| References |
|---|
| General References
| Not Available |