Showing Protein T-lymphoma invasion and metastasis-inducing protein 2 (CDBP03820)
| Identification | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HMDB Protein ID | CDBP03820 | |||||||||||||||||||||||||||||
| Secondary Accession Numbers | Not Available | |||||||||||||||||||||||||||||
| Name | T-lymphoma invasion and metastasis-inducing protein 2 | |||||||||||||||||||||||||||||
| Description | Not Available | |||||||||||||||||||||||||||||
| Synonyms |
|
|||||||||||||||||||||||||||||
| Gene Name | TIAM2 | |||||||||||||||||||||||||||||
| Protein Type | Receptor | |||||||||||||||||||||||||||||
| Biological Properties | ||||||||||||||||||||||||||||||
| General Function | Involved in Rho guanyl-nucleotide exchange factor activity | |||||||||||||||||||||||||||||
| Specific Function | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. Activates specifically RAC1, but not CDC42 and RHOA | |||||||||||||||||||||||||||||
| GO Classification |
|
|||||||||||||||||||||||||||||
| Cellular Location |
|
|||||||||||||||||||||||||||||
| Pathways | Not Available | |||||||||||||||||||||||||||||
| Gene Properties | ||||||||||||||||||||||||||||||
| Chromosome Location | Chromosome:6 | |||||||||||||||||||||||||||||
| Locus | 6q25.2 | |||||||||||||||||||||||||||||
| SNPs | TIAM2 | |||||||||||||||||||||||||||||
| Gene Sequence |
>5106 bp ATGGGCAACTCCGACAGTCAGTACACCCTTCAAGGATCTAAAAATCATAGCAATACTATT ACTGGTGCTAAGCAAATTCCTTGCTCCCTGAAAATACGTGGCATTCATGCAAAAGAGGAA AAGTCATTGCATGGATGGGGTCACGGAAGCAACGGAGCAGGTTACAAGTCCAGGTCCCTG GCCCGAAGCTGCCTTTCTCACTTTAAGAGTAACCAGCCTTACGCATCGAGACTCGGTGGC CCCACATGCAAGGTCTCCAGAGGTGTTGCCTACTCCACGCACAGGACAAATGCCCCAGGG AAGGATTTCCAGGGCATCAGTGCTGCTTTCTCAACTGAGAATGGCTTCCACTCTGTTGGC CACGAGCTGGCAGATAACCACATCACCTCCAGAGACTGCAACGGACACCTTCTCAACTGC TACGGGAGGAATGAGAGCATTGCCTCCACCCCACCGGGCGAAGACCGCAAGAGCCCCCGA GTGCTCATCAAAACGCTGGGGAAGCTGGATGGGTGTTTAAGGGTCGAGTTCCACAATGGT GGCAACCCCAGCAAAGTGCCTGCAGAGGACTGCAGTGAGCCGGTGCAGCTGCTGAGGTAC TCACCTACCTTAGCATCGGAAACCTCCCCTGTGCCTGAAGCCAGGAGGGGGTCCAGCGCC GATTCCCTGCCCAGCCATCGCCCCTCTCCCACGGACTCTCGCCTGCGGTCCAGCAAAGGC AGCTCCCTGAGTTCTGAGTCATCCTGGTACGACTCCCCTTGGGGCAATGCTGGAGAGCTG AGCGAGGCTGAGGGCTCCTTCCTGGCCCCCGGCATGCCTGACCCCAGTCTCCATGCCAGC TTCCCACCTGGCGATGCCAAAAAGCCTTTCAACCAAAGCTCTTCCCTCTCCTCCCTCCGG GAACTGTACAAAGATGCCAACCTGGGGAGCCTCTCCCCCTCAGGTATCCGCCTTTCTGAT GAATACATGGGCACGCATGCCAGCCTGAGCAACCGTGTCTCTTTTGCTTCCGACATTGAT GTGCCCTCCAGAGTGGCACACGGGGACCCCATCCAGTACAGTTCCTTCACTCTCCCCTGT CGGAAGCCCAAAGCCTTTGTTGAGGATACTGCGAAGAAGGACTCCCTCAAAGCCAGGATG CGACGGATCAGTGACTGGACGGGAAGCCTCTCAAGGAAGAAAAGGAAACTCCAGGAGCCG AGGTCCAAGGAGGGCAGTGACTACTTTGACAGTCGCTCTGATGGACTGAATACAGATGTG CAGGGATCCTCCCAGGCATCTGCTTTTCTGTGGTCAGGGGGCTCTACTCAGATCCTGTCT CAGAGAAGTGAATCCACACATGCGATTGGCAGCGATCCCCTCCGGCAGAACATTTATGAG AATTTCATGCGAGAGTTGGAAATGAGCAGGACCAACACTGAGAACATAGAAACATCTACA GAAACCGCCGAGTCCAGCAGCGAGTCACTCAGCTCTCTGGAACAGCTGGATCTGCTCTTT GAGAAGGAACAGGGGGTGGTCCGGAAGGCCGGGTGGCTCTTCTTCAAGCCCCTGGTCACT GTGCAGAAGGAAAGGAAGCTTGAGCTGGTGGCACGAAGGAAATGGAAACAGTACTGGGTA ACGCTGAAAGGATGCACGCTGCTGTTTTATGAGACCTATGGGAAGAATTCCATGGATCAG AGCAGTGCCCCTCGGTGTGCTCTGTTTGCAGAAGACAGCATAGTGCAGTCTGTTCCAGAG CATCCCAAGAAAGAAAATGTGTTCTGCCTCAGCAACTCCTTTGGAGATGTCTACCTTTTC CAGGCCACCAGCCAGACAGATCTAGAAAACTGGGTCACTGCTGTACACTCTGCTTGTGCA TCCCTTTTTGCAAAGAAGCATGGGAAAGAGGACACGCTGCGGCTGCTGAAGAACCAGACC AAAAACCTGCTTCAGAAGATAGACATGGACAGCAAGATGAAGAAGATGGCAGAGCTGCAG CTGTCCGTGGTGAGCGACCCAAAGAACAGGAAAGCCATAGAGAACCAGATCCAGCAATGG GAGCAGAATCTTGAGAAATTTCACATGGATCTGTTCAGGATGCGCTGCTATCTGGCCAGC CTACAAGGTGGGGAGTTACCGAACCCAAAGAGTCTCCTTGCAGCCGCCAGCCGCCCCTCC AAGCTGGCCCTCGGCAGGCTGGGCATCTTGTCTGTTTCCTCTTTCCATGCTCTGGTATGT TCTAGAGATGACTCTGCTCTCCGGAAAAGGACACTGTCACTGACCCAGCGAGGGAGAAAC AAGAAGGGAATATTTTCTTCGTTAAAAGGGCTGGACACACTGGCCAGAAAAGGCAAGGAG AAGAGACCTTCTATAACTCAGGTCGATGAACTTCTGCATATATATGGTTCAACAGTAGAC GGTGTTCCCCGAGACAATGCATGGGAAATCCAGACTTATGTCCACTTTCAGGACAATCAC GGAGTTACTGTAGGGATCAAGCCAGAGCACAGAGTAGAAGATATTTTGACTTTGGCATGC AAGATGAGGCAGTTGGAACCCAGCCATTATGGCCTACAGCTTCGAAAATTAGTAGATGAC AATGTTGAGTATTGCATCCCTGCACCATATGAATATATGCAACAACAGGTTTATGATGAA ATAGAAGTCTTTCCACTAAATGTTTATGACGTGCAGCTCACGAAGACTGGGAGTGTGTGT GACTTTGGGTTTGCAGTTACAGCGCAGGTGGATGAGCGTCAGCATCTCAGCCGGATATTT ATAAGCGACGTTCTTCCCGATGGCCTGGCGTATGGGGAAGGGCTGAGAAAGGGCAATGAG ATCATGACCTTAAATGGGGAAGCTGTGTCTGATCTTGACCTTAAGCAGATGGAGGCCCTG TTTTCTGAGAAGAGCGTCGGACTCACTCTGATTGCCCGGCCTCCGGACACAAAAGCAACC CTGTGTACATCCTGGTCAGACAGTGACCTGTTCTCCAGGGACCAGAAGAGTCTGCTGCCC CCTCCTAACCAGTCCCAACTGCTGGAGGAATTCCTGGATAACTTTAAAAAGAATACAGCC AATGATTTCAGCAACGTCCCTGATATCACAACAGGTCTGAAAAGGAGTCAGACAGATGGC ACTCTGGATCAGGTTTCCCACAGGGAGAAAATGGAGCAGACATTCAGGAGTGCTGAGCAG ATCACTGCACTGTGCAGGAGTTTTAACGACAGTCAGGCCAACGGCATGGAAGGACCGCGG GAGAATCAGGATCCTCCTCCGAGGCCTCTGGCCCGCCACCTGTCTGATGCAGACCGCCTC CGCAAAGTCATCCAGGAGCTTGTGGACACAGAGAAGTCCTACGTGAAGGATTTGAGCTGC CTCTTTGAATTATACTTGGAGCCACTTCAGAATGAGACCTTTCTTACCCAAGATGAGATG GAGTCACTTTTTGGAAGTTTGCCAGAGATGCTTGAGTTTCAGAAGGTGTTTCTGGAGACC CTGGAGGATGGGATTTCAGCATCATCTGACTTTAACACCCTAGAAACCCCCTCACAGTTT AGAAAATTACTGTTTTCCCTTGGAGGCTCTTTCCTTTATTACGCGGACCACTTTAAACTG TACAGTGGATTCTGTGCTAACCATATCAAAGTACAGAAGGTTCTGGAGCGAGCTAAAACT GACAAAGCCTTCAAGGCTTTTCTGGACGCCCGGAACCCCACCAAGCAGCATTCCTCCACG CTGGAGTCCTACCTCATCAAGCCGGTTCAGAGAGTGCTCAAGTACCCGCTGCTGCTCAAG GAGCTGGTGTCCCTGACGGACCAGGAGAGCGAGGAGCACTACCACCTGACGGAAGCACTA AAGGCAATGGAGAAAGTAGCGAGCCACATCAATGAGATGCAGAAGATCTATGAGGATTAT GGGACCGTGTTTGACCAGCTAGTAGCTGAGCAGAGCGGAACAGAGAAGGAGGTAACAGAA CTTTCGATGGGAGAGCTTCTGATGCACTCTACGGTTTCCTGGTTGAATCCATTTCTGTCT CTAGGAAAAGCTAGAAAGGACCTTGAGCTCACAGTATTTGTTTTTAAGAGAGCCGTCATA CTGGTTTATAAAGAAAACTGCAAACTGAAAAAGAAATTGCCCTCGAATTCCCGGCCTGCA CACAACTCTACTGACTTGGACCCATTTAAATTCCGCTGGTTGATCCCCATCTCCGCGCTT CAAGTCAGACTGGGGAATCCAGCAGGGACAGAAAATAATTCCATATGGGAACTGATCCAT ACGAAGTCAGAAATAGAAGGACGGCCAGAAACCATCTTTCAGTTGTGTTGCAGTGACAGT GAAAGCAAAACCAACATTGTTAAGGTGATTCGTTCTATTCTGAGGGAGAACTTCAGGCGT CACATAAAGTGTGAATTACCACTGGAGAAAACGTGTAAGGATCGCCTGGTACCTCTTAAG AACCGAGTTCCTGTTTCGGCCAAATTAGCTTCATCCAGGTCTTTAAAAGTCCTGAAGAAT TCCTCCAGCAACGAGTGGACCGGTGAGACTGGCAAGGGAACCTTGCTGGACTCTGACGAG GGCAGCTTGAGCAGCGGCACCCAGAGCAGCGGCTGCCCCACGGCTGAGGGCAGGCAGGAC TCCAAGAGCACTTCTCCCGGGAAATACCCACACCCCGGCTTGGCAGATTTTGCCGACAAT CTCATCAAAGAGAGTGACATCCTGAGCGATGAAGATGATGACCACCGTCAGACTGTGAAG CAGGGCAGCCCTACTAAAGACATCGAAATTCAGTTCCAGAGACTGAGGATTTCCGAGGAC CCAGACGTTCACCCCGAGGCTGAGCAGCAGCCTGGCCCGGAGTCGGGTGAGGGTCAGAAA GGAGGAGAGCAGCCCAAACTGGTCCGGGGGCACTTCTGCCCCATTAAACGAAAAGCCAAC AGCACCAAGAGGGACAGAGGAACTTTGCTCAAGGCGCAGATCCGTCACCAGTCCCTTGAC AGTCAGTCTGAAAATGCCACCATCGACCTAAATTCTGTTCTAGAGCGAGAATTCAGTGTC CAGAGTTTAACATCTGTTGTCAGTGAGGAGTGTTTTTATGAAACAGAGAGCCACGGAAAA TCATAG |
|||||||||||||||||||||||||||||
| Protein Properties | ||||||||||||||||||||||||||||||
| Number of Residues | 1701 | |||||||||||||||||||||||||||||
| Molecular Weight | 190101.0 | |||||||||||||||||||||||||||||
| Theoretical pI | 7.21 | |||||||||||||||||||||||||||||
| Pfam Domain Function | ||||||||||||||||||||||||||||||
| Signals |
|
|||||||||||||||||||||||||||||
| Transmembrane Regions |
|
|||||||||||||||||||||||||||||
| Protein Sequence |
>T-lymphoma invasion and metastasis-inducing protein 2 MGNSDSQYTLQGSKNHSNTITGAKQIPCSLKIRGIHAKEEKSLHGWGHGSNGAGYKSRSL ARSCLSHFKSNQPYASRLGGPTCKVSRGVAYSTHRTNAPGKDFQGISAAFSTENGFHSVG HELADNHITSRDCNGHLLNCYGRNESIASTPPGEDRKSPRVLIKTLGKLDGCLRVEFHNG GNPSKVPAEDCSEPVQLLRYSPTLASETSPVPEARRGSSADSLPSHRPSPTDSRLRSSKG SSLSSESSWYDSPWGNAGELSEAEGSFLAPGMPDPSLHASFPPGDAKKPFNQSSSLSSLR ELYKDANLGSLSPSGIRLSDEYMGTHASLSNRVSFASDIDVPSRVAHGDPIQYSSFTLPC RKPKAFVEDTAKKDSLKARMRRISDWTGSLSRKKRKLQEPRSKEGSDYFDSRSDGLNTDV QGSSQASAFLWSGGSTQILSQRSESTHAIGSDPLRQNIYENFMRELEMSRTNTENIETST ETAESSSESLSSLEQLDLLFEKEQGVVRKAGWLFFKPLVTVQKERKLELVARRKWKQYWV TLKGCTLLFYETYGKNSMDQSSAPRCALFAEDSIVQSVPEHPKKENVFCLSNSFGDVYLF QATSQTDLENWVTAVHSACASLFAKKHGKEDTLRLLKNQTKNLLQKIDMDSKMKKMAELQ LSVVSDPKNRKAIENQIQQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSLLAAASRPS KLALGRLGILSVSSFHALVCSRDDSALRKRTLSLTQRGRNKKGIFSSLKGLDTLARKGKE KRPSITQVDELLHIYGSTVDGVPRDNAWEIQTYVHFQDNHGVTVGIKPEHRVEDILTLAC KMRQLEPSHYGLQLRKLVDDNVEYCIPAPYEYMQQQVYDEIEVFPLNVYDVQLTKTGSVC DFGFAVTAQVDERQHLSRIFISDVLPDGLAYGEGLRKGNEIMTLNGEAVSDLDLKQMEAL FSEKSVGLTLIARPPDTKATLCTSWSDSDLFSRDQKSLLPPPNQSQLLEEFLDNFKKNTA NDFSNVPDITTGLKRSQTDGTLDQVSHREKMEQTFRSAEQITALCRSFNDSQANGMEGPR ENQDPPPRSLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEM ESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKL YSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLK ELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTE LSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPA HNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDS ESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKN SSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADN LIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPESGEGQK GGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLEREFSV QSLTSVVSEECFYETESHGKS |
|||||||||||||||||||||||||||||
| External Links | ||||||||||||||||||||||||||||||
| GenBank ID Protein | 58331187 | |||||||||||||||||||||||||||||
| UniProtKB/Swiss-Prot ID | Q8IVF5 | |||||||||||||||||||||||||||||
| UniProtKB/Swiss-Prot Entry Name | TIAM2_HUMAN | |||||||||||||||||||||||||||||
| PDB IDs | Not Available | |||||||||||||||||||||||||||||
| GenBank Gene ID | NM_012454.3 | |||||||||||||||||||||||||||||
| GeneCard ID | TIAM2 | |||||||||||||||||||||||||||||
| GenAtlas ID | TIAM2 | |||||||||||||||||||||||||||||
| HGNC ID | HGNC:11806 | |||||||||||||||||||||||||||||
| References | ||||||||||||||||||||||||||||||
| General References | Not Available | |||||||||||||||||||||||||||||