| Identification |
|---|
| HMDB Protein ID
| CDBP03674 |
| Secondary Accession Numbers
| Not Available |
| Name
| Importin subunit alpha-7 |
| Description
| Not Available |
| Synonyms
|
- Karyopherin subunit alpha-6
|
| Gene Name
| KPNA6 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus |
| GO Classification
|
| Component |
| intracellular organelle part |
| nuclear part |
| cell part |
| intracellular part |
| cytoplasm |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| nuclear pore |
| organelle part |
| Function |
| binding |
| protein transporter activity |
| transporter activity |
| substrate-specific transporter activity |
| Process |
| establishment of localization |
| transport |
| protein transport |
| protein import into nucleus |
| intracellular protein transport |
| protein targeting |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p35.1 |
| SNPs
| KPNA6 |
| Gene Sequence
|
>1611 bp
ATGGAGACCATGGCGAGCCCAGGGAAAGACAATTATCGAATGAAGAGCTATAAGAACAAT
GCTCTAAACCCTGAAGAAATGAGACGAAGAAGAGAGGAAGAGGGCATTCAGCTCCGGAAG
CAGAAGCGAGAGCAACAACTTTTTAAACGGAGAAATGTGGAGCTGATTAATGAAGAAGCT
GCCATGTTCGATAGTCTTCTCATGGACTCTTATGTGAGCTCTACCACTGGGGAGAGTGTG
ATCACAAGAGAGATGGTGGAGATGCTCTTTTCTGATGATTCTGACCTGCAGTTAGCAACC
ACACAGAAATTCCGGAAACTGCTCTCCAAAGAGCCTAGTCCTCCAATAGATGAAGTTATC
AACACTCCAAGAGTGGTGGATCGGTTCGTGGAGTTTCTGAAGAGGAATGAGAATTGTACA
TTACAGTTTGAAGCTGCCTGGGCTCTAACGAATATTGCCTCTGGAACCTCTCAGCAGACC
AAAATTGTCATTGAAGCAGGGGCTGTCCCCATTTTTATAGAGCTGCTTAATTCAGACTTT
GAGGATGTTCAGGAACAGGCAGTCTGGGCACTGGGAAACATAGCTGGAGATAGCTCTGTT
TGCCGAGATTACGTCTTGAACTGTTCCATCCTTAATCCTTTGTTAACACTCCTTACCAAG
TCCACACGACTGACGATGACACGGAATGCAGTCTGGGCCCTGTCAAATCTCTGCCGAGGG
AAAAACCCACCCCCAGAGTTTGCAAAGGTCTCTCCTTGTTTGCCTGTACTGTCTCGCCTA
CTCTTCAGCAGCGACTCGGACTTGCTGGCAGATGCTTGCTGGGCCCTTTCTTATCTGTCT
GATGGCCCCAATGAGAAGATCCAGGCAGTCATAGACTCCGGAGTCTGCCGGAGATTGGTA
GAGCTGCTGATGCACAATGATTACAAAGTGGCTTCTCCTGCCCTGAGAGCCGTGGGTAAC
ATCGTCACTGGGGATGACATCCAGACCCAGGTCATTCTTAACTGTTCAGCCCTACCTTGC
CTTCTCCACTTGTTGAGCAGTCCCAAGGAGTCAATCCGGAAGGAAGCTTGCTGGACTATT
TCAAATATTACTGCTGGCAACAGGGCTCAAATACAGGCTGTTATAGATGCAAATATCTTC
CCTGTGTTGATCGAAATCCTTCAGAAAGCAGAGTTTCGTACAAGGAAAGAGGCAGCCTGG
GCCATCACCAATGCCACATCAGGAGGAACCCCTGAGCAGATCAGGTACCTGGTCTCACTG
GGCTGCATCAAACCCCTATGTGACTTGCTGACTGTAATGGATTCGAAGATTGTGCAAGTG
GCCCTCAATGGACTGGAGAACATCCTGCGGCTTGGAGAGCAAGAGGGCAAGCGCAGTGGC
TCAGGGGTCAATCCTTATTGTGGCCTCATAGAGGAAGCCTATGGCTTGGATAAAATTGAG
TTTCTCCAGAGCCACGAGAACCAGGAGATCTACCAGAAGGCCTTCGACCTCATTGAGCAC
TACTTTGGTGTAGAAGACGATGATAGCAGCCTGGCTCCCCAAGTCGATGAAACGCAACAG
CAGTTCATCTTCCAGCAGCCTGAGGCCCCCATGGAGGGCTTCCAGCTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 536 |
| Molecular Weight
| 60028.9 |
| Theoretical pI
| 4.62 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Importin subunit alpha-7
METMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEA
AMFDSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVI
NTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDF
EDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRG
KNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLV
ELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTI
SNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSL
GCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIE
FLQSHENQEIYQKAFDLIEHYFGVEDDDSSLAPQVDETQQQFIFQQPEAPMEGFQL
|
| External Links |
|---|
| GenBank ID Protein
| 3091280 |
| UniProtKB/Swiss-Prot ID
| O60684 |
| UniProtKB/Swiss-Prot Entry Name
| IMA7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF060543 |
| GeneCard ID
| KPNA6 |
| GenAtlas ID
| KPNA6 |
| HGNC ID
| HGNC:6399 |
| References |
|---|
| General References
| Not Available |