Cannabis Compound Database: Showing Protein GTP cyclohydrolase 1 (CDBP00881)

Identification Biological properties Gene properties Protein properties External links References XML Show 7 compounds

Identification

HMDB Protein ID

CDBP00881

Secondary Accession Numbers

Not Available

Name

GTP cyclohydrolase 1

Description

Not Available

Synonyms

GTP cyclohydrolase I
GTP-CH-I

Gene Name

GCH1

Protein Type

Enzyme

Biological Properties

General Function

Involved in GTP cyclohydrolase I activity

Specific Function

Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.

GO Classification

Biological Process
negative regulation of blood pressure
induction of apoptosis
response to interferon-gamma
response to tumor necrosis factor
7,8-dihydroneopterin 3'-triphosphate biosynthetic process
neuromuscular process controlling posture
positive regulation of nitric-oxide synthase activity
protein heterooligomerization
regulation of lung blood pressure
protein homooligomerization
regulation of blood pressure
tetrahydrobiopterin biosynthetic process
response to pain
nitric oxide biosynthetic process
GTP catabolic process
tetrahydrofolate biosynthetic process
dopamine biosynthetic process
response to lipopolysaccharide
vasodilation
Cellular Component
cytoplasmic vesicle
protein complex
cytosol
nuclear membrane
Component
cell part
intracellular part
cytoplasm
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
cyclohydrolase activity
gtp cyclohydrolase activity
gtp cyclohydrolase i activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Molecular Function
coenzyme binding
zinc ion binding
GTP cyclohydrolase I activity
calcium ion binding
GTP binding
Process
metabolic process
cellular aromatic compound metabolic process
folic acid and derivative metabolic process
tetrahydrofolate biosynthetic process
cellular metabolic process
folic acid and derivative biosynthetic process

Cellular Location

Nucleus
Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Pterine Biosynthesis
7,8-dihydroneopterin triphosphate biosynthesis	Not Available	Not Available
Folate biosynthesis	Not Available
Dopa-responsive dystonia		Not Available
Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency		Not Available

Gene Properties

Chromosome Location

Locus

14q22.1-q22.2

SNPs

GCH1

Gene Sequence

>753 bp
ATGGAGAAGGGCCCTGTGCGGGCACCGGCGGAGAAGCCGCGGGGCGCCAGGTGCAGCAAT
GGGTTCCCCGAGCGGGATCCGCCGCGGCCCGGGCCCAGCAGGCCGGCGGAGAAGCCCCCG
CGGCCCGAGGCCAAGAGCGCGCAGCCCGCGGACGGCTGGAAGGGCGAGCGGCCCCGCAGC
GAGGAGGATAACGAGCTGAACCTCCCTAACCTGGCAGCCGCCTACTCGTCCATCCTGAGC
TCGCTGGGCGAGAACCCCCAGCGGCAAGGGCTGCTCAAGACGCCCTGGAGGGCGGCCTCG
GCCATGCAGTTCTTCACCAAGGGCTACCAGGAGACCATCTCAGATGTCCTAAACGATGCT
ATATTTGATGAAGATCATGATGAGATGGTGATTGTGAAGGACATAGACATGTTTTCCATG
TGTGAGCATCACTTGGTTCCATTTGTTGGAAAGGTCCATATTGGTTATCTTCCTAACAAG
CAAGTCCTTGGCCTCAGCAAACTTGCGAGGATTGTAGAAATCTATAGTAGAAGACTACAA
GTTCAGGAGCGCCTTACAAAACAAATTGCTGTAGCAATCACGGAAGCCTTGCGGCCTGCT
GGAGTCGGGGTAGTGGTTGAAGCAACACACATGTGTATGGTAATGCGAGGTGTACAGAAA
ATGAACAGCAAAACTGTGACCAGCACAATGTTGGGTGTGTTCCGGGAGGATCCAAAGACT
CGGGAAGAGTTCCTGACTCTCATTAGGAGCTGA

Protein Properties

Number of Residues

250

Molecular Weight

27902.855

Theoretical pI

8.556

Pfam Domain Function

GTP_cyclohydroI (PF01227 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>GTP cyclohydrolase 1
MEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEAKSAQPADGWKGERPRS
EEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLNDA
IFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQ
VQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKT
REEFLTLIRS

External Links

GenBank ID Protein

19343964

UniProtKB/Swiss-Prot ID

P30793

UniProtKB/Swiss-Prot Entry Name

GCH1_HUMAN

PDB IDs