| Identification |
|---|
| HMDB Protein ID
| CDBP03832 |
| Secondary Accession Numbers
| Not Available |
| Name
| Exportin-7 |
| Description
| Not Available |
| Synonyms
|
- Exp7
- Ran-binding protein 16
|
| Gene Name
| XPO7 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus |
| GO Classification
|
| Function |
| binding |
| protein transporter activity |
| transporter activity |
| substrate-specific transporter activity |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
|
| Cellular Location
|
- Nucleus
- Cytoplasm (Probable)
- Nucleus (Probable)
- nuclear pore complex (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8p21 |
| SNPs
| XPO7 |
| Gene Sequence
|
>3264 bp
ATGGCGGATCATGTGCAGAGCCTGGCCCAACTAGAGAATCTGTGCAAACAGCTGTATGAA
ACCACAGACACAACCACTCGACTCCAGGCAGAGAAAGCCTTGGTTGAATTTACCAACAGC
CCTGATTGCCTGAGCAAGTGCCAGCTACTCCTCGAAAGAGGAAGTTCCTCTTACTCCCAG
TTACTGGCAGCTACATGCCTTACCAAGCTTGTATCACGCACAAACAACCCCCTACCATTG
GAACAGCGAATAGATATTCGGAACTATGTGCTCAACTACCTTGCCACTCGGCCGAAGTTG
GCTACTTTCGTGACACAAGCACTTATTCAGTTATATGCCAGAATCACAAAACTGGGCTGG
TTTGACTGTCAGAAGGATGACTATGTCTTCAGAAATGCAATCACAGACGTCACAAGGTTT
TTACAGGATAGTGTTGAATACTGCATCATTGGTGTCACAATTTTATCTCAGCTAACCAAT
GAAATTAATCAAGCAGACACCACCCATCCTTTAACCAAGCACAGAAAAATAGCCTCTTCT
TTTCGCGATTCATCATTATTTGATATCTTCACACTTTCCTGCAATTTACTAAAACAGGCT
TCAGGAAAGAATCTAAACTTGAATGATGAAAGTCAGCATGGCTTGCTCATGCAACTGCTC
AAGCTCACTCATAACTGCCTCAACTTTGACTTCATCGGCACTTCCACTGATGAGTCCTCA
GACGACCTGTGTACAGTGCAGATTCCCACCAGCTGGAGATCAGCCTTCTTAGATTCTTCA
ACCTTGCAGCTGTTTTTTGACCTGTATCATTCCATCCCTCCTTCATTTTCACCTCTGGTA
TTATCCTGCTTGGTACAGATCGCTTCAGTCAGAAGATCCCTGTTTAACAATGCAGAGAGG
GCCAAGTTTCTCTCTCATCTTGTTGATGGTGTTAAACGAATACTGGAAAACCCACAGAGT
TTATCAGACCCAAACAATTACCATGAGTTTTGCAGACTACTGGCCCGATTGAAGAGTAAC
TATCAACTGGGAGAATTGGTAAAGGTGGAAAACTACCCTGAGGTCATCCGATTGATAGCC
AACTTCACAGTGACCAGCCTACAGCACTGGGAATTTGCTCCAAATAGTGTGCACTATCTT
CTGAGCCTGTGGCAGCGGCTGGCAGCCTCTGTGCCGTATGTCAAAGCCACAGAGCCCCAC
ATGCTGGAAACTTACACTCCTGAGGTCACCAAAGCCTACATCACATCCCGGTTGGAATCT
GTGCACATCATACTGAGAGATGGCCTGGAAGATCCCCTGGAGGATACGGGGCTGGTCCAG
CAGCAGTTGGACCAGCTGTCCACCATTGGGCGTTGTGAATATGAGAAGACGTGTGCACTC
CTCGTGCAGTTGTTTGACCAGTCGGCCCAGTCGTACCAGGAGCTGCTACAGAGCGCCAGC
GCAAGCCCAATGGACATTGCAGTGCAGGAGGGAAGGCTGACATGGCTGGTTTACATTATT
GGAGCAGTGATCGGTGGCCGGGTTTCTTTTGCCAGCACTGATGAGCAAGACGCCATGGAT
GGTGAGCTTGTCTGTCGGGTGCTCCAGCTGATGAACCTAACAGATTCTCGTTTGGCCCAG
GCGGGTAATGAGAAGCTAGAGTTGGCCATGCTGAGCTTTTTTGAACAGTTTCGTAAGATC
TACATTGGGGACCAAGTGCAGAAATCCTCTAAGCTGTACCGCCGACTCTCAGAAGTTCTG
GGCTTGAATGATGAGACCATGGTCCTAAGCGTCTTCATAGGAAAAATCATCACCAACTTG
AAGTACTGGGGCCGTTGTGAACCAATCACCTCCAAGACACTACAGCTTCTCAATGACCTG
TCCATTGGGTACAGTAGCGTAAGGAAGCTAGTGAAGCTTAGTGCGGTACAGTTCATGCTG
AACAATCACACGAGCGAGCACTTTTCATTTTTGGGTATTAACAATCAGTCCAACCTGACA
GACATGCGGTGTCGGACTACCTTCTACACAGCACTTGGGCGTCTCCTCATGGTGGATTTA
GGAGAGGATGAAGATCAGTATGAGCAGTTCATGCTGCCACTCACAGCAGCATTTGAGGCT
GTGGCCCAGATGTTTAGCACCAATAGTTTCAACGAGCAGGAGGCAAAGCGAACTCTAGTT
GGCCTAGTAAGAGACCTGAGAGGGATCGCTTTCGCTTTCAATGCCAAGACCAGCTTCATG
ATGCTCTTTGAATGGATATATCCATCCTATATGCCAATTCTCCAACGGGCAATTGAGCTC
TGGTACCATGATCCAGCCTGTACTACACCTGTACTCAAGTTGATGGCTGAATTGGTTCAT
AATAGGTCCCAGCGACTCCAGTTTGATGTCTCTTCCCCCAATGGCATCTTACTCTTCCGA
GAAACCAGCAAGATGATAACAATGTATGGCAATCGCATCCTGACACTAGGAGAGGTCCCA
AAGGATCAGGTCTATGCTCTGAAGCTCAAGGGCATCTCCATCTGCTTCTCCATGCTGAAG
GCTGCTCTCAGTGGGAGTTACGTCAATTTCGGAGTCTTTCGTCTCTATGGAGACGATGCC
CTGGACAATGCTCTGCAGACCTTCATCAAGCTGCTCCTCTCTATTCCTCACAGTGATCTC
TTGGATTACCCCAAGCTCAGCCAGTCTTATTATTCACTACTGGAAGTCCTGACCCAGGAC
CATATGAACTTTATTGCAAGCCTGGAACCTCACGTCATCATGTATATTCTCTCTTCCATT
TCTGAAGGACTTACTGCACTTGACACCATGGTATGCACAGGCTGCTGCTCCTGCCTGGAC
CACATTGTGACATACCTCTTCAAGCAGCTGTCACGTAGCACCAAGAAGAGGACCACACCC
CTGAACCAGGAGAGCGACCGCTTTCTGCACATCATGCAGCAGCATCCAGAGATGATCCAG
CAGATGCTGTCCACGGTGCTGAACATCATCATCTTTGAAGACTGTAGGAACCAGTGGTCT
ATGTCCCGACCACTACTTGGCTTGATATTGCTTAATGAAAAGTATTTTTCTGACCTAAGA
AACAGTATTGTGAACAGCCAGCCACCGGAGAAGCAGCAGGCCATGCACCTGTGTTTTGAG
AACCTGATGGAAGGCATCGAGCGAAATCTTCTTACGAAAAACAGAGACAGGTTCACCCAG
AACCTGTCAGCATTCCGTCGAGAAGTCAACGACTCAATGAAGAATTCCACTTATGGCGTG
AATAGCAATGACATGATGAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1087 |
| Molecular Weight
| 123906.1 |
| Theoretical pI
| 6.27 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Exportin-7
MADHVQSLAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQ
LLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLATRPKLATFVTQALIQLYARITKLGW
FDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQADTTHPLTKHRKIASS
FRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESS
DDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIASVRRSLFNNAER
AKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPEVIRLIA
NFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLES
VHIILRDGLEDPLEDTGLVQQQLDQLSTIGRCEYEKTCALLVQLFDQSAQSYQELLQSAS
ASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQ
AGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKIITNL
KYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSEHFSFLGINNQSNLT
DMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRTLV
GLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVH
NRSQRLQFDVSSPNGILLFRETSKMITMYGNRILTLGEVPKDQVYALKLKGISICFSMLK
AALSGSYVNFGVFRLYGDDALDNALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQD
HMNFIASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTP
LNQESDRFLHIMQQHPEMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLR
NSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTYGV
NSNDMMS
|
| External Links |
|---|
| GenBank ID Protein
| 154448892 |
| UniProtKB/Swiss-Prot ID
| Q9UIA9 |
| UniProtKB/Swiss-Prot Entry Name
| XPO7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015024.4 |
| GeneCard ID
| XPO7 |
| GenAtlas ID
| XPO7 |
| HGNC ID
| HGNC:14108 |
| References |
|---|
| General References
| Not Available |