Identification |
HMDB Protein ID
| CDBP03609 |
Secondary Accession Numbers
| Not Available |
Name
| FYVE, RhoGEF and PH domain-containing protein 6 |
Description
| Not Available |
Synonyms
|
- Zinc finger FYVE domain-containing protein 24
|
Gene Name
| FGD6 |
Protein Type
| Metal Binding |
Biological Properties |
General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
Specific Function
| May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape |
GO Classification
|
Component |
cell part |
intracellular |
Function |
transition metal ion binding |
zinc ion binding |
enzyme regulator activity |
nucleoside-triphosphatase regulator activity |
gtpase regulator activity |
small gtpase regulator activity |
ion binding |
cation binding |
metal ion binding |
binding |
ras guanyl-nucleotide exchange factor activity |
rho guanyl-nucleotide exchange factor activity |
Process |
regulation of ras protein signal transduction |
regulation of rho protein signal transduction |
biological regulation |
regulation of biological process |
regulation of cellular process |
regulation of cell communication |
regulation of signal transduction |
regulation of small gtpase mediated signal transduction |
|
Cellular Location
|
- Cytoplasm
- Cytoplasm (Probable)
- cytoskeleton (Probable)
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 12q22 |
SNPs
| FGD6 |
Gene Sequence
|
>4293 bp
ATGACTTCTGCAGCCGAGATAAAGAAGCCACCAGTGGCCCCCAAGCCCAAGTTTGTTGTG
GCAAATAATAAGCCAGCCCCACCTCCTATTGCACCTAAACCCGACATTGTGATTTCTAGT
GTTCCACAGTCGACAAAGAAAATGAAACCAGCAATAGCCCCAAAACCAAAAGTCCTGAAG
ACCTCACCTGTTCGAGAGATTGGGCAGTCGCCATCAAGGAAAATCATGTTGAACCTGGAA
GGGCATAAACAGGAATTAGCTGAAAGCACTGACAACTTTAATTGTAAATATGAAGGCAAT
CAGAGCAATGATTATATTTCACCAATGTGTTCCTGCAGTTCTGAGTGTATCCATAAGCTG
GGCCATAGAGAGAATTTGTGTGTAAAGCAGCTTGTTTTAGAGCCCCTGGAAATGAATGAA
AATTTAGAAAACAGTAAAATTGATGAGACTTTGACTATAAAAACTAGGAGTAAATGTGAT
TTGTATGGTGAAAAAGCCAAGAACCAGGGTGGGGTTGTTTTAAAGGCAAGCGTTTTAGAA
GAGGAGCTCAAAGATGCCTTAATACACCAAATGCCACCTTTTATTTCTGCACAGAAGCAC
AGGCCCACAGACAGCCCAGAAATGAATGGTGGCTGTAATTCAAATGGACAATTCAGAATT
GAATTTGCGGATTTGTCACCTTCCCCATCCAGCTTTGAAAAAGTTCCTGATCATCACAGT
TGCCACTTACAGCTTCCTAGTGATGAATGTGAACATTTTGAAACTTGCCAGGATGACAGT
GAAAAAAGCAATAATTGCTTTCAGTCATCTGAACTAGAGGCTCTGGAAAATGGGAAAAGG
AGTACTTTAATATCTTCAGATGGAGTTAGTAAGAAATCAGAAGTCAAAGACCTTGGTCCC
TTAGAAATTCATTTAGTACCATATACCCCAAAATTTCCAACTCCCAAGCCCAGAAAGACA
CGAACTGCTCGTCTGTTACGCCAAAAGTGTGTAGATACTCCTAGTGAAAGCACTGAAGAA
CCGGGGAATTCAGACAGTAGCTCTTCCTGTCTTACTGAAAATAGTTTGAAAATCAATAAA
ATCAGTGTTCTGCATCAGAATGTTTTGTGTAAGCAGGAACAGGTGGATAAAATGAAGCTA
GGAAATAAAAGTGAATTGAATATGGAATCCAACAGTGATGCACAGGACTTAGTCAATTCA
CAGAAAGCCATGTGTAATGAAACAACTTCCTTTGAAAAAATGGCACCTTCTTTTGATAAA
GACTCTAATTTGAGTTCTGACAGCACAACTGTAGATGGTTCTAGTATGTCGCTTGCTGTG
GACGAAGGGACCGGTTTTATAAGATGTACTGTATCTATGAGCCTGCCTAAGCAGCTCAAA
TTAACTTGCAATGAACATTTGCAATCTGGGAGAAACCTGGGAGTTTCTGCCCCTCAAATG
CAAAAGGAATCTGTTATAAAAGAGGAAAATTCTCTACGAATTGTCCCCAAAAAACCTCAA
AGACATAGCTTGCCTGCTACAGGAGTGCTTAAAAAGGCTGCCTCCGAGGAGCTTTTGGAA
AAAAGTTCTTATCCTTCAAGTGAAGAAAAAAGTTCAGAGAAGAGTCTAGAAAGAAATCAC
CTTCAGCATTTGTGTGCCCAAAACCGTGGTGTGTCATCCTCCTTTGATATGCCTAAACGG
GCTTCAGAAAAGCCAGTGTGGAAGTTACCTCATCCTATTTTACCCTTTTCAGGGAACCCA
GAATTCTTAAAGTCTGTCACCGTATCGTCAAACAGTGAGCCTTCAACAGCCCTAACCAAG
CCCAGAGCAAAATCGTTATCTGCTATGGATGTGGAAAAGTGCACTAAGCCTTGCAAAGAC
TCTACAAAGAAAAACTCTTTTAAAAAGTTGCTCAGCATGAAACTGTCCATCTGTTTCATG
AAGAGTGACTTTCAAAAATTTTGGTCCAAGAGTAGCCAACTCGGAGACACCACCACAGGC
CACCTCTCCAGTGGGGAGCAGAAGGGGATTGAAAGTGATTGGCAAGGCTTGTTGGTAGGA
GAGGAGAAGAGAAGTAAACCCATCAAGGCATATTCCACAGAAAACTATAGCCTGGAATCT
CAAAAGAAGAGGAAGAAGTCTCGGGGCCAGACCAGTGCAGCTAATGGTCTGAGAGCTGAG
TCTTTGGATGACCAAATGCTCTCCCGGGAGTCATCATCTCAGGCACCTTACAAGTCTGTT
ACAAGCCTCTGTGCACCGGAGTATGAAAATATACGCCATTATGAGGAAATACCAGAGTAC
GAGAACTTGCCATTTATTATGGCTATACGGAAAACTCAAGAGTTGGAATGGCAGAATTCC
AGCAGCATGGAGGACGCTGATGCAAATGTGTATGAGGTAGAAGAGCCGTATGAAGCTCCA
GATGGCCAGCTGCAGCTTGGACCCAGACATCAGCATTCCAGTTCAGGAGCATCCCAGGAG
GAACAGAATGATCTTGGTCTTGGTGACCTTCCCTCTGATGAGGAGGAAATCATCAACAGT
TCTGATGAAGATGATGTCAGCTCTGAGTCAAGTAAAGGAGAGCCTGACCCACTGGAAGAT
AAACAGGATGAAGATAATGGAATGAAAAGTAAAGTTCATCATATTGCCAAGGAGATCATG
AGCTCAGAGAAAGTGTTTGTGGATGTGTTAAAACTTTTGCATATTGATTTCCGGGATGCA
GTAGCTCATGCTTCCAGGCAACTTGGGAAACCAGTGATTGAGGACCGGATTCTAAATCAG
ATCCTATACTACTTGCCTCAGCTGTATGAGCTCAACCGGGATCTCTTGAAGGAACTGGAG
GAAAGAATGTTGCACTGGACTGAACAACAAAGAATTGCTGATATCTTTGTAAAGAAGGGA
CCATATCTAAAAATGTATTCCACATACATCAAAGAATTTGATAAGAATATAGCCTTGCTG
GATGAACAGTGCAAGAAAAATCCAGGTTTTGCTGCTGTTGTTAGAGAATTTGAGATGAGC
CCTCGCTGTGCTAATCTGGCCCTCAAGCACTACCTGCTCAAGCCGGTTCAGAGGATCCCC
CAGTACAGGCTGTTGCTGACAGATTATTTGAAGAATCTCATAGAAGATGCTGGAGATTAC
AGAGACACTCAAGATGCCCTTGCTGTTGTTATAGAGGTAGCCAACCACGCCAATGACACC
ATGAAGCAAGGAGACAACTTTCAGAAACTTATGCAAATTCAGTACAGCTTAAATGGACAC
CATGAAATTGTGCAGCCTGGTCGGGTTTTTCTCAAAGAAGGAATTCTGATGAAGCTGTCT
CGGAAAGTGATGCAACCTCGAATGTTTTTCCTGTTTAATGATGCCCTGCTGTATACAACA
CCAGTGCAGTCTGGGATGTATAAACTGAACAACATGCTCTCACTGGCTGGAATGAAGGTC
AGAAAACCTACCCAAGAAGCCTATCAGAATGAATTAAAGATTGAAAGTGTAGAACGTTCC
TTCATTCTCTCAGCCAGTTCTGCCACAGAAAGGGATGAATGGCTAGAAGCGATTTCCAGG
GCAATAGAAGAGTATGCCAAGAAAAGAATCACCTTCTGTCCTAGTAGGAGTCTTGATGAG
GCAGACTCAGAAAATAAAGAAGAAGTTAGTCCTCTTGGATCGAAGGCTCCCATCTGGATT
CCTGATACCAGAGCCACAATGTGTATGATCTGCACAAGCGAATTCACTCTCACCTGGAGA
CGACACCACTGCCGGGCCTGTGGAAAGATTGTATGCCAAGCTTGTTCGTCTAATAAGTAT
GGCTTAGATTACCTGAAAAATCAACCAGCAAGAGTATGTGAACATTGTTTCCAAGAACTG
CAGAAATTAGATCACCAGCACTCCCCTAGGATTGGATCTCCTGGAAATCACAAATCTCCT
TCAAGTGCCTTATCATCAGTCTTACATAGCATTCCATCAGGGAGGAAACAGAAAAAAATC
CCAGCTGCTCTCAAAGAAGTATCAGCAAACACAGAGGATTCTTCTATGAGTGGCTACTTG
TACAGATCAAAGGGCAATAAAAAACCCTGGAAACACTTTTGGTTTGTCATAAAAAATAAA
GTACTATATACATATGCTGCAAGTGAGGACGTGGCCGCTTTGGAGAGTCAGCCTTTATTA
GGATTCACTGTTATTCAAGTTAAAGATGAGAATTCCGAGTCTAAAGTATTTCAGTTACTG
CACAAAAACATGTTATTTTATGTATTCAAAGCAGAGGATGCTCATTCGGCTCAGAAGTGG
ATAGAAGCATTTCAGGAAGGCACAATATTGTAG
|
Protein Properties |
Number of Residues
| 1430 |
Molecular Weight
| 160814.9 |
Theoretical pI
| 7.03 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>FYVE, RhoGEF and PH domain-containing protein 6
MTSAAEIKKPPVAPKPKFVVANNKPAPPPIAPKPDIVISSVPQSTKKMKPAIAPKPKVLK
TSPVREIGQSPSRKIMLNLEGHKQELAESTDNFNCKYEGNQSNDYISPMCSCSSECIHKL
GHRENLCVKQLVLEPLEMNENLENSKIDETLTIKTRSKCDLYGEKAKNQGGVVLKASVLE
EELKDALIHQMPPFISAQKHRPTDSPEMNGGCNSNGQFRIEFADLSPSPSSFEKVPDHHS
CHLQLPSDECEHFETCQDDSEKSNNCFQSSELEALENGKRSTLISSDGVSKKSEVKDLGP
LEIHLVPYTPKFPTPKPRKTRTARLLRQKCVDTPSESTEEPGNSDSSSSCLTENSLKINK
ISVLHQNVLCKQEQVDKMKLGNKSELNMESNSDAQDLVNSQKAMCNETTSFEKMAPSFDK
DSNLSSDSTTVDGSSMSLAVDEGTGFIRCTVSMSLPKQLKLTCNEHLQSGRNLGVSAPQM
QKESVIKEENSLRIVPKKPQRHSLPATGVLKKAASEELLEKSSYPSSEEKSSEKSLERNH
LQHLCAQNRGVSSSFDMPKRASEKPVWKLPHPILPFSGNPEFLKSVTVSSNSEPSTALTK
PRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSMKLSICFMKSDFQKFWSKSSQLGDTTTG
HLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAE
SLDDQMLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELEWQNS
SSMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQNDLGLGDLPSDEEEIINS
SDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDA
VAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKG
PYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIP
QYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGH
HEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKV
RKPTQEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDE
ADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKY
GLDYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKI
PAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLL
GFTVIQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGTIL
|
External Links |
GenBank ID Protein
| 154240686 |
UniProtKB/Swiss-Prot ID
| Q6ZV73 |
UniProtKB/Swiss-Prot Entry Name
| FGD6_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_018351.3 |
GeneCard ID
| FGD6 |
GenAtlas ID
| FGD6 |
HGNC ID
| HGNC:21740 |
References |
General References
| Not Available |