| Identification |
|---|
| HMDB Protein ID
| CDBP03185 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rho GTPase-activating protein 32 |
| Description
| Not Available |
| Synonyms
|
- Brain-specific Rho GTPase-activating protein
- GAB-associated Cdc42/Rac GTPase-activating protein
- GC-GAP
- GTPase regulator interacting with TrkA
- Rho-type GTPase-activating protein 32
- Rho/Cdc42/Rac GTPase-activating protein RICS
- RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling
- p200RhoGAP
- p250GAP
|
| Gene Name
| ARHGAP32 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| phospholipid binding |
| phosphoinositide binding |
| binding |
| protein binding |
| lipid binding |
| Process |
| cellular process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| cell communication |
|
| Cellular Location
|
- Cytoplasm
- Golgi apparatus membrane
- Endosome membrane
- Membrane
- Endoplasmic reticulum membrane
- Cell junction
- synapse
- Cell projection
- dendritic spine
- postsynaptic cell membrane
- postsynaptic density
- cell cortex
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q24.3 |
| SNPs
| ARHGAP32 |
| Gene Sequence
|
>6264 bp
ATGGAGACTGAAAGTGAGAGTAGCACTTTAGGGGATGACAGTGTCTTCTGGTTGGAGTCT
GAAGTTATAATCCAGGTGACTGACTGTGAAGAGGAAGAAAGGGAAGAGAAGTTCAGGAAG
ATGAAGTCCTCAGTACATTCTGAAGAAGATGATTTTGTTCCAGAGCTACATAGAAATGTA
CACCCTCGAGAGCGGCCTGATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGAT
GTTCCAGAGATTCCTGGAGATCTTACTCTTAAGACGTGTGGCAGTACAGCCAGTATGAAG
GTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGT
GCGCATTTCCATTATGAGAATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAA
CAGAATGAAGTAATGAAAAATGGCTGTGAATCTAAAGAGCTGGTCTACCTCGTGCAGATT
GCTTGTCAGGGAAAAAGTTGGATTGTTAAAAGAAGTTATGAAGATTTTCGGGTACTTGAT
AAACATCTTCATCTGTGTATTTATGACCGAAGATTTTCCCAGCTCTCAGAACTTCCCCGT
TCTGACACCCTGAAGGACAGTCCAGAGTCGGTCACTCAGATGCTTATGGCTTACCTGTCA
CGCCTTTCAGCTATCGCTGGCAACAAGATCAACTGTGGGCCCGCCCTTACCTGGATGGAG
ATTGATAATAAGGGAAATCACCTTTTGGTTCATGAGGAGTCATCCATCAACACTCCTGCT
GTCGGTGCTGCCCATGTTATCAAGAGGTACACTGCTCGGGCCCCTGACGAACTGACCTTA
GAGGTGGGAGACATTGTTTCTGTTATTGACATGCCCCCGAAAGTGTTAAGCACATGGTGG
AGAGGCAAGCACGGATTCCAGGTGGGACTCTTCCCTGGACACTGTGTTGAGTTAATTAAC
CAAAAAGTTCCCCAGTCAGTGACCAACTCAGTGCCAAAACCAGTGTCTAAAAAGCACGGC
AAGCTCATTACGTTCTTACGAACATTCATGAAGTCTCGTCCAACAAAACAGAAGCTGAAG
CAGCGGGGAATCTTGAAAGAGAGGGTGTTTGGTTGTGACCTGGGGGAACACCTTCTAAAT
TCTGGTTTTGAAGTGCCGCAGGTTCTTCAAAGCTGCACAGCATTCATTGAGAGATATGGC
ATCGTGGATGGAATCTATCGCCTTTCTGGTGTTGCCTCCAATATCCAGAGACTACGCCAT
GAATTTGACTCTGAGCACGTCCCCGACCTGACGAAAGAACCGTATGTTCAGGACATCCAT
TCTGTGGGTTCCCTATGTAAGCTGTACTTCCGGGAACTCCCAAACCCTCTGCTTACCTAC
CAGCTGTATGAGAAATTTTCTGATGCAGTTTCAGCAGCAACAGATGAAGAAAGGCTGATA
AAAATCCACGATGTCATCCAGCAGCTCCCCCCACCACACTACAGAACACTGGAGTTCCTG
ATGAGACACTTGTCTCTTCTAGCTGACTATTGTTCCATCACAAATATGCATGCAAAAAAT
CTAGCAATTGTTTGGGCTCCAAACCTGTTAAGATCAAAACAGATAGAATCTGCCTGCTTC
AGTGGAACAGCAGCTTTCATGGAAGTGAGGATTCAGTCTGTGGTTGTTGAGTTCATCCTG
AATCACGTTGATGTGCTGTTCAGCGGCAGAATCAGCATGGCCATGCAAGAGGGGGCAGCT
TCTCTATCAAGGCCCAAGTCCCTCCTGGTATCCTCTCCATCCACCAAACTGCTGACATTG
GAAGAGGCCCAGGCACGAACACAAGCTCAGGTCAATTCTCCAATTGTGACGGAAAATAAA
TATATCGAAGTAGGAGAAGGACCTGCTGCACTTCAGGGGAAATTTCATACCATAATTGAG
TTCCCACTTGAAAGAAAGAGGCCTCAAAATAAGATGAAAAAGTCTCCTGTGGGTAGCTGG
CGTTCCTTTTTCAACTTGGGGAAATCATCATCTGTTTCTAAACGAAAGCTGCAGCGGAAT
GAGAGTGAGCCTTCAGAGATGAAAGCCATGGCTCTGAAAGGTGGCAGGGCAGAAGGAACC
CTCCGTTCAGCTAAAAGTGAGGAGTCTCTTACATCTCTCCATGCAGTTGATGGTGATTCT
AAGCTCTTCCGACCCAGAAGACCCAGATCTTCCAGTGATGCACTGTCTGCCTCTTTTAAT
GGAGAAATGCTGGGGAACCGCTGTAACTCCTATGATAATCTGCCTCATGACAATGAGAGT
GAGGAGGAAGGAGGGCTGCTTCATATCCCAGCCCTTATGTCTCCTCATTCAGCTGAGGAT
GTTGACTTGAGCCCACCAGACATTGGAGTAGCCAGCCTGGATTTTGATCCAATGTCATTT
CAATGTAGTCCTCCTAAGGCCGAATCAGAATGTCTGGAGAGTGGTGCTTCCTTTTTAGAT
TCACCAGGATACTCCAAGGATAAACCAAGTGCCAATAAAAAGGATGCAGAAACAGGTAGT
AGCCAATGTCAGACTCCAGGAAGCACAGCAAGCTCTGAACCTGTCTCTCCTCTTCAGGAG
AAACTGAGTCCATTCTTTACCCTGGACTTGAGCCCAACTGAAGATAAATCATCTAAGCCA
TCCTCCTTTACTGAAAAGGTCGTCTATGCTTTCTCTCCGAAGATAGGACGGAAATTAAGC
AAATCACCTTCTATGAGCATATCTGAGCCAATTTCAGTGACCCTACCACCACGGGTGTCA
GAAGTCATTGGTACAGTCTCAAATACCACAGCTCAGAATGCATCATCTTCAACCTGGGAC
AAATGCGTTGAAGAAAGGGATGCCACAAATAGATCCCCCACCCAGATAGTAAAGATGAAA
ACAAATGAGACAGTTGCCCAAGAAGCATATGAATCTGAAGTCCAGCCCCTGGACCAGGTG
GCTGCTGAAGAAGTAGAATTGCCAGGGAAAGAGGATCAGTCTGTCTCAAGCAGTCAGAGT
AAGGCTGTAGCTTCTGGACAGACTCAGACAGGAGCAGTTACCCATGACCCCCCTCAGGAT
TCCGTTCCTGTCAGTTCAGTCTCTCTTATCCCACCACCACCGCCTCCGAAAAATGTTGCC
CGAATGTTGGCGCTAGCATTAGCTGAGTCCGCACAGCAAGCCTCAACTCAGTCATTGAAG
AGACCAGGGACCTCTCAGGCTGGGTATACAAATTATGGAGACATAGCGGTGGCTACAACT
GAAGATAATCTGTCCAGTTCTTACTCTGCAGTTGCTCTAGATAAGGCCTATTTCCAAACC
GATCGACCAGCAGAGCAGTTCCACCTCCAGAATAATGCACCAGGAAACTGTGACCATCCT
CTACCAGAGACAACAGCTACTGGGGATCCTACCCATTCCAACACAACTGAATCTGGGGAG
CAACATCACCAAGTAGACTTAACAGGGAATCAGCCACATCAAGCATATTTATCTGGGGAC
CCAGAAAAGGCCAGAATTACTTCAGTTCCCTTAGACTCAGAGAAGTCTGATGATCATGTA
AGTTTCCCTGAAGACCAGTCTGGGAAGAACAGTATGCCAACTGTCTCCTTCTTGGATCAG
GACCAGTCTCCACCCCGTTTCTACAGTGGAGATCAGCCTCCTTCTTATCTTGGTGCAAGT
GTGGATAAACTCCATCACCCTTTAGAATTTGCAGACAAATCTCCCACACCTCCTAATTTA
CCTAGCGATAAAATCTACCCTCCTTCTGGGTCCCCCGAAGAGAATACCAGCACAGCCACC
ATGACTTACATGACAACTACTCCAGCAACAGCCCAAATGAGCACCAAGGAAGCCAGCTGG
GATGTGGCTGAACAACCCACCACTGCTGATTTTGCTGCTGCCACACTTCAGCGCACGCAC
AGAACTAATCGTCCCCTTCCCCCTCCGCCTTCCCAGAGATCTGCAGAGCAGCCACCAGTT
GTGGGGCAGGTACAAGCAGCAACCAATATAGGATTAAATAATTCCCACAAGGTTCAAGGA
GTAGTTCCAGTTCCAGAGAGGCCACCTGAACCTCGAGCCATGGATGACCCTGCGTCTGCC
TTCATCAGTGACAGTGGTGCTGCTGCTGCTCAGTGTCCCATGGCTACAGCTGTCCAGCCA
GGCCTGCCTGAGAAAGTGCGGGACGGTGCCCGGGTCCCGCTGCTGCACCTGCGCGCCGAG
TCTGTCCCTGCGCATCCCTGTGGCTTTCCTGCACCACTGCCCCCCACCAGGATGATGGAG
AGTAAGATGATTGCTGCCATACACTCCAGCAGTGCAGATGCCACCAGCAGTTCAAATTAT
CATTCCTTTGTCACTGCTTCATCCACCTCTGTGGACGATGCATTGCCTTTACCACTTCCT
GTCCCACAACCTAAGCATGCTTCTCAGAAAACAGTTTACTCCTCCTTTGCTAGGCCCGAT
GTCACCACTGAACCCTTTGGTCCAGATAACTGTTTGCATTTCAATATGACTCCAAACTGC
CAGTACCGTCCCCAGAGTGTACCTCCCCATCACAATAAATTGGAGCAGCACCAAGTGTAT
GGTGCCAGGTCAGAGCCACCAGCCTCCATGGGTCTTCGTTATAACACATATGTGGCCCCA
GGAAGAAACGCATCTGGACACCACTCCAAGCCATGCAGCCGGGTCGAGTATGTGTCTTCT
TTGAGCTCCTCTGTCAGGAATACCTGTTACCCCGAAGACATTCCACCGTACCCTACCATC
CGGAGAGTGCAGTCTCTCCATGCTCCGCCGTCTTCCATGATTCGCTCTGTTCCCATTTCA
CGGACAGAAGTTCCCCCAGATGATGAGCCAGCCTACTGCCCAAGACCTCTGTACCAATAT
AAGCCATATCAGTCCTCCCAGGCCCGCTCAGATTATCATGTCACTCAGCTTCAGCCTTAC
TTTGAGAATGGCCGGGTCCACTACAGGTATAGCCCATATTCCAGTTCTTCTAGTTCCTAT
TACAGTCCAGATGGGGCCCTGTGTGATGTGGATGCCTATGGCACAGTCCAGTTGAGACCC
CTTCACCGCCTTCCCAATCGAGACTTTGCTTTCTACAATCCTAGGCTGCAAGGAAAGAGC
TTGTACAGTTATGCTGGTTTGGCTCCACGTCCCCGGGCCAACGTGACTGGCTATTTCTCT
CCCAACGACCATAATGTAGTCAGCATGCCTCCGGCTGCTGATGTGAAGCACACCTACACC
TCATGGGATCTTGAGGACATGGAAAAATACCGCATGCAGTCCATCCGGAGAGAGAGCCGT
GCTCGGCAGAAGGTGAAAGGGCCTGTCATGTCCCAATATGATAACATGACCCCGGCGGTG
CAGGACGACTTGGGTGGGATCTATGTCATCCATCTGCGTAGTAAATCAGATCCTGGGAAA
ACTGGACTTCTCTCAGTGGCAGAAGGAAAGGAGAGCCGCCATGCAGCCAAGGCCATCAGT
CCCGAGGGAGAGGACCGCTTCTATAGGAGGCATCCCGAGGCAGAGATGGACAGAGCCCAC
CATCACGGAGGCCATGGTAGCACGCAGCCGGAGAAGCCATCCCTGCCTCAGAAGCAGAGC
AGCCTGAGGAGCAGGAAGCTTCCTGACATGGGCTGCAGTCTTCCTGAGCACAGGGCACAC
CAAGAAGCAAGCCATAGGCAGTTCTGTGAGTCAAAGAATGGGCCCCCTTATCCCCAGGGA
GCTGGCCAGTTAGATTATGGGTCCAAAGGGATTCCAGACACTTCTGAGCCAGTCAGCTAC
CACAACTCTGGAGTAAAATATGCTGCATCCGGGCAAGAATCTTTAAGACTGAACCACAAA
GAGGTAAGGCTCTCCAAAGAGATGGAGCGACCCTGGGTTAGGCAGCCTTCTGCCCCAGAG
AAACACTCCAGAGACTGCTACAAGGAGGAAGAACACCTCACTCAGTCAATCGTCCCACCC
CCTAAACCAGAGAGGAGTCATAGCCTCAAACTCCATCATACCCAGAACGTGGAGAGGGAC
CCCAGTGTGCTGTACCAGTACCAACCACACGGCAAGCGCCAGAGCAGTGTGACTGTTGTG
TCCCAGTATGATAACCTGGAAGATTACCACTCCCTGCCTCAGCACCAGCGAGGAGTCTTT
GGAGGGGGCGGCATGGGGACGTATGTGCCCCCTGGCTTTCCCCATCCACAGAGCAGGACC
TATGCTACAGCGTTGGGTCAAGGGGCCTTCCTGCCCGCAGAGTTGTCCTTGCAGCATCCT
GAAACACAGATCCATGCAGAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 2087 |
| Molecular Weight
| 230527.1 |
| Theoretical pI
| 6.73 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rho GTPase-activating protein 32
METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNV
HPRERPDWEETLSAMARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAEC
AHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLD
KHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWME
IDNKGNHLLVHEESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWW
RGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLK
QRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRH
EFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLI
KIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACF
SGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLLVSSPSTKLLTL
EEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQNKMKKSPVGSW
RSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAVDGDS
KLFRPRRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNESEEEGGLLHIPALMSPHSAED
VDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDSPGYSKDKPSANKKDAETGS
SQCQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEDKSSKPSSFTEKVVYAFSPKIGRKLS
KSPSMSISEPISVTLPPRVSEVIGTVSNTTAQNASSSTWDKCVEERDATNRSPTQIVKMK
TNETVAQEAYESEVQPLDQVAAEEVELPGKEDQSVSSSQSKAVASGQTQTGAVTHDPPQD
SVPVSSVSLIPPPPPPKNVARMLALALAESAQQASTQSLKRPGTSQAGYTNYGDIAVATT
EDNLSSSYSAVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNTTESGE
QHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGKNSMPTVSFLDQ
DQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPPNLPSDKIYPPSGSPEENTSTAT
MTYMTTTPATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPPPSQRSAEQPPV
VGQVQAATNIGLNNSHKVQGVVPVPERPPEPRAMDDPASAFISDSGAAAAQCPMATAVQP
GLPEKVRDGARVPLLHLRAESVPAHPCGFPAPLPPTRMMESKMIAAIHSSSADATSSSNY
HSFVTASSTSVDDALPLPLPVPQPKHASQKTVYSSFARPDVTTEPFGPDNCLHFNMTPNC
QYRPQSVPPHHNKLEQHQVYGARSEPPASMGLRYNTYVAPGRNASGHHSKPCSRVEYVSS
LSSSVRNTCYPEDIPPYPTIRRVQSLHAPPSSMIRSVPISRTEVPPDDEPAYCPRPLYQY
KPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPDGALCDVDAYGTVQLRP
LHRLPNRDFAFYNPRLQGKSLYSYAGLAPRPRANVTGYFSPNDHNVVSMPPAADVKHTYT
SWDLEDMEKYRMQSIRRESRARQKVKGPVMSQYDNMTPAVQDDLGGIYVIHLRSKSDPGK
TGLLSVAEGKESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHGGHGSTQPEKPSLPQKQS
SLRSRKLPDMGCSLPEHRAHQEASHRQFCESKNGPPYPQGAGQLDYGSKGIPDTSEPVSY
HNSGVKYAASGQESLRLNHKEVRLSKEMERPWVRQPSAPEKHSRDCYKEEEHLTQSIVPP
PKPERSHSLKLHHTQNVERDPSVLYQYQPHGKRQSSVTVVSQYDNLEDYHSLPQHQRGVF
GGGGMGTYVPPGFPHPQSRTYATALGQGAFLPAELSLQHPETQIHAE
|
| External Links |
|---|
| GenBank ID Protein
| 218083800 |
| UniProtKB/Swiss-Prot ID
| A7KAX9 |
| UniProtKB/Swiss-Prot Entry Name
| RHG32_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001142685.1 |
| GeneCard ID
| ARHGAP32 |
| GenAtlas ID
| ARHGAP32 |
| HGNC ID
| HGNC:17399 |
| References |
|---|
| General References
| Not Available |