| Identification |
|---|
| HMDB Protein ID
| CDBP03186 |
| Secondary Accession Numbers
| Not Available |
| Name
| Regulating synaptic membrane exocytosis protein 1 |
| Description
| Not Available |
| Synonyms
|
- RIM 1
- Rab-3-interacting molecule 1
- Rab-3-interacting protein 2
|
| Gene Name
| RIMS1 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short- term synaptic plasticity |
| GO Classification
|
| Function |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| enzyme regulator activity |
| rab gtpase binding |
| protein binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| small gtpase regulator activity |
| ion binding |
| cation binding |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
|
| Cellular Location
|
- Cell membrane
- Peripheral membrane protein
- Peripheral membrane protein
- Cell junction
- Cell junction
- synapse
- synapse
- presynaptic cell membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q12-q13 |
| SNPs
| RIMS1 |
| Gene Sequence
|
>5079 bp
ATGTCCTCGGCCGTGGGGCCCCGCGGTCCTCGCCCACCCACGGTGCCTCCCCCCATGCAA
GAGCTGCCCGACCTGAGCCACCTGACCGAAGAGGAGAGGAACATTATCATGGCAGTGATG
GACCGGCAGAAGGAAGAGGAGGAAAAAGAAGAAGCCATGCTCAAGTGTGTTGTCAGGGAC
ATGGCGAAGCCTGCTGCCTGCAAAACACCAAGAAATGCTGAAAACCAGCCCCACCAACCT
TCACCGAGATTGCATCAACAGTTTGAAAGCTATAAGGAACAAGTGAGAAAAATAGGGGAA
GAAGCGCGGCGTTACCAGGGCGAGCACAAAGACGATGCTCCGACTTGTGGAATCTGTCAT
AAAACAAAGTTTGCTGATGGGTGCGGTCATCTCTGCTCCTATTGTCGCACTAAGTTCTGT
GCGCGCTGCGGAGGCCGCGTGTCTCTACGGTCAAACAACGAGGACAAAGTGGTTATGTGG
GTATGCAATTTATGTCGAAAGCAACAAGAAATCTTAACCAAATCTGGGGCATGGTTCTTT
GGAAGTGGCCCTCAGCAGACAAGTCAGGATGGAACCCTGAGTGATACAGCTACAGGTGCT
GGCTCTGAGGTACCAAGAGAAAAGAAAGCACGACTCCAAGAGCGATCGCGGTCTCAGACA
CCCCTAAGCACAGCAGCTGCCTCCTCCCAGGATGCTGCTCCTCCCAGCGCACCACCAGAC
AGGAGCAAAGGGGCTGAGCCCTCGCAGCAAGCCTTGGGGCCTGAACAGAAGCAGGCTTCA
TCCAGGTCTAGAAGTGAACCTCCTAGAGAGAGAAAGAAGACCCCAGGGCTTTCCGAGCAG
AATGGCAAAGGAGCCCTGAAGAGCGAGCGGAAACGCGTGCCAAAGACCTCAGCGCAGCCC
GTGGAGGGGGCCGTCGAAGAACGGGAGCGCAAAGAAAGGCGGGAAAGCCGAAGGCTTGAG
AAAGGGCGATCACAGGATTACCCAGACACGCCGGAAAAACGGGATGAGGGCAAAGCGGCG
GATGAGGAAAAGCAAAGAAAAGAGGAGGATTATCAGACCAGGTACCGCAGCGACCCGAAC
CTAGCTCGGTACCCGGTGAAACCGCCGCCTGAGGAGCAGCAGATGCGCATGCACGCCCGG
GTGTCCCGCGCCAGGCACGAGCGGCGCCACAGCGACGTGGCGCTCCCGCGCACCGAGGCG
GGCGCGGCGCTGCCGGAGGGCAAGGCCGGCAAACGCGCGCCGGCGGCAGCCAGGGCCTCG
CCGCCGGACTCGCCGCGGGCTTACTCGGCTGAGAGAACTGCGGAGACCAGGGCGCCGGGC
GCCAAGCAGCTAACGAACCACAGCCCGCCGGCGCCCAGACATGGGCCGGTTCCCGCAGAA
GCCCCGGAGCTCAAAGCCCAGGAGCCCCTCAGGAAGCAGAGCCGCCTGGACCCCAGCTCG
GCGGTCCTCATGCGGAAGGCCAAGCGCGAGAAGGTGGAGACCATGCTGCGGAACGACTCT
TTGAGCTCAGACCAGTCCGAGTCGGTGCGGCCGTCCCCGCCCAAGCCGCACCGGTCCAAG
AGAGGCGGCAAGAAGCGGCAGATGTCGGTGAGCAGCTCTGAGGAGGAGGGCGTGTCGACG
CCCGAGTACACCAGCTGCGAGGACGTGGAGCTGGAGAGCGAGAGCGTCAGCGAGAAAGGT
GATTTGGATTATTACTGGTTGGATCCTGCCACGTGGCACAGCCGGGAGACATCACCTATT
AGTTCGCATCCTGTAACGTGGCAACCATCTAAAGAGGGGGACCGATTAATTGGACGTGTT
ATTCTTAACAAGAGAACAACCATGCCCAAAGACTCAGGTGCATTGCTGGGTCTGAAAGTT
GTTGGAGGAAAAATGACTGACTTAGGACGACTTGGTGCTTTCATCACCAAAGTAAAGAAG
GGTAGCCTAGCAGATGTAGTTGGACACCTAAGAGCAGGGGATGAAGTTCTAGAATGGAAT
GGTAAACCCCTGCCGGGAGCTACAAATGAAGAAGTTTACAACATTATTTTAGAATCAAAA
TCAGAACCTCAAGTTGAAATTATTGTTTCAAGGCCTATTGGTGACATTCCCCGGATTCCT
GAGAGCTCCCACCCTCCACTGGAGTCCAGTTCAAGTTCCTTTGAATCTCAGAAGATGGAA
AGGCCTTCCATTTCTGTTATTTCTCCAACAAGTCCTGGAGCTCTAAAAGATGCCCCACAA
GTCTTACCAGGGCAACTTTCTGTGAAGTTGTGGTATGATAAAGTGGGACACCAGCTGATT
GTAAATGTTCTGCAAGCAACAGATCTACCTGCTAGAGTAGATGGACGTCCTCGAAATCCC
TATGTAAAAATGTATTTTCTTCCAGATAGAAGTGATAAAAGTAAAAGGAGGACCAAAACA
GTAAAGAAAATACTAGAACCAAAATGGAATCAAACTTTTGTCTATTCACATGTACATCGT
AGAGATTTTAGAGAACGAATGTTAGAAATAACTGTGTGGGACCAACCAAGAGTGCAAGAA
GAAGAAAGTGAATTTCTTGGAGAGATCCTCATAGAATTGGAGACAGCGCTTTTAGATGAT
GAACCGCATTGGTATAAACTTCAGACACATGATGAGTCTTCACTACCTCTGCCTCAGCCA
TCACCTTTCATGCCAAGGCGACATATTCATGGAGAAAGCTCTAGCAAAAAGCTACAAAGA
TCTCAGCGAATCAGTGATAGTGACATCTCAGATTATGAGGTTGATGATGGTATTGGCGTA
GTTCCTCCAGTAGGCTATAGGTCTAGTGCTAGAGAAAGTAAATCTACAACATTAACTGTG
CCAGAACAGCAAAGAACAACTCATCACCGCTCACGTTCAGTATCTCCTCATCGCGGCAAT
GATCAGGGAAAGCCGCGTTCACGTTTACCAAATGTGCCATTACAGAGGAGTTTAGATGAA
ATTCATCCAACAAGAAGGTCACGTTCTCCAACCAGACACCATGATGCCTCCCGAAGTCCA
GTTGATCATAGAACCAGAGATGTGGATAGTCAGTATTTATCAGAACAAGACAGTGAGCTT
CTTATGCTGCCCAGAGCAAAACGAGGACGAAGTGCAGAATGCCTACATACTACCAGACAT
CTTGTTAGGCACTATAAAACATTACCTCCCAAGATGCCTTTATTACAGAGCAGTTCTCAC
TGGAATATTTACAGCTCAATTCTGCCTGCACATACTAAGACCAAATCAGTGACTAGACAG
GACATTTCCCTTCATCATGAATGCTTTAACTCAACAGTATTGAGATTTACTGATGAAATA
CTGGTTAGTGAACTGCAGCCCTTTCTTGACAGGGCTAGGAGTGCTAGTACCAACTGCTTG
AGACCAGATACTAGTTTGCATTCACCAGAACGAGAAAGGGGTAGATGGTCCCCCTCCCTA
GATAGGAGACGACCTCCTAGTCCCAGGATTCAAATCCAGCATGCGTCTCCGGAGAATGAC
AGGCACTCCAGAAAGTCTGAAAGATCTAGCATCCAAAAACAGACTAGGAAAGGCACTGCC
TCTGATGCAGAAAGGGTTCTCCCAACATGTCTTTCTAGAAGGGGACACGCAGCCCCAAGA
GCAACTGATCAGCCAGTCATTAGGGGAAAACATCCTGCTCGCTCAAGGTCGAGTGAGCAC
TCTAGTATCAGAACACTGTGTTCTATGCACCACCTTGTCCCTGGAGGGTCGGCGCCACCT
TCTCCGCTTCTGACAAGAATGCACCGACAGAGAAGTCCAACACAATCTCCTCCAGCAGAC
ACATCGTTCAGCAGTCGCAGGGGAAGACAGCTCCCACAAGTGCCAGTGAGAAGCGGCAGT
ATAGAACAAGCAAGCTTAGTAGTGGAGGAGCGAACAAGACAGATGAAAATGAAAGTGCAT
CGATTTAAGCAGACAACAGGGTCTGGTTCTAGTCAAGAACTTGATCGCGAGCAATATTCC
AAGTATAACATACATAAAGATCAGTACAGAAGCTGTGATAACGTCTCTGCCAAATCATCA
GATAGTGATGTCAGTGATGTTTCCGCCATTTCCCGAACCAGCAGTGCCTCACGCCTCAGC
AGCACAAGCTTTATGTCAGAGCAATCTGAGCGCCCCAGGGGTAGAATCAGTTCATTTACC
CCCAAAATGCAAGGCAGACGGATGGGGACTTCAGGAAGATCCATCATGAAGAGCACCAGT
GTCAGTGGAGAGATGTACACACTGGAGCATAATGACGGCAGCCAGTCAGACACAGCTGTG
GGTACAGTTGGAGCAGGTGGAAAGAAACGGAGATCCAGCCTTAGTGCCAAAGTGGTTGCC
ATAGTGTCTCGAAGGAGTAGAAGCACATCCCAGCTTAGTCAAACAGAGTCGGGCCACAAA
AAGTTAAAAAGTACCATCCAGAGAAGCACAGAAACAGGCATGGCAGCTGAAATGAGAAAG
ATGGTAAGGCAGCCGAGCCGAGAGTCTACTGATGGCAGCATCAACAGTTACAGCTCTGAG
GGCAATTTAATATTTCCTGGAGTGCGACTGGGAGCTGACAGTCAATTCAGTGATTTTCTT
GATGGATTGGGACCAGCCCAGCTTGTTGGCCGCCAAACCCTTGCCACCCCTGCAATGGGT
GATATACAAATAGGAATGGAGGACAAAAAGGGCCAATTAGAAGTGGAAGTCATTAGAGCA
CGAAGCCTCACACAAAAGCCTGGTTCCAAATCTACACCTGCTCCATATGTCAAAGTATAT
CTTTTGGAAAATGGGGCCTGTATAGCCAAGAAGAAGACAAGAATTGCACGAAAAACCCTT
GATCCTTTGTATCAGCAGTCTCTGGTTTTTGATGAAAGTCCACAGGGTAAAGTTCTTCAG
GTGATTGTCTGGGGAGACTATGGCAGAATGGACCACAAATGCTTTATGGGTGTGGCTCAG
ATCTTGTTGGAAGAACTCGACCTGTCCAGCATGGTGATCGGATGGTACAAATTGTTCCCA
CCGTCCTCACTGGTGGATCCCACACTCACTCCCCTCACCCGGCGGGCTTCCCAGTCATCT
CTGGAAAGTTCAACTGGGCCTCCCTGTATTCGATCATAG
|
| Protein Properties |
|---|
| Number of Residues
| 1692 |
| Molecular Weight
| 189070.9 |
| Theoretical pI
| 10.24 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Regulating synaptic membrane exocytosis protein 1
MSSAVGPRGPRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRD
MAKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICH
KTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFF
GSGPQQTSQDGTLSDTATGAGSEVPREKKARLQERSRSQTPLSTAAASSQDAAPPSAPPD
RSKGAEPSQQALGPEQKQASSRSRSEPPRERKKTPGLSEQNGKGALKSERKRVPKTSAQP
VEGAVEERERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPN
LARYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAGAALPEGKAGKRAPAAARAS
PPDSPRAYSAERTAETRAPGAKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSRLDPSS
AVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVST
PEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRV
ILNKRTTMPKDSGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWN
GKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKME
RPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNP
YVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQE
EESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQR
SQRISDSDISDYEVDDGIGVVPPVGYRSSARESKSTTLTVPEQQRTTHHRSRSVSPHRGN
DQGKPRSRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSEL
LMLPRAKRGRSAECLHTTRHLVRHYKTLPPKMPLLQSSSHWNIYSSILPAHTKTKSVTRQ
DISLHHECFNSTVLRFTDEILVSELQPFLDRARSASTNCLRPDTSLHSPERERGRWSPSL
DRRRPPSPRIQIQHASPENDRHSRKSERSSIQKQTRKGTASDAERVLPTCLSRRGHAAPR
ATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPAD
TSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYS
KYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSSTSFMSEQSERPRGRISSFT
PKMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVA
IVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSE
GNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRA
RSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQ
VIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSS
LESSTGPPCIRS
|
| External Links |
|---|
| GenBank ID Protein
| 41054864 |
| UniProtKB/Swiss-Prot ID
| Q86UR5 |
| UniProtKB/Swiss-Prot Entry Name
| RIMS1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014989.4 |
| GeneCard ID
| RIMS1 |
| GenAtlas ID
| RIMS1 |
| HGNC ID
| HGNC:17282 |
| References |
|---|
| General References
| Not Available |