Showing Protein T-lymphoma invasion and metastasis-inducing protein 1 (CDBP03819)
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| HMDB Protein ID | CDBP03819 | |||||||||||||||||||||||||||||
| Secondary Accession Numbers | Not Available | |||||||||||||||||||||||||||||
| Name | T-lymphoma invasion and metastasis-inducing protein 1 | |||||||||||||||||||||||||||||
| Description | Not Available | |||||||||||||||||||||||||||||
| Synonyms |
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| Gene Name | TIAM1 | |||||||||||||||||||||||||||||
| Protein Type | Receptor | |||||||||||||||||||||||||||||
| Biological Properties | ||||||||||||||||||||||||||||||
| General Function | Involved in Rho guanyl-nucleotide exchange factor activity | |||||||||||||||||||||||||||||
| Specific Function | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA | |||||||||||||||||||||||||||||
| GO Classification |
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| Cellular Location | Not Available | |||||||||||||||||||||||||||||
| Pathways | Not Available | |||||||||||||||||||||||||||||
| Gene Properties | ||||||||||||||||||||||||||||||
| Chromosome Location | Chromosome:2 | |||||||||||||||||||||||||||||
| Locus | 21q22.1|21q22.11 | |||||||||||||||||||||||||||||
| SNPs | TIAM1 | |||||||||||||||||||||||||||||
| Gene Sequence |
>4776 bp ATGGGAAACGCAGAAAGTCAACATGTAGAGCACGAGTTTTATGGAGAAAAGCATGCCAGC CTGGGGCGCAAGCACACTTCCCGCTCCCTGCGCCTCTCGCACAAGACGCGGAGGACCAGG CACGCTTCCTCGGGGAAGGTGATCCACAGGAACTCCGAAGTGAGCACCCGATCCAGCAGC ACCCCCAGCATCCCCCAGTCCCTGGCTGAAAATGGCCTGGAGCCCTTCTCCCAAGATGGT ACCCTAGAAGACTTCGGGAGCCCCATCTGGGTGGACCGAGTGGACATGGGCTTGAGACCT GTGTCTTACACTGACTCTTCTGTCACTCCCAGCGTAGACAGCAGCATCGTCCTCACAGCA GCCTCTGTGCAGAGCATGCCAGACACTGAGGAGAGCAGGCTTTACGGGGATGACGCTACA TATTTGGCTGAGGGAGGCAGGAGGCAGCATTCCTATACATCCAATGGGCCCACTTTCATG GAGACGGCGAGCTTTAAGAAGAAACGCTCCAAATCTGCAGACATCTGGCGGGAGGACAGC CTGGAATTCTCACTCTCTGATCTGAGCCAAGAACATTTAACAAGCAACGAAGAAATCTTG GGTTCCGCCGAAGAGAAGGACTGCGAGGAGGCTCGGGGGATGGAAACGCGGGCGAGTCCG CGGCAGCTCAGCACCTGTCAGAGAGCCAATTCCTTGGGTGACTTGTATGCTCAGAAAAAC TCTGGAGTGACAGCAAACGGGGGGCCGGGGAGCAAATTTGCAGGCTACTGTCGGAATTTG GTGTCTGATATTCCCAATCTTGCAAACCATAAGATGCCACCAGCTGCTGCTGAAGAGACT CCTCCGTACAGTAATTATAACACACTTCCCTGTAGGAAATCTCACTGTCTCTCTGAAGGT GCCACCAACCCACAAATTAGCCATAGCAACAGCATGCAAGGCAGAAGAGCTAAAACAACT CAGGATGTTAATGCAGGCGAGGGCAGTGAGTTTGCAGACAGTGGGATTGAAGGGGCCACT ACCGACACGGACCTCCTGTCCAGGCGATCTAATGCCACCAACTCCAGCTACTCACCCACC ACAGGCCGGGCCTTTGTGGGCAGCGACAGCGGCAGCAGCTCCACCGGGGATGCGGCTCGT CAGGGGGTGTACGAGAACTTCCGGCGGGAGCTGGAGATGAGCACCACCAACAGCGAGAGC CTGGAGGAGGCCGGCTCGGCGCACAGCGATGAGCAGAGCAGCGGCACCCTGAGCTCTCCG GGCCAGTCGGACATCCTGCTGACCGCCGCACAGGGCACGGTGCGCAAGGCCGGCGCCCTG GCCGTCAAGAACTTCCTGGTGCACAAGAAGAACAAGAAGGTGGAGTCAGCCACCCGGAGG AAGTGGAAGCACTACTGGGTGTCCCTGAAAGGATGCACGCTATTTTTCTACGAGAGCGAC GGCAGGTCTGGGATAGACCACAACAGCATCCCCAAACACGCCGTCTGGGTGGAGAACAGC ATTGTGCAGGCGGTGCCTGAGCACCCCAAGAAGGACTTTGTCTTCTGCCTCAGCAATTCC CTGGGTGATGCCTTCCTTTTTCAGACCACTAGCCAGACGGAGCTTGAAAACTGGATCACC GCCATCCACTCTGCCTGCGCCACTGCGGTCGCGAGGCACCACCACAAGGAAGACACGCTC CGACTCCTGAAATCAGAGATCAAAAAACTGGAACAGAAGATTGACATGGATGAAAAGATG AAGAAAATGGGTGAAATGCAGCTGTCTTCAGTCACTGACTCAAAGAAAAAGAAAACAATA TTAGATCAGATCTTTGTCTGGGAGCAAAATCTCGAGCAGTTCCAAATGGACCTGTTTCGT TTCCGCTGTTATTTAGCCAGCCTTCAGGGTGGGGAGCTGCCAAACCCCAAAAGGCTTCTC GCTTTTGCAAGTCGACCAACGAAAGTGGCCATGGGCCGCCTTGGAATCTTTTCGGTATCA TCGTTTCATGCCCTGGTGGCAGCACGCACTGGTGAAACTGGAGTGAGAAGACGTACTCAG GCCATGTCCAGATCCGCGAGCAAGCGAAGGAGCAGGTTTTCTTCTCTGTGGGGTCTGGAT ACTACCTCCAAAAAGAAGCAGGGACGGCCAAGCATCAATCAGGTGTTTGGAGAGGGAACC GAAGCTGTAAAGAAATCTTTAGAGGGAATATTTGATGACATTGTTCCAGATGGCAAGAGG GAGAAAGAAGTGGTCTTACCTAACGTTCACCAGCACAACCCTGACTGCGACATTTGGGTC CACGAGTATTTCACTCCATCCTGGTTCTGTCTGCCCAATAATCAGCCTGCCCTGACGGTC GTCCGGCCAGGCGACACTGCACGGGACACCCTGGAGCTGATTTGCAAGACACATCAACTG GATCATTCTGCTCATTACCTGCGCCTGAAATTTCTAATAGAAAACAAAATGCAGCTCTAT GTTCCACAGCCCGAGGAAGACATCTATGAGCTGCTGTACAAAGAAATTGAAATCTGTCCA AAAGTCACTCAGAGCATCCACATTGAGAAGTCAGATACAGCTGCTGATACTTACGGGTTT TCACTTTCTTCTGTGGAAGAAGATGGTATTCGAAGGCTGTACGTGAATAGTGTGAAGGAA ACCGGTTTAGCTTCCAAGAAAGGCCTGAAAGCAGGAGATGAGATTCTTGAGATCAATAAT CGTGCTGCTGACGCCCTGAACTCTTCTATGCTCAAAGATTTCCTCTCACAGCCCTCGCTG GGCCTCCTGGTGAGGACCTACCCCGAGCTGGAGGAAGGAGTGGAGCTGCTGGAAAGCCCG CCCCACCGAGTGGACGGCCCTGCCGACCTTGGCGAGAGCCCCCTCGCCTTTCTCACCAGC AACCCAGGGCACAGCCTTTGCAGCGAGCAGGGCAGCAGTGCTGAGACCGCTCCAGAGGAG ACCGAGGGGCCAGACTTGGAATCCTCAGATGAGACTGATCACAGCAGCAAGAGTACAGAA CAGGTGGCCGCATTTTGCCGCAGTTTGCATGAGATGAACCCCTCTGACCAGAGCCCATCT CCTCAGGACTCCACGGGGCCTCAGCTGGCGACCATGAGACAACTCTCGGATGCAGATAAG CTGCGCAAGGTGATCTGCGAGCTCCTGGAGACGGAGCGCACCTACGTGAAGGATTTAAAC TGTCTTATGGAGAGATACCTAAAGCCTCTTCAAAAAGAAACTTTTCTCACCCAGGATGAG CTTGACGTGCTTTTTGGAAATTTAACGGAAATGGTAGAGTTTCAAGTAGAATTCCTTAAA ACTCTAGAAGATGGAGTGAGACTGGTACCTGATTTGGAAAAGCTTGAGAAGGTTGATCAA TTTAAGAAAGTGCTGTTCTCTCTGGGGGGATCATTCCTGTATTATGCTGACCGCTTCAAG CTCTACAGTGCCTTCTGCGCCAGCCACACAAAAGTTCCCAAGGTCCTGGTGAAAGCCAAG ACAGACACGGCTTTCAAGGCATTCTTGGATGCCCAGAACCCGAAGCAGCAGCACTCATCC ACGCTGGAGTCGTACCTCATCAAGCCCATCCAGAGGATCCTCAAGTACCCACTTCTGCTC AGGGAGCTGTTCGCCCTGACCGATGCGGAGAGCGAGGAGCACTACCACCTGGACGTGGCC ATCAAGACCATGAACAAGGTTGCCAGTCACATCAATGAGATGCAGAAAATCCATGAAGAG TTTGGGGCTGTGTTTGACCAGCTGATTGCTGAACAGACTGGTGAGAAAAAAGAGGTTGCA GATCTGAGCATGGGAGACCTGCTTTTGCACACTACCGTGATCTGGCTGAACCCGCCGGCC TCGCTGGGCAAGTGGAAAAAGGAACCAGAGTTGGCAGCATTCGTCTTCAAAACTGCTGTG GTCCTTGTGTATAAAGATGGTTCCAAACAGAAGAAGAAACTTGTAGGATCTCACAGGCTT TCCATTTATGAGGACTGGGACCCCTTCAGATTTCGACACATGATCCCCACGGAAGCGCTG CAGGTTCGAGCTTTGGCGAGTGCAGATGCAGAGGCAAATGCCGTGTGTGAAATTGTCCAT GTAAAATCCGAGTCTGAAGGGAGGCCGGAGAGGGTCTTTCACTTGTGCTGCAGCTCCCCA GAGAGCCGAAAGGATTTCCTAAAGGCTGTGCATTCAATCCTGCGTGATAAGCACAGAAGA CAGCTCCTCAAAACCGAGAGCCTTCCCTCATCCCAGCAATATGTCCCTTTTGGAGGCAAA AGATTGTGTGCACTGAAGGGGGCCAGGCCGGCCATGAGCAGGGCAGTGTCTGCCCCAAGC AAGTCTCTTGGGAGGAGGAGGCGGCGGCTGGCTCGAAACAGGTTTACCATTGATTCTGAT GCCGTCTCCGCAAGCAGCCCGGAGAAAGAGTCCCAGCAGCCCCCCGGTGGTGGGGACACT GACCGATGGGTAGAGGAGCAGTTTGATCTTGCTCAGTATGAGGAGCAAGATGACATCAAG GAGACAGACATCCTCAGTGACGATGATGAGTTCTGTGAGTCCGTGAAGGGTGCCTCAGTG GACAGAGACCTGCAGGAGCGGCTTCAGGCCACCTCCATCAGTCAGCGGGAAAGAGGCCGG AAAACCCTGGATAGTCACGCGTCCCGCATGGCACAGCTCAAGAAGCAAGCTGCCCTGTCG GGGATCAATGGAGGCCTGGAGAGCGCAAGCGAGGAAGTCATTTGGGTTAGGCGTGAAGAC TTTGCCCCCTCCAGGAAACTGAACACTGAGATCTGA |
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| Protein Properties | ||||||||||||||||||||||||||||||
| Number of Residues | 1591 | |||||||||||||||||||||||||||||
| Molecular Weight | 177506.5 | |||||||||||||||||||||||||||||
| Theoretical pI | 6.58 | |||||||||||||||||||||||||||||
| Pfam Domain Function | ||||||||||||||||||||||||||||||
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>T-lymphoma invasion and metastasis-inducing protein 1 MGNAESQHVEHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKVIHRNSEVSTRSSS TPSIPQSLAENGLEPFSQDGTLEDFGSPIWVDRVDMGLRPVSYTDSSVTPSVDSSIVLTA ASVQSMPDTEESRLYGDDATYLAEGGRRQHSYTSNGPTFMETASFKKKRSKSADIWREDS LEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETRASPRQLSTCQRANSLGDLYAQKN SGVTANGGPGSKFAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYNTLPCRKSHCLSEG ATNPQISHSNSMQGRRAKTTQDVNAGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPT TGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSP GQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESD GRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWIT AIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDSKKKKTI LDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLAFASRPTKVAMGRLGIFSVS SFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPSINQVFGEGT EAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTV VRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLYVPQPEEDIYELLYKEIEICP KVTQSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASKKGLKAGDEILEINN RAADALNSSMLKDFLSQPSLGLLVRTYPELEEGVELLESPPHRVDGPADLGESPLAFLTS NPGHSLCSEQGSSAETAPEETEGPDLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPS PQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDE LDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFK LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLL RELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVA DLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRL SIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSP ESRKDFLKAVHSILRDKHRRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPS KSLGRRRRRLARNRFTIDSDAVSASSPEKESQQPPGGGDTDRWVEEQFDLAQYEEQDDIK ETDILSDDDEFCESVKGASVDRDLQERLQATSISQRERGRKTLDSHASRMAQLKKQAALS GINGGLESASEEVIWVRREDFAPSRKLNTEI |
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| External Links | ||||||||||||||||||||||||||||||
| GenBank ID Protein | 115583670 | |||||||||||||||||||||||||||||
| UniProtKB/Swiss-Prot ID | Q13009 | |||||||||||||||||||||||||||||
| UniProtKB/Swiss-Prot Entry Name | TIAM1_HUMAN | |||||||||||||||||||||||||||||
| PDB IDs | ||||||||||||||||||||||||||||||
| GenBank Gene ID | NM_003253.2 | |||||||||||||||||||||||||||||
| GeneCard ID | TIAM1 | |||||||||||||||||||||||||||||
| GenAtlas ID | TIAM1 | |||||||||||||||||||||||||||||
| HGNC ID | HGNC:11805 | |||||||||||||||||||||||||||||
| References | ||||||||||||||||||||||||||||||
| General References | Not Available | |||||||||||||||||||||||||||||