| Identification |
|---|
| HMDB Protein ID
| CDBP03819 |
| Secondary Accession Numbers
| Not Available |
| Name
| T-lymphoma invasion and metastasis-inducing protein 1 |
| Description
| Not Available |
| Synonyms
|
- TIAM-1
|
| Gene Name
| TIAM1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| small gtpase regulator activity |
| binding |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| receptor signaling protein activity |
| enzyme regulator activity |
| protein binding |
| molecular transducer activity |
| signal transducer activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| guanyl-nucleotide exchange factor activity |
| Process |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signaling pathway |
| signaling |
| signaling pathway |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 21q22.1|21q22.11 |
| SNPs
| TIAM1 |
| Gene Sequence
|
>4776 bp
ATGGGAAACGCAGAAAGTCAACATGTAGAGCACGAGTTTTATGGAGAAAAGCATGCCAGC
CTGGGGCGCAAGCACACTTCCCGCTCCCTGCGCCTCTCGCACAAGACGCGGAGGACCAGG
CACGCTTCCTCGGGGAAGGTGATCCACAGGAACTCCGAAGTGAGCACCCGATCCAGCAGC
ACCCCCAGCATCCCCCAGTCCCTGGCTGAAAATGGCCTGGAGCCCTTCTCCCAAGATGGT
ACCCTAGAAGACTTCGGGAGCCCCATCTGGGTGGACCGAGTGGACATGGGCTTGAGACCT
GTGTCTTACACTGACTCTTCTGTCACTCCCAGCGTAGACAGCAGCATCGTCCTCACAGCA
GCCTCTGTGCAGAGCATGCCAGACACTGAGGAGAGCAGGCTTTACGGGGATGACGCTACA
TATTTGGCTGAGGGAGGCAGGAGGCAGCATTCCTATACATCCAATGGGCCCACTTTCATG
GAGACGGCGAGCTTTAAGAAGAAACGCTCCAAATCTGCAGACATCTGGCGGGAGGACAGC
CTGGAATTCTCACTCTCTGATCTGAGCCAAGAACATTTAACAAGCAACGAAGAAATCTTG
GGTTCCGCCGAAGAGAAGGACTGCGAGGAGGCTCGGGGGATGGAAACGCGGGCGAGTCCG
CGGCAGCTCAGCACCTGTCAGAGAGCCAATTCCTTGGGTGACTTGTATGCTCAGAAAAAC
TCTGGAGTGACAGCAAACGGGGGGCCGGGGAGCAAATTTGCAGGCTACTGTCGGAATTTG
GTGTCTGATATTCCCAATCTTGCAAACCATAAGATGCCACCAGCTGCTGCTGAAGAGACT
CCTCCGTACAGTAATTATAACACACTTCCCTGTAGGAAATCTCACTGTCTCTCTGAAGGT
GCCACCAACCCACAAATTAGCCATAGCAACAGCATGCAAGGCAGAAGAGCTAAAACAACT
CAGGATGTTAATGCAGGCGAGGGCAGTGAGTTTGCAGACAGTGGGATTGAAGGGGCCACT
ACCGACACGGACCTCCTGTCCAGGCGATCTAATGCCACCAACTCCAGCTACTCACCCACC
ACAGGCCGGGCCTTTGTGGGCAGCGACAGCGGCAGCAGCTCCACCGGGGATGCGGCTCGT
CAGGGGGTGTACGAGAACTTCCGGCGGGAGCTGGAGATGAGCACCACCAACAGCGAGAGC
CTGGAGGAGGCCGGCTCGGCGCACAGCGATGAGCAGAGCAGCGGCACCCTGAGCTCTCCG
GGCCAGTCGGACATCCTGCTGACCGCCGCACAGGGCACGGTGCGCAAGGCCGGCGCCCTG
GCCGTCAAGAACTTCCTGGTGCACAAGAAGAACAAGAAGGTGGAGTCAGCCACCCGGAGG
AAGTGGAAGCACTACTGGGTGTCCCTGAAAGGATGCACGCTATTTTTCTACGAGAGCGAC
GGCAGGTCTGGGATAGACCACAACAGCATCCCCAAACACGCCGTCTGGGTGGAGAACAGC
ATTGTGCAGGCGGTGCCTGAGCACCCCAAGAAGGACTTTGTCTTCTGCCTCAGCAATTCC
CTGGGTGATGCCTTCCTTTTTCAGACCACTAGCCAGACGGAGCTTGAAAACTGGATCACC
GCCATCCACTCTGCCTGCGCCACTGCGGTCGCGAGGCACCACCACAAGGAAGACACGCTC
CGACTCCTGAAATCAGAGATCAAAAAACTGGAACAGAAGATTGACATGGATGAAAAGATG
AAGAAAATGGGTGAAATGCAGCTGTCTTCAGTCACTGACTCAAAGAAAAAGAAAACAATA
TTAGATCAGATCTTTGTCTGGGAGCAAAATCTCGAGCAGTTCCAAATGGACCTGTTTCGT
TTCCGCTGTTATTTAGCCAGCCTTCAGGGTGGGGAGCTGCCAAACCCCAAAAGGCTTCTC
GCTTTTGCAAGTCGACCAACGAAAGTGGCCATGGGCCGCCTTGGAATCTTTTCGGTATCA
TCGTTTCATGCCCTGGTGGCAGCACGCACTGGTGAAACTGGAGTGAGAAGACGTACTCAG
GCCATGTCCAGATCCGCGAGCAAGCGAAGGAGCAGGTTTTCTTCTCTGTGGGGTCTGGAT
ACTACCTCCAAAAAGAAGCAGGGACGGCCAAGCATCAATCAGGTGTTTGGAGAGGGAACC
GAAGCTGTAAAGAAATCTTTAGAGGGAATATTTGATGACATTGTTCCAGATGGCAAGAGG
GAGAAAGAAGTGGTCTTACCTAACGTTCACCAGCACAACCCTGACTGCGACATTTGGGTC
CACGAGTATTTCACTCCATCCTGGTTCTGTCTGCCCAATAATCAGCCTGCCCTGACGGTC
GTCCGGCCAGGCGACACTGCACGGGACACCCTGGAGCTGATTTGCAAGACACATCAACTG
GATCATTCTGCTCATTACCTGCGCCTGAAATTTCTAATAGAAAACAAAATGCAGCTCTAT
GTTCCACAGCCCGAGGAAGACATCTATGAGCTGCTGTACAAAGAAATTGAAATCTGTCCA
AAAGTCACTCAGAGCATCCACATTGAGAAGTCAGATACAGCTGCTGATACTTACGGGTTT
TCACTTTCTTCTGTGGAAGAAGATGGTATTCGAAGGCTGTACGTGAATAGTGTGAAGGAA
ACCGGTTTAGCTTCCAAGAAAGGCCTGAAAGCAGGAGATGAGATTCTTGAGATCAATAAT
CGTGCTGCTGACGCCCTGAACTCTTCTATGCTCAAAGATTTCCTCTCACAGCCCTCGCTG
GGCCTCCTGGTGAGGACCTACCCCGAGCTGGAGGAAGGAGTGGAGCTGCTGGAAAGCCCG
CCCCACCGAGTGGACGGCCCTGCCGACCTTGGCGAGAGCCCCCTCGCCTTTCTCACCAGC
AACCCAGGGCACAGCCTTTGCAGCGAGCAGGGCAGCAGTGCTGAGACCGCTCCAGAGGAG
ACCGAGGGGCCAGACTTGGAATCCTCAGATGAGACTGATCACAGCAGCAAGAGTACAGAA
CAGGTGGCCGCATTTTGCCGCAGTTTGCATGAGATGAACCCCTCTGACCAGAGCCCATCT
CCTCAGGACTCCACGGGGCCTCAGCTGGCGACCATGAGACAACTCTCGGATGCAGATAAG
CTGCGCAAGGTGATCTGCGAGCTCCTGGAGACGGAGCGCACCTACGTGAAGGATTTAAAC
TGTCTTATGGAGAGATACCTAAAGCCTCTTCAAAAAGAAACTTTTCTCACCCAGGATGAG
CTTGACGTGCTTTTTGGAAATTTAACGGAAATGGTAGAGTTTCAAGTAGAATTCCTTAAA
ACTCTAGAAGATGGAGTGAGACTGGTACCTGATTTGGAAAAGCTTGAGAAGGTTGATCAA
TTTAAGAAAGTGCTGTTCTCTCTGGGGGGATCATTCCTGTATTATGCTGACCGCTTCAAG
CTCTACAGTGCCTTCTGCGCCAGCCACACAAAAGTTCCCAAGGTCCTGGTGAAAGCCAAG
ACAGACACGGCTTTCAAGGCATTCTTGGATGCCCAGAACCCGAAGCAGCAGCACTCATCC
ACGCTGGAGTCGTACCTCATCAAGCCCATCCAGAGGATCCTCAAGTACCCACTTCTGCTC
AGGGAGCTGTTCGCCCTGACCGATGCGGAGAGCGAGGAGCACTACCACCTGGACGTGGCC
ATCAAGACCATGAACAAGGTTGCCAGTCACATCAATGAGATGCAGAAAATCCATGAAGAG
TTTGGGGCTGTGTTTGACCAGCTGATTGCTGAACAGACTGGTGAGAAAAAAGAGGTTGCA
GATCTGAGCATGGGAGACCTGCTTTTGCACACTACCGTGATCTGGCTGAACCCGCCGGCC
TCGCTGGGCAAGTGGAAAAAGGAACCAGAGTTGGCAGCATTCGTCTTCAAAACTGCTGTG
GTCCTTGTGTATAAAGATGGTTCCAAACAGAAGAAGAAACTTGTAGGATCTCACAGGCTT
TCCATTTATGAGGACTGGGACCCCTTCAGATTTCGACACATGATCCCCACGGAAGCGCTG
CAGGTTCGAGCTTTGGCGAGTGCAGATGCAGAGGCAAATGCCGTGTGTGAAATTGTCCAT
GTAAAATCCGAGTCTGAAGGGAGGCCGGAGAGGGTCTTTCACTTGTGCTGCAGCTCCCCA
GAGAGCCGAAAGGATTTCCTAAAGGCTGTGCATTCAATCCTGCGTGATAAGCACAGAAGA
CAGCTCCTCAAAACCGAGAGCCTTCCCTCATCCCAGCAATATGTCCCTTTTGGAGGCAAA
AGATTGTGTGCACTGAAGGGGGCCAGGCCGGCCATGAGCAGGGCAGTGTCTGCCCCAAGC
AAGTCTCTTGGGAGGAGGAGGCGGCGGCTGGCTCGAAACAGGTTTACCATTGATTCTGAT
GCCGTCTCCGCAAGCAGCCCGGAGAAAGAGTCCCAGCAGCCCCCCGGTGGTGGGGACACT
GACCGATGGGTAGAGGAGCAGTTTGATCTTGCTCAGTATGAGGAGCAAGATGACATCAAG
GAGACAGACATCCTCAGTGACGATGATGAGTTCTGTGAGTCCGTGAAGGGTGCCTCAGTG
GACAGAGACCTGCAGGAGCGGCTTCAGGCCACCTCCATCAGTCAGCGGGAAAGAGGCCGG
AAAACCCTGGATAGTCACGCGTCCCGCATGGCACAGCTCAAGAAGCAAGCTGCCCTGTCG
GGGATCAATGGAGGCCTGGAGAGCGCAAGCGAGGAAGTCATTTGGGTTAGGCGTGAAGAC
TTTGCCCCCTCCAGGAAACTGAACACTGAGATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1591 |
| Molecular Weight
| 177506.5 |
| Theoretical pI
| 6.58 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>T-lymphoma invasion and metastasis-inducing protein 1
MGNAESQHVEHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKVIHRNSEVSTRSSS
TPSIPQSLAENGLEPFSQDGTLEDFGSPIWVDRVDMGLRPVSYTDSSVTPSVDSSIVLTA
ASVQSMPDTEESRLYGDDATYLAEGGRRQHSYTSNGPTFMETASFKKKRSKSADIWREDS
LEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETRASPRQLSTCQRANSLGDLYAQKN
SGVTANGGPGSKFAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYNTLPCRKSHCLSEG
ATNPQISHSNSMQGRRAKTTQDVNAGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPT
TGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSP
GQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESD
GRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWIT
AIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDSKKKKTI
LDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLAFASRPTKVAMGRLGIFSVS
SFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPSINQVFGEGT
EAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTV
VRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLYVPQPEEDIYELLYKEIEICP
KVTQSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASKKGLKAGDEILEINN
RAADALNSSMLKDFLSQPSLGLLVRTYPELEEGVELLESPPHRVDGPADLGESPLAFLTS
NPGHSLCSEQGSSAETAPEETEGPDLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPS
PQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDE
LDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFK
LYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLL
RELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVA
DLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRL
SIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSP
ESRKDFLKAVHSILRDKHRRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPS
KSLGRRRRRLARNRFTIDSDAVSASSPEKESQQPPGGGDTDRWVEEQFDLAQYEEQDDIK
ETDILSDDDEFCESVKGASVDRDLQERLQATSISQRERGRKTLDSHASRMAQLKKQAALS
GINGGLESASEEVIWVRREDFAPSRKLNTEI
|
| External Links |
|---|
| GenBank ID Protein
| 115583670 |
| UniProtKB/Swiss-Prot ID
| Q13009 |
| UniProtKB/Swiss-Prot Entry Name
| TIAM1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_003253.2 |
| GeneCard ID
| TIAM1 |
| GenAtlas ID
| TIAM1 |
| HGNC ID
| HGNC:11805 |
| References |
|---|
| General References
| Not Available |