| Identification |
|---|
| HMDB Protein ID
| CDBP01705 |
| Secondary Accession Numbers
| Not Available |
| Name
| GTP cyclohydrolase 1 feedback regulatory protein |
| Description
| Not Available |
| Synonyms
|
- GFRP
- GTP cyclohydrolase I feedback regulatory protein
- p35
|
| Gene Name
| GCHFR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine |
| GO Classification
|
| Function |
| protein binding |
| binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of biosynthetic process |
| negative regulation of biosynthetic process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- cytosol
- Nucleus membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Pterine Biosynthesis |    |  | | Dopa-responsive dystonia |    | Not Available | | Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency |    | Not Available | | Hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency (ptps) |    | Not Available | | Hyperphenylalaninemia due to dhpr-deficiency |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 15q15 |
| SNPs
| GCHFR |
| Gene Sequence
|
>255 bp
ATGCCCTACCTGCTCATCAGCACCCAGATCCGCATGGAGGTGGGCCCCACTATGGTGGGC
GATGAACAGTCGGATCCAGAGCTGATGCAGCATCTGGGGGCTTCAAAGAGAAGAGCCTTG
GGAAACAACTTTTATGAATACTACGTCGATGACCCTCCCCGCATAGTCCTGGACAAGCTG
GAACGCAGGGGCTTCCGTGTGCTGAGCATGACGGGGGTGGGCCAGACGCTGGTGTGGTGT
CTGCACAAGGAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 84 |
| Molecular Weight
| 9698.2 |
| Theoretical pI
| 6.51 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>GTP cyclohydrolase 1 feedback regulatory protein
MPYLLISTQIRMEVGPTMVGDEQSDPELMQHLGASKRRALGNNFYEYYVDDPPRIVLDKL
ERRGFRVLSMTGVGQTLVWCLHKE
|
| External Links |
|---|
| GenBank ID Protein
| 189053191 |
| UniProtKB/Swiss-Prot ID
| P30047 |
| UniProtKB/Swiss-Prot Entry Name
| GFRP_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK311872 |
| GeneCard ID
| GCHFR |
| GenAtlas ID
| GCHFR |
| HGNC ID
| HGNC:4194 |
| References |
|---|
| General References
| Not Available |