Identification |
HMDB Protein ID
| CDBP04665 |
Secondary Accession Numbers
| Not Available |
Name
| Ninein |
Description
| Not Available |
Synonyms
|
- GSK3B-interacting protein
- Glycogen synthase kinase 3 beta-interacting protein
- hNinein
|
Gene Name
| NIN |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in calcium ion binding |
Specific Function
| Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules |
GO Classification
|
Not Available
|
Cellular Location
|
- Cytoplasm
- cytoskeleton
- centrosome
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 14q22.1 |
SNPs
| NIN |
Gene Sequence
|
>6273 bp
ATGGATGAGGTGGAGCAGGACCAGCATGAGGCCCGACTCAAGGAGCTGTTTGACAGTTTT
GACACGACGGGCACAGGGTCCCTGGGGCAGGAGGAACTCACCGACCTTTGCCACATGTTG
AGCTTGGAGGAGGTGGCCCCAGTGCTGCAGCAGACATTACTTCAGGACAACCTCTTGGGC
AGGGTACATTTTGACCAATTTAAAGAAGCATTAATACTCATCTTGTCCAGAACTCTGTCA
AATGAAGAACACTTTCAAGAACCAGACTGCTCACTAGAAGCTCAGCCCAAATATGTTAGA
GGTGGGAAGCGTTACGGACGAAGGTCCTTGCCCGAGTTCCAAGAGTCCGTGGAGGAGTTT
CCTGAAGTGACGGTGATTGAGCCACTGGATGAAGAAGCGCGGCCTTCACACATCCCAGCC
GGTGACTGCAGTGAGCACTGGAAGACGCAACGCAGTGAGGAGTATGAAGCGGAAGGCCAG
TTAAGGTTTTGGAACCCAGATGACTTGAATGCTTCACAGAGTGGATCTTCCCCTCCCCAA
GACTGGATAGAAGAGAAACTGCAAGAAGTTTGTGAAGATTTGGGGATCACCCGTGATGGT
CACCTGAACCGGAAGAAGCTGGTCTCCATCTGTGAGCAGTATGGTTTACAGAATGTGGAT
GGAGAGATGCTCGAGGAAGTATTCCATAATCTTGATCCTGACGGTACAATGAGTGTAGAA
GATTTTTTCTATGGTTTGTTTAAAAATGGAAAATCTCTTACACCATCAGCATCTACTCCA
TATAGACAACTAAAAAGGCACCTTTCCATGCAGTCTTTCGATGAGAGTGGACGACGTACC
ACAACCTCATCAGCAATGACAAGTACCATTGGCTTTCGGGTCTTCTCCTGCCTGGATGAT
GGGATGGGCCATGCATCTGTGGAGAGAATACTGGACACCTGGCAGGAAGAGGGCATTGAG
AACAGCCAGGAGATCCTGAAGGCCTTGGATTTCAGCCTCGATGGAAACATCAATTTGACA
GAATTAACACTGGCCCTTGAAAATGAACTTTTGGTTACCAAGAACAGCATTCACCAGGCG
GCTCTGGCCAGCTTTAAGGCTGAAATCCGGCATTTGTTGGAACGAGTTGATCAGGTGGTC
AGAGAAAAAGAGAAGCTACGGTCAGATCTGGACAAGGCCGAGAAGCTCAAGTCTTTAATG
GCCTCGGAGGTGGATGATCACCATGCGGCCATAGAGCGGCGGAATGAGTACAACCTCAGG
AAACTGGATGAAGAGTACAAGGAGCGAATAGCAGCCTTAAAAAATGAACTCCGAAAAGAG
AGAGAGCAGATCCTGCAGCAGGCAGGCAAGCAGCGTTTAGAACTTGAACAGGAAATTGAA
AAGGCAAAAACAGAAGAGAACTATATCCGGGACCGCCTTGCCCTCTCTTTAAAGGAAAAC
AGTCGTCTGGAAAATGAGCTTCTAGAAAATGCAGAGAAGTTGGCAGAATATGAGAATCTG
ACAAACAAACTTCAGAGAAATTTGGAAAATGTGTTAGCAGAAAAGTTTGGTGACCTCGAT
CCTAGCAGTGCTGAGTTCTTCCTGCAAGAAGAGAGACTGACACAGATGAGAAATGAATAT
GAGCGGCAGTGCAGGGTACTACAAGACCAAGTAGATGAACTCCAGTCTGAGCTGGAAGAA
TATCGTGCACAAGGCAGAGTGCTCAGGCTTCCGTTGAAGAACTCACCGTCAGAAGAAGTT
GAGGCTAACAGCGGTGGCATTGAGCCCGAACACGGGCTCGGTTCTGAAGAATGCAATCCA
TTGAATATGAGCATTGAGGCAGAGCTGGTCATTGAACAGATGAAAGAACAACATCACAGG
GACATATGTTGCCTCAGACTGGAGCTCGAAGATAAAGTGCGCCATTATGAAAAGCAGCTG
GACGAAACCGTGGTCAGCTGCAAGAAGGCACAGGAGAACATGAAGCAAAGGCATGAGAAC
GAAACGCACACCTTAGAAAAACAAATAAGTGACCTTAAAAATGAAATTGCTGAACTTCAG
GGGCAAGCAGCAGTGCTCAAGGAGGCACATCATGAGGCCACTTGCAGGCATGAGGAGGAG
AAAAAACAACTGCAAGTGAAGCTTGAGGAGGAAAAGACTCACCTGCAGGAGAAGCTGAGG
CTGCAACATGAGATGGAGCTCAAGGCTAGACTGACACAGGCTCAAGCAAGCTTTGAGCGG
GAGAGGGAAGGCCTTCAGAGTAGCGCCTGGACAGAAGAGAAGGTGAGAGGCTTGACTCAG
GAACTAGAGCAGTTTCACCAGGAGCAGCTGACAAGCCTGGTGGAGAAACACACTCTTGAG
AAAGAGGAGTTAAGAAAAGAGCTCTTGGAAAAGCACCAAAGGGAGCTTCAGGAGGGAAGG
GAAAAAATGGAAACAGAGTGTAATAGAAGAACCTCTCAAATAGAAGCCCAGTTTCAGTCT
GATTGTCAGAAAGTCACTGAGAGGTGTGAAAGCGCTCTGCAAAGCCTGGAGGGGCGCTAC
CGCCAAGAGCTGAAGGACCTCCAGGAACAGCAGCGTGAGGAGAAATCCCAGTGGGAATTT
GAGAAGGACGAGCTCACCCAGGAGTGTGCGGAAGCCCAGGAGCTGCTGAAAGAGACTCTT
AAGAGAGAGAAAACAACTTCTCTGGTCCTGACCCAGGAGAGAGAGATGCTGGAGAAAACA
TACAAAGAACATTTGAACAGCATGGTCGTCGAGAGACAGCAGCTACTCCAAGACCTGGAA
GACCTAAGAAATGTATCTGAAACCCAGCAAAGCCTGCTGTCTGACCAGATACTTGAGCTG
AAGAGCAGTCACAAAAGGGAACTGAGGGAGCGTGAGGAGGTCCTGTGCCAGGCAGGGGCT
TCGGAGCAGCTGGCCAGCCAGCGGCTGGAAAGACTAGAAATGGAACATGACCAGGAAAGG
CAGGAAATGATGTCCAAGCTTCTAGCCATGGAGAACATTCACAAAGCGACCTGTGAGACA
GCAGATCGAGAAAGAGCCGAGATGAGCACAGAAATCTCCAGACTTCAGAGTAAAATAAAG
GAAATGCAGCAGGCAACATCTCCTCTCTCAATGCTTCAGAGTGGTTGCCAGGTGATAGGA
GAGGAGGAGGTGGAAGGAGATGGAGCCCTGTCCCTGCTTCAGCAAGGGGAGCAGCTGTTG
GAAGAAAATGGGGACGTCCTCTTAAGCCTGCAGAGAGCTCATGAACAGGCAGTGAAGGAA
AATGTGAAAATGGCTACTGAAATTTCTAGATTGCAACAGAGGCTACAAAAGTTAGAGCCA
GGGTTAGTAATGTCTTCTTGTTTGGATGAGCCAGCTACTGAGTTTTTTGGAAATACTGCG
GAACAAACAGAGCCGTTTTTACAGCAAAACCGAACGAAGCAAGTAGAAGGTGTGACCAGG
CGGCATGTCCTAAGTGACCTGGAAGATGATGAGGTCCGGGACCTGGGAAGTACAGGGACG
AGCTCTGTTCAGAGACAGGAAGTCAAAATAGAGGAGTCTGAAGCTTCAGTAGAGGGTTTT
TCTGAGCTTGAAAACAGTGAAGAGACCAGGACTGAATCCTGGGAGCTGAAGAATCAGATT
AGTCAGCTTCAGGAACAGCTAATGATGTTATGTGCGGACTGTGATCGAGCTTCTGAAAAG
AAACAGGACCTACTTTTTGATGTTTCTGTGCTAAAAAAGAAACTGAAGATGCTTGAGAGA
ATCCCTGAGGCTTCTCCCAAATATAAGCTGTTGTATGAAGATGTGAGCCGAGAAAATGAC
TGCCTTCAGGAAGAGCTGAGAATGATGGAGACACGCTACGATGAGGCACTAGAAAATAAC
AAAGAACTCACTGCAGAGGTTTTCAGGTTGCAGGATGAGCTGAAGAAAATGGAGGAAGTC
ACTGAAACATTCCTCAGCCTGGAAAAGAGTTACGATGAGGTCAAAATAGAAAATGAGGAG
CTGAATGTTCTGGTTTTGAGACTTCAAGGCAAGATTGAGAAGCTTCAGGAAAGCGTGGTC
CAGCGGTGTGACTGCTGCTTATGGGAAGCCAGTTTAGAGAACCTGGAAATCGAACCTGAT
GGAAATATACTCCAGCTCAATCAGACACTGGAAGAGTGTGTGCCCAGGGTTAGGAGTGTA
CATCATGTCATAGAGGAATGTAAGCAAGAAAACCAGTACCTTGAGGGGAACACACAGCTC
TTGGAAAAAGTAAAAGCACATGAAATTGCCTGGTTACATGGAACAATTCAGACACATCAA
GAAAGGCCAAGAGTACAGAATCAAGTTATACTGGAGGAAAACACTACTCTCCTAGGCTTT
CAAGACAAACATTTTCAGCATCAGGCCACCATAGCAGAGTTAGAACTGGAGAAAACAAAG
TTACAGGAGCTGACTAGGAAGTTGAAGGAGAGAGTCACTATTTTAGTTAAGCAAAAAGAT
GTACTTTCTCACGGAGAAAAGGAGGAAGAGCTGAAGGCAATGATGCATGACTTGCAGATC
ACGTGCAGTGAGATGCAGCAAAAAGTTGAACTTCTGAGATATGAATCTGAAAAGCTTCAA
CAGGAAAATTCTATTTTGAGAAATGAAATTACTACTTTAAATGAAGAAGATAGCATTTCT
AACCTGAAATTAGGGACATTAAATGGATCTCAGGAAGAAATGTGGCAAAAAACGGAAACT
GTAAAACAAGAAAATGCTGCAGTTCAGAAGATGGTTGAAAATTTAAAGAAACAGATTTCA
GAATTAAAAATCAAAAACCAACAATTGGATTTGGAAAATACAGAACTTAGCCAAAAGAAC
TCTCAAAACCAGGAAAAACTGCAAGAACTTAATCAACGTCTAACAGAAATGCTATGCCAG
AAGGAAAAAGAGCCAGGAAACAGTGCATTGGAGGAACGGGAACAAGAGAAGTTTAATCTG
AAAGAAGAACTGGAACGTTGTAAAGTGCAGTCCTCCACTTTAGTGTCTTCTCTGGAGGCG
GAGCTCTCTGAAGTTAAAATACAGACCCATATTGTGCAACAGGAAAACCACCTTCTCAAA
GATGAACTGGAGAAAATGAAACAGCTGCACAGATGTCCCGATCTCTCTGACTTCCAGCAA
AAAATCTCTAGTGTTCTAAGCTACAACGAAAAACTGCTGAAAGAAAAGGAAGCTCTGAGT
GAGGAATTAAATAGCTGTGTCGATAAGTTGGCAAAATCAAGTCTTTTAGAGCATAGAATT
GCGACGATGAAGCAGGAACAGAAATCCTGGGAACATCAGAGTGCGAGCTTAAAGTCACAG
CTGGTGGCTTCTCAGGAAAAGGTTCAGAATTTAGAAGACACCGTGCAGAATGTAAACCTG
CAAATGTCCCGGATGAAATCTGACCTACGAGTGACTCAGCAGGAAAAGGAGGCTTTAAAA
CAAGAAGTGATGTCTTTACATAAGCAACTTCAGAATGCTGGTGGCAAGAGCTGGGCCCCA
GAGATAGCTACTCATCCATCAGGGCTCCATAACCAGCAGAAAAGGCTGTCCTGGGACAAG
TTGGATCATCTGATGAATGAGGAACAGCAGCTGCTTTGGCAAGAGAATGAGAGGCTCCAG
ACCATGGTACAGAACACCAAAGCCGAACTCACGCACTCCCGGGAGAAGGTCCGTCAGTTG
GAATCCAATCTTCTTCCCAAGCACCAAAAACATCTAAACCCATCAGGTACCATGAATCCC
ACAGAGCAAGAAAAATTGAGCTTAAAGAGAGAGTGTGATCAGTTTCAGAAAGAACAATCT
CCTGCTAACAGGAAGGTCAGTCAGATGAATTCCCTTGAACAAGAATTAGAAACAATTCAT
TTGGAAAATGAAGGCCTGAAAAAGAAACAAGTAAAACTGGATGAGCAGCTCATGGAGATG
CAGCACCTGAGGTCCACTGCGACGCCTAGCCCGTCCCCTCATGCTTGGGATTTGCAGCTG
CTCCAGCAGCAAGCCTGTCCGATGGTGCCCAGGGAGCAGTTTCTGCAGCTTCAACGCCAG
CTGCTGCAGGCAGAAAGGATAAACCAGCACCTGCAGGAGGAACTTGAAAACAGGACCTCC
GAAACCAACACACCACAGGGAAACCAGGAACAACTGGTAACTGTCATGGAGGAACGAATG
ATAGAAGTTGAACAGAAACTGAAACTAGTGAAAAGGCTTCTTCAAGAGAAAGTGAATCAG
CTCAAAGAACAAGTGAGCCTACCCGGTCATCTCTGTTCACCCACCTCACATTCCAGCTTT
AACTCCAGTTTTACATCCCTTTATTGCCATTAA
|
Protein Properties |
Number of Residues
| 2090 |
Molecular Weight
| 243288.5 |
Theoretical pI
| 4.7 |
Pfam Domain Function
|
Not Available |
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Ninein
MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG
RVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQESVEEF
PEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQ
DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGTMSVE
DFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD
GMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA
ALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLR
KLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKEN
SRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEY
ERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNP
LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN
ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLR
LQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLE
KEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRY
RQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKT
YKEHLNSMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGA
SEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIK
EMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKE
NVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTR
RHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQI
SQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSREND
CLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEE
LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSV
HHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGF
QDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQI
TCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTET
VKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ
KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLK
DELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRI
ATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALK
QEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQENERLQ
TMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQS
PANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQL
LQQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERM
IEVEQKLKLVKRLLQEKVNQLKEQVSLPGHLCSPTSHSSFNSSFTSLYCH
|
External Links |
GenBank ID Protein
| 33946321 |
UniProtKB/Swiss-Prot ID
| Q8N4C6 |
UniProtKB/Swiss-Prot Entry Name
| NIN_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_182946.1 |
GeneCard ID
| NIN |
GenAtlas ID
| NIN |
HGNC ID
| HGNC:14906 |
References |
General References
| Not Available |