Cannabis Compound Database: Showing Protein ADP-ribosylation factor GTPase-activating protein 2 (CDBP03520)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03520

Secondary Accession Numbers

Not Available

Name

ADP-ribosylation factor GTPase-activating protein 2

Description

Not Available

Synonyms

ARF GAP 2
GTPase-activating protein ZNF289
Zinc finger protein 289

Gene Name

ARFGAP2

Protein Type

Enzyme

Biological Properties

General Function

Involved in ARF GTPase activator activity

Specific Function

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes

GO Classification

Function
small gtpase regulator activity
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
enzyme regulator activity
arf gtpase activator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of metabolic process
regulation of cellular metabolic process
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
regulation of nucleotide metabolic process
regulation of nucleotide catabolic process
regulation of purine nucleotide catabolic process
regulation of gtp catabolic process
regulation of gtpase activity
regulation of ras gtpase activity
regulation of arf gtpase activity
biological regulation
regulation of biological process

Cellular Location

Cytoplasm
Golgi apparatus membrane
Peripheral membrane protein
Cytoplasmic side

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

11p11.2-p11.12

SNPs

ARFGAP2

Gene Sequence

>1566 bp
ATGGCGGCGGAGCCGAACAAGACCGAAATCCAGACTCTTTTTAAGAGGCTTCGCGCAGTT
CCAACCAACAAGGCCTGTTTCGACTGCGGCGCCAAGAATCCGAGTTGGGCCAGCATCACG
TACGGTGTTTTCTTGTGCATTGACTGTTCCGGGGTGCACCGCTCCCTGGGCGTCCATCTG
AGCTTCATCAGGTCCACAGAGTTGGATTCCAACTGGAACTGGTTCCAGCTGAGGTGTATG
CAGGTCGGCGGGAATGCCAATGCGACGGCTTTTTTTCGCCAACATGGATGCACAGCCAAT
GATGCCAACACCAAATATAATAGCCGAGCTGCCCAGATGTACCGGGAGAAGATCCGGCAG
CTGGGGAGTGCGGCCCTGGCTAGGCATGGCACTGATCTTTGGATAGACAACATGAGTAGT
GCCGTTCCTAATCACTCCCCAGAGAAGAAGGACTCTGATTTCTTCACAGAACACACTCAA
CCCCCTGCCTGGGATGCGCCAGCCACTGAGCCTTCAGGGACCCAGCAGCCAGCCCCGTCT
ACAGAGAGCAGTGGCCTGGCACAGCCGGAGCATGGCCCCAACACAGACCTGCTTGGCACC
TCACCCAAAGCCTCACTGGAACTGAAAAGCTCCATCATTGGCAAGAAGAAGCCAGCAGCA
GCTAAGAAAGGGCTGGGTGCCAAGAAAGGCCTAGGGGCCCAGAAGGTGAGCAGCCAGAGC
TTCAGTGAGATTGAGCGGCAGGCTCAGGTGGCAGAGAAGCTCCGTGAGCAGCAGGCAGCC
GATGCCAAGAAGCAGGCGGAGGAGTCCATGGTCGCCTCCATGCGTCTGGCCTACCAGGAG
CTCCAGATTGATCGTAAGAAAGAGGAAAAGAAGCTACAGAATCTGGAAGGGAAGAAGCGA
GAGCAGGCAGAAAGGTTGGGCATGGGCTTGGTATCCCGAAGCTCTGTCTCCCACTCCGTG
CTGTCTGAGATGCAGGTGATTGAGCAGGAAACCCCAGTGAGTGCAAAATCCTCTCGCTCG
CAGCTGGACTTGTTTGACGATGTTGGTACTTTCGCCTCTGGACCCCCAAAGTACAAGGAC
AATCCCTTTTCCTTAGGGGAAAGCTTTGGCTCCCGCTGGGATACAGATGCTGCCTGGGGT
ATGGACAGGGTAGAGGAGAAGGAGCCAGAAGTGACCATCTCAAGCATCCGGCCTATTTCA
GAAAGAGCCACAAACCGGAGGGAAGTGGAGAGCCGGAGCTCAGGCCTCGAGTCTAGTGAG
GCGCGTCAGAAATTCGCAGGAGCCAAAGCCATCTCATCTGACATGTTCTTTGGGCGGGAG
GTGGATGCGGAGTATGAGGCCAGGTCTCGGCTGCAGCAGCTCTCAGGCAGCAGTGCCATC
AGCTCTTCAGACCTCTTTGGGGACATGGATGGAGCTCACGGAGCAGGAAGTGTATCTCTG
GGGAACGTGCTGCCTACAGCGGACATTGCCCAGTTTAAGCAGGGTGTCAAGTCTGTGGCT
GGGAAAATGGCTGTGCTGGCCAATGGTGTGATGAATTCCTTGCAGGATCGCTACGGTTCC
TACTGA

Protein Properties

Number of Residues

521

Molecular Weight

56719.9

Theoretical pI

8.13

Pfam Domain Function

ArfGap (PF01412 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>ADP-ribosylation factor GTPase-activating protein 2
MAAEPNKTEIQTLFKRLRAVPTNKACFDCGAKNPSWASITYGVFLCIDCSGVHRSLGVHL
SFIRSTELDSNWNWFQLRCMQVGGNANATAFFRQHGCTANDANTKYNSRAAQMYREKIRQ
LGSAALARHGTDLWIDNMSSAVPNHSPEKKDSDFFTEHTQPPAWDAPATEPSGTQQPAPS
TESSGLAQPEHGPNTDLLGTSPKASLELKSSIIGKKKPAAAKKGLGAKKGLGAQKVSSQS
FSEIERQAQVAEKLREQQAADAKKQAEESMVASMRLAYQELQIDRKKEEKKLQNLEGKKR
EQAERLGMGLVSRSSVSHSVLSEMQVIEQETPVSAKSSRSQLDLFDDVGTFASGPPKYKD
NPFSLGESFGSRWDTDAAWGMDRVEEKEPEVTISSIRPISERATNRREVESRSSGLESSE
ARQKFAGAKAISSDMFFGREVDAEYEARSRLQQLSGSSAISSSDLFGDMDGAHGAGSVSL
GNVLPTADIAQFKQGVKSVAGKMAVLANGVMNSLQDRYGSY

External Links

GenBank ID Protein

31543983

UniProtKB/Swiss-Prot ID

Q8N6H7

UniProtKB/Swiss-Prot Entry Name

ARFG2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_032389.3

GeneCard ID