| Identification |
|---|
| HMDB Protein ID
| CDBP03833 |
| Secondary Accession Numbers
| Not Available |
| Name
| Exportin-T |
| Description
| Not Available |
| Synonyms
|
- Exportin(tRNA)
- tRNA exportin
|
| Gene Name
| XPOT |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus |
| GO Classification
|
| Function |
| binding |
| protein transporter activity |
| transporter activity |
| substrate-specific transporter activity |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q14.2 |
| SNPs
| XPOT |
| Gene Sequence
|
>2889 bp
ATGGATGAACAGGCTCTATTAGGGCTAAATCCAAATGCTGATTCAGACTTTAGACAAAGG
GCCCTGGCCTATTTTGAGCAGTTAAAAATTTCCCCAGATGCCTGGCAGGTGTGTGCAGAA
GCTCTAGCCCAGAGGACATACAGTGATGATCATGTGAAGTTTTTCTGCTTTCAAGTACTG
GAACATCAAGTTAAATACAAATACTCAGAACTAACCACTGTTCAACAACAGCTAATTAGG
GAGACGCTCATATCATGGCTGCAAGCTCAGATGCTGAATCCCCAACCAGAGAAGACCTTT
ATACGAAATAAAGCCGCCCAAGTCTTCGCCTTGCTTTTTGTTACAGAGTATCTCACTAAG
TGGCCCAAGTTTTTTTTTGACATTCTCTCAGTAGTGGACCTAAATCCAAGGGGAGTAGAT
CTCTACCTGCGAATCCTCATGGCTATTGATTCAGAGTTGGTGGATCGTGATGTGGTGCAT
ACATCAGAGGAGGCTCGTAGGAATACTCTCATAAAAGATACCATGAGGGAACAGTGCATT
CCAAATCTGGTGGAATCATGGTACCAAATATTACAAAATTATCAGTTTACTAATTCTGAA
GTGACGTGTCAGTGCCTTGAAGTAGTTGGGGCTTATGTCTCTTGGATAGACTTATCCCTT
ATAGCCAATGATAGGTTTATAAATATGCTGCTAGGTCATATGTCAATAGAAGTTCTACGG
GAAGAAGCATGTGACTGTTTATTTGAAGTTGTAAATAAAGGAATGGACCCTGTTGATAAA
ATGAAACTAGTGGAATCTTTGTGTCAAGTATTACAGTCTGCTGGGTTTTTCAGCATTGAC
CAGGAAGAAGATGTTGACTTCCTGGCCAGATTTTCTAAGTTGGTAAATGGAATGGGACAG
TCATTGATAGTTAGTTGGAGTAAATTAATTAAGAATGGGGATATTAAGAATGCTCAAGAG
GCACTACAAGCTATTGAAACAAAAGTGGCACTGATGTTGCAGCTACTAATTCATGAGGAT
GATGATATTTCTTCTAATATTATTGGATTTTGTTACGATTATCTTCATATTTTGAAACAG
CTTACAGTGCTCTCGGATCAGCAAAAAGCTAATGTAGAGGCAATCATGTTGGCCGTTATG
AAAAAATTGACTTACGATGAAGAATATAACTTTGAAAATGAGGGTGAAGATGAAGCCATG
TTTGTAGAATATAGAAAACAACTGAAGTTACTGTTGGACAGGCTTGCTCAAGTTTCACCA
GAGTTACTACTGGCCTCTGTTCGCAGAGTTTTTAGTTCTACACTGCAGAATTGGCAGACT
ACACGGTTTATGGAAGTTGAAGTAGCAATAAGATTGCTGTATATGTTGGCAGAAGCTCTT
CCAGTATCTCATGGTGCTCACTTCTCAGGTGATGTTTCAAAAGCTAGTGCTTTGCAGGAT
ATGATGCGAACTCTGGTAACATCAGGAGTCAGTTCCTATCAGCATACATCTGTGACATTG
GAGTTCTTCGAAACTGTTGTTAGATATGAAAAGTTTTTCACAGTTGAACCTCAGCACATT
CCATGTGTACTAATGGCTTTCTTAGATCACAGAGGTCTGCGGCATTCCAGTGCAAAAGTT
CGGAGCAGGACGGCTTACCTGTTTTCTAGATTTGTCAAATCTCTCAATAAGCAAATGAAT
CCTTTCATTGAGGATATTTTGAATAGAATACAAGATTTATTAGAGCTTTCTCCACCTGAG
AATGGCCACCAGTCCTTACTGAGCAGCGATGATCAACTTTTTATTTATGAGACAGCTGGA
GTGCTGATTGTTAATAGTGAATATCCGGCAGAAAGGAAACAAGCCTTAATGAGGAATCTG
TTGACTCCACTAATGGAGAAGTTTAAAATTCTGTTAGAAAAGTTGATGCTGGCACAAGAT
GAAGAAAGGCAAGCCTCTCTAGCAGACTGTCTTAACCATGCTGTTGGATTTGCAAGTCGA
ACCAGTAAAGCTTTCAGCAACAAACAGACTGTGAAACAATGTGGCTGTTCCGAAGTTTAT
CTGGACTGTTTACAGACATTCTTGCCAGCCCTCAGTTGTCCCTTACAAAAGGATATTCTC
AGAAGTGGAGTCCGTACTTTCCTTCATCGAATGATTATTTGCCTGGAGGAAGAAGTTCTT
CCGTTCATTCCATCTGCTTCAGAACATATGCTCAAAGATTGTGAAGCAAAAGATCTCCAG
GAGTTCATTCCTCTTATCAACCAGATTACGGCCAAATTCAAGATACAGGTATCCCCGTTT
TTACAACAGATGTTCATGCCCCTGCTTCATGCAATTTTTGAAGTGCTGCTCCGGCCAGCA
GAAGAAAATGACCAGTCTGCTGCTTTAGAGAAGCAGATGTTGCGGAGGAGTTACTTTGCT
TTCCTGCAAACAGTCACAGGCAGTGGGATGAGCGAAGTTATAGCAAATCAAGGTGCAGAG
AATGTAGAAAGAGTGTTGGTTACTGTTATCCAAGGAGCAGTTGAATATCCAGATCCAATT
GCACAGAAAACATGTTTTATCATCCTCTCAAAGTTGGTAGAACTCTGGGGAGGTAAAGAT
GGACCAGTGGGATTTGCTGATTTTGTTTATAAGCACATTGTCCCCGCATGTTTCCTAGCA
CCTTTAAAACAAACCTTTGACCTGGCAGATGCACAAACAGTATTGGCTTTATCTGAGTGT
GCAGTGACACTGAAAACAATTCATCTCAAACGGGGCCCAGAATGTGTTCAGTATCTTCAA
CAAGAATACCTGCCCTCCTTGCAAGTAGCTCCAGAAATAATTCAGGAGTTTTGTCAAGCG
CTTCAGCAGCCTGATGCTAAAGTTTTTAAAAATTACTTAAAGGTGTTCTTCCAGAGAGCA
AAGCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 962 |
| Molecular Weight
| 109963.2 |
| Theoretical pI
| 5.05 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Exportin-T
MDEQALLGLNPNADSDFRQRALAYFEQLKISPDAWQVCAEALAQRTYSDDHVKFFCFQVL
EHQVKYKYSELTTVQQQLIRETLISWLQAQMLNPQPEKTFIRNKAAQVFALLFVTEYLTK
WPKFFFDILSVVDLNPRGVDLYLRILMAIDSELVDRDVVHTSEEARRNTLIKDTMREQCI
PNLVESWYQILQNYQFTNSEVTCQCLEVVGAYVSWIDLSLIANDRFINMLLGHMSIEVLR
EEACDCLFEVVNKGMDPVDKMKLVESLCQVLQSAGFFSIDQEEDVDFLARFSKLVNGMGQ
SLIVSWSKLIKNGDIKNAQEALQAIETKVALMLQLLIHEDDDISSNIIGFCYDYLHILKQ
LTVLSDQQKANVEAIMLAVMKKLTYDEEYNFENEGEDEAMFVEYRKQLKLLLDRLAQVSP
ELLLASVRRVFSSTLQNWQTTRFMEVEVAIRLLYMLAEALPVSHGAHFSGDVSKASALQD
MMRTLVTSGVSSYQHTSVTLEFFETVVRYEKFFTVEPQHIPCVLMAFLDHRGLRHSSAKV
RSRTAYLFSRFVKSLNKQMNPFIEDILNRIQDLLELSPPENGHQSLLSSDDQLFIYETAG
VLIVNSEYPAERKQALMRNLLTPLMEKFKILLEKLMLAQDEERQASLADCLNHAVGFASR
TSKAFSNKQTVKQCGCSEVYLDCLQTFLPALSCPLQKDILRSGVRTFLHRMIICLEEEVL
PFIPSASEHMLKDCEAKDLQEFIPLINQITAKFKIQVSPFLQQMFMPLLHAIFEVLLRPA
EENDQSAALEKQMLRRSYFAFLQTVTGSGMSEVIANQGAENVERVLVTVIQGAVEYPDPI
AQKTCFIILSKLVELWGGKDGPVGFADFVYKHIVPACFLAPLKQTFDLADAQTVLALSEC
AVTLKTIHLKRGPECVQYLQQEYLPSLQVAPEIIQEFCQALQQPDAKVFKNYLKVFFQRA
KP
|
| External Links |
|---|
| GenBank ID Protein
| 8051636 |
| UniProtKB/Swiss-Prot ID
| O43592 |
| UniProtKB/Swiss-Prot Entry Name
| XPOT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_007235.3 |
| GeneCard ID
| XPOT |
| GenAtlas ID
| XPOT |
| HGNC ID
| HGNC:12826 |
| References |
|---|
| General References
| Not Available |