Identification |
HMDB Protein ID
| CDBP02125 |
Secondary Accession Numbers
| Not Available |
Name
| Lysophosphatidic acid receptor 2 |
Description
| Not Available |
Synonyms
|
- LPA receptor 2
- LPA-2
- Lysophosphatidic acid receptor Edg-4
|
Gene Name
| LPAR2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in G-protein coupled receptor protein signaling pathway |
Specific Function
| Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation |
GO Classification
|
Component |
integral to membrane |
cell part |
membrane part |
intrinsic to membrane |
Function |
bioactive lipid receptor activity |
lysosphingolipid and lysophosphatidic acid receptor activity |
receptor activity |
transmembrane receptor activity |
molecular transducer activity |
signal transducer activity |
g-protein coupled receptor activity |
Process |
signaling |
signaling pathway |
cell surface receptor linked signaling pathway |
g-protein coupled receptor protein signaling pathway |
|
Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
- Cell surface
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Lysophosphatidic Acid LPA2 Signalling | | Not Available |
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 19p12 |
SNPs
| LPAR2 |
Gene Sequence
|
>1056 bp
ATGGTCATCATGGGCCAGTGCTACTACAACGAGACCATCGGCTTCTTCTATAACAACAGT
GGCAAAGAGCTCAGCTCCCACTGGCGGCCCAAGGATGTGGTCGTGGTGGCACTGGGGCTG
ACCGTCAGCGTGCTGGTGCTGCTGACCAATCTGCTGGTCATAGCAGCCATCGCCTCCAAC
CGCCGCTTCCACCAGCCCATCTACTACCTGCTCGGCAATCTGGCCGCGGCTGACCTCTTC
GCGGGCGTGGCCTACCTCTTCCTCATGTTCCACACTGGTCCCCGCACAGCCCGACTTTCA
CTTGAGGGCTGGTTCCTGCGGCAGGGCTTGCTGGACACAAGCCTCACTGCGTCGGTGGCC
ACACTGCTGGCCATCGCCGTGGAGCGGCACCGCAGTGTGATGGCCGTGCAGCTGCACAGC
CGCCTGCCCCGTGGCCGCGTGGTCATGCTCATTGTGGGCGTGTGGGTGGCTGCCCTGGGC
CTGGGGCTGCTGCCTGCCCACTCCTGGCACTGCCTCTGTGCCCTGGACCGCTGCTCACGC
ATGGCACCCCTGCTCAGCCGCTCCTATTTGGCCGTCTGGGCTCTGTCGAGCCTGCTTGTC
TTCCTGCTCATGGTGGCTGTGTACACCCGCATTTTCTTCTACGTGCGGCGGCGAGTGCAG
CGCATGGCAGAGCATGTCAGCTGCCACCCCCGCTACCGAGAGACCACGCTCAGCCTGGTC
AAGACTGTTGTCATCATCCTGGGGGCGTTCGTGGTCTGCTGGACACCAGGCCAGGTGGTA
CTGCTCCTGGATGGTTTAGGCTGTGAGTCCTGCAATGTCCTGGCTGTAGAAAAGTACTTC
CTACTGTTGGCCGAGGCCAACTCACTGGTCAATGCTGCTGTGTACTCTTGCCGAGATGCT
GAGATGCGCCGCACCTTCCGCCGCCTTCTCTGCTGCGCGTGCCTCCGCCAGTCCACCCGC
GAGTCTGTCCACTATACATCCTCTGCCCAGGGAGGTGCCAGCACTCGCATCATGCTTCCC
GAGAACGGCCACCCACTGATGGACTCCACCCTTTAG
|
Protein Properties |
Number of Residues
| 351 |
Molecular Weight
| 39083.8 |
Theoretical pI
| 9.42 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["34-54", "70-90", "104-126", "147-167", "189-209", "243-263", "280-297"]
|
Protein Sequence
|
>Lysophosphatidic acid receptor 2
MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASN
RRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVA
TLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSR
MAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLV
KTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDA
EMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
|
External Links |
GenBank ID Protein
| 2213635 |
UniProtKB/Swiss-Prot ID
| Q9HBW0 |
UniProtKB/Swiss-Prot Entry Name
| LPAR2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AC002306 |
GeneCard ID
| LPAR2 |
GenAtlas ID
| LPAR2 |
HGNC ID
| HGNC:3168 |
References |
General References
| Not Available |