Showing Protein ADP-ribosylation factor GTPase-activating protein 3 (CDBP03521)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03521
Secondary Accession Numbers Not Available
Name ADP-ribosylation factor GTPase-activating protein 3
Description Not Available
Synonyms
  1. ARF GAP 3
Gene Name ARFGAP3
Protein Type Enzyme
Biological Properties
General Function Involved in ARF GTPase activator activity
Specific Function GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes
GO Classification
Function
small gtpase regulator activity
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
enzyme regulator activity
arf gtpase activator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of cellular metabolic process
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
regulation of nucleotide metabolic process
regulation of nucleotide catabolic process
regulation of purine nucleotide catabolic process
regulation of gtp catabolic process
regulation of gtpase activity
regulation of ras gtpase activity
regulation of arf gtpase activity
biological regulation
regulation of biological process
regulation of metabolic process
Cellular Location
  1. Cytoplasm
  2. Golgi apparatus membrane
  3. Peripheral membrane protein
  4. Cytoplasmic side
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 22q13.2
SNPs ARFGAP3
Gene Sequence 
>1551 bp
ATGGGGGACCCCAGCAAGCAGGACATCTTGACCATCTTCAAGCGCCTCCGCTCGGTGCCC
ACTAACAAGGTGTGTTTTGATTGTGGTGCCAAAAATCCCAGCTGGGCAAGCATAACCTAT
GGAGTGTTCCTTTGCATTGATTGCTCAGGGTCCCACCGGTCACTTGGTGTTCACTTGAGT
TTTATTCGATCTACAGAGTTGGATTCCAACTGGTCATGGTTTCAGTTGCGATGCATGCAA
GTCGGAGGAAACGCTAGTGCATCTTCCTTTTTTCATCAACATGGGTGTTCCACCAATGAC
ACCAATGCCAAGTACAACAGTCGTGCTGCTCAGCTCTATAGGGAGAAAATCAAATCGCTC
GCCTCTCAAGCAACACGGAAGCATGGCACTGATCTGTGGCTTGATAGTTGTGTGGTTCCA
CCTTTGTCCCCTCCACCAAAGGAGGAAGATTTTTTTGCCTCTCACGTTTCTCCTGAGGTG
AGTGACACAGCGTGGGCATCAGCAATAGCAGAACCATCTTCTTTAACATCAAGGCCTGTG
GAAACCACTTTGGAAAATAATGAAGGTGGACAAGAGCAAGGACCAAGTGTGGAAGGTCTT
AATGTACCAACAAAGGCTACTTTAGAGGTATCCTCTATCATAAAAAAGAAACCAAATCAA
GCTAAAAAAGGCCTTGGGGCCAAAAAAGGAAGTTTGGGAGCTCAGAAACTGGCAAACACA
TGCTTTAATGAAATTGAAAAACAAGCTCAAGCTGCGGATAAAATGAAGGAGCAGGAAGAC
CTGGCCAAGGTGGTATCTAAAGAAGAATCAATTGTTTCATCATTACGATTAGCCTATAAG
GATCTTGAAATTCAAATGAAGAAAGACGAAAAGATGAACATTAGTGGCAAAAAAAATGTT
GACTCAGACAGACTCGGCATGGGATTTGGAAATTGCAGAAGTGTTATTTCACATTCAGTG
ACTTCAGATATGCAGACCATAGAGCAGGAATCACCCATTATGGCAAAACCAAGAAAAAAG
TATAATGATGACAGTGACGATTCATATTTTACTTCCAGCTCAAGTTACTTTGACGAGCCA
GTGGAGTTAAGGAGCAGTTCTTTCTCTAGCTGGGATGACAGTTCAGATTCCTATTGGAAA
AAAGAGACCAGCAAAGATACTGAAACAGTTCTGAAAACCACAGGCTATTCAGACAGACCT
ACTGCTCGCCGCAAGCCAGATTATGAGCCAGTTGAAAATACAGATGAGGCCCAGAAGAAG
TTTGGCAATGTCAAGGCCATTTCATCAGATATGTATTTTGGAAGACAATCCCAGGCTGAT
TATGAGACCAGGGCCCGCCTAGAGAGGCTGTCGGCAAGTTCCTCCATAAGCTCGGCTGAT
CTGTTCGAGGAGCCGAGGAAGCAGCCAGCAGGGAACTACAGCCTGTCCAGTGTGCTGCCC
AACGCCCCCGACATGGCGCAGTTCAAGCAGGGAGTGAGATCGGTTGCTGGAAAACTCTCC
GTCTTTGCTAATGGAGTCGTGACTTCAATTCAGGATCGCTACGGTTCTTAA
Protein Properties
Number of Residues 516
Molecular Weight 56927.9
Theoretical pI 7.41
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>ADP-ribosylation factor GTPase-activating protein 3
MGDPSKQDILTIFKRLRSVPTNKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLS
FIRSTELDSNWSWFQLRCMQVGGNASASSFFHQHGCSTNDTNAKYNSRAAQLYREKIKSL
ASQATRKHGTDLWLDSCVVPPLSPPPKEEDFFASHVSPEVSDTAWASAIAEPSSLTSRPV
ETTLENNEGGQEQGPSVEGLNVPTKATLEVSSIIKKKPNQAKKGLGAKKGSLGAQKLANT
CFNEIEKQAQAADKMKEQEDLAKVVSKEESIVSSLRLAYKDLEIQMKKDEKMNISGKKNV
DSDRLGMGFGNCRSVISHSVTSDMQTIEQESPIMAKPRKKYNDDSDDSYFTSSSSYFDEP
VELRSSSFSSWDDSSDSYWKKETSKDTETVLKTTGYSDRPTARRKPDYEPVENTDEAQKK
FGNVKAISSDMYFGRQSQADYETRARLERLSASSSISSADLFEEPRKQPAGNYSLSSVLP
NAPDMAQFKQGVRSVAGKLSVFANGVVTSIQDRYGS
GenBank ID Protein 7211442
UniProtKB/Swiss-Prot ID Q9NP61
UniProtKB/Swiss-Prot Entry Name ARFG3_HUMAN
PDB IDs Not Available
GenBank Gene ID AF111847
GeneCard ID ARFGAP3
GenAtlas ID ARFGAP3
HGNC ID HGNC:661
References
General References Not Available