Cannabis Compound Database: Showing Protein ADP-ribosylation factor GTPase-activating protein 3 (CDBP03521)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03521

Secondary Accession Numbers

Not Available

Name

ADP-ribosylation factor GTPase-activating protein 3

Description

Not Available

Synonyms

ARF GAP 3

Gene Name

ARFGAP3

Protein Type

Enzyme

Biological Properties

General Function

Involved in ARF GTPase activator activity

Specific Function

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes

GO Classification

Function
small gtpase regulator activity
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
enzyme regulator activity
arf gtpase activator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of cellular metabolic process
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
regulation of nucleotide metabolic process
regulation of nucleotide catabolic process
regulation of purine nucleotide catabolic process
regulation of gtp catabolic process
regulation of gtpase activity
regulation of ras gtpase activity
regulation of arf gtpase activity
biological regulation
regulation of biological process
regulation of metabolic process

Cellular Location

Cytoplasm
Golgi apparatus membrane
Peripheral membrane protein
Cytoplasmic side

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:2

Locus

22q13.2

SNPs

ARFGAP3

Gene Sequence

>1551 bp
ATGGGGGACCCCAGCAAGCAGGACATCTTGACCATCTTCAAGCGCCTCCGCTCGGTGCCC
ACTAACAAGGTGTGTTTTGATTGTGGTGCCAAAAATCCCAGCTGGGCAAGCATAACCTAT
GGAGTGTTCCTTTGCATTGATTGCTCAGGGTCCCACCGGTCACTTGGTGTTCACTTGAGT
TTTATTCGATCTACAGAGTTGGATTCCAACTGGTCATGGTTTCAGTTGCGATGCATGCAA
GTCGGAGGAAACGCTAGTGCATCTTCCTTTTTTCATCAACATGGGTGTTCCACCAATGAC
ACCAATGCCAAGTACAACAGTCGTGCTGCTCAGCTCTATAGGGAGAAAATCAAATCGCTC
GCCTCTCAAGCAACACGGAAGCATGGCACTGATCTGTGGCTTGATAGTTGTGTGGTTCCA
CCTTTGTCCCCTCCACCAAAGGAGGAAGATTTTTTTGCCTCTCACGTTTCTCCTGAGGTG
AGTGACACAGCGTGGGCATCAGCAATAGCAGAACCATCTTCTTTAACATCAAGGCCTGTG
GAAACCACTTTGGAAAATAATGAAGGTGGACAAGAGCAAGGACCAAGTGTGGAAGGTCTT
AATGTACCAACAAAGGCTACTTTAGAGGTATCCTCTATCATAAAAAAGAAACCAAATCAA
GCTAAAAAAGGCCTTGGGGCCAAAAAAGGAAGTTTGGGAGCTCAGAAACTGGCAAACACA
TGCTTTAATGAAATTGAAAAACAAGCTCAAGCTGCGGATAAAATGAAGGAGCAGGAAGAC
CTGGCCAAGGTGGTATCTAAAGAAGAATCAATTGTTTCATCATTACGATTAGCCTATAAG
GATCTTGAAATTCAAATGAAGAAAGACGAAAAGATGAACATTAGTGGCAAAAAAAATGTT
GACTCAGACAGACTCGGCATGGGATTTGGAAATTGCAGAAGTGTTATTTCACATTCAGTG
ACTTCAGATATGCAGACCATAGAGCAGGAATCACCCATTATGGCAAAACCAAGAAAAAAG
TATAATGATGACAGTGACGATTCATATTTTACTTCCAGCTCAAGTTACTTTGACGAGCCA
GTGGAGTTAAGGAGCAGTTCTTTCTCTAGCTGGGATGACAGTTCAGATTCCTATTGGAAA
AAAGAGACCAGCAAAGATACTGAAACAGTTCTGAAAACCACAGGCTATTCAGACAGACCT
ACTGCTCGCCGCAAGCCAGATTATGAGCCAGTTGAAAATACAGATGAGGCCCAGAAGAAG
TTTGGCAATGTCAAGGCCATTTCATCAGATATGTATTTTGGAAGACAATCCCAGGCTGAT
TATGAGACCAGGGCCCGCCTAGAGAGGCTGTCGGCAAGTTCCTCCATAAGCTCGGCTGAT
CTGTTCGAGGAGCCGAGGAAGCAGCCAGCAGGGAACTACAGCCTGTCCAGTGTGCTGCCC
AACGCCCCCGACATGGCGCAGTTCAAGCAGGGAGTGAGATCGGTTGCTGGAAAACTCTCC
GTCTTTGCTAATGGAGTCGTGACTTCAATTCAGGATCGCTACGGTTCTTAA

Protein Properties

Number of Residues

516

Molecular Weight

56927.9

Theoretical pI

7.41

Pfam Domain Function

ArfGap (PF01412 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>ADP-ribosylation factor GTPase-activating protein 3
MGDPSKQDILTIFKRLRSVPTNKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLS
FIRSTELDSNWSWFQLRCMQVGGNASASSFFHQHGCSTNDTNAKYNSRAAQLYREKIKSL
ASQATRKHGTDLWLDSCVVPPLSPPPKEEDFFASHVSPEVSDTAWASAIAEPSSLTSRPV
ETTLENNEGGQEQGPSVEGLNVPTKATLEVSSIIKKKPNQAKKGLGAKKGSLGAQKLANT
CFNEIEKQAQAADKMKEQEDLAKVVSKEESIVSSLRLAYKDLEIQMKKDEKMNISGKKNV
DSDRLGMGFGNCRSVISHSVTSDMQTIEQESPIMAKPRKKYNDDSDDSYFTSSSSYFDEP
VELRSSSFSSWDDSSDSYWKKETSKDTETVLKTTGYSDRPTARRKPDYEPVENTDEAQKK
FGNVKAISSDMYFGRQSQADYETRARLERLSASSSISSADLFEEPRKQPAGNYSLSSVLP
NAPDMAQFKQGVRSVAGKLSVFANGVVTSIQDRYGS

External Links

GenBank ID Protein

7211442

UniProtKB/Swiss-Prot ID

Q9NP61

UniProtKB/Swiss-Prot Entry Name

ARFG3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF111847

GeneCard ID