Cannabis Compound Database: Showing Protein Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (CDBP00832)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP00832

Secondary Accession Numbers

Not Available

Name

Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Description

Not Available

Synonyms

SCS-alpha
Succinyl-CoA synthetase subunit alpha

Gene Name

SUCLG1

Protein Type

Enzyme

Biological Properties

General Function

Involved in catalytic activity

Specific Function

Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity).

GO Classification

Biological Process
small molecule metabolic process
tricarboxylic acid cycle
succinyl-CoA metabolic process
succinate metabolic process
Cellular Component
mitochondrial matrix
plasma membrane
succinate-CoA ligase complex (GDP-forming)
mitochondrial inner membrane
Function
succinate-coa ligase (adp-forming) activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
atp citrate synthase activity
binding
catalytic activity
transferase activity
ligase activity
ligase activity, forming carbon-sulfur bonds
coa-ligase activity
succinate-coa ligase activity
Molecular Function
ATP citrate synthase activity
cofactor binding
succinate-CoA ligase (ADP-forming) activity
succinate-CoA ligase (GDP-forming) activity
GTP binding
GDP binding
Process
metabolic process

Cellular Location

Mitochondrion

Pathways

Name	SMPDB/Pathwhiz	KEGG
tricarboxylic acid cycle	Not Available	Not Available
Citrate cycle (TCA cycle)	Not Available
Citric Acid Cycle
Congenital lactic acidosis		Not Available
Fumarase deficiency		Not Available

Gene Properties

Chromosome Location

Locus

2p11.2

SNPs

SUCLG1

Gene Sequence

>1041 bp
ATGACCGCAACCCTTGCCGCTGCCGCTGACATCGCTACCATGGTCTCCGGCAGCAGCGGC
CTCGCCGCCGCCCGTCTCCTGTCGCGCAGCTTCCTCCTGCCGCAGAATGGAATTCGGCAT
TGTTCCTACACAGCTTCTCGGCAACATCTCTATGTTGATAAAAATACAAAGATTATTTGC
CAGGGTTTCACTGGCAAACAGGGCACCTTTCACAGCCAGCAGGCATTGGAATATGGCACC
AAACTCGTTGGAGGAACCACTCCAGGGAAAGGAGGCCAGACACATCTGGGCTTACCTGTC
TTTAATACTGTGAAGGAGGCCAAAGAACAGACAGGAGCAACGGCTTCTGTCATTTATGTT
CCTCCGCCTTTTGCTGCTGCTGCCATTAATGAAGCTATTGAGGCAGAAATTCCCTTGGTT
GTGTGTATCACTGAAGGAATTCCCCAGCAGGACATGGTACGAGTCAAGCACAAACTGCTG
CGCCAGGAAAAGACAAGGCTAATTGGGCCCAACTGCCCTGGAGTCATCAATCCTGGAGAA
TGTAAAATTGGCATCATGCCTGGCCATATTCACAAAAAAGGAAGGATTGGCATTGTGTCC
AGATCTGGCACCCTGACTTATGAAGCAGTTCACCAAACAACGCAAGTTGGATTGGGGCAG
TCTTTGTGCGTTGGCATTGGAGGTGATCCTTTTAATGGAACAGATTTTATTGACTGCCTC
GAAATCTTTTTGAACGATTCTGCCACAGAAGGCATCATATTGATTGGTGAAATTGGTGGT
AATGCAGAAGAGAATGCTGCAGAATTTTTGAAGCAACATAATTCAGGTCCAAATTCCAAG
CCTGTAGTGTCCTTCATTGCTGGTTTAACTGCTCCTCCTGGGAGAAGAATGGGTCATGCC
GGGGCAATTATTGCTGGAGGAAAAGGTGGAGCTAAAGAGAAGATCTCTGCCCTTCAGAGT
GCAGGAGTTGTGGTCAGTATGTCTCCTGCACAGCTGGGAACCACGATCTACAAGGAATTT
GAAAAGAGGAAGATGCTATGA

Protein Properties

Number of Residues

346

Molecular Weight

36249.505

Theoretical pI

8.789

Pfam Domain Function

CoA_binding (PF02629 )
Ligase_CoA (PF00549 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial
MTATLAAAADIATMVSGSSGLAAARLLSRSFLLPQNGIRHCSYTASRQHLYVDKNTKIIC
QGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYV
PPPFAAAAINEAIEAEIPLVVCITEGIPQQDMVRVKHKLLRQEKTRLIGPNCPGVINPGE
CKIGIMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFIDCL
EIFLNDSATEGIILIGEIGGNAEENAAEFLKQHNSGPNSKPVVSFIAGLTAPPGRRMGHA
GAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTIYKEFEKRKML

External Links

GenBank ID Protein

109452591

UniProtKB/Swiss-Prot ID

P53597

UniProtKB/Swiss-Prot Entry Name

SUCA_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_003849.3

GeneCard ID