| Identification |
|---|
| HMDB Protein ID
| CDBP03672 |
| Secondary Accession Numbers
| Not Available |
| Name
| Importin subunit alpha-4 |
| Description
| Not Available |
| Synonyms
|
- Importin alpha Q1
- Karyopherin subunit alpha-4
- Qip1
|
| Gene Name
| KPNA4 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a nonclassical NLS |
| GO Classification
|
| Component |
| intracellular part |
| cytoplasm |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| nuclear pore |
| organelle part |
| intracellular organelle part |
| nuclear part |
| cell part |
| Function |
| binding |
| protein transporter activity |
| transporter activity |
| substrate-specific transporter activity |
| Process |
| protein transport |
| protein import into nucleus |
| intracellular protein transport |
| protein targeting |
| establishment of localization |
| transport |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q25.33 |
| SNPs
| KPNA4 |
| Gene Sequence
|
>1566 bp
ATGGCGGACAACGAGAAACTGGACAACCAACGGCTCAAGAATTTCAAGAACAAAGGCCGC
GACTTGGAGACTATGAGAAGACAACGAAATGAAGTTGTAGTTGAATTAAGGAAGAATAAA
AGAGATGAACATCTCTTAAAGAGAAGGAATGTACCACATGAAGATATCTGTGAAGACTCT
GATATAGATGGTGATTATAGAGTGCAAAATACCTCTCTAGAAGCTATTGTTCAAAATGCT
TCAAGTGATAACCAAGGAATTCAATTAAGTGCAGTTCAAGCTGCTAGGAAGCTTTTGTCC
AGTGATCGAAATCCACCAATTGATGACTTAATAAAATCTGGAATATTGCCCATTTTAGTC
CATTGTCTTGAAAGAGATGACAATCCTTCTTTACAGTTTGAAGCTGCATGGGCTTTGACA
AACATTGCATCTGGAACTTCTGAACAAACTCAAGCAGTAGTTCAGTCCAATGCTGTGCCA
CTTTTCCTGAGGCTTCTCCATTCACCCCATCAGAATGTCTGTGAGCAAGCAGTGTGGGCA
TTGGGAAATATCATAGGTGATGGGCCCCAGTGTAGAGATTATGTCATAAGTCTTGGAGTT
GTGAAACCTTTACTTTCCTTCATAAGTCCATCTATTCCTATAACATTCTTAAGAAATGTT
ACTTGGGTTATGGTCAACTTATGTCGCCACAAAGACCCACCACCACCAATGGAAACCATT
CAGGAGATTCTTCCAGCCCTTTGTGTTTTAATTCATCACACAGATGTAAATATACTGGTA
GACACAGTCTGGGCCCTCTCTTACCTTACTGATGCTGGCAATGAACAAATACAGATGGTA
ATAGACTCTGGAATAGTTCCTCATTTGGTTCCTCTGCTCAGCCACCAGGAAGTTAAAGTT
CAGACTGCTGCACTTAGAGCTGTGGGCAACATTGTTACTGGAACTGATGAGCAAACACAA
GTAGTTTTGAACTGTGATGCTCTTTCACACTTCCCAGCACTCCTGACACATCCCAAAGAG
AAAATTAATAAAGAAGCAGTGTGGTTCCTCTCCAACATCACTGCAGGAAATCAGCAGCAG
GTACAGGCAGTAATTGATGCCAATCTTGTACCAATGATAATACACCTTTTGGATAAGGGG
GATTTTGGCACTCAAAAAGAAGCTGCTTGGGCCATAAGTAACTTAACAATTAGTGGAAGG
AAAGATCAAGTGGCTTACCTTATCCAACAAAATGTTATCCCACCTTTTTGCAACTTGCTG
ACTGTAAAAGATGCACAAGTTGTGCAAGTAGTACTCGATGGACTAAGTAATATATTAAAA
ATGGCTGAAGATGAGGCAGAAACCATAGGCAATCTTATAGAAGAATGTGGAGGGCTGGAG
AAAATTGAACAACTTCAAAATCATGAAAATGAAGACATCTACAAATTGGCCTATGAGATC
ATTGATCAGTTCTTCTCTTCAGATGATATTGATGAAGACCCTAGCCTTGTTCCAGAGGCA
ATTCAAGGCGGAACATTTGGTTTCAATTCATCTGCCAATGTACCAACAGAAGGGTTCCAG
TTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 521 |
| Molecular Weight
| 57886.3 |
| Theoretical pI
| 4.56 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Importin subunit alpha-4
MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDS
DIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILV
HCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWA
LGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETI
QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKV
QTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQ
VQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLL
TVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEI
IDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF
|
| External Links |
|---|
| GenBank ID Protein
| 1944125 |
| UniProtKB/Swiss-Prot ID
| O00629 |
| UniProtKB/Swiss-Prot Entry Name
| IMA4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB002533 |
| GeneCard ID
| KPNA4 |
| GenAtlas ID
| KPNA4 |
| HGNC ID
| HGNC:6397 |
| References |
|---|
| General References
| Not Available |