Showing Protein Signal recognition particle receptor subunit alpha (CDBP03798)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03798
Secondary Accession Numbers Not Available
Name Signal recognition particle receptor subunit alpha
Description Not Available
Synonyms
  1. DP-alpha
  2. Docking protein alpha
  3. SR-alpha
Gene Name SRPR
Protein Type Receptor
Biological Properties
General Function Involved in nucleotide binding
Specific Function Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system
GO Classification
Component
receptor complex
macromolecular complex
protein complex
signal recognition particle receptor complex
Function
signal recognition particle binding
nucleoside-triphosphatase activity
ribonucleoprotein binding
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
purine nucleotide binding
binding
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
protein binding
gtpase activity
Process
protein targeting to membrane
cotranslational protein targeting to membrane
establishment of localization
transport
protein transport
srp-dependent cotranslational protein targeting to membrane
intracellular protein transport
protein targeting
Cellular Location
  1. Peripheral membrane protein
  2. Endoplasmic reticulum membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11q24.2
SNPs SRPR
Gene Sequence 
>1917 bp
ATGCTCGACTTCTTCACCATTTTCTCCAAGGGCGGGCTTGTGCTCTGGTGCTTCCAGGGC
GTTAGCGACTCATGCACCGGACCCGTTAACGCGTTGATTCGTTCCGTGCTGCTGCAGGAA
CGGGGAGGTAACAACTCCTTCACCCATGAGGCACTCACACTCAAGTATAAACTGGACAAC
CAGTTTGAGCTGGTGTTTGTGGTTGGTTTTCAGAAGATCCTGACACTGACATATGTAGAC
AAATTGATAGATGACGTGCATCGGCTGTTTCGGGACAAGTACCGCACAGAGATCCAACAG
CAAAGTGCTTTAAGTTTATTAAATGGCACTTTTGATTTCCAAAATGACTTCCTGCGGCTC
CTTCGTGAAGCAGAGGAGAGCAGTAAGATCCGTGCTCCCACTACCATGAAGAAATTTGAA
GATTCTGAAAAGGCCAAGAAACCTGTGAGGTCCATGATTGAGACACGGGGGGAAAAGCCC
AAGGAAAAAGCAAAGAATAGCAAAAAAAAGGGGGCCAAGAAGGAAGGTTCTGATGGTCCT
TTGGCTACCAGCAAACCAGTCCCTGCAGAAAAGTCAGGTCTTCCAGTGGGTCCTGAGAAC
GGAGTAGAACTTTCCAAAGAGGAGCTGATCCGCAGGAAGCGCGAGGAGTTCATTCAGAAG
CATGGGAGGGGTATGGAGAAGTCCAACAAGTCCACGAAGTCAGATGCTCCAAAGGAGAAG
GGCAAAAAAGCACCCCGGGTGTGGGAACTGGGTGGCTGTGCTAACAAAGAAGTGTTGGAT
TACAGTACTCCCACCACCAATGGAACCCCTGAGGCTGCCTTGTCTGAGGACATCAACCTG
ATTCGAGGGACTGGGTCTGGGGGGCAGCTTCAGGATCTGGACTGCAGCAGCTCTGATGAC
GAAGGGGCTGCTCAAAACTCTACCAAACCTAGTGCGACCAAGGGAACACTGGGTGGCATG
TTTGGTATGCTGAAGGGCCTTGTGGGTTCAAAGAGCTTGAGTCGTGAAGACATGGAATCT
GTGCTGGACAAGATGCGTGATCATCTCATTGCTAAGAACGTGGCTGCAGACATTGCCGTC
CAGCTCTGTGAATCTGTTGCCAACAAGTTGGAAGGGAAGGTGATGGGGACGTTCAGCACG
GTGACTTCCACAGTAAAGCAAGCCCTACAGGAGTCCCTGGTGCAGATTCTGCAGCCACAG
CGTCGTGTAGACATGCTCCGGGACATCATGGATGCCCAGCGTCGCCAGCGCCCTTATGTC
GTCACCTTCTGCGGCGTTAATGGAGTGGGGAAATCTACTAATCTTGCCAAGATTTCCTTC
TGGTTGTTAGAGAATGGCTTCAGTGTCCTCATTGCTGCCTGTGATACATTTCGTGCTGGG
GCCGTGGAGCAGCTGCGTACACACACCCGGCGTTTGAGTGCCCTACACCCTCCAGAGAAG
CATGGTGGCCGCACCATGGTGCAGTTGTTTGAAAAGGGCTATGGCAAGGATGCTGCTGGC
ATTGCCATGGAAGCCATTGCTTTTGCACGTAACCAAGGCTTTGACGTGGTGCTGGTGGAC
ACGGCAGGCCGCATGCAAGACAATGCCCCTCTGATGACTGCCCTGGCCAAACTCATTACT
GTCAATACACCTGATTTGGTGCTGTTTGTAGGAGAAGCCTTAGTAGGCAATGAAGCCGTG
GACCAGCTGGTCAAGTTCAACAGAGCCTTGGCTGACCATTCTATGGCTCAGACACCTCGG
CTCATTGATGGCATTGTTCTTACCAAATTTGATACCATTGATGACAAGGTGGGAGCTGCT
ATTTCTATGACGTACATCACAAGCAAACCCATCGTCTTTGTGGGCACCGGCCAGACCTAC
TGTGACCTACGCAGCCTCAATGCCAAGGCTGTGGTGGCTGCCCTCATGAAGGCTTAA
Protein Properties
Number of Residues 638
Molecular Weight 69810.6
Theoretical pI 9.46
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Signal recognition particle receptor subunit alpha
MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHEALTLKYKLDN
QFELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRL
LREAEESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKPKEKAKNSKKKGAKKEGSDGP
LATSKPVPAEKSGLPVGPENGVELSKEELIRRKREEFIQKHGRGMEKSNKSTKSDAPKEK
GKKAPRVWELGGCANKEVLDYSTPTTNGTPEAALSEDINLIRGTGSGGQLQDLDCSSSDD
EGAAQNSTKPSATKGTLGGMFGMLKGLVGSKSLSREDMESVLDKMRDHLIAKNVAADIAV
QLCESVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRRQRPYV
VTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPPEK
HGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLIT
VNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAA
ISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA
GenBank ID Protein 189065456
UniProtKB/Swiss-Prot ID P08240
UniProtKB/Swiss-Prot Entry Name SRPR_HUMAN
PDB IDs Not Available
GenBank Gene ID AK312377
GeneCard ID SRPR
GenAtlas ID SRPR
HGNC ID HGNC:11307
References
General References Not Available