Identification |
HMDB Protein ID
| CDBP03677 |
Secondary Accession Numbers
| Not Available |
Name
| Importin-13 |
Description
| Not Available |
Synonyms
|
- Imp13
- Kap13
- Karyopherin-13
- Ran-binding protein 13
- RanBP13
|
Gene Name
| IPO13 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in binding |
Specific Function
| Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 |
GO Classification
|
Function |
protein transporter activity |
transporter activity |
substrate-specific transporter activity |
binding |
Process |
establishment of localization |
transport |
protein transport |
intracellular protein transport |
|
Cellular Location
|
- Nucleus
- Cytoplasm
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 1p34.1 |
SNPs
| IPO13 |
Gene Sequence
|
>2892 bp
ATGGAGCGGCGGGAGGAGCAGCCGGGGGCTGCAGGGGCTGGAGCAGCACCAGCCTTGGAC
TTCACTGTGGAGAACGTGGAGAAGGCGCTGCACCAGCTCTACTATGATCCCAACATTGAG
AATAAGAACCTGGCTCAGAAGTGGCTGATGCAGGCCCAGGTCTCCCCACAGGCCTGGCAC
TTCAGCTGGCAGCTACTGCAGCCCGACAAGGTACCAGAGATCCAGTACTTTGGGGCCAGT
GCTCTTCACATCAAGATCTCTCGCTACTGGAGTGACATCCCCACTGACCAGTATGAAAGC
CTAAAGGCACAGCTCTTCACCCAGATCACCCGCTTTGCCAGTGGCTCCAAGATTGTACTG
ACTCGGCTGTGCGTGGCACTGGCCTCACTGGCTCTCAGCATGATGCCTGACGCTTGGCCA
TGTGCTGTGGCAGATATGGTACGACTCTTCCAGGCTGAGGACTCACCAGTGGATGGGCAG
GGCCGCTGCCTAGCCCTGTTAGAGCTGCTGACAGTGCTGCCTGAGGAGTTCCAGACCAGT
CGCCTACCCCAGTACCGCAAAGGCCTGGTGCGGACCAGCCTGGCGGTGGAATGTGGGGCT
GTCTTCCCGCTGCTGGAGCAGCTGCTACAGCAGCCCAGCTCACCCAGCTGTGTGCGTCAG
AAGGTGCTCAAGTGTTTCTCCAGCTGGGTGCAGCTGGAGGTGCCGCTGCAGGACTGTGAG
GCGCTCATTCAGGCTGCCTTTGCTGCTCTGCAGGACTCGGAGCTCTTCGACAGCAGTGTG
GAGGCCATTGTGAATGCCATCTCACAGCCTGATGCCCAGAGGTACGTGAACACACTCCTG
AAACTCATCCCGCTGGTGCTGGGTCTGCAGGAACAACTGCGGCAGGCAGTGCAGAATGGG
GACATGGAGACCTCCCATGGCATCTGTCGCATCGCTGTGGCCCTGGGCGAGAACCACTCC
CGGGCCTTGCTGGACCAAGTAGAGCACTGGCAGAGTTTCCTGGCACTCGTCAACATGATT
ATGTTCTGCACAGGCATCCCTGGCCACTATCCTGTCAATGAGACCACCAGCTCCCTAACC
CTCACCTTCTGGTACACACTGCAGGATGATATTCTATCCTTTGAGGCAGAGAAGCAGGCT
GTATACCAGCAGGTGTACCGGCCAGTCTACTTCCAGCTGGTGGATGTGCTTCTGCACAAG
GCCCAGTTCCCTTCTGATGAGGAATATGGATTCTGGTCCTCAGACGAGAAGGAGCAGTTC
CGAATTTACAGGGTGGACATCTCAGACACGCTCATGTATGTCTATGAGATGTTGGGGGCC
GAGCTGCTCAGCAACCTCTATGACAAGCTGGGTCGTTTGCTCACCAGCTCAGAGGAGCCC
TACTCCTGGCAGCACACAGAGGCCCTCCTCTACGGCTTCCAATCCATCGCAGAGACCATT
GACGTCAACTATTCTGATGTGGTGCCTGGGCTCATTGGCCTCATCCCACGGATCAGCATC
AGCAACGTGCAGCTGGCAGACACTGTCATGTTCACCATTGGAGCTCTGTCTGAATGGCTG
GCTGACCACCCCGTCATGATCAACAGTGTTCTGCCCTTGGTACTGCATGCCCTAGGCAAT
CCTGAGCTGTCTGTCTCTTCTGTGTCCACCCTCAAGAAGATCTGCCGAGAGTGCAAGTAT
GACCTGCCTCCCTATGCTGCCAACATTGTGGCTGTGTCCCAGGATGTGCTGATGAAACAG
ATCCACAAGACAAGCCAGTGCATGTGGCTGATGCAGGCGCTGGGCTTCCTGCTGTCAGCT
CTTCAAGTGGAGGAGATCCTTAAGAACCTGCACTCGCTTATCTCACCCTATATCCAGCAA
CTGGAGAAGCTGGCAGAGGAGATACCCAATCCCTCCAACAAGCTGGCCATTGTTCACATC
TTGGGGCTTCTCTCCAACCTCTTCACCACACTGGACATCAGTCATCATGAGGATGATCAT
GAAGGCCCTGAGCTTCGGAAGCTGCCAGTGCCACAGGGACCCAACCCCGTGGTGGTGGTG
CTGCAGCAGGTCTTCCAGCTTATCCAGAAGGTGCTGAGCAAATGGTTGAATGATGCCCAG
GTTGTGGAGGCGGTGTGCGCTATCTTTGAGAAGTCTGTTAAGACGCTGCTGGATGACTTT
GCCCCCATGGTGCCACAGCTGTGTGAGATGCTGGGTCGGATGTACAGCACCATCCCCCAG
GCCTCTGCTCTTGACCTCACTCGACAGCTGGTCCACATCTTTGCTCATGAGCCTGCCCAC
TTTCCCCCAATTGAGGCCCTCTTCCTGCTCGTCACCTCCGTCACACTCACTCTCTTCCAG
CAAGGGCCCAGGGATCATCCTGATATTGTTGATTCATTTATGCAACTCCTGGCACAGGCT
CTGAAGCGGAAGCCAGATTTGTTCCTGTGTGAACGATTGGATGTCAAAGCTGTGTTCCAG
TGTGCTGTGCTGGCCCTCAAGTTCCCTGAGGCACCTACTGTCAAGGCCTCCTGTGGCTTC
TTTACAGAGCTGCTGCCTCGGTGTGGGGAAGTAGAGTCTGTGGGAAAGGTGGTACAGGAA
GACGGTCGTATGCTGCTCATAGCAGTGCTGGAGGCCATTGGGGGCCAGGCCTCCCGCAGC
CTCATGGACTGCTTTGCCGATATCCTGTTCGCCCTGAACAAGCACTGCTTCAGCCTCCTG
AGCATGTGGATCAAGGAGGCCCTGCAGCCACCTGGTTTCCCCTCTGCCCGCCTCAGCCCT
GAACAGAAGGATACCTTCAGCCAGCAGATCCTTCGCGAGCGAGTGAACAAGAGGCGGGTG
AAGGAGATGGTGAAGGAGTTCACACTGCTGTGCCGGGGTCTCCATGGCACAGATTACACA
GCTGACTACTGA
|
Protein Properties |
Number of Residues
| 963 |
Molecular Weight
| 108194.1 |
Theoretical pI
| 4.95 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Importin-13
MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWH
FSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVL
TRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDGQGRCLALLELLTVLPEEFQTS
RLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCE
ALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNG
DMETSHGICRIAVALGENHSRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLT
LTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQF
RIYRVDISDTLMYVYEMLGAELLSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETI
DVNYSDVVPGLIGLIPRISISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHALGN
PELSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSA
LQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILGLLSNLFTTLDISHHEDDH
EGPELRKLPVPQGPNPVVVVLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDF
APMVPQLCEMLGRMYSTIPQASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLTLFQ
QGPRDHPDIVDSFMQLLAQALKRKPDLFLCERLDVKAVFQCAVLALKFPEAPTVKASCGF
FTELLPRCGEVESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLL
SMWIKEALQPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYT
ADY
|
External Links |
GenBank ID Protein
| 224831257 |
UniProtKB/Swiss-Prot ID
| O94829 |
UniProtKB/Swiss-Prot Entry Name
| IPO13_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_014652.3 |
GeneCard ID
| IPO13 |
GenAtlas ID
| IPO13 |
HGNC ID
| HGNC:16853 |
References |
General References
| Not Available |