Identification
HMDB Protein ID CDBP03829
Secondary Accession Numbers Not Available
Name Exportin-2
Description Not Available
Synonyms
  1. Cellular apoptosis susceptibility protein
  2. Chromosome segregation 1-like protein
  3. Exp2
  4. Importin-alpha re-exporter
Gene Name CSE1L
Protein Type Enzyme
Biological Properties
General Function Involved in binding
Specific Function Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
GO Classification
Component
cell part
intracellular part
cytoplasm
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
nuclear export signal receptor activity
importin-alpha export receptor activity
transporter activity
substrate-specific transporter activity
binding
protein binding
protein transporter activity
Process
establishment of localization
transport
protein transport
cell proliferation
intracellular protein transport
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 20q13
SNPs CSE1L
Gene Sequence
>2916 bp
ATGGAACTCAGCGATGCAAATCTGCAAACACTAACAGAATATTTAAAGAAAACACTTGAT
CCTGATCCTGCCATCCGACGTCCAGCTGAGAAATTTCTTGAATCTGTTGAAGGAAATCAG
AATTATCCACTGTTGCTTTTGACATTACTGGAGAAGTCCCAGGATAATGTTATCAAAGTA
TGTGCTTCAGTAACATTCAAAAACTATATTAAAAGGAACTGGAGAATTGTTGAAGATGAA
CCAAACAAAATTTGTGAAGCCGATCGAGTGGCCATTAAAGCCAACATAGTGCACTTGATG
CTTAGCAGCCCAGAGCAAATTCAGAAGCAGTTAAGTGATGCAATTAGCATTATTGGCAGA
GAAGATTTTCCACAGAAATGGCCTGACTTGCTGACAGAAATGGTGAATCGCTTTCAGAGT
GGAGATTTCCATGTTATTAATGGAGTCCTCCGTACAGCACATTCATTATTTAAAAGATAC
CGTCATGAATTTAAGTCAAACGAGTTATGGACTGAAATTAAGCTTGTTCTGGATGCCTTT
GCTTTGCCTTTGACTAATCTTTTTAAGGCCACTATTGAACTCTGCAGTACCCATGCAAAT
GATGCCTCTGCCCTGAGGATTCTGTTTTCTTCCCTGATCCTGATCTCAAAATTGTTCTAT
AGTTTAAACTTTCAGGATCTCCCTGAATTTTTTGAAGATAATATGGAAACTTGGATGAAT
AATTTTCATACTCTCTTAACATTGGATAATAAGCTTTTACAAACTGATGATGAAGAGGAA
GCCGGCTTATTGGAGCTCTTAAAATCCCAGATTTGTGATAATGCCGCACTCTATGCACAA
AAGTACGATGAAGAATTCCAGCGATACCTGCCTCGTTTTGTTACAGCCATCTGGAATTTA
CTAGTTACAACGGGTCAAGAGGTTAAATATGATTTGTTGGTAAGTAATGCAATTCAATTT
CTGGCTTCAGTTTGTGAGAGACCTCATTATAAGAATCTATTTGAGGACCAGAACACGCTG
ACAAGTATCTGTGAAAAGGTTATTGTGCCTAACATGGAATTTAGAGCTGCTGATGAAGAA
GCATTTGAAGATAATTCTGAGGAGTACATAAGGAGAGATTTGGAAGGATCTGATATTGAT
ACTAGACGCAGGGCTGCTTGTGATCTGGTACGAGGATTATGCAAGTTTTTTGAGGGACCT
GTGACAGGAATCTTCTCTGGTTATGTTAATTCCATGCTGCAGGAATACGCAAAAAATCCA
TCTGTCAACTGGAAACACAAAGATGCAGCCATCTACCTAGTGACATCTTTGGCATCAAAA
GCCCAAACACAGAAGCATGGAATTACACAAGCAAATGAACTTGTAAACCTAACTGAGTTC
TTTGTGAATCACATCCTCCCTGATTTAAAATCAGCTAATGTGAATGAATTTCCTGTCCTT
AAAGCTGACGGTATCAAATATATTATGATTTTTAGAAATCAAGTGCCAAAAGAACATCTT
TTAGTCTCGATTCCTCTCTTGATTAATCATCTTCAAGCTGAAAGTATTGTTGTTCATACT
TACGCAGCTCATGCTCTTGAACGGCTCTTTACTATGCGAGGGCCTAACAATGCCACTCTC
TTTACAGCTGCAGAAATCGCACCGTTTGTTGAGATTCTGCTAACAAACCTTTTCAAAGCT
CTCACACTTCCTGGCTCTTCAGAAAATGAATATATTATGAAAGCTATCATGAGAAGTTTT
TCTCTCCTACAAGAAGCCATAATCCCCTACATCCCTACTCTCATCACTCAGCTTACACAG
AAGCTATTAGCTGTTAGTAAGAACCCAAGCAAACCTCACTTTAATCACTACATGTTTGAA
GCAATATGTTTATCCATAAGAATAACTTGCAAAGCTAACCCTGCTGCTGTTGTAAATTTT
GAGGAGGCTTTGTTTTTGGTGTTTACTGAAATCTTACAAAATGATGTGCAAGAATTTATT
CCATACGTCTTTCAAGTGATGTCTTTGCTTCTGGAAACACACAAAAATGACATCCCGTCT
TCCTATATGGCCTTATTTCCTCATCTCCTTCAGCCAGTGCTTTGGGAAAGAACAGGAAAT
ATTCCTGCTCTAGTGAGGCTTCTTCAAGCATTCTTAGAACGCGGTTCAAACACAATAGCA
AGTGCTGCAGCTGACAAAATTCCTGGGTTACTAGGTGTCTTTCAGAAGCTGATTGCATCC
AAAGCAAATGACCACCAAGGTTTTTATCTTCTAAACAGTATAATAGAGCACATGCCTCCT
GAATCAGTTGACCAATATAGGAAACAAATCTTCATTCTGCTATTCCAGAGACTTCAGAAT
TCCAAAACAACCAAGTTTATCAAGAGTTTTTTAGTCTTTATTAATTTGTATTGCATAAAA
TATGGGGCACTAGCACTACAAGAAATATTTGATGGTATACAACCAAAAATGTTTGGAATG
GTTTTGGAAAAAATTATTATTCCTGAAATTCAGAAGGTATCTGGAAATGTAGAGAAAAAG
ATCTGTGCGGTTGGCATAACCAAATTACTAACAGAATGTCCCCCAATGATGGACACTGAG
TATACCAAACTGTGGACTCCATTATTACAGTCTTTGATTGGTCTTTTTGAGTTACCCGAA
GATGATACCATTCCTGATGAGGAACATTTTATTGACATAGAAGATACACCAGGATATCAG
ACTGCCTTCTCACAGTTGGCATTTGCTGGGAAAAAAGAGCATGATCCTGTAGGTCAAATG
GTGAATAACCCCAAAATTCACCTGGCACAGTCACTTCACAAGTTGTCTACCGCCTGTCCA
GGAAGGGTTCCATCAATGGTGAGCACCAGCCTGAATGCAGAAGCGCTCCAGTATCTCCAA
GGGTACCTTCAGGCAGCCAGTGTGACACTGCTTTAA
Protein Properties
Number of Residues 971
Molecular Weight 110415.5
Theoretical pI 5.55
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Exportin-2
MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKV
CASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGR
EDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAF
ALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMN
NFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNL
LVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEE
AFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNP
SVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSANVNEFPVL
KADGIKYIMIFRNQVPKEHLLVSIPLLINHLQAESIVVHTYAAHALERLFTMRGPNNATL
FTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQ
KLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFI
PYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVRLLQAFLERGSNTIA
SAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQN
SKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKK
ICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIEDTPGYQ
TAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQ
GYLQAASVTLL
GenBank ID Protein 29029559
UniProtKB/Swiss-Prot ID P55060
UniProtKB/Swiss-Prot Entry Name XPO2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001316.2
GeneCard ID CSE1L
GenAtlas ID CSE1L
HGNC ID HGNC:2431
References
General References Not Available