Cannabis Compound Database: Showing Protein 2'-5'-oligoadenylate synthase 3 (CDBP03706)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03706

Secondary Accession Numbers

Not Available

Name

2'-5'-oligoadenylate synthase 3

Description

Not Available

Synonyms

(2-5')oligo(A) synthase 3
2-5A synthase 3
p100 OAS
p100OAS

Gene Name

OAS3

Protein Type

Enzyme

Biological Properties

General Function

Involved in RNA binding

Specific Function

May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate

GO Classification

Function
nucleotidyltransferase activity
nucleic acid binding
rna binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
Process
immune system process
immune response

Cellular Location

Cytoplasmic

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

12q24.2

SNPs

OAS3

Gene Sequence

>3264 bp
ATGGACTTGTACAGCACCCCGGCCGCTGCGCTGGACAGGTTCGTGGCCAGAAAGCTGCAG
CCGCGGAAGGAGTTCGTAGAGAAGGCGCGGCGCGCTCTGGGCGCCCTGGCCGCTGCTCTG
AGGGAGCGCGGGGGCCGCCTCGGTGCTGCTGCCCCGCGGGTGCTGAAAACTGTCAAGGGA
GGCTCCTCGGGCCGGGGCACAGCTCTCAAGGGTGGCTGTGATTCTGAACTTGTCATCTTC
CTCGACTGCTTCAAGAGCTATGTGGACCAGAGGGCCCGCCGTGCAGAGATCCTCAGTGAG
ATGCGGGCATCGCTGGAATCCTGGTGGCAGAACCCAGTCCCTGGTCTGAGACTCACGTTT
CCTGAGCAGAGCGTGCCTGGGGCCCTGCAGTTCCGCCTGACATCCGTAGATCTTGAGGAC
TGGATGGATGTTAGCCTGGTGCCTGCCTTCAATGTCCTGGGTCAGGCCGGCTCCGGCGTC
AAACCCAAGCCACAAGTCTACTCTACCCTCCTCAACAGTGGCTGCCAAGGGGGCGAGCAT
GCGGCCTGCTTCACAGAGCTGCGGAGGAACTTTGTGAACATTCGCCCAGCCAAGTTGAAG
AACCTAATCTTGCTGGTGAAGCACTGGTACCACCAGGTGTGCCTACAGGGGTTGTGGAAG
GAGACGCTGCCCCCGGTCTATGCCCTGGAATTGCTGACCATCTTCGCCTGGGAGCAGGGC
TGTAAGAAGGATGCTTTCAGCCTAGCCGAAGGCCTCCGAACTGTCCTGGGCCTGATCCAA
CAGCATCAGCACCTGTGTGTTTTCTGGACTGTCAACTATGGCTTCGAGGACCCTGCAGTT
GGGCAGTTCTTGCAGCGGCAGCTTAAGAGACCCAGGCCTGTGATCCTGGACCCAGCTGAC
CCCACATGGGACCTGGGGAATGGGGCAGCCTGGCACTGGGATTTGCTAGCCCAGGAGGCA
GCATCCTGCTATGACCACCCATGCTTTCTGAGGGGGATGGGGGACCCAGTGCAGTCTTGG
AAGGGGCCGGGCCTTCCACGTGCTGGATGCTCAGGTTTGGGCCACCCCATCCAGCTAGAC
CCTAACCAGAAGACCCCTGAAAACAGCAAGAGCCTCAATGCTGTGTACCCAAGAGCAGGG
AGCAAACCTCCCTCATGCCCAGCTCCTGGCCCCACTGGGGCAGCCAGCATCGTCCCCTCT
GTGCCGGGAATGGCCTTGGACCTGTCTCAGATCCCCACCAAGGAGCTGGACCGCTTCATC
CAGGACCACCTGAAGCCGAGCCCCCAGTTCCAGGAGCAGGTGAAAAAGGCCATCGACATC
ATCTTGCGCTGCCTCCATGAGAACTGTGTTCACAAGGCCTCAAGAGTCAGTAAAGGGGGC
TCATTTGGCCGGGGCACAGACCTAAGGGATGGCTGTGATGTTGAACTCATCATCTTCCTC
AACTGCTTCACGGACTACAAGGACCAGGGGCCCCGCCGCGCAGAGATCCTTGATGAGATG
CGAGCGCACGTAGAATCCTGGTGGCAGGACCAGGTGCCCAGCCTGAGCCTTCAGTTTCCT
GAGCAGAATGTGCCTGAGGCTCTGCAGTTCCAGCTGGTGTCCACAGCCCTGAAGAGCTGG
ACGGATGTTAGCCTGCTGCCTGCCTTCGATGCTGTGGGGCAGCTCAGTTCTGGCACCAAA
CCAAATCCCCAGGTCTACTCAAGGCTCCTCACCAGTGGCTGCCAGGAGGGCGAGCATAAG
GCCTGCTTCGCAGAGCTGCGGAGGAACTTCATGAACATTCGCCCTGTCAAGCTGAAGAAC
CTGATTCTGCTGGTGAAGCACTGGTACCGCCAGGTTGCGGCTCAGAACAAAGGAAAAGGA
CCAGCCCCTGCCTCTCTGCCCCCAGCCTATGCCCTGGAGCTCCTCACCATCTTTGCCTGG
GAGCAGGGCTGCAGGCAGGATTGTTTCAACATGGCCCAAGGCTTCCGGACGGTGCTGGGG
CTCGTGCAACAGCATCAGCAGCTCTGTGTCTACTGGACGGTCAACTATAGCACTGAGGAC
CCAGCCATGAGAATGCACCTTCTTGGCCAGCTTCGAAAACCCAGACCCCTGGTCCTGGAC
CCCGCTGATCCCACCTGGAACGTGGGCCACGGTAGCTGGGAGCTGTTGGCCCAGGAAGCA
GCAGCGCTGGGGATGCAGGCCTGCTTTCTGAGTAGAGACGGGACATCTGTGCAGCCCTGG
GATGTGATGCCAGCCCTCCTTTACCAAACCCCAGCTGGGGACCTTGACAAGTTCATCAGT
GAATTTCTCCAGCCCAACCGCCAGTTCCTGGCCCAGGTGAACAAGGCCGTTGATACCATC
TGTTCATTTTTGAAGGAAAACTGCTTCCGGAATTCTCCCATCAAAGTGATCAAGGTGGTC
AAGGGTGGCTCTTCAGCCAAAGGCACAGCTCTGCGAGGCCGCTCAGATGCCGACCTCGTG
GTGTTCCTCAGCTGCTTCAGCCAGTTCACTGAGCAGGGCAACAAGCGGGCCGAGATCATC
TCCGAGATCCGAGCCCAGCTGGAGGCATGTCAACAGGAGCGGCAGTTCGAGGTCAAGTTT
GAAGTCTCCAAATGGGAGAATCCCCGCGTGCTGAGCTTCTCACTGACATCCCAGACGATG
CTGGACCAGAGTGTGGACTTTGATGTGCTGCCAGCCTTTGACGCCCTAGGCCAGCTGGTC
TCTGGCTCCAGGCCCAGCTCTCAAGTCTACGTCGACCTCATCCACAGCTACAGCAATGCG
GGCGAGTACTCCACCTGCTTCACAGAGCTACAACGGGACTTCATCATCTCTCGCCCTACC
AAGCTGAAGAGCCTGATCCGGCTGGTGAAGCACTGGTACCAGCAGTGTACCAAGATCTCC
AAGGGGAGAGGCTCCCTACCCCCACAGCACGGGCTGGAACTCCTGACTGTGTATGCCTGG
GAGCAGGGCCGGAAGGACTCCCAGTTCAACATGGCTGAGGGCTTCCGCACGGTCCTGGAG
CTGGTCACCCAGTACCGCCAGCTCTGTATCTACTGGACCATCAACTACAACGCCAAGGAC
AAGACTGTTGGAGACTTCCTGAAACAGCAGCTTCAGAAGCCCAGGCCTATCATCCTGGAT
CCGGCTGACCCGACAGGCAACCTGGGCCACAATGCCCGCTGGGACCTGCTGGCCAAGGAA
GCTGCAGCCTGCACATCTGCCCTGTGCTGCATGGGACGGAATGGCATCCCCATCCAGCCA
TGGCCAGTGAAGGCTGCTGTGTGA

Protein Properties

Number of Residues

1087

Molecular Weight

121164.1

Theoretical pI

8.47

Pfam Domain Function

NTP_transf_2 (PF01909 )
OAS1_C (PF10421 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>2'-5'-oligoadenylate synthase 3
MDLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKG
GSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTF
PEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGCQGGEH
AACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIFAWEQG
CKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVILDPAD
PTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGCSGLGHPIQLD
PNQKTPENSKSLNAVYPRAGSKPPSCPAPGPTGAASIVPSVPGMALDLSQIPTKELDRFI
QDHLKPSPQFQEQVKKAIDIILRCLHENCVHKASRVSKGGSFGRGTDLRDGCDVELIIFL
NCFTDYKDQGPRRAEILDEMRAHVESWWQDQVPSLSLQFPEQNVPEALQFQLVSTALKSW
TDVSLLPAFDAVGQLSSGTKPNPQVYSRLLTSGCQEGEHKACFAELRRNFMNIRPVKLKN
LILLVKHWYRQVAAQNKGKGPAPASLPPAYALELLTIFAWEQGCRQDCFNMAQGFRTVLG
LVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKPRPLVLDPADPTWNVGHGSWELLAQEA
AALGMQACFLSRDGTSVQPWDVMPALLYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTI
CSFLKENCFRNSPIKVIKVVKGGSSAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEII
SEIRAQLEACQQERQFEVKFEVSKWENPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLV
SGSRPSSQVYVDLIHSYSNAGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKIS
KGRGSLPPQHGLELLTVYAWEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKD
KTVGDFLKQQLQKPRPIILDPADPTGNLGHNARWDLLAKEAAACTSALCCMGRNGIPIQP
WPVKAAV

External Links

GenBank ID Protein

11527773

UniProtKB/Swiss-Prot ID

Q9Y6K5

UniProtKB/Swiss-Prot Entry Name

OAS3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AB044545

GeneCard ID