Identification
HMDB Protein ID CDBP03799
Secondary Accession Numbers Not Available
Name Sex-determining region Y protein
Description Not Available
Synonyms
  1. Testis-determining factor
Gene Name SRY
Protein Type Transcription Factor
Biological Properties
General Function Involved in DNA binding
Specific Function Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'
GO Classification
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
binding
protein binding
nucleic acid binding
dna binding
sequence-specific dna binding transcription factor activity
Process
developmental process involved in reproduction
sex determination
male sex determination
reproductive process
Cellular Location
  1. Cytoplasm
  2. Nucleus speckle
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs SRY
Gene Sequence
>615 bp
ATGCAATCATATGCTTCTGCTATGTTAAGCGTATTCAACAGCGATGATTACAGTCCAGCT
GTGCAAGAGAATATTCCCGCTCTCCGGAGAAGCTCTTCCTTCCTTTGCACTGAAAGCTGT
AACTCTAAGTATCAGTGTGAAACGGGAGAAAACAGTAAAGGCAACGTCCAGGATAGAGTG
AAGCGACCCATGAACGCATTCATCGTGTGGTCTCGCGATCAGAGGCGCAAGATGGCTCTA
GAGAATCCCAGAATGCGAAACTCAGAGATCAGCAAGCAGCTGGGATACCAGTGGAAAATG
CTTACTGAAGCCGAAAAATGGCCATTCTTCCAGGAGGCACAGAAATTACAGGCCATGCAC
AGAGAGAAATACCCGAATTATAAGTATCGACCTCGTCGGAAGGCGAAGATGCTGCCGAAG
AATTGCAGTTTGCTTCCCGCAGATCCCGCTTCGGTACTCTGCAGCGAAGTGCAACTGGAC
AACAGGTTGTACAGGGATGACTGTACGAAAGCCACACACTCAAGAATGGAGCACCAGCTA
GGCCACTTACCGCCCATCAACGCAGCCAGCTCACCGCAGCAACGGGACCGCTACAGCCAC
TGGACAAAGCTGTAG
Protein Properties
Number of Residues 204
Molecular Weight 23884.0
Theoretical pI 9.91
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Sex-determining region Y protein
MQSYASAMLSVFNSDDYSPAVQENIPALRRSSSFLCTESCNSKYQCETGENSKGNVQDRV
KRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMH
REKYPNYKYRPRRKAKMLPKNCSLLPADPASVLCSEVQLDNRLYRDDCTKATHSRMEHQL
GHLPPINAASSPQQRDRYSHWTKL
GenBank ID Protein 49902356
UniProtKB/Swiss-Prot ID Q05066
UniProtKB/Swiss-Prot Entry Name SRY_HUMAN
PDB IDs
GenBank Gene ID BC074923
GeneCard ID SRY
GenAtlas ID SRY
HGNC ID HGNC:11311
References
General References Not Available