| Identification |
|---|
| HMDB Protein ID
| CDBP03799 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sex-determining region Y protein |
| Description
| Not Available |
| Synonyms
|
- Testis-determining factor
|
| Gene Name
| SRY |
| Protein Type
| Transcription Factor |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' |
| GO Classification
|
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| Function |
| binding |
| protein binding |
| nucleic acid binding |
| dna binding |
| sequence-specific dna binding transcription factor activity |
| Process |
| developmental process involved in reproduction |
| sex determination |
| male sex determination |
| reproductive process |
|
| Cellular Location
|
- Cytoplasm
- Nucleus speckle
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| SRY |
| Gene Sequence
|
>615 bp
ATGCAATCATATGCTTCTGCTATGTTAAGCGTATTCAACAGCGATGATTACAGTCCAGCT
GTGCAAGAGAATATTCCCGCTCTCCGGAGAAGCTCTTCCTTCCTTTGCACTGAAAGCTGT
AACTCTAAGTATCAGTGTGAAACGGGAGAAAACAGTAAAGGCAACGTCCAGGATAGAGTG
AAGCGACCCATGAACGCATTCATCGTGTGGTCTCGCGATCAGAGGCGCAAGATGGCTCTA
GAGAATCCCAGAATGCGAAACTCAGAGATCAGCAAGCAGCTGGGATACCAGTGGAAAATG
CTTACTGAAGCCGAAAAATGGCCATTCTTCCAGGAGGCACAGAAATTACAGGCCATGCAC
AGAGAGAAATACCCGAATTATAAGTATCGACCTCGTCGGAAGGCGAAGATGCTGCCGAAG
AATTGCAGTTTGCTTCCCGCAGATCCCGCTTCGGTACTCTGCAGCGAAGTGCAACTGGAC
AACAGGTTGTACAGGGATGACTGTACGAAAGCCACACACTCAAGAATGGAGCACCAGCTA
GGCCACTTACCGCCCATCAACGCAGCCAGCTCACCGCAGCAACGGGACCGCTACAGCCAC
TGGACAAAGCTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 204 |
| Molecular Weight
| 23884.0 |
| Theoretical pI
| 9.91 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Sex-determining region Y protein
MQSYASAMLSVFNSDDYSPAVQENIPALRRSSSFLCTESCNSKYQCETGENSKGNVQDRV
KRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMH
REKYPNYKYRPRRKAKMLPKNCSLLPADPASVLCSEVQLDNRLYRDDCTKATHSRMEHQL
GHLPPINAASSPQQRDRYSHWTKL
|
| External Links |
|---|
| GenBank ID Protein
| 49902356 |
| UniProtKB/Swiss-Prot ID
| Q05066 |
| UniProtKB/Swiss-Prot Entry Name
| SRY_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC074923 |
| GeneCard ID
| SRY |
| GenAtlas ID
| SRY |
| HGNC ID
| HGNC:11311 |
| References |
|---|
| General References
| Not Available |