| Identification |
|---|
| HMDB Protein ID
| CDBP03678 |
| Secondary Accession Numbers
| Not Available |
| Name
| Importin-4 |
| Description
| Not Available |
| Synonyms
|
- Imp4
- Imp4b
- Importin-4b
- Ran-binding protein 4
- RanBP4
|
| Gene Name
| IPO4 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS |
| GO Classification
|
| Function |
| protein transporter activity |
| transporter activity |
| substrate-specific transporter activity |
| binding |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 14q12 |
| SNPs
| IPO4 |
| Gene Sequence
|
>3246 bp
ATGGAGTCAGCCGGGCTAGAGCAGCTCCTACGGGAGCTGCTGCTACCGGACACCGAGCGC
ATCCGTCGGGCCACGGAACAGCTCCAGATCGTTCTTCGGGCCCCCGCCGCTTTGCCGGCT
CTCTGCGACCTGCTAGCCTCGGCGGCCGACCCCCAGATCCGCCAGTTTGCGGCCGTGCTG
ACCCGCAGACGACTGAACACCCGCTGGCGACGGCTGGCGGCGGAGCAACGGGAGAGCCTC
AAGTCCCTGATCCTGACGGCCCTGCAGAGAGAAACAGAGCACTGTGTGAGCCTCAGCCTG
GCCCAGCTCTCAGCCACCATTTTTCGAAAGGAAGGCTTGGAGGCCTGGCCACAGCTTTTG
CAGCTGCTTCAGCACAGTACCCACAGCCCCCACAGCCCAGAGAGAGAGATGGGGCTTTTG
CTGCTAAGTGTGGTGGTGACCTCCCGGCCCGAGGCCTTCCAACCCCACCACCGGGAGCTT
CTTCGGCTTCTGAATGAGACTCTTGGTGAGGTGGGCTCTCCTGGGCTGCTCTTCTACTCC
CTGCGCACTCTGACCACCATGGCTCCCTACCTCAGCACTGAAGATGTGCCTCTCGCTCGG
ATGTTGGTGCCCAAGCTGATCATGGCCATGCAGACTCTGATCCCCATAGATGAGGCAAAG
GCCTGTGAGGCCCTTGAGGCTTTGGATGAACTGTTGGAGTCAGAGGTGCCGGTCATCACC
CCCTACCTCTCTGAAGTCCTCACATTCTGCCTGGAGGTAGCTAGAAATGTGGCCCTGGGC
AATGCGATACGCATACGTATTCTCTGCTGCCTCACTTTCTTGGTCAAAGTCAAGAGCAAG
GCCTTACTGAAGAATCGTCTCCTGCCACCCTTGCTGCACACCCTTTTCCCCATTGTGGCT
GCTGAGCCCCCACCAGGCCAGTTGGATCCCGAGGACCAGGATTCAGAAGAGGAAGAGTTG
GAGATTGAGCTGATGGGGGAGACTCCCAAGCATTTCGCTGTACAAGTTGTGGACATGCTG
GCACTACACCTGCCCCCCGAGAAGCTCTGTCCCCAGCTGATGCCCATGTTGGAAGAGGCT
TTGCGGAGCGAGAGCCCATACCAGCGCAAAGCTGGACTCCTGGTGCTGGCCGTGCTGTCT
GACGGAGCTGGCGACCACATCAGGCAGAGACTGCTGCCCCCACTGCTGCAGATTGTGTGC
AAGGGCCTGGAGGACCCCTCGCAAGTTGTACGCAATGCTGCGCTGTTTGCCCTGGGCCAG
TTCTCAGAAAACCTACAGCCCCATATCAGCAGCTATTCAAGGGAGGTAATGCCACTGCTC
CTCGCCTACTTGAAGTCGGTGCCTCTTGGACACACACACCACCTAGCCAAGGCCTGCTAT
GCCCTGGAGAATTTTGTGGAGAACCTAGGGCCCAAGGTGCAGCCCTACCTTCCGGAGCTT
ATGGAATGCATGCTGCAGCTTCTGAGGAACCCCAGCAGTCCCCGGGCCAAGGAGCTGGCT
GTGAGCGCCCTGGGAGCCATTGCTACGGCTGCCCAGGTCTCGCTGCTGCCCTACTTCCCT
GCCATCATGGAGCACCTGCGGGAATTCCTGTTAACAGGCCGTGAGGACCTTCAGCCTGTG
CAGATCCAGAGCCTGGAGACACTGGGGGTGCTGGCACGAGCAGTGGGGGAGCCCATGAGG
CCGCTGGCTGAGGAATGCTGCCAGCTGGGTCTGGGCCTCTGCGACCAGGTAGACGACGCT
GACTTGCGGCGCTGCACGTACAGCCTATTTGCAGCCTTATCGGGTCTGATGGGTGAGGGC
CTGGCGCCCCACTTGGAACAGATCACCACGCTCATGCTGCTGTCACTGCGTTCCACCGAG
GGCATTGTGCCTCAGTATGACGGGAGCAGCTCCTTCCTTCTGTTTGACGATGAGAGTGAT
GGGGAAGAAGAGGAGGAGCTCATGGATGAGGATGTGGAAGAAGAGGATGACTCAGAGATC
TCAGGGTACAGCGTGGAGAATGCCTTCTTCGATGAGAAGGAAGACACCTGTGCTGCCGTG
GGGGAGATCTCTGTGAACACCAGTGTGGCCTTCCTTCCATACATGGAAAGTGTCTTTGAA
GAAGTATTTAAACTGCTGGAGTGCCCTCACCTGAATGTGCGGAAGGCAGCCCATGAGGCT
CTGGGTCAGTTTTGCTGTGCACTGCACAAGGCCTGTCAAAGCTGCCCCTCGGAACCCAAC
ACTGCTGCTTTGCAGGCTGCCCTGGCCCGAGTCGTGCCATCCTACATGCAGGCAGTGAAC
AGGGAGCGGGAACGCCAGGTGGTGATGGCCGTGCTGGAGGCCCTGACAGGGGTGCTCCGC
AGCTGTGGGACCCTCACACTGAAGCCCCCTGGGCGCCTCGCTGAGCTCTGTGGCGTGCTC
AAGGCTGTGCTGCAGAGGAAGACAGCCTGTCAGGATACTGACGAGGAGGAGGAAGAGGAA
GATGATGATCAGGCTGAATACGACGCCATGTTGCTGGAGCACGCTGGAGAGGCCATCCCT
GCCCTGGCAGCCGCGGCTGGGGGAGACTCCTTTGCCCCATTCTTTGCCGGTTTCCTGCCA
TTATTGGTGTGCAAGACAAAACAGGGCTGCACAGTGGCAGAGAAGTCCTTTGCAGTGGGG
ACCTTGGCAGAGACTATTCAGGGCCTGGGTGCTGCCTCAGCCCAGTTTGTGTCTCGGCTG
CTCCCTGTGCTGTTGAGCACCGCCCAAGAGGCAGACCCCGAGGTGCGAAGCAATGCCATC
TTCGGGATGGGCGTGCTGGCAGAGCATGGGGGCCACCCTGCCCAGGAACACTTCCCCAAG
CTGCTGGGGCTCCTTTTTCCCCTCCTGGCGCGGGAGCGACATGATCGTGTCCGTGACAAC
ATCTGTGGGGCACTTGCCCGCCTGTTGATGGCCAGTCCCACCAGGAAACCAGAGCCCCAG
GTGCTGGCTGCCCTACTGCATGCCCTGCCACTGAAGGAGGACTTGGAGGAGTGGGTCACC
ATTGGGCGCCTCTTCAGCTTCCTGTACCAGAGCAGCCCTGACCAGGTTATAGATGTGGCT
CCCGAGCTTCTGCGTATCTGCAGCCTCATTCTGGCTGACAACAAGATCCCACCAGACACC
AAGGCCGCACTGTTGCTGCTCCTGACGTTCCTGGCCAAACAGCACACCGACAGCTTTCAA
GCAGCTCTGGGCTCACTGCCTGTTGACAAGGCTCAGGAGCTCCAGGCTGTACTGGGCCTC
TCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1081 |
| Molecular Weight
| 118713.8 |
| Theoretical pI
| 4.6 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Importin-4
MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVL
TRRRLNTRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKEGLEAWPQLL
QLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVGSPGLLFYS
LRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDEAKACEALEALDELLESEVPVIT
PYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHTLFPIVA
AEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEA
LRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQ
FSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPEL
MECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDLQPV
QIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEG
LAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEI
SGYSVENAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEA
LGQFCCALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLR
SCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIP
ALAAAAGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRL
LPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDN
ICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVA
PELLRICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGL
S
|
| External Links |
|---|
| GenBank ID Protein
| 18700635 |
| UniProtKB/Swiss-Prot ID
| Q8TEX9 |
| UniProtKB/Swiss-Prot Entry Name
| IPO4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF411122 |
| GeneCard ID
| IPO4 |
| GenAtlas ID
| IPO4 |
| HGNC ID
| HGNC:19426 |
| References |
|---|
| General References
| Not Available |