Cannabis Compound Database: Showing Protein Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (CDBP01548)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP01548

Secondary Accession Numbers

Not Available

Name

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

Description

Not Available

Synonyms

Development and differentiation-enhancing factor 2
PAG3
PAP
Paxillin-associated protein with ARF GAP activity 3
Pyk2 C-terminus-associated protein

Gene Name

ASAP2

Protein Type

Metal Binding

Biological Properties

General Function

Involved in ARF GTPase activator activity

Specific Function

Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration

GO Classification

Function
small gtpase regulator activity
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
enzyme regulator activity
arf gtpase activator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of biological process
regulation of metabolic process
regulation of cellular metabolic process
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
regulation of nucleotide metabolic process
regulation of nucleotide catabolic process
regulation of purine nucleotide catabolic process
regulation of gtp catabolic process
regulation of gtpase activity
regulation of ras gtpase activity
regulation of arf gtpase activity
biological regulation

Cellular Location

Cell membrane
Cytoplasm
Peripheral membrane protein
Peripheral membrane protein
Golgi apparatus
Golgi stack membrane

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:2

Locus

2p25|2p24

SNPs

ASAP2

Gene Sequence

>3021 bp
ATGCCGGACCAGATCTCCGTGTCGGAATTCGTGGCCGAGACCCATGAGGACTACAAGGCG
CCCACGGCCTCCAGCTTCACCACCCGCACGGCGCAGTGCCGGAACACTGTGGCGGCCATC
GAGGAGGCTTTGGACGTGGACCGGATGGTTCTTTACAAAATGAAGAAATCCGTGAAAGCA
ATCAACAGCTCTGGGCTGGCTCACGTGGAAAATGAAGAGCAGTACACCCAGGCTCTGGAG
AAGTTTGGCGGCAACTGTGTATGCAGAGATGACCCAGATTTAGGAAGTGCGTTCCTGAAG
TTCTCAGTGTTTACAAAGGAGTTGACAGCACTTTTCAAAAACCTGATTCAGAATATGAAC
AACATAATCTCCTTCCCTTTGGACAGTTTGCTGAAGGGGGACCTGAAAGGAGTGAAAGGG
GATCTGAAAAAGCCTTTTGATAAAGCTTGGAAGGACTATGAAACAAAAATAACCAAGATA
GAAAAGGAGAAAAAGGAACACGCCAAGCTCCATGGGATGATTCGGACTGAAATAAGCGGA
GCGGAAATTGCCGAAGAGATGGAAAAGGAGAGGCGCTTCTTCCAGCTACAGATGTGCGAG
TATCTGCTGAAGGTCAACGAAATCAAGATTAAAAAGGGAGTAGATTTACTTCAGAATCTG
ATCAAATACTTTCATGCCCAATGCAATTTTTTTCAGGATGGACTCAAAGCCGTGGAAAGC
CTCAAACCTTCCATTGAAACGCTGTCTACGGATCTTCACACGATCAAACAGGCCCAGGAT
GAAGAAAGAAGGCAGTTGATACAGCTTCGAGATATTTTGAAATCCGCATTGCAGGTTGAA
CAGAAAGAGGACTCCCAAATTCGTCAGAGCACAGCTTATAGCTTACATCAGCCTCAGGGA
AACAAGGAACATGGGACCGAGCGGAACGGCAGCCTCTACAAGAAGAGTGACGGGATCCGA
AAAGTGTGGCAGAAAAGGAAATGTTCAGTTAAAAATGGTTTTCTGACCATATCCCATGGT
ACCGCTAACCGGCCTCCTGCAAAGCTCAACCTGCTAACCTGCCAGGTGAAGACCAACCCT
GAGGAGAAGAAGTGCTTTGACCTCATTTCACATGACAGAACTTACCACTTTCAAGCTGAA
GATGAACAGGAATGTCAAATATGGATGTCTGTGCTGCAAAATAGCAAAGAAGAAGCTTTA
AACAATGCATTTAAGGGGGATGACAATACTGGAGAAAATAACATCGTCCAAGAACTGACA
AAGGAGATCATCTCAGAAGTGCAGAGGATGACGGGCAATGACGTCTGCTGTGACTGTGGG
GCGCCAGATCCTACATGGCTTTCCACCAACCTGGGCATCCTGACCTGCATCGAGTGTTCC
GGAATCCACCGAGAGCTGGGGGTTCATTATTCCAGGATGCAGTCCCTGACCTTAGATGTA
CTGGGAACATCTGAGCTGCTGCTCGCCAAGAATATTGGGAATGCAGGCTTTAATGAGATC
ATGGAATGTTGCCTACCAGCTGAGGACTCAGTCAAACCCAACCCAGGCAGCGACATGAAT
GCAAGAAAGGACTACATCACAGCCAAGTACATCGAGAGGAGATACGCAAGGAAGAAGCAC
GCGGATAACGCGGCGAAGCTTCACAGTCTTTGCGAGGCCGTCAAAACGAGAGATATTTTT
GGATTGCTCCAAGCTTATGCTGATGGTGTGGATCTTACGGAAAAAATCCCACTGGCCAAC
GGACATGAGCCGGATGAAACGGCCCTCCACCTTGCAGTCAGATCCGTGGATCGAACCTCT
CTTCACATTGTAGACTTTTTAGTTCAGAACAGTGGGAACCTGGATAAACAGACAGGGAAA
GGCAGCACAGCCCTGCACTACTGCTGCCTGACCGACAATGCCGAGTGCCTCAAGTTGCTC
CTGCGGGGGAAGGCCTCCATCGAGATAGCAAACGAGTCAGGAGAGACTCCGCTGGACATT
GCCAAGCGCCTCAAGCACGAGCACTGTGAGGAGCTGCTGACCCAAGCCTTATCTGGAAGA
TTTAATTCTCACGTTCACGTTGAATATGAATGGCGACTACTCCACGAAGACCTGGATGAA
AGTGATGACGACATGGATGAGAAATTGCAGCCCAGTCCCAACCGGCGGGAAGACCGGCCC
ATCAGCTTCTACCAGCTGGGCTCCAACCAGCTTCAGTCTAACGCTGTATCTTTGGCCAGA
GATGCTGCAAACCTTGCCAAGGAGAAGCAGAGGGCTTTCATGCCCAGCATCTTGCAGAAT
GAGACTTACGGAGCCCTCCTGAGTGGCAGCCCACCTCCCGCCCAGCCTGCAGCCCCCAGC
ACCACCAGCGCCCCCCCGCTTCCTCCACGGAATGTTGGCAAAGTTCAGACAGCCTCCTCT
GCTAACACCCTGTGGAAGACAAACTCTGTAAGTGTGGACGGTGGAAGCCGGCAGCGATCT
TCGTCAGATCCGCCAGCTGTCCATCCACCGCTGCCCCCTCTTCGCGTGACATCTACCAAT
CCCCTGACCCCCACGCCGCCCCCACCCGTTGCCAAGACGCCCAGCGTAATGGAAGCCTTG
AGCCAGCCGAGCAAGCCTGCCCCGCCTGGGATCTCACAGATCAGGCCCCCACCTCTGCCC
CCACAGCCGCCCAGCCGCCTCCCGCAGAAGAAGCCTGCGCCGGGGGCTGACAAGTCCACC
CCACTGACCAACAAAGGCCAACCGAGAGGACCTGTGGATCTCTCTGCAACGGAAGCTCTG
GGTCCTCTGTCCAATGCTATGGTCCTGCAGCCCCCTGCACCCATGCCTAGGAAGTCGCAG
GCAACCAAGTTGAAGCCTAAGCGGGTGAAAGCGCTCTATAACTGTGTGGCTGACAACCCC
GATGAGCTCACCTTCTCCGAGGGGGATGTGATCATCGTGGACGGGGAGGAGGACCAGGAG
TGGTGGATTGGCCACATTGATGGAGATCCTGGTCGCAAAGGCGCATTCCCGGTGTCATTT
GTGCACTTTATCGCTGACTGA

Protein Properties

Number of Residues

1006

Molecular Weight

111649.6

Theoretical pI

6.66

Pfam Domain Function

Ank (PF00023 )
PH (PF00169 )
SH3_1 (PF00018 )
ArfGap (PF01412 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKA
INSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMN
NIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISG
AEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVES
LKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQG
NKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNP
EEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELT
KEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV
LGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKH
ADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTS
LHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDI
AKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRP
ISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPS
TTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHPPLPPLRVTSTN
PLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKST
PLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNP
DELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD

External Links

GenBank ID Protein

4502249

UniProtKB/Swiss-Prot ID

O43150

UniProtKB/Swiss-Prot Entry Name

ASAP2_HUMAN

PDB IDs