| Identification |
|---|
| HMDB Protein ID
| CDBP03821 |
| Secondary Accession Numbers
| Not Available |
| Name
| Transportin-1 |
| Description
| Not Available |
| Synonyms
|
- Importin beta-2
- Karyopherin beta-2
- M9 region interaction protein
- MIP
|
| Gene Name
| TNPO1 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in nuclear import of M9- containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, and SRP19. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev |
| GO Classification
|
| Function |
| transporter activity |
| substrate-specific transporter activity |
| binding |
| protein transporter activity |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q13.2 |
| SNPs
| TNPO1 |
| Gene Sequence
|
>2697 bp
ATGGTGTGGGACCGGCAAACCAAGATGGAGTATGAGTGGAAACCTGACGAGCAAGGGCTT
CAGCAAATCCTGCAGCTGTTGAAGGAGTCCCAGTCCCCAGACACCACCATCCAGAGAACC
GTGCAACAAAAACTGGAACAACTTAATCAGTATCCAGACTTTAACAACTACTTGATTTTT
GTTCTTACAAAATTAAAATCTGAAGATGAACCCACAAGATCATTGAGTGGTCTTATCTTG
AAGAATAATGTGAAAGCACACTTTCAGAACTTCCCAAATGGTGTAACAGACTTTATTAAA
AGTGAATGTTTAAATAATATTGGTGACTCCTCTCCTCTGATTAGAGCCACTGTTGGTATT
TTGATCACAACTATAGCCTCCAAGGGAGAATTGCAGAATTGGCCTGACCTCTTACCAAAA
CTCTGTAGCCTGTTGGATTCTGAAGATTATAATACCTGTGAGGGAGCATTTGGTGCCCTT
CAGAAGATTTGTGAAGATTCTGCTGAGATTTTAGACAGTGATGTTTTAGATCGTCCTCTC
AACATCATGATTCCCAAATTTTTACAGTTCTTCAAGCATAGTAGTCCAAAAATAAGGTCT
CACGCTGTTGCATGTGTCAATCAGTTTATCATCAGTAGGACTCAAGCTCTAATGTTGCAC
ATTGATTCTTTTATTGAGAATCTCTTTGCATTAGCTGGTGATGAAGAACCAGAGGTACGG
AAAAATGTGTGCCGAGCACTTGTGATGTTGCTCGAAGTTCGAATGGATCGCCTGCTTCCT
CACATGCATAATATAGTTGAGTACATGCTACAGAGGACTCAAGATCAAGATGAAAATGTG
GCTTTAGAAGCCTGTGAATTTTGGCTAACTTTAGCTGAACAGCCAATATGCAAAGATGTA
CTCGTAAGGCATCTTCCTAAGTTGATTCCTGTGTTAGTGAATGGCATGAAGTACTCAGAC
ATAGATATTATCCTACTTAAGGGTGATGTTGAAGAAGACGAAACGATTCCTGATAGTGAA
CAGGATATACGGCCACGTTTTCACCGATCGAGGACGGTGGCTCAGCAGCATGATGAAGAT
GGAATTGAAGAGGAAGATGATGATGATGATGAAATTGATGATGATGATACAATTTCTGAC
TGGAATCTAAGAAAATGTTCTGCTGCTGCCCTGGATGTTCTTGCAAATGTGTATCGTGAT
GAACTGCTGCCACATATTTTGCCCCTTTTGAAAGAATTACTTTTTCATCATGAATGGGTT
GTTAAAGAATCAGGCATTTTGGTTTTAGGAGCAATTGCTGAAGGTTGCATGCAGGGCATG
ATTCCATACTTGCCTGAGCTTATTCCTCACCTTATTCAGTGCCTCTCTGATAAAAAGGCT
CTTGTGCGTTCCATAACATGCTGGACTCTTAGCCGCTATGCACACTGGGTGGTCAGCCAG
CCGCCAGACACGTACCTGAAGCCATTAATGACAGAATTGCTAAAGCGCATCCTGGACAGC
AACAAGAGAGTACAAGAAGCTGCCTGCAGTGCCTTTGCTACCCTAGAAGAGGAGGCTTGT
ACAGAACTTGTTCCTTACCTTGCTTATATACTTGATACCCTGGTCTTTGCATTTAGTAAA
TACCAGCATAAGAACCTGCTCATTCTTTACGATGCCATAGGAACATTAGCAGATTCAGTA
GGACATCATTTAAACAAACCAGAATATATTCAGATGCTAATGCCTCCACTGATCCAGAAA
TGGAACATGTTAAAGGATGAAGATAAAGATCTCTTCCCTTTACTTGAGTGCCTATCTTCA
GTTGCCACAGCACTGCAGTCTGGATTCCTTCCGTACTGTGAACCTGTGTATCAGCGTTGT
GTAAACCTAGTACAGAAGACTCTTGCACAAGCCATGCTAAACAATGCTCAACCAGATCAA
TATGAAGCTCCAGATAAAGATTTTATGATAGTGGCTCTTGATTTACTGAGTGGCCTGGCT
GAAGGACTTGGAGGCAACATTGAACAGCTGGTAGCCCGAAGTAACATCCTGACACTAATG
TATCAGTGCATGCAGGATAAAATGCCAGAAGTTCGACAGAGTTCTTTTGCCCTGTTAGGT
GACCTCACAAAAGCTTGCTTTCAGCATGTTAAGCCTTGTATAGCTGATTTCATGCCAATA
TTGGGAACCAACCTAAATCCAGAATTCATTTCAGTCTGCAACAATGCCACATGGGCAATT
GGAGAAATCTCCATTCAAATGGGTATAGAGATGCAGCCTTATATTCCTATGGTGTTGCAC
CAGCTTGTAGAAATCATTAACAGACCCAACACACCAAAGACGTTGTTAGAGAATACAGCA
ATAACAATTGGTCGTCTTGGTTACGTTTGTCCTCAAGAGGTGGCCCCCATGCTACAGCAG
TTTATAAGACCCTGGTGCACCTCTCTGAGAAACATAAGAGACAATGAGGAAAAGGATTCA
GCATTCCGTGGAATTTGTACCATGATCAGTGTGAATCCCAGTGGCGTAATCCAAGATTTT
ATATTTTTTTGTGATGCCGTTGCATCATGGATTAACCCAAAAGATGATCTCAGAGACATG
TTCTGTAAGATCCTTCATGGATTTAAAAATCAAGTTGGCGATGAAAATTGGAGGCGTTTC
TCTGACCAGTTTCCTCTTCCCTTAAAAGAGCGTCTTGCAGCTTTTTATGGTGTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 898 |
| Molecular Weight
| 102354.0 |
| Theoretical pI
| 4.59 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Transportin-1
MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED
GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV
VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ
PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK
YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS
VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI
LGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTA
ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF
IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
|
| External Links |
|---|
| GenBank ID Protein
| 133925811 |
| UniProtKB/Swiss-Prot ID
| Q92973 |
| UniProtKB/Swiss-Prot Entry Name
| TNPO1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_002270.3 |
| GeneCard ID
| TNPO1 |
| GenAtlas ID
| TNPO1 |
| HGNC ID
| HGNC:6401 |
| References |
|---|
| General References
| Not Available |