Cannabis Compound Database: Showing Compound Card for Adenosine monophosphate (CDB004790)

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Record Information

Version

1.0

Created at

2020-04-17 18:37:02 UTC

Updated at

2020-12-07 19:10:56 UTC

CannabisDB ID

CDB004790

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Adenosine monophosphate

Description

Adenosine monophosphate, also known as adenylic acid or 5'-AMP, belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached. Adenosine monophosphate is a drug which is used for nutritional supplementation, also for treating dietary shortage or imbalance. Adenosine monophosphate is a strong basic compound (based on its pKa). Adenosine monophosphate exists in all living species, ranging from bacteria to humans. In humans, adenosine monophosphate is involved in the metabolic disorder called the canavan disease pathway. Outside of the human body, Adenosine monophosphate is found, on average, in the highest concentration within beers. Adenosine monophosphate has also been detected, but not quantified in, several different foods, such as spinachs, cowpea, parsley, arctic blackberries, and kumquats. This could make adenosine monophosphate a potential biomarker for the consumption of these foods. A purine ribonucleoside 5'-monophosphate having adenine as the nucleobase. Adenosine monophosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
5'-Adenosine monophosphate	ChEBI
5'-Adenylic acid	ChEBI
5'-AMP	ChEBI
5'-O-Phosphonoadenosine	ChEBI
Adenosine 5'-(dihydrogen phosphate)	ChEBI
Adenosine 5'-phosphate	ChEBI
Adenosine phosphate	ChEBI
Adenosine-5'-monophosphoric acid	ChEBI
Adenosine-5'p	ChEBI
Adenosini phosphas	ChEBI
Adenylate	ChEBI
Adenylic acid	ChEBI
Ado5'p	ChEBI
AMP	ChEBI
Fosfato de adenosina	ChEBI
pA	ChEBI
PAdo	ChEBI
Phosphate d'adenosine	ChEBI
Adenosine 5'-monophosphate	Kegg
Adenyl	Kegg
5'-Adenosine monophosphoric acid	Generator
5'-Adenylate	Generator
Adenosine 5'-(dihydrogen phosphoric acid)	Generator
Adenosine 5'-phosphoric acid	Generator
Adenosine phosphoric acid	Generator
Adenosine-5'-monophosphate	Generator
Phosphoric acid d'adenosine	Generator
Adenosine 5'-monophosphoric acid	Generator
Adenosine monophosphoric acid	Generator
Adenosine 5'-phosphorate	HMDB
Adenosine-5'-monophosphorate	HMDB
Adenosine-5-monophosphorate	HMDB
Adenosine-5-monophosphoric acid	HMDB
Adenosine-monophosphate	HMDB
Adenosine-phosphate	HMDB
Adenovite	HMDB
Cardiomone	HMDB
Lycedan	HMDB
Muscle adenylate	HMDB
Muscle adenylic acid	HMDB
My-b-den	HMDB
My-beta-den	HMDB
Phosaden	HMDB
Phosphaden	HMDB
Phosphentaside	HMDB
5'-Phosphate, adenosine	HMDB
Acid, 2'-adenylic	HMDB
2'-Adenylic acid	HMDB
Adenosine 3' phosphate	HMDB
Disodium, adenosine phosphate	HMDB
Phosphate dipotassium, adenosine	HMDB
Adenosine 2'-phosphate	HMDB
Adenosine 5' phosphate	HMDB
Adenosine phosphate dipotassium	HMDB
Dipotassium, adenosine phosphate	HMDB
2' Adenylic acid	HMDB
5' Adenylic acid	HMDB
Acid, 5'-adenylic	HMDB
Adenosine 3'-phosphate	HMDB
monoPhosphate, 2'-adenosine	HMDB
Phosphate disodium, adenosine	HMDB
2' Adenosine monophosphate	HMDB
2'-AMP	HMDB
2'-Adenosine monophosphate	HMDB
Adenosine 2' phosphate	HMDB
Adenosine phosphate disodium	HMDB

Chemical Formula

C₁₀H₁₄N₅O₇P

Average Molecular Weight

347.22

Monoisotopic Molecular Weight

347.0631

IUPAC Name

{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

Traditional Name

adenylate

CAS Registry Number

61-19-8

SMILES

NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1

InChI Identifier

InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

InChI Key

UDMBCSSLTHHNCD-KQYNXXCUSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Purine nucleotides

Sub Class

Purine ribonucleotides

Direct Parent

Purine ribonucleoside monophosphates

Alternative Parents

Substituents

Purine ribonucleoside monophosphate
Pentose phosphate
Pentose-5-phosphate
Glycosyl compound
N-glycosyl compound
6-aminopurine
Monosaccharide phosphate
Pentose monosaccharide
Imidazopyrimidine
Purine
Aminopyrimidine
Monoalkyl phosphate
Alkyl phosphate
Monosaccharide
Pyrimidine
Imidolactam
N-substituted imidazole
Organic phosphoric acid derivative
Phosphoric acid ester
Tetrahydrofuran
Azole
Imidazole
Heteroaromatic compound
Secondary alcohol
1,2-diol
Organoheterocyclic compound
Oxacycle
Azacycle
Organonitrogen compound
Primary amine
Hydrocarbon derivative
Organic oxide
Alcohol
Organopnictogen compound
Organic oxygen compound
Organic nitrogen compound
Organooxygen compound
Amine
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

adenosine 5'-phosphate (CHEBI:16027 )
purine ribonucleoside 5'-monophosphate (CHEBI:16027 )
Ribonucleotides (C00020 )

Ontology

Endogenous

Biological location:

Tissue and substructures:

Biofluid and excreta:

Subcellular:

Cell and elements:

Extracellular

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	195 °C	Not Available
Boiling Point	798.5 °C	Wikipedia
Water Solubility	10 mg/mL at 20 °C	BEILSTEIN
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-3.1	ALOGPS
logP	-4.7	ChemAxon
logS	-2	ALOGPS
pKa (Strongest Acidic)	1.22	ChemAxon
pKa (Strongest Basic)	3.92	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	10	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	186.07 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	74.07 m³·mol⁻¹	ChemAxon
Polarizability	29.96 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	Adenosine monophosphate, 5 TMS, GC-MS Spectrum	splash10-014i-0974000000-7ce25c09f93913b81e9b	Spectrum
GC-MS	Adenosine monophosphate, 4 TMS, GC-MS Spectrum	splash10-014i-0975000000-8175538459abaf92d36f	Spectrum
GC-MS	Adenosine monophosphate, non-derivatized, GC-MS Spectrum	splash10-014i-0974000000-7ce25c09f93913b81e9b	Spectrum
GC-MS	Adenosine monophosphate, non-derivatized, GC-MS Spectrum	splash10-014i-0975000000-8175538459abaf92d36f	Spectrum
Predicted GC-MS	Adenosine monophosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-002b-9713000000-019182f931e395f479cd	Spectrum
Predicted GC-MS	Adenosine monophosphate, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0gl0-4942400000-fb8ced86745a4de1b047	Spectrum
Predicted GC-MS	Adenosine monophosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TMS_2_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TMS_2_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TMS_2_6, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TMS_2_7, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TMS_2_8, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TBDMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TBDMS_2_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TBDMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Adenosine monophosphate, TBDMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-052b-0209001000-f6c3cf706bb3b839d180	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-053s-0395300000-e2a342872025e6e960ae	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-0900000000-2b9fb262817de641a5cd	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-053r-0007920000-ee7bab39079e225a1b07	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-0109000000-52331e416cbdd8218b97	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-3900000000-ddc799b6e2bb5d5ac9a6	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-0900000000-68d6660e0cfbfb8f02ad	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-0900000000-27f73c3a0a9566986a0e	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03dm-0007009001-639c5cafae90b10dfc5f	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-0290000000-e0b5612abd24736e70da	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0a4i-0039210000-3e5b716531d739ca25d9	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0002-0009000000-9232b7438abb1f6256b6	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0007-2109007000-3e1cf347bd9e054b9368	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0006-0002009000-b840e6edcca65562937b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-0190000000-948ec97ae442eda212cb	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0002-0009000000-bd1c10704f289141803a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-0002-0109000000-433eab5bd833cd92f290	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positive	splash10-000b-0709000000-fa268a51905a453bc6f5	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-002b-9104000000-bc358c1d8c03290fc49d	2012-08-31	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-0913000000-52bfdec6ec6f2f9422f4	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000i-0900000000-9bf867ba72f77732e0ce	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-000i-1900000000-fab6495d31eac8de123c	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0032-6709000000-fd9ea223f556b17d2d3a	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0059-8900000000-3937203187746280b10a	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9200000000-5947ff2a364087cb0e38	2016-09-12	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Transcription/Translation	Not Available	Not Available
Purine Metabolism
Urea Cycle
Histidine Metabolism
Ethanol Degradation		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
5'-nucleotidase	NT5E	6q14-q21	P21589	details
Cytosolic 5'-nucleotidase 1B	NT5C1B	2p24.2	Q96P26	details
Cytosolic 5'-nucleotidase 1A	NT5C1A	1p34.3-p33	Q9BXI3	details
5'(3')-deoxyribonucleotidase, cytosolic type	NT5C		Q8TCD5	details
Deoxycytidine kinase	DCK	4q13.3-q21.1	P27707	details
5'(3')-deoxyribonucleotidase, mitochondrial	NT5M		Q9NPB1	details
Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	20q11.22	Q9NR19	details
Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	20p11.23-p11.21	Q9NUB1	details
Ectonucleoside triphosphate diphosphohydrolase 1	ENTPD1	10q24	P49961	details
Soluble calcium-activated nucleotidase 1	CANT1	17q25.3	Q8WVQ1	details
Ectonucleoside triphosphate diphosphohydrolase 3	ENTPD3	3p21.3	O75355	details
Serum paraoxonase/lactonase 3	PON3	7q21.3	Q15166	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3	6q22	O14638	details
Phenylalanine--tRNA ligase alpha subunit	FARSA	19p13.2	Q9Y285	details
Phenylalanine--tRNA ligase, mitochondrial	FARS2	6p25.1	O95363	details
Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	5q31	P49419	details
3'(2'),5'-bisphosphate nucleotidase 1	BPNT1	1q41	O95861	details
ADP-dependent glucokinase	ADPGK	15q24.1	Q9BRR6	details
Glycogen phosphorylase, liver form	PYGL	14q21-q22	P06737	details
Glycogen phosphorylase, muscle form	PYGM	11q12-q13.2	P11217	details
Glycogen phosphorylase, brain form	PYGB	20p11.21	P11216	details
Adenine phosphoribosyltransferase	APRT	16q24	P07741	details
Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	Xq26.1	P00492	details
Biotin--protein ligase	HLCS	21q22.13	P50747	details
Phenylalanine--tRNA ligase beta subunit	FARSB	2q36.1	Q9NSD9	details
Ubiquitin-conjugating enzyme E2 A	UBE2A	Xq24	P49459	details
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	12p13	Q13956	details
Adenylate kinase isoenzyme 1	AK1	9q34.1	P00568	details
NEDD8-conjugating enzyme Ubc12	UBE2M	19q13.43	P61081	details
Ubiquitin/ISG15-conjugating enzyme E2 L6	UBE2L6	11q12	O14933	details
Glycine--tRNA ligase	GARS	7p15	P41250	details
Ribose-phosphate pyrophosphokinase 3	PRPS1L1	7p21.1	P21108	details
Bifunctional glutamate/proline--tRNA ligase	EPRS	1q41	P07814	details
Long-chain-fatty-acid--CoA ligase 4	ACSL4	Xq22.3-q23	O60488	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	2q32.1	P54750	details
GTP:AMP phosphotransferase, mitochondrial	AK3	9p24.1	Q9UIJ7	details
Tryptophan--tRNA ligase, cytoplasmic	WARS	14q32.31	P23381	details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	15q25.3	O60658	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	12q13	Q01064	details
Long-chain-fatty-acid--CoA ligase 1	ACSL1	4q35	P33121	details
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	PDE3B	11p15.1	Q13370	details
Ubiquitin-conjugating enzyme E2 G1	UBE2G1	17p13.2	P62253	details
Glutamine--tRNA ligase	QARS	3p21.31	P47897	details
Threonine--tRNA ligase, cytoplasmic	TARS	5p13.2	P26639	details
Asparagine synthetase [glutamine-hydrolyzing]	ASNS	7q21.3	P08243	details
Ubiquitin-conjugating enzyme E2 E2	UBE2E2	3p24.2	Q96LR5	details
Adenylosuccinate lyase	ADSL	22q13.2	P30566	details
Adenylate kinase isoenzyme 4, mitochondrial	AK4	1p31.3	P27144	details
Ubiquitin-conjugating enzyme E2 D2	UBE2D2	5q31.2	P62837	details
DNA ligase 4	LIG4	13q33-q34	P49917	details
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	8q13	Q13946	details
Arginine--tRNA ligase, cytoplasmic	RARS	5q35.1	P54136	details
GMP synthase [glutamine-hydrolyzing]	GMPS	3q24	P49915	details
Ubiquitin-conjugating enzyme E2 B	UBE2B	5q31.1	P63146	details
Probable leucine--tRNA ligase, mitochondrial	LARS2	3p21.3	Q15031	details
AMP deaminase 3	AMPD3	11p15	Q01432	details
Ubiquitin-conjugating enzyme E2 J2	UBE2J2	1p36.33	Q8N2K1	details
AMP deaminase 2	AMPD2	1p13.3	Q01433	details
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	12p12	Q14432	details
Ubiquitin-conjugating enzyme E2 L3	UBE2L3	22q11.21	P68036	details
RNA 3'-terminal phosphate cyclase	RTCA	1p21.2	O00442	details
Adenylate kinase 7	AK7	14q32.2	Q96M32	details
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	6q26	Q9Y233	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	PDE1C	7p14.3	Q14123	details
Tyrosine--tRNA ligase, cytoplasmic	YARS	1p35.1	P54577	details
DNA ligase 3	LIG3	17q11.2-q12	P49916	details
Aspartate--tRNA ligase, cytoplasmic	DARS	2q21.3	P14868	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	1p31	Q07343	details
Ubiquitin-conjugating enzyme E2 D3	UBE2D3	4q24	P61077	details
Asparagine--tRNA ligase, cytoplasmic	NARS	18q21.31	O43776	details
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	6q23-q24	Q9NP56	details
Lysine--tRNA ligase	KARS	16q23.1	Q15046	details
Isoleucine--tRNA ligase, cytoplasmic	IARS	9q21	P41252	details
Bis(5'-adenosyl)-triphosphatase	FHIT	3p14.2	P49789	details
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	PDE9A	21q22.3	O76083	details
cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	11q13.4	O00408	details
Ubiquitin-like modifier-activating enzyme 1	UBA1		P22314	details
Tyrosine--tRNA ligase, mitochondrial	YARS2	12p11.21	Q9Y2Z4	details
Ubiquitin-conjugating enzyme E2 E1	UBE2E1	3p24.2	P51965	details
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]	NUDT2	9p13	P50583	details
Long-chain-fatty-acid--CoA ligase 6	ACSL6	5q31	Q9UKU0	details
Methionine--tRNA ligase, cytoplasmic	MARS	12q13	P56192	details
Alanine--tRNA ligase, cytoplasmic	AARS	16q22	P49588	details
Tryptophan--tRNA ligase, mitochondrial	WARS2	1p12	Q9UGM6	details
ADP-sugar pyrophosphatase	NUDT5	10p14	Q9UKK9	details
Ribose-phosphate pyrophosphokinase 1	PRPS1	Xq21.32-q24	P60891	details
Serine--tRNA ligase, mitochondrial	SARS2	19q13.2	Q9NP81	details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	5q13.3	O95263	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	19p13.11	Q08493	details
Ribose-phosphate pyrophosphokinase 2	PRPS2	Xp22.2	P11908	details
Thiamin pyrophosphokinase 1	TPK1	7q34-q35	Q9H3S4	details
SUMO-conjugating enzyme UBC9	UBE2I	16p13.3	P63279	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	5q12	Q08499	details
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	17q25	P18545	details
ADP-ribose pyrophosphatase, mitochondrial	NUDT9	4q22.1	Q9BW91	details
Adenosine kinase	ADK	10q11-q24	P55263	details
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	PDE6D	2q35-q36	O43924	details
Probable histidine--tRNA ligase, mitochondrial	HARS2	5q31.3	P49590	details
Ubiquitin-conjugating enzyme E2 J1	UBE2J1	6q15	Q9Y385	details
Long-chain-fatty-acid--CoA ligase 5	ACSL5	10q25.1-q25.2	Q9ULC5	details
Histidine--tRNA ligase, cytoplasmic	HARS	5q31.3	P12081	details
Serine--tRNA ligase, cytoplasmic	SARS	1p13.3	P49591	details
Long-chain-fatty-acid--CoA ligase 3	ACSL3	2q34-q35	O95573	details
Leucine--tRNA ligase, cytoplasmic	LARS	5q32	Q9P2J5	details
Ubiquitin-conjugating enzyme E2 C	UBE2C	20q13.12	O00762	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	19p13.2	P27815	details
Valine--tRNA ligase	VARS	6p21.3	P26640	details
Adenylate kinase isoenzyme 5	AK5	1p31	Q9Y6K8	details
Selenide, water dikinase 1	SEPHS1	10p14	P49903	details
Ubiquitin-conjugating enzyme E2 N	UBE2N	12q22	P61088	details
cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	4q27	O76074	details
Argininosuccinate synthase	ASS1	9q34.1	P00966	details
AMP deaminase 1	AMPD1	1p13	P23109	details
Selenide, water dikinase 2	SEPHS2	16p11.2	Q99611	details
DNA ligase 1	LIG1	19q13.2-q13.3	P18858	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
Very long-chain acyl-CoA synthetase	SLC27A2	15q21.2	O14975	details
Adenylyltransferase and sulfurtransferase MOCS3	MOCS3	20q13.13	O95396	details
E3 ubiquitin-protein ligase NEDD4-like	NEDD4L	18q21	Q96PU5	details
E3 ubiquitin-protein ligase Mdm2	MDM2	12q14.3-q15	Q00987	details
Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)	DAK	11q12.2	Q3LXA3	details
Phosphopantothenate--cysteine ligase	PPCS	1p34.2	Q9HAB8	details
Bile acyl-CoA synthetase	SLC27A5	19q13.43	Q9Y2P5	details
Cytosolic 5'-nucleotidase 3	NT5C3	7p14.3	Q9H0P0	details
Glutamine-dependent NAD(+) synthetase	NADSYN1	11q13.4	Q6IA69	details
Cytosolic purine 5'-nucleotidase	NT5C2	10q24.32	P49902	details
Adenylate kinase 2, mitochondrial	AK2	1p34	P54819	details
Acetoacetyl-CoA synthetase	AACS	12q24.31	Q86V21	details
Acyl-coenzyme A synthetase ACSM1, mitochondrial	ACSM1	16p12.3	Q08AH1	details
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	2q31.2	Q9HCR9	details
Probable arginine--tRNA ligase, mitochondrial	RARS2	6q16.1	Q5T160	details
Probable cysteine--tRNA ligase, mitochondrial	CARS2	13q34	Q9HA77	details
Probable glutamate--tRNA ligase, mitochondrial	EARS2	16p12.2	Q5JPH6	details
Acyl-CoA synthetase family member 4	AASDH	4q12	Q4L235	details
Peroxisomal NADH pyrophosphatase NUDT12	NUDT12	5q21.2	Q9BQG2	details
ACSS2 protein	ACSS2	20q11.22	Q96FY7	details
Valine--tRNA ligase, mitochondrial	VARS2	6p21.33	Q5ST30	details
E3 ubiquitin-protein ligase CBL	CBL	11q23.3	P22681	details
Ectonucleoside triphosphate diphosphohydrolase 8	ENTPD8	9q34.3	Q5MY95	details
Acyl-coenzyme A synthetase ACSM6, mitochondrial	ACSM6	10q23.33	Q6P461	details
Probable E3 ubiquitin-protein ligase HERC1	HERC1	15q22	Q15751	details
E3 ubiquitin-protein ligase HERC2	HERC2	15q13	O95714	details
Acyl-coenzyme A synthetase ACSM2A, mitochondrial	ACSM2A	16p12.3	Q08AH3	details
Acyl-coenzyme A synthetase ACSM2B, mitochondrial	ACSM2B	16p12.3	Q68CK6	details
Acyl-coenzyme A synthetase ACSM3, mitochondrial	ACSM3	16p13.11	Q53FZ2	details
Acyl-coenzyme A synthetase ACSM5, mitochondrial	ACSM5	16p12.3	Q6NUN0	details
Inositol monophosphatase 3	IMPAD1	8q12.1	Q9NX62	details
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha	NUDT10	Xp11.23	Q8NFP7	details
Diphosphoinositol polyphosphate phosphohydrolase 3-beta	NUDT11	Xp11.22	Q96G61	details
Carnosine synthase 1	CARNS1	11q13.2	A5YM72	details
Acyl-coenzyme A synthetase ACSM4, mitochondrial	ACSM4	12p13.31	P0C7M7	details
Probable threonine--tRNA ligase 2, cytoplasmic	TARSL2	15q26.3	A2RTX5	details
Threonine--tRNA ligase, mitochondrial	TARS2	1q21.3	Q9BW92	details
Methionine--tRNA ligase, mitochondrial	MARS2	2q33.1	Q96GW9	details
Aspartate--tRNA ligase, mitochondrial	DARS2	1q25.1	Q6PI48	details
Cysteine--tRNA ligase, cytoplasmic	CARS	11p15.5	P49589	details
FARSLA protein	FARSLA		Q6IBR2	details
Probable asparagine--tRNA ligase, mitochondrial	NARS2	11q14.1	Q96I59	details
SUMO-activating enzyme subunit 2	UBA2	19q12	Q9UBT2	details
E3 ubiquitin-protein ligase HUWE1	HUWE1		Q7Z6Z7	details
E3 ubiquitin-protein ligase Topors	TOPORS	9p21	Q9NS56	details
STIP1 homology and U-box containing protein 1 (STIP1 homology and U- box containing protein 1, isoform CRA_c)	STUB1	16p13.3	Q9UNE7	details
Ubiquitin conjugation factor E4 B	UBE4B	1p36.3	O95155	details
Membrane-associated ring finger (C3HC4) 6 (Membrane-associated ring finger (C3HC4) 6, isoform CRA_a)	MARCH6		O60337	details
TGIF-interacting ubiquitin ligase 1			Q9H0M0	details
NEDD4-like E3 ubiquitin-protein ligase WWP2	WWP2	16q22.1	O00308	details
E3 ubiquitin-protein ligase MARCH3	MARCH3	5q23.2	Q86UD3	details
NEDD8-conjugating enzyme UBE2F	UBE2F	2q37.3	Q969M7	details
Ubiquitin-conjugating enzyme E2 U	UBE2U	1p31.3	Q5VVX9	details
Probable E3 ubiquitin-protein ligase MARCH10	MARCH10	17q23.2	Q8NA82	details
E3 ubiquitin-protein ligase UBR1	UBR1	15q13	Q8IWV7	details
E3 ubiquitin-protein ligase MARCH8	MARCH8	10q11.21	Q5T0T0	details
E3 ubiquitin-protein ligase ZNRF2	ZNRF2	7p14.3	Q8NHG8	details
E3 ubiquitin-protein ligase TRIM32	TRIM32	9q33.1	Q13049	details
Probable E3 ubiquitin-protein ligase MYCBP2	MYCBP2	13q22	O75592	details
E3 ubiquitin-protein ligase MGRN1	MGRN1	16p13.3	O60291	details
E3 ubiquitin-protein ligase UBR2	UBR2	6p21.1	Q8IWV8	details
E3 ubiquitin-protein ligase UBR4	UBR4	1p36.13	Q5T4S7	details
E3 ubiquitin-protein ligase AMFR	AMFR	16q21	Q9UKV5	details
Ubiquitin-conjugating enzyme E2 S	UBE2S	19q13.43	Q16763	details
Pre-mRNA-processing factor 19	PRPF19	11q12.2	Q9UMS4	details
Myosin regulatory light chain interacting protein (Myosin regulatory light chain interacting protein, isoform CRA_a)	MYLIP		Q8WY64	details
HNP95	hNp95		Q96T88	details
Putative ubiquitin-conjugating enzyme E2 N-like	UBE2NL		Q5JXB2	details
Midline-1	MID1		O15344	details
E3 ubiquitin-protein ligase NEDD4	NEDD4	15q	P46934	details
CCR4-NOT transcription complex subunit 4	CNOT4	7q22-qter	O95628	details
E3 ubiquitin-protein ligase MARCH2	MARCH2	19p13.2	Q9P0N8	details
E3 ubiquitin-protein ligase UBR5	UBR5	8q22	O95071	details
E3 ubiquitin-protein ligase TRIM33	TRIM33	1p13.1	Q9UPN9	details
E3 ubiquitin-protein ligase MARCH5	MARCH5	10q23.32-q23.33	Q9NX47	details
Ubiquitin-conjugating enzyme E2 R2	UBE2R2	9p13.3	Q712K3	details
E3 ubiquitin-protein ligase MARCH1	MARCH1	4q32.2	Q8TCQ1	details
E3 ubiquitin-protein ligase FANCL	FANCL	2p16.1	Q9NW38	details
Ubiquitin-like modifier-activating enzyme 6	UBA6	4q13.2	A0AVT1	details
Ubiquitin-conjugating enzyme E2 W	UBE2W	8q21.11	Q96B02	details
Galactosyl transferase-associated protein	GTAP		Q29SN7	details
E3 ubiquitin-protein ligase CHFR	CHFR	12q24.33	Q96EP1	details
Ring finger protein 20	RNF20		Q5VTR2	details
E3 ubiquitin-protein ligase RAD18	RAD18	3p25-p24	Q9NS91	details
E3 ubiquitin ligase SMURF1	SMURF1	7q22.1	Q9HCE7	details
Baculoviral IAP repeat-containing protein 6	BIRC6	2p22.3	Q9NR09	details
E3 ubiquitin-protein ligase MARCH4	MARCH4	2q35	Q9P2E8	details
E3 ubiquitin-protein ligase CCNB1IP1	CCNB1IP1	14q11.2	Q9NPC3	details
E3 ubiquitin-protein ligase RNF5	RNF5	6p21.3	Q99942	details
Ubiquitin-conjugating enzyme E2 O	UBE2O	17q25.1	Q9C0C9	details
Praja 1	PJA1		A2A322	details
RFWD2 protein	RFWD2	1q25.1-q25.2	Q05CT6	details
E3 ubiquitin-protein ligase SMURF2	SMURF2	17q22-q23	Q9HAU4	details
E3 ubiquitin-protein ligase SIAH1	SIAH1	16q12	Q8IUQ4	details
E3 ubiquitin-protein ligase SIAH2	SIAH2	3q25	O43255	details
E3 ubiquitin-protein ligase MARCH7	MARCH7	2q24.2	Q9H992	details
Ubiquitin-conjugating enzyme E2 Z	UBE2Z	17q21.32	Q9H832	details
Ubiquitin-like modifier-activating enzyme 7	UBA7	3p21	P41226	details
Ubiquitin carrier protein	UBE2H	7q32	A4D1L5	details
Ubiquitin-protein ligase E3A	UBE3A	15q11.2	Q05086	details
E3 ubiquitin-protein ligase RNF128	RNF128		Q8TEB7	details
E3 ubiquitin-protein ligase TRIM11	TRIM11	1q42.13	Q96F44	details
BRCA1 associated protein variant			Q59H81	details
E3 ubiquitin-protein ligase synoviolin	SYVN1	11q13	Q86TM6	details
E3 ubiquitin-protein ligase TRIM63	TRIM63	1p34-p33	Q969Q1	details
E3 ubiquitin-protein ligase LNX	LNX1	4q12	Q8TBB1	details
E3 ubiquitin-protein ligase ZNRF1	ZNRF1	16q23.1	Q8ND25	details
Tripartite motif-containing protein 5	TRIM5	11p15	Q9C035	details
Ubiquitin-protein ligase E3B	UBE3B	12q24.11	Q7Z3V4	details
E3 ubiquitin-protein ligase RNF8	RNF8	6p21.3	O76064	details
E3 ubiquitin-protein ligase LRSAM1	LRSAM1	9q33.3	Q6UWE0	details
Ubiquitin-conjugating enzyme E2 Q2	UBE2Q2	15q24.2	Q8WVN8	details
E3 ubiquitin-protein ligase MARCH9	MARCH9	12q14.1	Q86YJ5	details
Probable E3 ubiquitin-protein ligase TRIP12	TRIP12	2q36.3	Q14669	details
E3 ubiquitin-protein ligase DZIP3	DZIP3	3q13.13	Q86Y13	details
Ubiquitin-protein ligase E3C	UBE3C	7q36.3	Q15386	details
Alanine--tRNA ligase, mitochondrial	AARS2	6p21.1	Q5JTZ9	details
Isoleucine--tRNA ligase, mitochondrial	IARS2	1q41	Q9NSE4	details
Lipoyltransferase 1, mitochondrial	LIPT1	2q11.2	Q9Y234	details
Probable proline--tRNA ligase, mitochondrial	PARS2	1p32.2	Q7L3T8	details
Long-chain-fatty-acid--CoA ligase ACSBG2	ACSBG2	19p13.3	Q5FVE4	details
Long-chain-fatty-acid--CoA ligase ACSBG1	ACSBG1	15q23-q24	Q96GR2	details
E3 ubiquitin-protein ligase MIB1	MIB1	18q11.2	Q86YT6	details
E3 ubiquitin-protein ligase RNF138	RNF138	18q12.1	Q8WVD3	details
E3 ubiquitin-protein ligase RING2	RNF2	1q25.3	Q99496	details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	AASDHPPT	11q22	Q9NRN7	details
SUMO-activating enzyme subunit 1	SAE1	19q13.32	Q9UBE0	details
Ubiquitin-conjugating enzyme E2 D4	UBE2D4	7p13	Q9Y2X8	details
Ubiquitin conjugation factor E4 A	UBE4A	11q23.3	Q14139	details
E3 ubiquitin-protein ligase RNF144B	RNF144B	6p22.3	Q7Z419	details
Acyl-CoA synthetase short-chain family member 3, mitochondrial	ACSS3	12q21.31	Q9H6R3	details
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase	ADPRM	17p13.1	Q3LIE5	details
Adenylate kinase isoenzyme 6	TAF9	5q11.2-q13.1	Q9Y3D8	details
Adenylate kinase 8	AK8	9q34.13	Q96MA6	details
tRNA-splicing ligase RtcB homolog	C22orf28	22q12	Q9Y3I0	details
Probable tRNA(His) guanylyltransferase	THG1L	5q33.3	Q9NWX6	details
E3 ubiquitin/ISG15 ligase TRIM25	TRIM25	17q23.2	Q14258	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Very long-chain acyl-CoA synthetase	SLC27A2	15q21.2	O14975	details
Transient receptor potential cation channel subfamily M member 2	TRPM2	21q22.3	O94759	details
Bile acyl-CoA synthetase	SLC27A5	19q13.43	Q9Y2P5	details
Acyl-CoA synthetase family member 4	AASDH	4q12	Q4L235	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
5'-nucleotidase	NT5E	6q14-q21	P21589	details
Cytosolic 5'-nucleotidase 1B	NT5C1B	2p24.2	Q96P26	details
Cytosolic 5'-nucleotidase 1A	NT5C1A	1p34.3-p33	Q9BXI3	details
5'(3')-deoxyribonucleotidase, cytosolic type	NT5C		Q8TCD5	details
5'(3')-deoxyribonucleotidase, mitochondrial	NT5M		Q9NPB1	details
Soluble calcium-activated nucleotidase 1	CANT1	17q25.3	Q8WVQ1	details
Serum paraoxonase/lactonase 3	PON3	7q21.3	Q15166	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3	6q22	O14638	details
Phenylalanine--tRNA ligase, mitochondrial	FARS2	6p25.1	O95363	details
ADP-dependent glucokinase	ADPGK	15q24.1	Q9BRR6	details
Phenylalanine--tRNA ligase beta subunit	FARSB	2q36.1	Q9NSD9	details
Ribose-phosphate pyrophosphokinase 3	PRPS1L1	7p21.1	P21108	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	2q32.1	P54750	details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	15q25.3	O60658	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	12q13	Q01064	details
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	PDE3B	11p15.1	Q13370	details
DNA ligase 4	LIG4	13q33-q34	P49917	details
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	8q13	Q13946	details
AMP deaminase 3	AMPD3	11p15	Q01432	details
AMP deaminase 2	AMPD2	1p13.3	Q01433	details
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	12p12	Q14432	details
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	6q26	Q9Y233	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	PDE1C	7p14.3	Q14123	details
DNA ligase 3	LIG3	17q11.2-q12	P49916	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	1p31	Q07343	details
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	6q23-q24	Q9NP56	details
Lysine--tRNA ligase	KARS	16q23.1	Q15046	details
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	PDE9A	21q22.3	O76083	details
cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	11q13.4	O00408	details
Alanine--tRNA ligase, cytoplasmic	AARS	16q22	P49588	details
Ribose-phosphate pyrophosphokinase 1	PRPS1	Xq21.32-q24	P60891	details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	5q13.3	O95263	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	19p13.11	Q08493	details
Ribose-phosphate pyrophosphokinase 2	PRPS2	Xp22.2	P11908	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	5q12	Q08499	details
Adenosine kinase	ADK	10q11-q24	P55263	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	19p13.2	P27815	details
cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	4q27	O76074	details
AMP deaminase 1	AMPD1	1p13	P23109	details
DNA ligase 1	LIG1	19q13.2-q13.3	P18858	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
Adenylyltransferase and sulfurtransferase MOCS3	MOCS3	20q13.13	O95396	details
E3 ubiquitin-protein ligase Mdm2	MDM2	12q14.3-q15	Q00987	details
Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)	DAK	11q12.2	Q3LXA3	details
Gephyrin	GPHN	14q23.3	Q9NQX3	details
Cytosolic 5'-nucleotidase 3	NT5C3	7p14.3	Q9H0P0	details
Cytosolic purine 5'-nucleotidase	NT5C2	10q24.32	P49902	details
Acyl-coenzyme A synthetase ACSM1, mitochondrial	ACSM1	16p12.3	Q08AH1	details
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	2q31.2	Q9HCR9	details
Probable cysteine--tRNA ligase, mitochondrial	CARS2	13q34	Q9HA77	details
Peroxisomal NADH pyrophosphatase NUDT12	NUDT12	5q21.2	Q9BQG2	details
E3 ubiquitin-protein ligase CBL	CBL	11q23.3	P22681	details
Signal transduction protein CBL-C	CBLC	19q13.2	Q9ULV8	details
Acyl-coenzyme A synthetase ACSM6, mitochondrial	ACSM6	10q23.33	Q6P461	details
E3 ubiquitin-protein ligase HERC2	HERC2	15q13	O95714	details
Acyl-coenzyme A synthetase ACSM2A, mitochondrial	ACSM2A	16p12.3	Q08AH3	details
Acyl-coenzyme A synthetase ACSM2B, mitochondrial	ACSM2B	16p12.3	Q68CK6	details
Acyl-coenzyme A synthetase ACSM3, mitochondrial	ACSM3	16p13.11	Q53FZ2	details
Acyl-coenzyme A synthetase ACSM5, mitochondrial	ACSM5	16p12.3	Q6NUN0	details
Inositol monophosphatase 3	IMPAD1	8q12.1	Q9NX62	details
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha	NUDT10	Xp11.23	Q8NFP7	details
Diphosphoinositol polyphosphate phosphohydrolase 3-beta	NUDT11	Xp11.22	Q96G61	details
Carnosine synthase 1	CARNS1	11q13.2	A5YM72	details
Acyl-coenzyme A synthetase ACSM4, mitochondrial	ACSM4	12p13.31	P0C7M7	details
Cysteine--tRNA ligase, cytoplasmic	CARS	11p15.5	P49589	details
E3 ubiquitin-protein ligase Topors	TOPORS	9p21	Q9NS56	details
Membrane-associated ring finger (C3HC4) 6 (Membrane-associated ring finger (C3HC4) 6, isoform CRA_a)	MARCH6		O60337	details
E3 ubiquitin-protein ligase MARCH3	MARCH3	5q23.2	Q86UD3	details
Probable E3 ubiquitin-protein ligase MARCH10	MARCH10	17q23.2	Q8NA82	details
E3 ubiquitin-protein ligase UBR1	UBR1	15q13	Q8IWV7	details
E3 ubiquitin-protein ligase MARCH8	MARCH8	10q11.21	Q5T0T0	details
E3 ubiquitin-protein ligase ZNRF2	ZNRF2	7p14.3	Q8NHG8	details
E3 ubiquitin-protein ligase TRIM32	TRIM32	9q33.1	Q13049	details
Probable E3 ubiquitin-protein ligase MYCBP2	MYCBP2	13q22	O75592	details
E3 ubiquitin-protein ligase MGRN1	MGRN1	16p13.3	O60291	details
E3 ubiquitin-protein ligase UBR2	UBR2	6p21.1	Q8IWV8	details
E3 ubiquitin-protein ligase UBR4	UBR4	1p36.13	Q5T4S7	details
E3 ubiquitin-protein ligase AMFR	AMFR	16q21	Q9UKV5	details
Myosin regulatory light chain interacting protein (Myosin regulatory light chain interacting protein, isoform CRA_a)	MYLIP		Q8WY64	details
HNP95	hNp95		Q96T88	details
Midline-1	MID1		O15344	details
CCR4-NOT transcription complex subunit 4	CNOT4	7q22-qter	O95628	details
E3 ubiquitin-protein ligase MARCH2	MARCH2	19p13.2	Q9P0N8	details
E3 ubiquitin-protein ligase UBR5	UBR5	8q22	O95071	details
E3 ubiquitin-protein ligase TRIM33	TRIM33	1p13.1	Q9UPN9	details
E3 ubiquitin-protein ligase MARCH5	MARCH5	10q23.32-q23.33	Q9NX47	details
E3 ubiquitin-protein ligase MARCH1	MARCH1	4q32.2	Q8TCQ1	details
E3 ubiquitin-protein ligase FANCL	FANCL	2p16.1	Q9NW38	details
E3 ubiquitin-protein ligase CHFR	CHFR	12q24.33	Q96EP1	details
E3 ubiquitin-protein ligase RAD18	RAD18	3p25-p24	Q9NS91	details
E3 ubiquitin-protein ligase MARCH4	MARCH4	2q35	Q9P2E8	details
E3 ubiquitin-protein ligase RNF5	RNF5	6p21.3	Q99942	details
Praja 1	PJA1		A2A322	details
RFWD2 protein	RFWD2	1q25.1-q25.2	Q05CT6	details
E3 ubiquitin-protein ligase SIAH1	SIAH1	16q12	Q8IUQ4	details
E3 ubiquitin-protein ligase SIAH2	SIAH2	3q25	O43255	details
E3 ubiquitin-protein ligase MARCH7	MARCH7	2q24.2	Q9H992	details
E3 ubiquitin-protein ligase RNF128	RNF128		Q8TEB7	details
E3 ubiquitin-protein ligase TRIM11	TRIM11	1q42.13	Q96F44	details
BRCA1 associated protein variant			Q59H81	details
E3 ubiquitin-protein ligase synoviolin	SYVN1	11q13	Q86TM6	details
E3 ubiquitin-protein ligase TRIM63	TRIM63	1p34-p33	Q969Q1	details
E3 ubiquitin-protein ligase LNX	LNX1	4q12	Q8TBB1	details
E3 ubiquitin-protein ligase ZNRF1	ZNRF1	16q23.1	Q8ND25	details
Tripartite motif-containing protein 5	TRIM5	11p15	Q9C035	details
E3 ubiquitin-protein ligase RNF8	RNF8	6p21.3	O76064	details
E3 ubiquitin-protein ligase LRSAM1	LRSAM1	9q33.3	Q6UWE0	details
E3 ubiquitin-protein ligase MARCH9	MARCH9	12q14.1	Q86YJ5	details
E3 ubiquitin-protein ligase DZIP3	DZIP3	3q13.13	Q86Y13	details
Alanine--tRNA ligase, mitochondrial	AARS2	6p21.1	Q5JTZ9	details
E3 ubiquitin-protein ligase MIB1	MIB1	18q11.2	Q86YT6	details
E3 ubiquitin-protein ligase RNF138	RNF138	18q12.1	Q8WVD3	details
E3 ubiquitin-protein ligase RING2	RNF2	1q25.3	Q99496	details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	AASDHPPT	11q22	Q9NRN7	details
E3 ubiquitin-protein ligase RNF144B	RNF144B	6p22.3	Q7Z419	details
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase	ADPRM	17p13.1	Q3LIE5	details
tRNA-splicing ligase RtcB homolog	C22orf28	22q12	Q9Y3I0	details
E3 ubiquitin/ISG15 ligase TRIM25	TRIM25	17q23.2	Q14258	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3	6q22	O14638	details
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	12p13	Q13956	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	2q32.1	P54750	details
Ubiquitin-conjugating enzyme E2 D1	UBE2D1	10q21.1	P51668	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	12q13	Q01064	details
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	PDE3B	11p15.1	Q13370	details
DNA ligase 4	LIG4	13q33-q34	P49917	details
Ubiquitin-conjugating enzyme E2 B	UBE2B	5q31.1	P63146	details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	PDE1C	7p14.3	Q14123	details
Tyrosine--tRNA ligase, cytoplasmic	YARS	1p35.1	P54577	details
Ubiquitin-conjugating enzyme E2 D3	UBE2D3	4q24	P61077	details
SUMO-conjugating enzyme UBC9	UBE2I	16p13.3	P63279	details
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	17q25	P18545	details
Ubiquitin-conjugating enzyme E2 N	UBE2N	12q22	P61088	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
Transient receptor potential cation channel subfamily M member 2	TRPM2	21q22.3	O94759	details
E3 ubiquitin-protein ligase CBL	CBL	11q23.3	P22681	details
Signal transduction protein CBL-C	CBLC	19q13.2	Q9ULV8	details
E3 ubiquitin-protein ligase LRSAM1	LRSAM1	9q33.3	Q6UWE0	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ubiquitin-conjugating enzyme E2 D1	UBE2D1	10q21.1	P51668	details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	15q25.3	O60658	details
Ubiquitin-conjugating enzyme E2 D2	UBE2D2	5q31.2	P62837	details
Ubiquitin-conjugating enzyme E2 L3	UBE2L3	22q11.21	P68036	details
Ubiquitin-conjugating enzyme E2 D3	UBE2D3	4q24	P61077	details
cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	11q13.4	O00408	details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	5q13.3	O95263	details
SUMO-conjugating enzyme UBC9	UBE2I	16p13.3	P63279	details
Ubiquitin-conjugating enzyme E2 N	UBE2N	12q22	P61088	details
DNA ligase 1	LIG1	19q13.2-q13.3	P18858	details
Cyclic AMP-responsive element-binding protein 1	CREB1	2q34	P16220	details
E3 ubiquitin/ISG15 ligase TRIM25	TRIM25	17q23.2	Q14258	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000045

DrugBank ID

DB00131

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

16027

References

General References

Not Available

Only showing the first 10 proteins. There are 409 proteins in total.

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Enzymes

Enzyme Details

1. 5'-nucleotidase

General function:: Involved in hydrolase activity
Specific function:: Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
Gene Name:: NT5E
Uniprot ID:: P21589
Molecular weight:: 57948.125

Enzyme Details

2. Cytosolic 5'-nucleotidase 1B

General function:: Involved in nucleotide binding
Specific function:: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).
Gene Name:: NT5C1B
Uniprot ID:: Q96P26
Molecular weight:: 68803.055

Enzyme Details

3. Cytosolic 5'-nucleotidase 1A

General function:: Involved in nucleotide binding
Specific function:: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
Gene Name:: NT5C1A
Uniprot ID:: Q9BXI3
Molecular weight:: 41020.145

Enzyme Details

4. 5'(3')-deoxyribonucleotidase, cytosolic type

General function:: Involved in metal ion binding
Specific function:: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Gene Name:: NT5C
Uniprot ID:: Q8TCD5
Molecular weight:: Not Available

Enzyme Details

5. Deoxycytidine kinase

General function:: Involved in ATP binding
Specific function:: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Gene Name:: DCK
Uniprot ID:: P27707
Molecular weight:: 30518.315

Enzyme Details

6. 5'(3')-deoxyribonucleotidase, mitochondrial

General function:: Involved in phosphatase activity
Specific function:: Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Gene Name:: NT5M
Uniprot ID:: Q9NPB1
Molecular weight:: Not Available

Enzyme Details

7. Acetyl-coenzyme A synthetase, cytoplasmic

General function:: Involved in acetate-CoA ligase activity
Specific function:: Activates acetate so that it can be used for lipid synthesis or for energy generation.
Gene Name:: ACSS2
Uniprot ID:: Q9NR19
Molecular weight:: 78579.11

Enzyme Details

8. Acetyl-coenzyme A synthetase 2-like, mitochondrial

General function:: Involved in acetate-CoA ligase activity
Specific function:: Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
Gene Name:: ACSS1
Uniprot ID:: Q9NUB1
Molecular weight:: 74625.88

Enzyme Details

9. Ectonucleoside triphosphate diphosphohydrolase 1

General function:: Involved in hydrolase activity
Specific function:: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:: ENTPD1
Uniprot ID:: P49961
Molecular weight:: 58706.0

Enzyme Details

10. Soluble calcium-activated nucleotidase 1

General function:: Involved in calcium ion binding
Specific function:: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:: CANT1
Uniprot ID:: Q8WVQ1
Molecular weight:: 44839.24

Transporters

Enzyme Details

1. Very long-chain acyl-CoA synthetase

General function:: Involved in catalytic activity
Specific function:: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
Gene Name:: SLC27A2
Uniprot ID:: O14975
Molecular weight:: 64614.99

Enzyme Details

2. Transient receptor potential cation channel subfamily M member 2

General function:: Involved in ion channel activity
Specific function:: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.
Gene Name:: TRPM2
Uniprot ID:: O94759
Molecular weight:: 171224.9

Enzyme Details

3. Bile acyl-CoA synthetase

General function:: Involved in catalytic activity
Specific function:: Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
Gene Name:: SLC27A5
Uniprot ID:: Q9Y2P5
Molecular weight:: 75384.375

Enzyme Details

4. Acyl-CoA synthetase family member 4

General function:: Involved in acyl carrier activity
Specific function:: Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA
Gene Name:: AASDH
Uniprot ID:: Q4L235
Molecular weight:: 122596.1

Only showing the first 10 proteins. There are 409 proteins in total.

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Showing Compound Card for Adenosine monophosphate (CDB004790)

Structure for CDB004790 (Adenosine monophosphate)

Enzymes

Transporters