Record Information
Version1.0
Created at2020-04-17 18:37:02 UTC
Updated at2020-12-07 19:10:56 UTC
CannabisDB IDCDB004790
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameAdenosine monophosphate
DescriptionAdenosine monophosphate, also known as adenylic acid or 5'-AMP, belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached. Adenosine monophosphate is a drug which is used for nutritional supplementation, also for treating dietary shortage or imbalance. Adenosine monophosphate is a strong basic compound (based on its pKa). Adenosine monophosphate exists in all living species, ranging from bacteria to humans. In humans, adenosine monophosphate is involved in the metabolic disorder called the canavan disease pathway. Outside of the human body, Adenosine monophosphate is found, on average, in the highest concentration within beers. Adenosine monophosphate has also been detected, but not quantified in, several different foods, such as spinachs, cowpea, parsley, arctic blackberries, and kumquats. This could make adenosine monophosphate a potential biomarker for the consumption of these foods. A purine ribonucleoside 5'-monophosphate having adenine as the nucleobase. Adenosine monophosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
5'-Adenosine monophosphateChEBI
5'-Adenylic acidChEBI
5'-AMPChEBI
5'-O-PhosphonoadenosineChEBI
Adenosine 5'-(dihydrogen phosphate)ChEBI
Adenosine 5'-phosphateChEBI
Adenosine phosphateChEBI
Adenosine-5'-monophosphoric acidChEBI
Adenosine-5'pChEBI
Adenosini phosphasChEBI
AdenylateChEBI
Adenylic acidChEBI
Ado5'pChEBI
AMPChEBI
Fosfato de adenosinaChEBI
pAChEBI
PAdoChEBI
Phosphate d'adenosineChEBI
Adenosine 5'-monophosphateKegg
AdenylKegg
5'-Adenosine monophosphoric acidGenerator
5'-AdenylateGenerator
Adenosine 5'-(dihydrogen phosphoric acid)Generator
Adenosine 5'-phosphoric acidGenerator
Adenosine phosphoric acidGenerator
Adenosine-5'-monophosphateGenerator
Phosphoric acid d'adenosineGenerator
Adenosine 5'-monophosphoric acidGenerator
Adenosine monophosphoric acidGenerator
Adenosine 5'-phosphorateHMDB
Adenosine-5'-monophosphorateHMDB
Adenosine-5-monophosphorateHMDB
Adenosine-5-monophosphoric acidHMDB
Adenosine-monophosphateHMDB
Adenosine-phosphateHMDB
AdenoviteHMDB
CardiomoneHMDB
LycedanHMDB
Muscle adenylateHMDB
Muscle adenylic acidHMDB
My-b-denHMDB
My-beta-denHMDB
PhosadenHMDB
PhosphadenHMDB
PhosphentasideHMDB
5'-Phosphate, adenosineHMDB
Acid, 2'-adenylicHMDB
2'-Adenylic acidHMDB
Adenosine 3' phosphateHMDB
Disodium, adenosine phosphateHMDB
Phosphate dipotassium, adenosineHMDB
Adenosine 2'-phosphateHMDB
Adenosine 5' phosphateHMDB
Adenosine phosphate dipotassiumHMDB
Dipotassium, adenosine phosphateHMDB
2' Adenylic acidHMDB
5' Adenylic acidHMDB
Acid, 5'-adenylicHMDB
Adenosine 3'-phosphateHMDB
monoPhosphate, 2'-adenosineHMDB
Phosphate disodium, adenosineHMDB
2' Adenosine monophosphateHMDB
2'-AMPHMDB
2'-Adenosine monophosphateHMDB
Adenosine 2' phosphateHMDB
Adenosine phosphate disodiumHMDB
Chemical FormulaC10H14N5O7P
Average Molecular Weight347.22
Monoisotopic Molecular Weight347.0631
IUPAC Name{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
Traditional Nameadenylate
CAS Registry Number61-19-8
SMILES
NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1
InChI Identifier
InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChI KeyUDMBCSSLTHHNCD-KQYNXXCUSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
ClassPurine nucleotides
Sub ClassPurine ribonucleotides
Direct ParentPurine ribonucleoside monophosphates
Alternative Parents
Substituents
  • Purine ribonucleoside monophosphate
  • Pentose phosphate
  • Pentose-5-phosphate
  • Glycosyl compound
  • N-glycosyl compound
  • 6-aminopurine
  • Monosaccharide phosphate
  • Pentose monosaccharide
  • Imidazopyrimidine
  • Purine
  • Aminopyrimidine
  • Monoalkyl phosphate
  • Alkyl phosphate
  • Monosaccharide
  • Pyrimidine
  • Imidolactam
  • N-substituted imidazole
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Tetrahydrofuran
  • Azole
  • Imidazole
  • Heteroaromatic compound
  • Secondary alcohol
  • 1,2-diol
  • Organoheterocyclic compound
  • Oxacycle
  • Azacycle
  • Organonitrogen compound
  • Primary amine
  • Hydrocarbon derivative
  • Organic oxide
  • Alcohol
  • Organopnictogen compound
  • Organic oxygen compound
  • Organic nitrogen compound
  • Organooxygen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Source:

Biological location:

Role

Industrial application:

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point195 °CNot Available
Boiling Point798.5 °CWikipedia
Water Solubility10 mg/mL at 20 °CBEILSTEIN
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-3.1ALOGPS
logP-4.7ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)1.22ChemAxon
pKa (Strongest Basic)3.92ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count10ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area186.07 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity74.07 m³·mol⁻¹ChemAxon
Polarizability29.96 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
GC-MSAdenosine monophosphate, 5 TMS, GC-MS Spectrumsplash10-014i-0974000000-7ce25c09f93913b81e9bSpectrum
GC-MSAdenosine monophosphate, 4 TMS, GC-MS Spectrumsplash10-014i-0975000000-8175538459abaf92d36fSpectrum
GC-MSAdenosine monophosphate, non-derivatized, GC-MS Spectrumsplash10-014i-0974000000-7ce25c09f93913b81e9bSpectrum
GC-MSAdenosine monophosphate, non-derivatized, GC-MS Spectrumsplash10-014i-0975000000-8175538459abaf92d36fSpectrum
Predicted GC-MSAdenosine monophosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-002b-9713000000-019182f931e395f479cdSpectrum
Predicted GC-MSAdenosine monophosphate, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0gl0-4942400000-fb8ced86745a4de1b047Spectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-052b-0209001000-f6c3cf706bb3b839d180Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-053s-0395300000-e2a342872025e6e960aeSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000i-0900000000-2b9fb262817de641a5cdSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-053r-0007920000-ee7bab39079e225a1b07Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0002-0109000000-52331e416cbdd8218b97Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-014i-3900000000-ddc799b6e2bb5d5ac9a6Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000i-0900000000-68d6660e0cfbfb8f02adSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000i-0900000000-27f73c3a0a9566986a0eSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-03dm-0007009001-639c5cafae90b10dfc5fSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-03di-0290000000-e0b5612abd24736e70daSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0a4i-0039210000-3e5b716531d739ca25d9Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0002-0009000000-9232b7438abb1f6256b6Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0007-2109007000-3e1cf347bd9e054b9368Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0006-0002009000-b840e6edcca65562937bSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-03di-0190000000-948ec97ae442eda212cbSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0002-0009000000-bd1c10704f289141803aSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-0002-0109000000-433eab5bd833cd92f290Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positivesplash10-000b-0709000000-fa268a51905a453bc6f5Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-002b-9104000000-bc358c1d8c03290fc49dSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-0913000000-52bfdec6ec6f2f9422f4Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-0900000000-9bf867ba72f77732e0ceSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000i-1900000000-fab6495d31eac8de123cSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0032-6709000000-fd9ea223f556b17d2d3aSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0059-8900000000-3937203187746280b10aSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9200000000-5947ff2a364087cb0e38Spectrum
NMR
TypeDescriptionView
1D NMR1H NMR SpectrumSpectrum
2D NMR[1H,1H] 2D NMR SpectrumSpectrum
2D NMR[1H,13C] 2D NMR SpectrumSpectrum
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
5'-nucleotidaseNT5E6q14-q21P21589 details
Cytosolic 5'-nucleotidase 1BNT5C1B2p24.2Q96P26 details
Cytosolic 5'-nucleotidase 1ANT5C1A1p34.3-p33Q9BXI3 details
5'(3')-deoxyribonucleotidase, cytosolic typeNT5CQ8TCD5 details
Deoxycytidine kinaseDCK4q13.3-q21.1P27707 details
5'(3')-deoxyribonucleotidase, mitochondrialNT5MQ9NPB1 details
Acetyl-coenzyme A synthetase, cytoplasmicACSS220q11.22Q9NR19 details
Acetyl-coenzyme A synthetase 2-like, mitochondrialACSS120p11.23-p11.21Q9NUB1 details
Ectonucleoside triphosphate diphosphohydrolase 1ENTPD110q24P49961 details
Soluble calcium-activated nucleotidase 1CANT117q25.3Q8WVQ1 details
Ectonucleoside triphosphate diphosphohydrolase 3ENTPD33p21.3O75355 details
Serum paraoxonase/lactonase 3PON37q21.3Q15166 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1ENPP16q22-q23P22413 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3ENPP36q22O14638 details
Phenylalanine--tRNA ligase alpha subunitFARSA19p13.2Q9Y285 details
Phenylalanine--tRNA ligase, mitochondrialFARS26p25.1O95363 details
Alpha-aminoadipic semialdehyde dehydrogenaseALDH7A15q31P49419 details
3'(2'),5'-bisphosphate nucleotidase 1BPNT11q41O95861 details
ADP-dependent glucokinaseADPGK15q24.1Q9BRR6 details
Glycogen phosphorylase, liver formPYGL14q21-q22P06737 details
Glycogen phosphorylase, muscle formPYGM11q12-q13.2P11217 details
Glycogen phosphorylase, brain formPYGB20p11.21P11216 details
Adenine phosphoribosyltransferaseAPRT16q24P07741 details
Hypoxanthine-guanine phosphoribosyltransferaseHPRT1Xq26.1P00492 details
Biotin--protein ligaseHLCS21q22.13P50747 details
Phenylalanine--tRNA ligase beta subunitFARSB2q36.1Q9NSD9 details
Ubiquitin-conjugating enzyme E2 AUBE2AXq24P49459 details
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPDE6H12p13Q13956 details
Adenylate kinase isoenzyme 1AK19q34.1P00568 details
NEDD8-conjugating enzyme Ubc12UBE2M19q13.43P61081 details
Ubiquitin/ISG15-conjugating enzyme E2 L6UBE2L611q12O14933 details
Glycine--tRNA ligaseGARS7p15P41250 details
Ribose-phosphate pyrophosphokinase 3PRPS1L17p21.1P21108 details
Bifunctional glutamate/proline--tRNA ligaseEPRS1q41P07814 details
Long-chain-fatty-acid--CoA ligase 4ACSL4Xq22.3-q23O60488 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1APDE1A2q32.1P54750 details
GTP:AMP phosphotransferase, mitochondrialAK39p24.1Q9UIJ7 details
Tryptophan--tRNA ligase, cytoplasmicWARS14q32.31P23381 details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8APDE8A15q25.3O60658 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BPDE1B12q13Q01064 details
Long-chain-fatty-acid--CoA ligase 1ACSL14q35P33121 details
cGMP-inhibited 3',5'-cyclic phosphodiesterase BPDE3B11p15.1Q13370 details
Ubiquitin-conjugating enzyme E2 G1UBE2G117p13.2P62253 details
Glutamine--tRNA ligaseQARS3p21.31P47897 details
Threonine--tRNA ligase, cytoplasmicTARS5p13.2P26639 details
Asparagine synthetase [glutamine-hydrolyzing]ASNS7q21.3P08243 details
Ubiquitin-conjugating enzyme E2 E2UBE2E23p24.2Q96LR5 details
Adenylosuccinate lyaseADSL22q13.2P30566 details
Adenylate kinase isoenzyme 4, mitochondrialAK41p31.3P27144 details
Ubiquitin-conjugating enzyme E2 D2UBE2D25q31.2P62837 details
DNA ligase 4LIG413q33-q34P49917 details
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7APDE7A8q13Q13946 details
Arginine--tRNA ligase, cytoplasmicRARS5q35.1P54136 details
GMP synthase [glutamine-hydrolyzing]GMPS3q24P49915 details
Ubiquitin-conjugating enzyme E2 BUBE2B5q31.1P63146 details
Probable leucine--tRNA ligase, mitochondrialLARS23p21.3Q15031 details
AMP deaminase 3AMPD311p15Q01432 details
Ubiquitin-conjugating enzyme E2 J2UBE2J21p36.33Q8N2K1 details
AMP deaminase 2AMPD21p13.3Q01433 details
cGMP-inhibited 3',5'-cyclic phosphodiesterase APDE3A12p12Q14432 details
Ubiquitin-conjugating enzyme E2 L3UBE2L322q11.21P68036 details
RNA 3'-terminal phosphate cyclaseRTCA1p21.2O00442 details
Adenylate kinase 7AK714q32.2Q96M32 details
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10APDE10A6q26Q9Y233 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CPDE1C7p14.3Q14123 details
Tyrosine--tRNA ligase, cytoplasmicYARS1p35.1P54577 details
DNA ligase 3LIG317q11.2-q12P49916 details
Aspartate--tRNA ligase, cytoplasmicDARS2q21.3P14868 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4BPDE4B1p31Q07343 details
Ubiquitin-conjugating enzyme E2 D3UBE2D34q24P61077 details
Asparagine--tRNA ligase, cytoplasmicNARS18q21.31O43776 details
cAMP-specific 3',5'-cyclic phosphodiesterase 7BPDE7B6q23-q24Q9NP56 details
Lysine--tRNA ligaseKARS16q23.1Q15046 details
Isoleucine--tRNA ligase, cytoplasmicIARS9q21P41252 details
Bis(5'-adenosyl)-triphosphataseFHIT3p14.2P49789 details
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9APDE9A21q22.3O76083 details
cGMP-dependent 3',5'-cyclic phosphodiesterasePDE2A11q13.4O00408 details
Ubiquitin-like modifier-activating enzyme 1UBA1P22314 details
Tyrosine--tRNA ligase, mitochondrialYARS212p11.21Q9Y2Z4 details
Ubiquitin-conjugating enzyme E2 E1UBE2E13p24.2P51965 details
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]NUDT29p13P50583 details
Long-chain-fatty-acid--CoA ligase 6ACSL65q31Q9UKU0 details
Methionine--tRNA ligase, cytoplasmicMARS12q13P56192 details
Alanine--tRNA ligase, cytoplasmicAARS16q22P49588 details
Tryptophan--tRNA ligase, mitochondrialWARS21p12Q9UGM6 details
ADP-sugar pyrophosphataseNUDT510p14Q9UKK9 details
Ribose-phosphate pyrophosphokinase 1PRPS1Xq21.32-q24P60891 details
Serine--tRNA ligase, mitochondrialSARS219q13.2Q9NP81 details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8BPDE8B5q13.3O95263 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4CPDE4C19p13.11Q08493 details
Ribose-phosphate pyrophosphokinase 2PRPS2Xp22.2P11908 details
Thiamin pyrophosphokinase 1TPK17q34-q35Q9H3S4 details
SUMO-conjugating enzyme UBC9UBE2I16p13.3P63279 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4DPDE4D5q12Q08499 details
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPDE6G17q25P18545 details
ADP-ribose pyrophosphatase, mitochondrialNUDT94q22.1Q9BW91 details
Adenosine kinaseADK10q11-q24P55263 details
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit deltaPDE6D2q35-q36O43924 details
Probable histidine--tRNA ligase, mitochondrialHARS25q31.3P49590 details
Ubiquitin-conjugating enzyme E2 J1UBE2J16q15Q9Y385 details
Long-chain-fatty-acid--CoA ligase 5ACSL510q25.1-q25.2Q9ULC5 details
Histidine--tRNA ligase, cytoplasmicHARS5q31.3P12081 details
Serine--tRNA ligase, cytoplasmicSARS1p13.3P49591 details
Long-chain-fatty-acid--CoA ligase 3ACSL32q34-q35O95573 details
Leucine--tRNA ligase, cytoplasmicLARS5q32Q9P2J5 details
Ubiquitin-conjugating enzyme E2 CUBE2C20q13.12O00762 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4APDE4A19p13.2P27815 details
Valine--tRNA ligaseVARS6p21.3P26640 details
Adenylate kinase isoenzyme 5AK51p31Q9Y6K8 details
Selenide, water dikinase 1SEPHS110p14P49903 details
Ubiquitin-conjugating enzyme E2 NUBE2N12q22P61088 details
cGMP-specific 3',5'-cyclic phosphodiesterasePDE5A4q27O76074 details
Argininosuccinate synthaseASS19q34.1P00966 details
AMP deaminase 1AMPD11p13P23109 details
Selenide, water dikinase 2SEPHS216p11.2Q99611 details
DNA ligase 1LIG119q13.2-q13.3P18858 details
Adenylate cyclase type 1ADCY17p13-p12Q08828 details
Very long-chain acyl-CoA synthetaseSLC27A215q21.2O14975 details
Adenylyltransferase and sulfurtransferase MOCS3MOCS320q13.13O95396 details
E3 ubiquitin-protein ligase NEDD4-likeNEDD4L18q21Q96PU5 details
E3 ubiquitin-protein ligase Mdm2MDM212q14.3-q15Q00987 details
Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)DAK11q12.2Q3LXA3 details
Phosphopantothenate--cysteine ligasePPCS1p34.2Q9HAB8 details
Bile acyl-CoA synthetaseSLC27A519q13.43Q9Y2P5 details
Cytosolic 5'-nucleotidase 3NT5C37p14.3Q9H0P0 details
Glutamine-dependent NAD(+) synthetaseNADSYN111q13.4Q6IA69 details
Cytosolic purine 5'-nucleotidaseNT5C210q24.32P49902 details
Adenylate kinase 2, mitochondrialAK21p34P54819 details
Acetoacetyl-CoA synthetaseAACS12q24.31Q86V21 details
Acyl-coenzyme A synthetase ACSM1, mitochondrialACSM116p12.3Q08AH1 details
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11APDE11A2q31.2Q9HCR9 details
Probable arginine--tRNA ligase, mitochondrialRARS26q16.1Q5T160 details
Probable cysteine--tRNA ligase, mitochondrialCARS213q34Q9HA77 details
Probable glutamate--tRNA ligase, mitochondrialEARS216p12.2Q5JPH6 details
Acyl-CoA synthetase family member 4AASDH4q12Q4L235 details
Peroxisomal NADH pyrophosphatase NUDT12NUDT125q21.2Q9BQG2 details
ACSS2 proteinACSS220q11.22Q96FY7 details
Valine--tRNA ligase, mitochondrialVARS26p21.33Q5ST30 details
E3 ubiquitin-protein ligase CBLCBL11q23.3P22681 details
Ectonucleoside triphosphate diphosphohydrolase 8ENTPD89q34.3Q5MY95 details
Acyl-coenzyme A synthetase ACSM6, mitochondrialACSM610q23.33Q6P461 details
Probable E3 ubiquitin-protein ligase HERC1HERC115q22Q15751 details
E3 ubiquitin-protein ligase HERC2HERC215q13O95714 details
Acyl-coenzyme A synthetase ACSM2A, mitochondrialACSM2A16p12.3Q08AH3 details
Acyl-coenzyme A synthetase ACSM2B, mitochondrialACSM2B16p12.3Q68CK6 details
Acyl-coenzyme A synthetase ACSM3, mitochondrialACSM316p13.11Q53FZ2 details
Acyl-coenzyme A synthetase ACSM5, mitochondrialACSM516p12.3Q6NUN0 details
Inositol monophosphatase 3IMPAD18q12.1Q9NX62 details
Diphosphoinositol polyphosphate phosphohydrolase 3-alphaNUDT10Xp11.23Q8NFP7 details
Diphosphoinositol polyphosphate phosphohydrolase 3-betaNUDT11Xp11.22Q96G61 details
Carnosine synthase 1CARNS111q13.2A5YM72 details
Acyl-coenzyme A synthetase ACSM4, mitochondrialACSM412p13.31P0C7M7 details
Probable threonine--tRNA ligase 2, cytoplasmicTARSL215q26.3A2RTX5 details
Threonine--tRNA ligase, mitochondrialTARS21q21.3Q9BW92 details
Methionine--tRNA ligase, mitochondrialMARS22q33.1Q96GW9 details
Aspartate--tRNA ligase, mitochondrialDARS21q25.1Q6PI48 details
Cysteine--tRNA ligase, cytoplasmicCARS11p15.5P49589 details
FARSLA proteinFARSLAQ6IBR2 details
Probable asparagine--tRNA ligase, mitochondrialNARS211q14.1Q96I59 details
SUMO-activating enzyme subunit 2UBA219q12Q9UBT2 details
E3 ubiquitin-protein ligase HUWE1HUWE1Q7Z6Z7 details
E3 ubiquitin-protein ligase ToporsTOPORS9p21Q9NS56 details
STIP1 homology and U-box containing protein 1 (STIP1 homology and U- box containing protein 1, isoform CRA_c)STUB116p13.3Q9UNE7 details
Ubiquitin conjugation factor E4 BUBE4B1p36.3O95155 details
Membrane-associated ring finger (C3HC4) 6 (Membrane-associated ring finger (C3HC4) 6, isoform CRA_a)MARCH6O60337 details
TGIF-interacting ubiquitin ligase 1Q9H0M0 details
NEDD4-like E3 ubiquitin-protein ligase WWP2WWP216q22.1O00308 details
E3 ubiquitin-protein ligase MARCH3MARCH35q23.2Q86UD3 details
NEDD8-conjugating enzyme UBE2FUBE2F2q37.3Q969M7 details
Ubiquitin-conjugating enzyme E2 UUBE2U1p31.3Q5VVX9 details
Probable E3 ubiquitin-protein ligase MARCH10MARCH1017q23.2Q8NA82 details
E3 ubiquitin-protein ligase UBR1UBR115q13Q8IWV7 details
E3 ubiquitin-protein ligase MARCH8MARCH810q11.21Q5T0T0 details
E3 ubiquitin-protein ligase ZNRF2ZNRF27p14.3Q8NHG8 details
E3 ubiquitin-protein ligase TRIM32TRIM329q33.1Q13049 details
Probable E3 ubiquitin-protein ligase MYCBP2MYCBP213q22O75592 details
E3 ubiquitin-protein ligase MGRN1MGRN116p13.3O60291 details
E3 ubiquitin-protein ligase UBR2UBR26p21.1Q8IWV8 details
E3 ubiquitin-protein ligase UBR4UBR41p36.13Q5T4S7 details
E3 ubiquitin-protein ligase AMFRAMFR16q21Q9UKV5 details
Ubiquitin-conjugating enzyme E2 SUBE2S19q13.43Q16763 details
Pre-mRNA-processing factor 19PRPF1911q12.2Q9UMS4 details
Myosin regulatory light chain interacting protein (Myosin regulatory light chain interacting protein, isoform CRA_a)MYLIPQ8WY64 details
HNP95hNp95Q96T88 details
Putative ubiquitin-conjugating enzyme E2 N-likeUBE2NLQ5JXB2 details
Midline-1MID1O15344 details
E3 ubiquitin-protein ligase NEDD4NEDD415qP46934 details
CCR4-NOT transcription complex subunit 4CNOT47q22-qterO95628 details
E3 ubiquitin-protein ligase MARCH2MARCH219p13.2Q9P0N8 details
E3 ubiquitin-protein ligase UBR5UBR58q22O95071 details
E3 ubiquitin-protein ligase TRIM33TRIM331p13.1Q9UPN9 details
E3 ubiquitin-protein ligase MARCH5MARCH510q23.32-q23.33Q9NX47 details
Ubiquitin-conjugating enzyme E2 R2UBE2R29p13.3Q712K3 details
E3 ubiquitin-protein ligase MARCH1MARCH14q32.2Q8TCQ1 details
E3 ubiquitin-protein ligase FANCLFANCL2p16.1Q9NW38 details
Ubiquitin-like modifier-activating enzyme 6UBA64q13.2A0AVT1 details
Ubiquitin-conjugating enzyme E2 WUBE2W8q21.11Q96B02 details
Galactosyl transferase-associated proteinGTAPQ29SN7 details
E3 ubiquitin-protein ligase CHFRCHFR12q24.33Q96EP1 details
Ring finger protein 20RNF20Q5VTR2 details
E3 ubiquitin-protein ligase RAD18RAD183p25-p24Q9NS91 details
E3 ubiquitin ligase SMURF1SMURF17q22.1Q9HCE7 details
Baculoviral IAP repeat-containing protein 6BIRC62p22.3Q9NR09 details
E3 ubiquitin-protein ligase MARCH4MARCH42q35Q9P2E8 details
E3 ubiquitin-protein ligase CCNB1IP1CCNB1IP114q11.2Q9NPC3 details
E3 ubiquitin-protein ligase RNF5RNF56p21.3Q99942 details
Ubiquitin-conjugating enzyme E2 OUBE2O17q25.1Q9C0C9 details
Praja 1PJA1A2A322 details
RFWD2 proteinRFWD21q25.1-q25.2Q05CT6 details
E3 ubiquitin-protein ligase SMURF2SMURF217q22-q23Q9HAU4 details
E3 ubiquitin-protein ligase SIAH1SIAH116q12Q8IUQ4 details
E3 ubiquitin-protein ligase SIAH2SIAH23q25O43255 details
E3 ubiquitin-protein ligase MARCH7MARCH72q24.2Q9H992 details
Ubiquitin-conjugating enzyme E2 ZUBE2Z17q21.32Q9H832 details
Ubiquitin-like modifier-activating enzyme 7UBA73p21P41226 details
Ubiquitin carrier proteinUBE2H7q32A4D1L5 details
Ubiquitin-protein ligase E3AUBE3A15q11.2Q05086 details
E3 ubiquitin-protein ligase RNF128RNF128Q8TEB7 details
E3 ubiquitin-protein ligase TRIM11TRIM111q42.13Q96F44 details
BRCA1 associated protein variantQ59H81 details
E3 ubiquitin-protein ligase synoviolinSYVN111q13Q86TM6 details
E3 ubiquitin-protein ligase TRIM63TRIM631p34-p33Q969Q1 details
E3 ubiquitin-protein ligase LNXLNX14q12Q8TBB1 details
E3 ubiquitin-protein ligase ZNRF1ZNRF116q23.1Q8ND25 details
Tripartite motif-containing protein 5TRIM511p15Q9C035 details
Ubiquitin-protein ligase E3BUBE3B12q24.11Q7Z3V4 details
E3 ubiquitin-protein ligase RNF8RNF86p21.3O76064 details
E3 ubiquitin-protein ligase LRSAM1LRSAM19q33.3Q6UWE0 details
Ubiquitin-conjugating enzyme E2 Q2UBE2Q215q24.2Q8WVN8 details
E3 ubiquitin-protein ligase MARCH9MARCH912q14.1Q86YJ5 details
Probable E3 ubiquitin-protein ligase TRIP12TRIP122q36.3Q14669 details
E3 ubiquitin-protein ligase DZIP3DZIP33q13.13Q86Y13 details
Ubiquitin-protein ligase E3CUBE3C7q36.3Q15386 details
Alanine--tRNA ligase, mitochondrialAARS26p21.1Q5JTZ9 details
Isoleucine--tRNA ligase, mitochondrialIARS21q41Q9NSE4 details
Lipoyltransferase 1, mitochondrialLIPT12q11.2Q9Y234 details
Probable proline--tRNA ligase, mitochondrialPARS21p32.2Q7L3T8 details
Long-chain-fatty-acid--CoA ligase ACSBG2ACSBG219p13.3Q5FVE4 details
Long-chain-fatty-acid--CoA ligase ACSBG1ACSBG115q23-q24Q96GR2 details
E3 ubiquitin-protein ligase MIB1MIB118q11.2Q86YT6 details
E3 ubiquitin-protein ligase RNF138RNF13818q12.1Q8WVD3 details
E3 ubiquitin-protein ligase RING2RNF21q25.3Q99496 details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferaseAASDHPPT11q22Q9NRN7 details
SUMO-activating enzyme subunit 1SAE119q13.32Q9UBE0 details
Ubiquitin-conjugating enzyme E2 D4UBE2D47p13Q9Y2X8 details
Ubiquitin conjugation factor E4 AUBE4A11q23.3Q14139 details
E3 ubiquitin-protein ligase RNF144BRNF144B6p22.3Q7Z419 details
Acyl-CoA synthetase short-chain family member 3, mitochondrialACSS312q21.31Q9H6R3 details
Manganese-dependent ADP-ribose/CDP-alcohol diphosphataseADPRM17p13.1Q3LIE5 details
Adenylate kinase isoenzyme 6TAF95q11.2-q13.1Q9Y3D8 details
Adenylate kinase 8AK89q34.13Q96MA6 details
tRNA-splicing ligase RtcB homologC22orf2822q12Q9Y3I0 details
Probable tRNA(His) guanylyltransferaseTHG1L5q33.3Q9NWX6 details
E3 ubiquitin/ISG15 ligase TRIM25TRIM2517q23.2Q14258 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Very long-chain acyl-CoA synthetaseSLC27A215q21.2O14975 details
Transient receptor potential cation channel subfamily M member 2TRPM221q22.3O94759 details
Bile acyl-CoA synthetaseSLC27A519q13.43Q9Y2P5 details
Acyl-CoA synthetase family member 4AASDH4q12Q4L235 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
5'-nucleotidaseNT5E6q14-q21P21589 details
Cytosolic 5'-nucleotidase 1BNT5C1B2p24.2Q96P26 details
Cytosolic 5'-nucleotidase 1ANT5C1A1p34.3-p33Q9BXI3 details
5'(3')-deoxyribonucleotidase, cytosolic typeNT5CQ8TCD5 details
5'(3')-deoxyribonucleotidase, mitochondrialNT5MQ9NPB1 details
Soluble calcium-activated nucleotidase 1CANT117q25.3Q8WVQ1 details
Serum paraoxonase/lactonase 3PON37q21.3Q15166 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1ENPP16q22-q23P22413 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3ENPP36q22O14638 details
Phenylalanine--tRNA ligase, mitochondrialFARS26p25.1O95363 details
ADP-dependent glucokinaseADPGK15q24.1Q9BRR6 details
Phenylalanine--tRNA ligase beta subunitFARSB2q36.1Q9NSD9 details
Ribose-phosphate pyrophosphokinase 3PRPS1L17p21.1P21108 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1APDE1A2q32.1P54750 details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8APDE8A15q25.3O60658 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BPDE1B12q13Q01064 details
cGMP-inhibited 3',5'-cyclic phosphodiesterase BPDE3B11p15.1Q13370 details
DNA ligase 4LIG413q33-q34P49917 details
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7APDE7A8q13Q13946 details
AMP deaminase 3AMPD311p15Q01432 details
AMP deaminase 2AMPD21p13.3Q01433 details
cGMP-inhibited 3',5'-cyclic phosphodiesterase APDE3A12p12Q14432 details
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10APDE10A6q26Q9Y233 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CPDE1C7p14.3Q14123 details
DNA ligase 3LIG317q11.2-q12P49916 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4BPDE4B1p31Q07343 details
cAMP-specific 3',5'-cyclic phosphodiesterase 7BPDE7B6q23-q24Q9NP56 details
Lysine--tRNA ligaseKARS16q23.1Q15046 details
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9APDE9A21q22.3O76083 details
cGMP-dependent 3',5'-cyclic phosphodiesterasePDE2A11q13.4O00408 details
Alanine--tRNA ligase, cytoplasmicAARS16q22P49588 details
Ribose-phosphate pyrophosphokinase 1PRPS1Xq21.32-q24P60891 details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8BPDE8B5q13.3O95263 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4CPDE4C19p13.11Q08493 details
Ribose-phosphate pyrophosphokinase 2PRPS2Xp22.2P11908 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4DPDE4D5q12Q08499 details
Adenosine kinaseADK10q11-q24P55263 details
cAMP-specific 3',5'-cyclic phosphodiesterase 4APDE4A19p13.2P27815 details
cGMP-specific 3',5'-cyclic phosphodiesterasePDE5A4q27O76074 details
AMP deaminase 1AMPD11p13P23109 details
DNA ligase 1LIG119q13.2-q13.3P18858 details
Adenylate cyclase type 1ADCY17p13-p12Q08828 details
Adenylyltransferase and sulfurtransferase MOCS3MOCS320q13.13O95396 details
E3 ubiquitin-protein ligase Mdm2MDM212q14.3-q15Q00987 details
Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)DAK11q12.2Q3LXA3 details
GephyrinGPHN14q23.3Q9NQX3 details
Cytosolic 5'-nucleotidase 3NT5C37p14.3Q9H0P0 details
Cytosolic purine 5'-nucleotidaseNT5C210q24.32P49902 details
Acyl-coenzyme A synthetase ACSM1, mitochondrialACSM116p12.3Q08AH1 details
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11APDE11A2q31.2Q9HCR9 details
Probable cysteine--tRNA ligase, mitochondrialCARS213q34Q9HA77 details
Peroxisomal NADH pyrophosphatase NUDT12NUDT125q21.2Q9BQG2 details
E3 ubiquitin-protein ligase CBLCBL11q23.3P22681 details
Signal transduction protein CBL-CCBLC19q13.2Q9ULV8 details
Acyl-coenzyme A synthetase ACSM6, mitochondrialACSM610q23.33Q6P461 details
E3 ubiquitin-protein ligase HERC2HERC215q13O95714 details
Acyl-coenzyme A synthetase ACSM2A, mitochondrialACSM2A16p12.3Q08AH3 details
Acyl-coenzyme A synthetase ACSM2B, mitochondrialACSM2B16p12.3Q68CK6 details
Acyl-coenzyme A synthetase ACSM3, mitochondrialACSM316p13.11Q53FZ2 details
Acyl-coenzyme A synthetase ACSM5, mitochondrialACSM516p12.3Q6NUN0 details
Inositol monophosphatase 3IMPAD18q12.1Q9NX62 details
Diphosphoinositol polyphosphate phosphohydrolase 3-alphaNUDT10Xp11.23Q8NFP7 details
Diphosphoinositol polyphosphate phosphohydrolase 3-betaNUDT11Xp11.22Q96G61 details
Carnosine synthase 1CARNS111q13.2A5YM72 details
Acyl-coenzyme A synthetase ACSM4, mitochondrialACSM412p13.31P0C7M7 details
Cysteine--tRNA ligase, cytoplasmicCARS11p15.5P49589 details
E3 ubiquitin-protein ligase ToporsTOPORS9p21Q9NS56 details
Membrane-associated ring finger (C3HC4) 6 (Membrane-associated ring finger (C3HC4) 6, isoform CRA_a)MARCH6O60337 details
E3 ubiquitin-protein ligase MARCH3MARCH35q23.2Q86UD3 details
Probable E3 ubiquitin-protein ligase MARCH10MARCH1017q23.2Q8NA82 details
E3 ubiquitin-protein ligase UBR1UBR115q13Q8IWV7 details
E3 ubiquitin-protein ligase MARCH8MARCH810q11.21Q5T0T0 details
E3 ubiquitin-protein ligase ZNRF2ZNRF27p14.3Q8NHG8 details
E3 ubiquitin-protein ligase TRIM32TRIM329q33.1Q13049 details
Probable E3 ubiquitin-protein ligase MYCBP2MYCBP213q22O75592 details
E3 ubiquitin-protein ligase MGRN1MGRN116p13.3O60291 details
E3 ubiquitin-protein ligase UBR2UBR26p21.1Q8IWV8 details
E3 ubiquitin-protein ligase UBR4UBR41p36.13Q5T4S7 details
E3 ubiquitin-protein ligase AMFRAMFR16q21Q9UKV5 details
Myosin regulatory light chain interacting protein (Myosin regulatory light chain interacting protein, isoform CRA_a)MYLIPQ8WY64 details
HNP95hNp95Q96T88 details
Midline-1MID1O15344 details
CCR4-NOT transcription complex subunit 4CNOT47q22-qterO95628 details
E3 ubiquitin-protein ligase MARCH2MARCH219p13.2Q9P0N8 details
E3 ubiquitin-protein ligase UBR5UBR58q22O95071 details
E3 ubiquitin-protein ligase TRIM33TRIM331p13.1Q9UPN9 details
E3 ubiquitin-protein ligase MARCH5MARCH510q23.32-q23.33Q9NX47 details
E3 ubiquitin-protein ligase MARCH1MARCH14q32.2Q8TCQ1 details
E3 ubiquitin-protein ligase FANCLFANCL2p16.1Q9NW38 details
E3 ubiquitin-protein ligase CHFRCHFR12q24.33Q96EP1 details
E3 ubiquitin-protein ligase RAD18RAD183p25-p24Q9NS91 details
E3 ubiquitin-protein ligase MARCH4MARCH42q35Q9P2E8 details
E3 ubiquitin-protein ligase RNF5RNF56p21.3Q99942 details
Praja 1PJA1A2A322 details
RFWD2 proteinRFWD21q25.1-q25.2Q05CT6 details
E3 ubiquitin-protein ligase SIAH1SIAH116q12Q8IUQ4 details
E3 ubiquitin-protein ligase SIAH2SIAH23q25O43255 details
E3 ubiquitin-protein ligase MARCH7MARCH72q24.2Q9H992 details
E3 ubiquitin-protein ligase RNF128RNF128Q8TEB7 details
E3 ubiquitin-protein ligase TRIM11TRIM111q42.13Q96F44 details
BRCA1 associated protein variantQ59H81 details
E3 ubiquitin-protein ligase synoviolinSYVN111q13Q86TM6 details
E3 ubiquitin-protein ligase TRIM63TRIM631p34-p33Q969Q1 details
E3 ubiquitin-protein ligase LNXLNX14q12Q8TBB1 details
E3 ubiquitin-protein ligase ZNRF1ZNRF116q23.1Q8ND25 details
Tripartite motif-containing protein 5TRIM511p15Q9C035 details
E3 ubiquitin-protein ligase RNF8RNF86p21.3O76064 details
E3 ubiquitin-protein ligase LRSAM1LRSAM19q33.3Q6UWE0 details
E3 ubiquitin-protein ligase MARCH9MARCH912q14.1Q86YJ5 details
E3 ubiquitin-protein ligase DZIP3DZIP33q13.13Q86Y13 details
Alanine--tRNA ligase, mitochondrialAARS26p21.1Q5JTZ9 details
E3 ubiquitin-protein ligase MIB1MIB118q11.2Q86YT6 details
E3 ubiquitin-protein ligase RNF138RNF13818q12.1Q8WVD3 details
E3 ubiquitin-protein ligase RING2RNF21q25.3Q99496 details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferaseAASDHPPT11q22Q9NRN7 details
E3 ubiquitin-protein ligase RNF144BRNF144B6p22.3Q7Z419 details
Manganese-dependent ADP-ribose/CDP-alcohol diphosphataseADPRM17p13.1Q3LIE5 details
tRNA-splicing ligase RtcB homologC22orf2822q12Q9Y3I0 details
E3 ubiquitin/ISG15 ligase TRIM25TRIM2517q23.2Q14258 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1ENPP16q22-q23P22413 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3ENPP36q22O14638 details
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPDE6H12p13Q13956 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1APDE1A2q32.1P54750 details
Ubiquitin-conjugating enzyme E2 D1UBE2D110q21.1P51668 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BPDE1B12q13Q01064 details
cGMP-inhibited 3',5'-cyclic phosphodiesterase BPDE3B11p15.1Q13370 details
DNA ligase 4LIG413q33-q34P49917 details
Ubiquitin-conjugating enzyme E2 BUBE2B5q31.1P63146 details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CPDE1C7p14.3Q14123 details
Tyrosine--tRNA ligase, cytoplasmicYARS1p35.1P54577 details
Ubiquitin-conjugating enzyme E2 D3UBE2D34q24P61077 details
SUMO-conjugating enzyme UBC9UBE2I16p13.3P63279 details
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPDE6G17q25P18545 details
Ubiquitin-conjugating enzyme E2 NUBE2N12q22P61088 details
Adenylate cyclase type 1ADCY17p13-p12Q08828 details
Transient receptor potential cation channel subfamily M member 2TRPM221q22.3O94759 details
E3 ubiquitin-protein ligase CBLCBL11q23.3P22681 details
Signal transduction protein CBL-CCBLC19q13.2Q9ULV8 details
E3 ubiquitin-protein ligase LRSAM1LRSAM19q33.3Q6UWE0 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Ubiquitin-conjugating enzyme E2 D1UBE2D110q21.1P51668 details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8APDE8A15q25.3O60658 details
Ubiquitin-conjugating enzyme E2 D2UBE2D25q31.2P62837 details
Ubiquitin-conjugating enzyme E2 L3UBE2L322q11.21P68036 details
Ubiquitin-conjugating enzyme E2 D3UBE2D34q24P61077 details
cGMP-dependent 3',5'-cyclic phosphodiesterasePDE2A11q13.4O00408 details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8BPDE8B5q13.3O95263 details
SUMO-conjugating enzyme UBC9UBE2I16p13.3P63279 details
Ubiquitin-conjugating enzyme E2 NUBE2N12q22P61088 details
DNA ligase 1LIG119q13.2-q13.3P18858 details
Cyclic AMP-responsive element-binding protein 1CREB12q34P16220 details
E3 ubiquitin/ISG15 ligase TRIM25TRIM2517q23.2Q14258 details
Concentrations Data
Not Available
HMDB IDHMDB0000045
DrugBank IDDB00131
Phenol Explorer Compound IDNot Available
FoodDB IDFDB030677
KNApSAcK IDC00019347
Chemspider ID5858
KEGG Compound IDC00020
BioCyc IDAMP
BiGG ID33534
Wikipedia LinkAdenylic_acid
METLIN ID5111
PubChem Compound6083
PDB IDNot Available
ChEBI ID16027
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 409 proteins in total.

Enzymes

General function:
Involved in hydrolase activity
Specific function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
Gene Name:
NT5E
Uniprot ID:
P21589
Molecular weight:
57948.125
General function:
Involved in nucleotide binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).
Gene Name:
NT5C1B
Uniprot ID:
Q96P26
Molecular weight:
68803.055
General function:
Involved in nucleotide binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
Gene Name:
NT5C1A
Uniprot ID:
Q9BXI3
Molecular weight:
41020.145
General function:
Involved in metal ion binding
Specific function:
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Gene Name:
NT5C
Uniprot ID:
Q8TCD5
Molecular weight:
Not Available
General function:
Involved in ATP binding
Specific function:
Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Gene Name:
DCK
Uniprot ID:
P27707
Molecular weight:
30518.315
General function:
Involved in phosphatase activity
Specific function:
Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Gene Name:
NT5M
Uniprot ID:
Q9NPB1
Molecular weight:
Not Available
General function:
Involved in acetate-CoA ligase activity
Specific function:
Activates acetate so that it can be used for lipid synthesis or for energy generation.
Gene Name:
ACSS2
Uniprot ID:
Q9NR19
Molecular weight:
78579.11
General function:
Involved in acetate-CoA ligase activity
Specific function:
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
Gene Name:
ACSS1
Uniprot ID:
Q9NUB1
Molecular weight:
74625.88
General function:
Involved in hydrolase activity
Specific function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:
ENTPD1
Uniprot ID:
P49961
Molecular weight:
58706.0
General function:
Involved in calcium ion binding
Specific function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:
CANT1
Uniprot ID:
Q8WVQ1
Molecular weight:
44839.24

Transporters

General function:
Involved in catalytic activity
Specific function:
Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
Gene Name:
SLC27A2
Uniprot ID:
O14975
Molecular weight:
64614.99
General function:
Involved in ion channel activity
Specific function:
Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.
Gene Name:
TRPM2
Uniprot ID:
O94759
Molecular weight:
171224.9
General function:
Involved in catalytic activity
Specific function:
Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
Gene Name:
SLC27A5
Uniprot ID:
Q9Y2P5
Molecular weight:
75384.375
General function:
Involved in acyl carrier activity
Specific function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA
Gene Name:
AASDH
Uniprot ID:
Q4L235
Molecular weight:
122596.1

Only showing the first 10 proteins. There are 409 proteins in total.