Showing Protein Deoxycytidine kinase (CDBP00007)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 6 compounds
Identification
HMDB Protein ID CDBP00007
Secondary Accession Numbers Not Available
Name Deoxycytidine kinase
Description Not Available
Synonyms
  1. dCK
Gene Name DCK
Protein Type Enzyme
Biological Properties
General Function Involved in ATP binding
Specific Function Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
GO Classification
Biological Process
purine nucleobase metabolic process
pyrimidine nucleoside salvage
pyrimidine nucleobase metabolic process
drug metabolic process
purine-containing compound salvage
deoxycytidine metabolic process
pyrimidine nucleotide metabolic process
Cellular Component
cytosol
nucleus
Function
phosphotransferase activity, alcohol group as acceptor
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
Molecular Function
deoxycytidine kinase activity
pyrimidine deoxyribonucleoside binding
magnesium ion binding
phosphotransferase activity, alcohol group as acceptor
ATP binding
drug binding
Process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Cellular Location
  1. Nucleus
Pathways
Gene Properties
Chromosome Location 4
Locus 4q13.3-q21.1
SNPs DCK
Gene Sequence 
>783 bp
ATGGCCACCCCGCCCAAGAGAAGCTGCCCGTCTTTCTCAGCCAGCTCTGAGGGGACCCGC
ATCAAGAAAATCTCCATCGAAGGGAACATCGCTGCAGGGAAGTCAACATTTGTGAATATC
CTTAAACAATTGTGTGAAGATTGGGAAGTGGTTCCTGAACCTGTTGCCAGATGGTGCAAT
GTTCAAAGTACTCAAGATGAATTTGAGGAACTTACAATGTCTCAGAAAAATGGTGGGAAT
GTTCTTCAGATGATGTATGAGAAACCTGAACGATGGTCTTTTACCTTCCAAACATATGCC
TGTCTCAGTCGAATAAGAGCTCAGCTTGCCTCTCTGAATGGCAAGCTCAAAGATGCAGAG
AAACCTGTATTATTTTTTGAACGATCTGTGTATAGTGACAGGTATATTTTTGCATCTAAT
TTGTATGAATCTGAATGCATGAATGAGACAGAGTGGACAATTTATCAAGACTGGCATGAC
TGGATGAATAACCAATTTGGCCAAAGCCTTGAATTGGATGGAATCATTTATCTTCAAGCC
ACTCCAGAGACATGCTTACATAGAATATATTTACGGGGAAGAAATGAAGAGCAAGGCATT
CCTCTTGAATATTTAGAGAAGCTTCATTATAAACATGAAAGCTGGCTCCTGCATAGGACA
CTGAAAACCAACTTCGATTATCTTCAAGAGGTGCCTATCTTAACACTGGATGTTAATGAA
GACTTTAAAGACAAATATGAAAGTCTGGTTGAAAAGGTCAAAGAGTTTTTGAGTACTTTG
TGA
Protein Properties
Number of Residues 260
Molecular Weight 30518.315
Theoretical pI 5.209
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Deoxycytidine kinase
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P27707
UniProtKB/Swiss-Prot Entry Name DCK_HUMAN
PDB IDs
GenBank Gene ID M60527
GeneCard ID DCK
GenAtlas ID DCK
HGNC ID HGNC:2704
References
General References Not Available