Cannabis Compound Database: Showing Protein Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (CDBP00532)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00532

Secondary Accession Numbers

Not Available

Name

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Description

Not Available

Synonyms

GMP-PDE gamma

Gene Name

PDE6H

Protein Type

Enzyme

Biological Properties

General Function

Involved in 3',5'-cyclic-nucleotide phosphodiesterase activity

Specific Function

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

GO Classification

Biological Process
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of G-protein coupled receptor protein signaling pathway
response to stimulus
visual perception
activation of MAPK activity
Function
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
gmp binding
cgmp binding
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
nucleoside binding
purine nucleoside binding
phosphoric ester hydrolase activity
phosphoric diester hydrolase activity
Molecular Function
cGMP binding
enzyme inhibitor activity
3',5'-cyclic-GMP phosphodiesterase activity
Process
multicellular organismal process
system process
neurological system process
sensory perception
sensory perception of light stimulus
visual perception

Cellular Location

Cytoplasmic

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

12p13

SNPs

PDE6H

Gene Sequence

>252 bp
ATGAGTGACAACACTACTCTGCCTGCTCCAGCTTCAAACCAGGGTCCTACCACCCCACGC
AAAGGCCCTCCCAAGTTCAAGCAGAGGCAGACTCGCCAATTCAAGAGTAAACCTCCAAAG
AAAGGTGTGAAAGGATTTGGAGATGACATTCCAGGAATGGAGGGGCTAGGAACAGATATC
ACAGTGATTTGTCCATGGGAGGCATTCAGCCACCTGGAATTGCATGAGCTCGCTCAGTTT
GGGATTATCTGA

Protein Properties

Number of Residues

Molecular Weight

9074.36

Theoretical pI

9.248

Pfam Domain Function

PDE6_gamma (PF04868 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
MSDNTTLPAPASNQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTDI
TVICPWEAFSHLELHELAQFGII

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

Q13956

UniProtKB/Swiss-Prot Entry Name

CNCG_HUMAN

PDB IDs

Not Available

GenBank Gene ID

D45399

GeneCard ID