| Identification |
|---|
| HMDB Protein ID
| CDBP00533 |
| Secondary Accession Numbers
| Not Available |
| Name
| Adenylate kinase isoenzyme 1 |
| Description
| Not Available |
| Synonyms
|
- AK 1
- ATP-AMP transphosphorylase 1
- Myokinase
|
| Gene Name
| AK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.
|
| GO Classification
|
| Biological Process |
| cell cycle arrest |
| nucleobase-containing small molecule interconversion |
| ATP metabolic process |
| Cellular Component |
| cytosol |
| plasma membrane |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| adenylate kinase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleobase, nucleoside, nucleotide kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| binding |
| catalytic activity |
| phosphotransferase activity, phosphate group as acceptor |
| transferase activity |
| Molecular Function |
| ATP binding |
| adenylate kinase activity |
| Process |
| nucleobase, nucleoside and nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| nucleotide metabolic process |
| purine nucleoside triphosphate metabolic process |
| purine ribonucleoside triphosphate metabolic process |
| atp metabolic process |
| purine nucleotide metabolic process |
| metabolic process |
| nitrogen compound metabolic process |
| cellular nitrogen compound metabolic process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Purine Metabolism |    |  | | Adenosine Deaminase Deficiency |    | Not Available | | Adenylosuccinate Lyase Deficiency |    | Not Available | | Gout or Kelley-Seegmiller Syndrome |    | Not Available | | Lesch-Nyhan Syndrome (LNS) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q34.1 |
| SNPs
| AK1 |
| Gene Sequence
|
>585 bp
ATGGAAGAGAAGCTGAAGAAAACCAAGATCATCTTTGTGGTGGGTGGGCCTGGCTCAGGG
AAGGGCACCCAGTGTGAGAAGATCGTGCAGAAGTATGGCTACACCCACCTCTCCACCGGG
GACCTCCTGCGGTCCGAGGTCAGCTCAGGCTCGGCCAGGGGCAAGAAGCTGTCGGAAATC
ATGGAGAAGGGGCAGCTGGTTCCACTGGAGACAGTGTTGGACATGCTCCGGGATGCCATG
GTGGCCAAAGTCAATACTTCCAAAGGCTTCCTGATTGATGGCTACCCGCGGGAGGTGCAG
CAAGGAGAAGAGTTTGAGCGACGGATTGGACAGCCCACACTGCTGCTGTATGTGGACGCA
GGCCCTGAGACCATGACCCAGCGGCTCTTGAAACGTGGAGAGACCAGCGGGCGTGTGGAC
GACAATGAGGAGACCATCAAAAAGCGGCTGGAGACCTATTACAAGGCCACAGAACCCGTC
ATCGCCTTCTATGAGAAACGTGGCATTGTGCGCAAGGTCAACGCTGAGGGCTCCGTGGAC
AGTGTCTTCTCCCAGGTCTGCACCCACCTGGACGCCCTAAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 194 |
| Molecular Weight
| 21634.725 |
| Theoretical pI
| 8.627 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Adenylate kinase isoenzyme 1
MEEKLKKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEI
MEKGQLVPLETVLDMLRDAMVAKVNTSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDA
GPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVD
SVFSQVCTHLDALK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P00568 |
| UniProtKB/Swiss-Prot Entry Name
| KAD1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB021871 |
| GeneCard ID
| AK1 |
| GenAtlas ID
| AK1 |
| HGNC ID
| HGNC:361 |
| References |
|---|
| General References
| Not Available |