| Identification |
|---|
| HMDB Protein ID
| CDBP02396 |
| Secondary Accession Numbers
| Not Available |
| Name
| Adenylate kinase 2, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- AK 2
- ATP-AMP transphosphorylase 2
|
| Gene Name
| AK2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Plays a key role in hematopoiesis.
|
| GO Classification
|
| Biological Process |
| nucleobase-containing small molecule interconversion |
| Cellular Component |
| mitochondrial inner membrane |
| mitochondrial intermembrane space |
| Function |
| nucleobase, nucleoside, nucleotide kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| binding |
| catalytic activity |
| nucleotide kinase activity |
| phosphotransferase activity, phosphate group as acceptor |
| transferase activity |
| adenylate kinase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| Molecular Function |
| ATP binding |
| adenylate kinase activity |
| Process |
| metabolic process |
| nitrogen compound metabolic process |
| cellular nitrogen compound metabolic process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
|
| Cellular Location
|
- Mitochondrion intermembrane space
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Tenofovir Metabolism Pathway |    | Not Available | | Adefovir Dipivoxil Metabolism Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p34 |
| SNPs
| AK2 |
| Gene Sequence
|
>720 bp
ATGGCTCCCAGCGTGCCAGCGGCAGAACCCGAGTATCCTAAAGGCATCCGGGCCGTGCTG
CTGGGGCCTCCCGGGGCCGGTAAAGGGACCCAGGCACCCAGATTGGCTGAAAACTTCTGT
GTCTGCCATTTAGCTACTGGGGACATGCTGAGGGCCATGGTGGCTTCTGGCTCAGAGCTA
GGAAAAAAGCTGAAGGCAACTATGGATGCTGGGAAACTGGTGAGTGATGAAATGGTAGTG
GAGCTCATTGAGAAGAATTTGGAGACCCCCTTGTGCAAAAATGGTTTTCTTCTGGATGGC
TTCCCTCGGACTGTGAGGCAGGCAGAAATGCTCGATGACCTCATGGAGAAGAGGAAAGAG
AAGCTTGATTCTGTGATTGAATTCAGCATCCCAGACTCTCTGCTGATCCGAAGAATCACA
GGAAGGCTGATTCACCCCAAGAGTGGCCGTTCCTACCACGAGGAGTTCAACCCTCCAAAA
GAGCCCATGAAAGATGACATCACCGGGGAACCCTTGATCCGTCGATCAGATGATAATGAA
AAGGCCTTGAAAATCCGCCTGCAAGCCTACCACACTCAAACCACCCCACTCATAGAGTAC
TACAGGAAACGGGGGATCCACTCCGCCATCGATGCATCCCAGACCCCCGATGTCGTGTTC
GCAAGCATCCTAGCAGCCTTCTCCAAAGCCACATGTAAAGACTTGGTTATGTTTATCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 239 |
| Molecular Weight
| 24648.125 |
| Theoretical pI
| 6.696 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Adenylate kinase 2, mitochondrial
MAPSVPAAEPEYPKGIRAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSEL
GKKLKATMDAGKLVSDEMVVELIEKNLETPLCKNGFLLDGFPRTVRQAEMLDDLMEKRKE
KLDSVIEFSIPDSLLIRRITGRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNE
KALKIRLQAYHTQTTPLIEYYRKRGIHSAIDASQTPDVVFASILAAFSKATCKDLVMFI
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P54819 |
| UniProtKB/Swiss-Prot Entry Name
| KAD2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| U39945 |
| GeneCard ID
| AK2 |
| GenAtlas ID
| AK2 |
| HGNC ID
| HGNC:362 |
| References |
|---|
| General References
| Not Available |