Identification
HMDB Protein ID CDBP00600
Secondary Accession Numbers Not Available
Name Thiamin pyrophosphokinase 1
Description Not Available
Synonyms
  1. PP20
  2. Placental protein 20
  3. Thiamine pyrophosphokinase 1
  4. hTPK1
Gene Name TPK1
Protein Type Enzyme
Biological Properties
General Function Involved in thiamin diphosphokinase activity
Specific Function Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.
GO Classification
Biological Process
thiamine diphosphate biosynthetic process
thiamine-containing compound metabolic process
thiamine metabolic process
Cellular Component
cytosol
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
diphosphotransferase activity
adenyl ribonucleotide binding
atp binding
thiamin diphosphokinase activity
Molecular Function
thiamine diphosphokinase activity
kinase activity
ATP binding
Process
cellular aromatic compound metabolic process
cellular metabolic process
thiamin diphosphate biosynthetic process
thiamin and derivative metabolic process
thiamin metabolic process
cofactor metabolic process
coenzyme metabolic process
metabolic process
coenzyme biosynthetic process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 7
Locus 7q34-q35
SNPs TPK1
Gene Sequence
>732 bp
ATGGAGCATGCCTTTACCCCGTTGGAGCCCCTGCTTTCCACTGGGAATTTGAAGTACTGC
CTTGTAATTCTTAATCAGCCTTTGGACAACTATTTTCGTCATCTTTGGAACAAAGCTCTT
TTAAGAGCCTGTGCCGATGGAGGTGCCAACCGCTTATATGATATCACCGAAGGAGAGAGA
GAAAGCTTTTTGCCTGAATTCATCAATGGAGACTTTGATTCTATTAGGCCTGAAGTCAGA
GAATACTATGCTACTAAGGGATGTGAGCTCATTTCAACTCCTGATCAAGACCACACTGAC
TTTACTAAGTGCCTTAAAATGCTCCAAAAGAAGATAGAAGAAAAAGACTTAAAGGTTGAT
GTGATCGTGACACTGGGAGGCCTTGCTGGGCGTTTTGACCAGATTATGGCATCTGTGAAT
ACCTTGTTCCAAGCGACTCACATCACTCCTTTTCCAATTATAATAATCCAAGAGGAATCG
CTGATCTACCTGCTCCAACCAGGAAAGCACAGGTTGCATGTAGACACTGGAATGGAGGGT
GATTGGTGTGGCCTTATTCCTGTTGGACAGCCTTGTATGCAGGTTACAACCACAGGCCTC
AAGTGGAACCTCACAAATGATGTGCTTGCTTTTGGAACATTGGTCAGTACTTCCAATACC
TACGACGGGTCTGGTGTTGTGACTGTGGAAACTGACCACCCACTCCTCTGGACCATGGCC
ATCAAAAGCTAA
Protein Properties
Number of Residues 243
Molecular Weight 27265.05
Theoretical pI 5.19
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Thiamin pyrophosphokinase 1
MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGER
ESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVD
VIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEG
DWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMA
IKS
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9H3S4
UniProtKB/Swiss-Prot Entry Name TPK1_HUMAN
PDB IDs
GenBank Gene ID AB028138
GeneCard ID TPK1
GenAtlas ID TPK1
HGNC ID HGNC:17358
References
General References Not Available