| Identification |
|---|
| HMDB Protein ID
| CDBP00600 |
| Secondary Accession Numbers
| Not Available |
| Name
| Thiamin pyrophosphokinase 1 |
| Description
| Not Available |
| Synonyms
|
- PP20
- Placental protein 20
- Thiamine pyrophosphokinase 1
- hTPK1
|
| Gene Name
| TPK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in thiamin diphosphokinase activity |
| Specific Function
| Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.
|
| GO Classification
|
| Biological Process |
| thiamine diphosphate biosynthetic process |
| thiamine-containing compound metabolic process |
| thiamine metabolic process |
| Cellular Component |
| cytosol |
| Function |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| diphosphotransferase activity |
| adenyl ribonucleotide binding |
| atp binding |
| thiamin diphosphokinase activity |
| Molecular Function |
| thiamine diphosphokinase activity |
| kinase activity |
| ATP binding |
| Process |
| cellular aromatic compound metabolic process |
| cellular metabolic process |
| thiamin diphosphate biosynthetic process |
| thiamin and derivative metabolic process |
| thiamin metabolic process |
| cofactor metabolic process |
| coenzyme metabolic process |
| metabolic process |
| coenzyme biosynthetic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | thiamine diphosphate biosynthesis | Not Available | Not Available | | Thiamine Metabolism |    |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7q34-q35 |
| SNPs
| TPK1 |
| Gene Sequence
|
>732 bp
ATGGAGCATGCCTTTACCCCGTTGGAGCCCCTGCTTTCCACTGGGAATTTGAAGTACTGC
CTTGTAATTCTTAATCAGCCTTTGGACAACTATTTTCGTCATCTTTGGAACAAAGCTCTT
TTAAGAGCCTGTGCCGATGGAGGTGCCAACCGCTTATATGATATCACCGAAGGAGAGAGA
GAAAGCTTTTTGCCTGAATTCATCAATGGAGACTTTGATTCTATTAGGCCTGAAGTCAGA
GAATACTATGCTACTAAGGGATGTGAGCTCATTTCAACTCCTGATCAAGACCACACTGAC
TTTACTAAGTGCCTTAAAATGCTCCAAAAGAAGATAGAAGAAAAAGACTTAAAGGTTGAT
GTGATCGTGACACTGGGAGGCCTTGCTGGGCGTTTTGACCAGATTATGGCATCTGTGAAT
ACCTTGTTCCAAGCGACTCACATCACTCCTTTTCCAATTATAATAATCCAAGAGGAATCG
CTGATCTACCTGCTCCAACCAGGAAAGCACAGGTTGCATGTAGACACTGGAATGGAGGGT
GATTGGTGTGGCCTTATTCCTGTTGGACAGCCTTGTATGCAGGTTACAACCACAGGCCTC
AAGTGGAACCTCACAAATGATGTGCTTGCTTTTGGAACATTGGTCAGTACTTCCAATACC
TACGACGGGTCTGGTGTTGTGACTGTGGAAACTGACCACCCACTCCTCTGGACCATGGCC
ATCAAAAGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 243 |
| Molecular Weight
| 27265.05 |
| Theoretical pI
| 5.19 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Thiamin pyrophosphokinase 1
MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGER
ESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVD
VIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEG
DWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMA
IKS
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9H3S4 |
| UniProtKB/Swiss-Prot Entry Name
| TPK1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB028138 |
| GeneCard ID
| TPK1 |
| GenAtlas ID
| TPK1 |
| HGNC ID
| HGNC:17358 |
| References |
|---|
| General References
| Not Available |