Record Information
Version1.0
Created at2020-04-17 19:08:01 UTC
Updated at2020-11-18 16:39:19 UTC
CannabisDB IDCDB005087
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameNADH
DescriptionNADH, also known as DPNH or b-nadh, belongs to the class of organic compounds known as (5'->5')-dinucleotides. These are dinucleotides where the two bases are connected via a (5'->5')-phosphodiester linkage. NADH is a strong basic compound (based on its pKa). NADH exists in all living species, ranging from bacteria to humans. A coenzyme found in all living cells; consists of two nucleotides joined through their 5'-phosphate groups, with one nucleotide containing an adenine base and the other containing nicotinamide. In humans, NADH is involved in doxorubicin metabolism pathway. NADH is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
1,4-DIHYDRONICOTINAMIDE adenine dinucleotideChEBI
DPNHChEBI
Nicotinamide adenine dinucleotide (reduced)ChEBI
Reduced nicotinamide adenine dinucleotideChEBI
b-DPNHHMDB
b-NADHHMDB
beta-DPNHHMDB
beta-NADHHMDB
Dihydrocodehydrogenase IHMDB
DihydrocozymaseHMDB
Dihydronicotinamide adenine dinucleotideHMDB
Dihydronicotinamide mononucleotideHMDB
ENADAHMDB
NADH2HMDB
Reduced codehydrogenase IHMDB
Reduced diphosphopyridine nucleotideHMDB
Reduced nicotinamide adenine diphosphateHMDB
Reduced nicotinamide-adenine dinucleotideHMDB
NadideHMDB
Coenzyme IHMDB
DPNHMDB
Diphosphopyridine nucleotideHMDB
Nicotinamide adenine dinucleotideHMDB
Nicotinamide-adenine dinucleotideHMDB
NADHMDB
Nucleotide, diphosphopyridineHMDB
Adenine dinucleotide, dihydronicotinamideHMDB
Dinucleotide, dihydronicotinamide adenineHMDB
Dinucleotide, nicotinamide-adenineHMDB
Chemical FormulaC21H29N7O14P2
Average Molecular Weight665.44
Monoisotopic Molecular Weight665.1248
IUPAC Name[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acid
Traditional NameNADH
CAS Registry Number58-68-4
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
InChI Identifier
InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChI KeyBOPGDPNILDQYTO-NNYOXOHSSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as (5'->5')-dinucleotides. These are dinucleotides where the two bases are connected via a (5'->5')-phosphodiester linkage.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
Class(5'->5')-dinucleotides
Sub ClassNot Available
Direct Parent(5'->5')-dinucleotides
Alternative Parents
Substituents
  • (5'->5')-dinucleotide
  • Purine nucleotide sugar
  • Purine ribonucleoside diphosphate
  • Purine ribonucleoside monophosphate
  • Nicotinamide-nucleotide
  • Pentose phosphate
  • Pentose-5-phosphate
  • Glycosyl compound
  • N-glycosyl compound
  • 6-aminopurine
  • Monosaccharide phosphate
  • N-substituted nicotinamide
  • Organic pyrophosphate
  • Imidazopyrimidine
  • Purine
  • Monoalkyl phosphate
  • Dihydropyridine
  • Aminopyrimidine
  • Pyrimidine
  • Imidolactam
  • Monosaccharide
  • N-substituted imidazole
  • Alkyl phosphate
  • Phosphoric acid ester
  • Hydropyridine
  • Organic phosphoric acid derivative
  • Heteroaromatic compound
  • Tetrahydrofuran
  • Imidazole
  • Vinylogous amide
  • Azole
  • Amino acid or derivatives
  • Primary carboxylic acid amide
  • Secondary alcohol
  • Carboxamide group
  • Organoheterocyclic compound
  • Enamine
  • Azacycle
  • Oxacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Alcohol
  • Organic nitrogen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Carbonyl group
  • Organic oxygen compound
  • Organopnictogen compound
  • Primary amine
  • Amine
  • Organic oxide
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting Point140.0 - 142.0 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-1.4ALOGPS
logP-5.9ChemAxon
logS-2.4ALOGPS
pKa (Strongest Acidic)1.85ChemAxon
pKa (Strongest Basic)4.01ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count16ChemAxon
Hydrogen Donor Count8ChemAxon
Polar Surface Area317.62 ŲChemAxon
Rotatable Bond Count11ChemAxon
Refractivity143 m³·mol⁻¹ChemAxon
Polarizability57.65 ųChemAxon
Number of Rings5ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSNADH, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-002b-1301902000-1a1639ad87019605438cSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-00n0-0210192000-bf07b6b154c5778067ceSpectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-0udi-0150291000-84ef746651797f0679a5Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-004i-0970000000-0688003193d7fc461235Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 35V, negativesplash10-00di-0190000000-775fe0fdd09a45ed6a96Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 35V, negativesplash10-052b-0019600000-3247f3ea96ec22c0e190Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 35V, negativesplash10-052b-0019600000-c62f2c56a1ce8a2874fbSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 32V, negativesplash10-03di-3212549000-5bb7a136d3e7ca7d8eddSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 30V, negativesplash10-00ea-1219600000-1e722b38e19c9839c336Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-0931104000-bf6579d19ee9bc297e13Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-0901000000-92672b1d4b96838f8652Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000i-1900000000-ef56d203da65089e145fSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-03e9-1900207000-f248eb28a7283de7118bSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-001i-1900100000-efadf1d6c54e9e86671dSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0a7i-3900000000-f258fc2bf1d8e54ac6daSpectrum
NMR
TypeDescriptionView
1D NMR1H NMR SpectrumSpectrum
2D NMR[1H,1H] 2D NMR SpectrumSpectrum
2D NMR[1H,13C] 2D NMR SpectrumSpectrum
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
Pyruvate dehydrogenase E1 component subunit beta, mitochondrialPDHB3p21.1-p14.2P11177 details
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialPDHA1Xp22.1P08559 details
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrialPDHA24q22-q23P29803 details
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrialALDH6A114q24.3Q02252 details
Dihydrolipoyl dehydrogenase, mitochondrialDLD7q31-q32P09622 details
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialDLAT11q23.1P10515 details
Aldo-keto reductase family 1 member C4AKR1C410p15.1P17516 details
15-hydroxyprostaglandin dehydrogenase [NAD(+)]HPGD4q34-q35P15428 details
TyrosinaseTYR11q14-q21P14679 details
Aldose reductaseAKR1B17q35P15121 details
Short-chain specific acyl-CoA dehydrogenase, mitochondrialACADS12q24.31P16219 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10NDUFB1016p13.3O96000 details
NADH-ubiquinone oxidoreductase chain 1MT-ND1P03886 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1NDUFB114q32.12O75438 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1ENPP16q22-q23P22413 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialNDUFS21q23O75306 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12NDUFA1212q22Q9UI09 details
NADH-cytochrome b5 reductase 3CYB5R322q13.2P00387 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1NDUFA1O15239 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2NDUFA4L212q13.3Q9NRX3 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3NDUFA319q13.42O95167 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8NDUFA89q33.2P51970 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4NDUFA47p21.3O00483 details
NADH-ubiquinone oxidoreductase chain 4LMT-ND4LP03901 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11NDUFA1119p13.3Q86Y39 details
Lathosterol oxidaseSC5DL11q23.3O75845 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrialNDUFB27q34O95178 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialNDUFS45q11.1O43181 details
NADH-ubiquinone oxidoreductase chain 5MT-ND5P03915 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialNDUFS311p11.11O75489 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5NDUFS51p34.2-p33O43920 details
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialNDUFV218p11.22P19404 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialNDUFA102q37.3O95299 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6NDUFA622q13.2P56556 details
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialNDUFV321q22.3P56181 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4NDUFB43q13.33O95168 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialNDUFS811q13O00217 details
NADH-ubiquinone oxidoreductase chain 2MT-ND2P03891 details
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrialALDH4A11p36P30038 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7NDUFA719p13.2O95182 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2NDUFA25q31O43678 details
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialNDUFS12q33-q34P28331 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialNDUFB53q26.33O43674 details
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialNDUFC14q31.1O43677 details
NADH dehydrogenase [ubiquinone] 1 subunit C2NDUFC211q14.1O95298 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3NDUFB32q31.3O43676 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7NDUFB719p13.12P17568 details
Acyl carrier protein, mitochondrialNDUFAB116p12.2O14561 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5NDUFA57q32Q16718 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialNDUFA912p13.3Q16795 details
NADH-ubiquinone oxidoreductase chain 4MT-ND4P03905 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialNDUFS719p13.3O75251 details
Xanthine dehydrogenase/oxidaseXDH2p23.1P47989 details
NADH-ubiquinone oxidoreductase chain 3MT-ND3P03897 details
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialNDUFV111q13P49821 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9NDUFB98q13.3Q9Y6M9 details
Methylenetetrahydrofolate reductaseMTHFR1p36.3P42898 details
NADH-ubiquinone oxidoreductase chain 6MT-ND6P03923 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13NDUFA1319p13.2Q9P0J0 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialNDUFS65p15.33O75380 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3ENPP36q22O14638 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6NDUFB69p21.1O95139 details
Glutathione reductase, mitochondrialGSR8p21.1P00390 details
Retinal dehydrogenase 1ALDH1A19q21.13P00352 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrialNDUFB810q24.31O95169 details
Retinal dehydrogenase 2ALDH1A215q21.3O94788 details
Succinate-semialdehyde dehydrogenase, mitochondrialALDH5A16p22P51649 details
Methylsterol monooxygenase 1MSMO14q32-q34Q15800 details
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylatingNSDHLXq28Q15738 details
4-trimethylaminobutyraldehyde dehydrogenaseALDH9A11q23.1P49189 details
Aldehyde dehydrogenase, dimeric NADP-preferringALDH3A117p11.2P30838 details
Alpha-aminoadipic semialdehyde dehydrogenaseALDH7A15q31P49419 details
Aldehyde dehydrogenase family 1 member A3ALDH1A315q26.3P47895 details
Aldehyde dehydrogenase, mitochondrialALDH212q24.2P05091 details
Fatty aldehyde dehydrogenaseALDH3A217p11.2P51648 details
Aldehyde dehydrogenase X, mitochondrialALDH1B19p11.1P30837 details
Pyrroline-5-carboxylate reductase 1, mitochondrialPYCR117q25.3P32322 details
Pyrroline-5-carboxylate reductase 2PYCR21q42.12Q96C36 details
Nicotinamide mononucleotide adenylyltransferase 1NMNAT11p36.22Q9HAN9 details
Nicotinamide mononucleotide adenylyltransferase 3NMNAT33q23Q96T66 details
Nicotinamide mononucleotide adenylyltransferase 2NMNAT21q25Q9BZQ4 details
Aldo-keto reductase family 1 member C3AKR1C310p15-p14P42330 details
3-hydroxyacyl-CoA dehydrogenase type-2HSD17B10Xp11.2Q99714 details
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialHADH4q22-q26Q16836 details
GDP-mannose 4,6 dehydrataseGMDS6p25O60547 details
Aldo-keto reductase family 1 member C1AKR1C110p15-p14Q04828 details
Aldo-keto reductase family 1 member C2AKR1C210p15-p14P52895 details
Glyoxylate reductase/hydroxypyruvate reductaseGRHPR9q12Q9UBQ7 details
3-hydroxyisobutyrate dehydrogenase, mitochondrialHIBADH7p15.2P31937 details
2-oxoglutarate dehydrogenase, mitochondrialOGDH7p14-p13Q02218 details
Estradiol 17-beta-dehydrogenase 2HSD17B216q24.1-q24.2P37059 details
Estradiol 17-beta-dehydrogenase 8HSD17B86p21.3Q92506 details
11-cis retinol dehydrogenaseRDH512q13-q14Q92781 details
Sorbitol dehydrogenaseSORD15q15.3Q00796 details
Alcohol dehydrogenase [NADP(+)]AKR1A11p33-p32P14550 details
Alcohol dehydrogenase 4ADH44q22P08319 details
D-beta-hydroxybutyrate dehydrogenase, mitochondrialBDH13q29Q02338 details
Aldehyde dehydrogenase family 3 member B2ALDH3B211q13P48448 details
Aldehyde dehydrogenase family 3 member B1ALDH3B111q13P43353 details
Dihydropteridine reductaseQDPR4p15.31P09417 details
7-dehydrocholesterol reductaseDHCR711q13.4Q9UBM7 details
Glutamate dehydrogenase 2, mitochondrialGLUD2Xq24-q25P49448 details
Aminomethyltransferase, mitochondrialAMT3p21.2-p21.1P48728 details
Glyceraldehyde-3-phosphate dehydrogenase, testis-specificGAPDHS19q13.12O14556 details
Glutamate dehydrogenase 1, mitochondrialGLUD110q23.3P00367 details
Glyceraldehyde-3-phosphate dehydrogenaseGAPDH12p13P04406 details
Biliverdin reductase ABLVRA7p13P53004 details
Flavin reductase (NADPH)BLVRB19q13.1-q13.2P30043 details
Adenylate cyclase type 7ADCY716q12.1P51828 details
Adenylate cyclase type 4ADCY414q12Q8NFM4 details
Adenylate cyclase type 6ADCY612q12-q13O43306 details
Adenylate cyclase type 5ADCY53q21.1O95622 details
Adenylate cyclase type 8ADCY88q24P40145 details
Adenylate cyclase type 9ADCY916p13.3O60503 details
Adenylate cyclase type 3ADCY32p23.3O60266 details
Adenylate cyclase type 1ADCY17p13-p12Q08828 details
Corticosteroid 11-beta-dehydrogenase isozyme 2HSD11B216q22P80365 details
Corticosteroid 11-beta-dehydrogenase isozyme 1HSD11B11q32-q41P28845 details
Alcohol dehydrogenase class-3ADH54q23P11766 details
Alcohol dehydrogenase 1BADH1B4q23P00325 details
Alcohol dehydrogenase class 4 mu/sigma chainADH74q23-q24P40394 details
Alcohol dehydrogenase 1AADH1A4q23P07327 details
Alcohol dehydrogenase 6ADH64q23P28332 details
Alcohol dehydrogenase 1CADH1C4q23P00326 details
Dihydrofolate reductaseDHFR5q11.2-q13.2P00374 details
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicGPD112q12-q13P21695 details
Testosterone 17-beta-dehydrogenase 3HSD17B39q22P37058 details
Estradiol 17-beta-dehydrogenase 1HSD17B117q11-q21P14061 details
3-keto-steroid reductaseHSD17B71q23P56937 details
Alpha-aminoadipic semialdehyde synthase, mitochondrialAASS7q31.3Q9UDR5 details
Malate dehydrogenase, mitochondrialMDH27cen-q22P40926 details
Malate dehydrogenase, cytoplasmicMDH12p13.3P40925 details
Inosine-5'-monophosphate dehydrogenase 2IMPDH23p21.2P12268 details
Inosine-5'-monophosphate dehydrogenase 1IMPDH17q31.3-q32P20839 details
L-lactate dehydrogenase A-like 6ALDHAL6A11p15.1Q6ZMR3 details
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrialIDH3B20p13O43837 details
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialIDH3A15q25.1-q25.2P50213 details
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialIDH3GXq28P51553 details
Tankyrase-2TNKS210q23.3Q9H2K2 details
dTDP-D-glucose 4,6-dehydrataseTGDS13q32.1O95455 details
NAD-dependent protein deacetylase sirtuin-6SIRT619p13.3Q8N6T7 details
UDP-glucose 4-epimeraseGALE1p36-p35Q14376 details
Poly [ADP-ribose] polymerase 3PARP33p21.31-p21.1Q9Y6F1 details
Ecto-ADP-ribosyltransferase 3ART34p15.1-p14Q13508 details
UDP-glucose 6-dehydrogenaseUGDH4p15.1O60701 details
Ecto-ADP-ribosyltransferase 5ART511p15.4Q96L15 details
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1ART111p15P52961 details
NAD(P) transhydrogenase, mitochondrialNNT5p12Q13423 details
Tankyrase-1TNKS8p23.1O95271 details
Poly [ADP-ribose] polymerase 1PARP11q41-q42P09874 details
Urocanate hydrataseUROC13q21.3Q96N76 details
ADP-ribosyl cyclase 2BST14p15Q10588 details
Poly [ADP-ribose] polymerase 2PARP214q11.2-q12Q9UGN5 details
NAD kinaseNADK1p36.33O95544 details
ADP-ribosyl cyclase 1CD384p15P28907 details
Ecto-ADP-ribosyltransferase 4ART412p13-p12Q93070 details
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialMTHFD22p13.1P13995 details
Adenylate cyclase type 2ADCY25p15.3Q08462 details
D-3-phosphoglycerate dehydrogenasePHGDH1p12O43175 details
C-1-tetrahydrofolate synthase, cytoplasmicMTHFD114q24P11586 details
Poly [ADP-ribose] polymerase 4PARP413q11Q9UKK3 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrialNDUFB11Q9NX14 details
NAD(P)H dehydrogenase [quinone] 1NQO116q22.1P15559 details
Proline dehydrogenase 1, mitochondrialPRODH22q11.21O43272 details
Dehydrogenase/reductase SDR family member 9DHRS92q31.1Q9BPW9 details
17-beta-hydroxysteroid dehydrogenase type 6HSD17B612q13O14756 details
Pyrroline-5-carboxylate reductase 3PYCRL8q24.3Q53H96 details
Glycine cleavage system H protein, mitochondrialGCSHP23434 details
UDP-glucuronic acid decarboxylase 1UXS12q12.2Q8NBZ7 details
Glutamine-dependent NAD(+) synthetaseNADSYN111q13.4Q6IA69 details
L-lactate dehydrogenase B chainLDHB12p12.2-p12.1P07195 details
L-lactate dehydrogenase C chainLDHC11p15.1P07864 details
L-lactate dehydrogenase A chainLDHA11p15.4P00338 details
L-lactate dehydrogenase A-like 6BLDHAL6B15q22.2Q9BYZ2 details
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1HSD3B11p13.1P14060 details
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2HSD3B21p13.1P26439 details
3 beta-hydroxysteroid dehydrogenase type 7HSD3B716p11.2Q9H2F3 details
Inositol-3-phosphate synthase 1ISYNA119p13.11Q9NPH2 details
3-hydroxybutyrate dehydrogenase type 2BDH24q24Q9BUT1 details
Glycerol-3-phosphate dehydrogenase 1-like proteinGPD1L3p22.3Q8N335 details
Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2MTHFD2L4q13.3Q9H903 details
NADH-cytochrome b5 reductase 1CYB5R11q32.1Q9UHQ9 details
NADH-cytochrome b5 reductase 2CYB5R211p15.4Q6BCY4 details
Cytochrome b5 reductase 4CYB5R46pter-q22.33Q7L1T6 details
NADH-cytochrome b5 reductase-likeCYB5RL1p32.3Q6IPT4 details
Probable saccharopine dehydrogenaseSCCPDH1q44Q8NBX0 details
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolaseMTHFD22p13.1Q7Z650 details
Acyl-CoA synthetase family member 4AASDH4q12Q4L235 details
Aminoadipate-semialdehyde synthaseAASS7q31.3A4D0W4 details
Peroxisomal NADH pyrophosphatase NUDT12NUDT125q21.2Q9BQG2 details
Inosine-5'-monophosphate dehydrogenaseIMPDH17q31.3-q32A4D0Z6 details
Peroxisomal coenzyme A diphosphatase NUDT7NUDT716q23.1P0C024 details
Estradiol 17-beta-dehydrogenase 12HSD17B1211p11.2Q53GQ0 details
NAD-dependent protein deacetylase sirtuin-1SIRT110q21.3Q96EB6 details
Complex I intermediate-associated protein 30, mitochondrialNDUFAF115q11.2-q21.3Q9Y375 details
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrialECSIT19p13.2Q9BQ95 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4NDUFAF46q16.1Q9P032 details
Mimitin, mitochondrialNDUFAF25q12.1Q8N183 details
MOSC domain-containing protein 2, mitochondrialMOSC21q41Q969Z3 details
2-oxoglutarate dehydrogenase-like, mitochondrialOGDHLQ9ULD0 details
NADH dehydrogenase (Ubiquinone) 1 beta subcomplex, 2, 8kDaNDUFB27q34A4D1T5 details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferaseAASDHPPT11q22Q9NRN7 details
Aldo-keto reductase family 1 member B10AKR1B10O60218 details
Dihydrofolate reductase, mitochondrialDHFRL13q11.1Q86XF0 details
ATP-dependent (S)-NAD(P)H-hydrate dehydrataseCARKD13q34Q8IW45 details
Epidermal retinol dehydrogenase 2SDR16C58q12.1Q8N3Y7 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Aldo-keto reductase family 1 member C4AKR1C410p15.1P17516 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11NDUFA1119p13.3Q86Y39 details
Acyl carrier protein, mitochondrialNDUFAB116p12.2O14561 details
Glycerol-3-phosphate dehydrogenase 1-like proteinGPD1L3p22.3Q8N335 details
Acyl-CoA synthetase family member 4AASDH4q12Q4L235 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1ENPP16q22-q23P22413 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialNDUFS21q23O75306 details
Lathosterol oxidaseSC5DL11q23.3O75845 details
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialNDUFV218p11.22P19404 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialNDUFS811q13O00217 details
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialNDUFS12q33-q34P28331 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialNDUFS719p13.3O75251 details
Xanthine dehydrogenase/oxidaseXDH2p23.1P47989 details
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialNDUFV111q13P49821 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3ENPP36q22O14638 details
Methylsterol monooxygenase 1MSMO14q32-q34Q15800 details
Cytochrome P450 4A11CYP4A111p33Q02928 details
Sorbitol dehydrogenaseSORD15q15.3Q00796 details
Alcohol dehydrogenase 4ADH44q22P08319 details
Biliverdin reductase ABLVRA7p13P53004 details
Adenylate cyclase type 7ADCY716q12.1P51828 details
Adenylate cyclase type 4ADCY414q12Q8NFM4 details
Adenylate cyclase type 6ADCY612q12-q13O43306 details
Adenylate cyclase type 5ADCY53q21.1O95622 details
Adenylate cyclase type 8ADCY88q24P40145 details
Adenylate cyclase type 9ADCY916p13.3O60503 details
Adenylate cyclase type 3ADCY32p23.3O60266 details
Adenylate cyclase type 1ADCY17p13-p12Q08828 details
Alcohol dehydrogenase class-3ADH54q23P11766 details
Alcohol dehydrogenase 1BADH1B4q23P00325 details
Alcohol dehydrogenase class 4 mu/sigma chainADH74q23-q24P40394 details
Alcohol dehydrogenase 1AADH1A4q23P07327 details
Alcohol dehydrogenase 6ADH64q23P28332 details
Alcohol dehydrogenase 1CADH1C4q23P00326 details
NADP-dependent malic enzymeME16q12P48163 details
NADP-dependent malic enzyme, mitochondrialME311cen-q22.3Q16798 details
NAD-dependent malic enzyme, mitochondrialME218q21P23368 details
Inosine-5'-monophosphate dehydrogenase 2IMPDH23p21.2P12268 details
Inosine-5'-monophosphate dehydrogenase 1IMPDH17q31.3-q32P20839 details
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrialIDH3B20p13O43837 details
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialIDH3A15q25.1-q25.2P50213 details
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialIDH3GXq28P51553 details
Tankyrase-2TNKS210q23.3Q9H2K2 details
NAD-dependent protein deacetylase sirtuin-6SIRT619p13.3Q8N6T7 details
Tankyrase-1TNKS8p23.1O95271 details
Poly [ADP-ribose] polymerase 1PARP11q41-q42P09874 details
NAD kinaseNADK1p36.33O95544 details
Adenylate cyclase type 2ADCY25p15.3Q08462 details
Cytochrome b5 reductase 4CYB5R46pter-q22.33Q7L1T6 details
Cytochrome P450 4A22CYP4A221p33Q5TCH4 details
Peroxisomal NADH pyrophosphatase NUDT12NUDT125q21.2Q9BQG2 details
Cytochrome b5 type BCYB5B16q22.1O43169 details
Peroxisomal coenzyme A diphosphatase NUDT7NUDT716q23.1P0C024 details
NAD-dependent protein deacetylase sirtuin-1SIRT110q21.3Q96EB6 details
MOSC domain-containing protein 2, mitochondrialMOSC21q41Q969Z3 details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferaseAASDHPPT11q22Q9NRN7 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
15-hydroxyprostaglandin dehydrogenase [NAD(+)]HPGD4q34-q35P15428 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1ENPP16q22-q23P22413 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3ENPP36q22O14638 details
Retinal dehydrogenase 2ALDH1A215q21.3O94788 details
Aldo-keto reductase family 1 member C3AKR1C310p15-p14P42330 details
Aldo-keto reductase family 1 member C2AKR1C210p15-p14P52895 details
Adenylate cyclase type 7ADCY716q12.1P51828 details
Adenylate cyclase type 4ADCY414q12Q8NFM4 details
Adenylate cyclase type 6ADCY612q12-q13O43306 details
Adenylate cyclase type 5ADCY53q21.1O95622 details
Adenylate cyclase type 8ADCY88q24P40145 details
Adenylate cyclase type 9ADCY916p13.3O60503 details
Adenylate cyclase type 3ADCY32p23.3O60266 details
Adenylate cyclase type 1ADCY17p13-p12Q08828 details
Alcohol dehydrogenase class 4 mu/sigma chainADH74q23-q24P40394 details
Tankyrase-2TNKS210q23.3Q9H2K2 details
Tankyrase-1TNKS8p23.1O95271 details
Poly [ADP-ribose] polymerase 1PARP11q41-q42P09874 details
ADP-ribosyl cyclase 1CD384p15P28907 details
Adenylate cyclase type 2ADCY25p15.3Q08462 details
NAD-dependent protein deacetylase sirtuin-1SIRT110q21.3Q96EB6 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Dihydrofolate reductaseDHFR5q11.2-q13.2P00374 details
NAD-dependent protein deacetylase sirtuin-6SIRT619p13.3Q8N6T7 details
Tankyrase-1TNKS8p23.1O95271 details
Poly [ADP-ribose] polymerase 1PARP11q41-q42P09874 details
ADP-ribosyl cyclase 1CD384p15P28907 details
NAD-dependent protein deacetylase sirtuin-1SIRT110q21.3Q96EB6 details
Concentrations Data
Not Available
HMDB IDHMDB0001487
DrugBank IDDB00157
Phenol Explorer Compound IDNot Available
FoodDB IDFDB022649
KNApSAcK IDC00019343
Chemspider ID903
KEGG Compound IDC00004
BioCyc IDNADH
BiGG ID33484
Wikipedia LinkNicotinamide_adenine_dinucleotide
METLIN ID3687
PubChem Compound439153
PDB IDNot Available
ChEBI ID16908
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 289 proteins in total.

Enzymes

General function:
Involved in catalytic activity
Specific function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:
PDHB
Uniprot ID:
P11177
Molecular weight:
39233.1
General function:
Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Specific function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:
PDHA1
Uniprot ID:
P08559
Molecular weight:
43295.255
General function:
Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Specific function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:
PDHA2
Uniprot ID:
P29803
Molecular weight:
42932.855
General function:
Involved in oxidoreductase activity
Specific function:
Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
Gene Name:
ALDH6A1
Uniprot ID:
Q02252
Molecular weight:
57839.31
General function:
Involved in oxidoreductase activity
Specific function:
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.
Gene Name:
DLD
Uniprot ID:
P09622
Molecular weight:
54176.91
General function:
Involved in acyltransferase activity
Specific function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:
DLAT
Uniprot ID:
P10515
Molecular weight:
68996.03
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Gene Name:
AKR1C4
Uniprot ID:
P17516
Molecular weight:
37094.57
General function:
Involved in oxidoreductase activity
Specific function:
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
Gene Name:
HPGD
Uniprot ID:
P15428
Molecular weight:
28977.105
General function:
Involved in oxidoreductase activity
Specific function:
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
Gene Name:
TYR
Uniprot ID:
P14679
Molecular weight:
60392.69
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Gene Name:
AKR1B1
Uniprot ID:
P15121
Molecular weight:
35853.125

Transporters

General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Gene Name:
AKR1C4
Uniprot ID:
P17516
Molecular weight:
37094.57
General function:
Involved in protein transporter activity
Specific function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Name:
NDUFA11
Uniprot ID:
Q86Y39
Molecular weight:
14852.0
General function:
Involved in acyl carrier activity
Specific function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain
Gene Name:
NDUFAB1
Uniprot ID:
O14561
Molecular weight:
17417.1
General function:
Involved in oxidoreductase activity
Specific function:
Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
Gene Name:
GPD1L
Uniprot ID:
Q8N335
Molecular weight:
38418.44
General function:
Involved in acyl carrier activity
Specific function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA
Gene Name:
AASDH
Uniprot ID:
Q4L235
Molecular weight:
122596.1

Only showing the first 10 proteins. There are 289 proteins in total.