| Identification |
|---|
| HMDB Protein ID
| CDBP00195 |
| Secondary Accession Numbers
| Not Available |
| Name
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- CI-ASHI
- Complex I-ASHI
- NADH-ubiquinone oxidoreductase ASHI subunit
|
| Gene Name
| NDUFB8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in NADH dehydrogenase activity |
| Specific Function
| Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone |
| GO Classification
|
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| mitochondrial membrane part |
| mitochondrial respiratory chain complex i |
| mitochondrion |
| cell part |
| membrane part |
| Function |
| catalytic activity |
| nadh dehydrogenase activity |
| nadh dehydrogenase (quinone) activity |
| nadh dehydrogenase (ubiquinone) activity |
| oxidoreductase activity |
| oxidoreductase activity, acting on nadh or nadph |
| Process |
| mitochondrial electron transport, nadh to ubiquinone |
| metabolic process |
| generation of precursor metabolites and energy |
| electron transport chain |
| respiratory electron transport chain |
| cellular metabolic process |
|
| Cellular Location
|
- Single-pass membrane protein
- Mitochondrion inner membrane
- Matrix side
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q24.31 |
| SNPs
| NDUFB8 |
| Gene Sequence
|
>561 bp
ATGGCGGTGGCCAGGGCCGGGGTCTTGGGAGTCCAGTGGCTGCAAAGGGCATCCCGGAAC
GTGATGCCGCTGGGCGCACGGACAGCCTCCCACATGACCAAGGACATGTTCCCGGGGCCC
TATCCTAGGACCCCAGAAGAACGGGCCGCCGCCGCCAAGAAGTATAATATGCGTGTGGAA
GACTACGAACCTTACCCGGATGATGGCATGGGGTATGGCGACTACCCGAAGCTCCCTGAC
CGCTCACAGCATGAGAGAGATCCATGGTATAGCTGGGACCAGCCGGGCCTGAGGTTGAAC
TGGGGTGAACCGATGCACTGGCACCTAGACATGTACAACAGGAACCGTGTGGATACATCC
CCCACACCTGTTTCTTGGCATGTCATGTGTATGCAGCTCTTCGGTTTCCTGGCTTTCATG
ATATTCATGTGCTGGGTGGGGGACGTGTACCCTGTCTACCAGCCTGTGGGACCAAAGCAG
TATCCTTACAATAATCTGTACCTGGAACGAGGCGGTGATCCCTCCAAAGAACCAGAGCGG
GTGGTTCACTATGAGATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 186 |
| Molecular Weight
| 21765.7 |
| Theoretical pI
| 6.79 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
MAVARAGVLGVQWLQRASRNVMPLGARTASHMTKDMFPGPYPRTPEERAAAAKKYNMRVE
DYEPYPDDGMGYGDYPKLPDRSQHERDPWYSWDQPGLRLNWGEPMHWHLDMYNRNRVDTS
PTPVSWHVMCMQLFGFLAFMIFMCWVGDVYPVYQPVGPKQYPYNNLYLERGGDPSKEPER
VVHYEI
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O95169 |
| UniProtKB/Swiss-Prot Entry Name
| NDUB8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF044958 |
| GeneCard ID
| NDUFB8 |
| GenAtlas ID
| NDUFB8 |
| HGNC ID
| HGNC:7703 |
| References |
|---|
| General References
| Not Available |